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Standard-definition White-light,High-definition White-light versus Narrow-band Imaging Endoscopy for Detecting Colorectal Adenomas:A Multicenter Randomized Controlled Trial

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Current Medical Science 2024年第3期44卷 554-560页

作者： Chang-wei DUAN Hui-hong ZHAI Hui XIE Xian-zong MA Dong-liang YU Lang YANG Xin WANG Yu-fen TANG Jie ZHANG Hui SU Jian-qiu sheng Jun-feng XU Peng jin Chinese PLA General Hospital and Medical School Beijing100853China Department of Gastroenterology Xuanwu HospitalCapital Medical UniversityBeijing100053China Department of Gastroenterology The Seventh Medical Center of Chinese PLA General HospitalBeijing100700China Senior Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing100853China

Objective This study aimed to compare the performance of standard-definition white-light endoscopy(SD-WL),high-definition white-light endoscopy(HD-WL),and high-definition narrow-band imaging(HD-NBI)in detecting colorectal lesions in the Chinese population.Methods This was a multicenter,single-blind,randomized,controlled trial with a non-inferiority design.Patients undergoing endoscopy for physical examination,screening,and surveillance were enrolled from July 2017 to December 2020.The primary outcome measure was the adenoma detection rate(ADR),defined as the proportion of patients with at least one adenoma detected.The associated factors for detecting adenomas were assessed using univariate and multivariate logistic regression.Results Out of 653 eligible patients enrolled,data from 596 patients were analyzed.The ADRs were 34.5%in the SD-WL group,33.5%in the HD-WL group,and 37.5%in the HD-NBI group(P=0.72).The advanced neoplasm detection rates(ANDRs)in the three arms were 17.1%,15.5%,and 10.4%(P=0.17).No significant differences were found between the SD group and HD group regarding ADR or ANDR(ADR:34.5%vs.35.6%,P=0.79;ANDR:17.1%vs.13.0%,P=0.16,respectively).Similar results were observed between the HD-WL group and HD-NBI group(ADR:33.5%vs.37.7%,P=0.45;ANDR:15.5%vs.10.4%,P=0.18,respectively).In the univariate and multivariate logistic regression analyses,neither HD-WL nor HD-NBI led to a significant difference in overall adenoma detection compared to SD-WL(HD-WL:OR 0.91,P=0.69;HD-NBI:OR 1.15,P=0.80).Conclusion HD-NBI and HD-WL are comparable to SD-WL for overall adenoma detection among Chinese outpatients.It can be concluded that HD-NBI or HD-WL is not superior to SD-WL,but more effective instruction may be needed to guide the selection of different endoscopic methods in the future.Our study’s conclusions may aid in the efficient allocation and utilization of limited colonoscopy resources,especially advanced imaging technologies.

关键词： standard-definition white-light endoscopy high-definition white-light endoscopy narrow-band imaging colonoscopy colorectal cancer screening adenoma detection rate

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Effect and Safety of herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling WEN Jian-xuan WU Li-yan ZENG Hui-yan ZHANG jin-ming LU Qi-yun he Liu SONG Wei SUN Lu LUO Lu-lu he Jia-li XIE Wen-wen LIANG Qing-shun HUANG Yuan ZHU sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng WU Ming-hui LI An-xiang HUANG jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled trial.Participants with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in China.All patients received basic treatments for glycemic management.Patients received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic course.If the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 weeks.The primary outcome was change in TCSS-TS score at 12 and 24 weeks.Secondary outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal nerve.Safety was also assessed.Results:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,respectively.After the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(Phe reduction of TCSS-TS score at 12 weeks and the increase of SNCV of median nerve at 24 weeks in the control group were greater than those in the intervention group(Phe number of adverse events did not differ significantly between groups(P>0.05),and no serious adverse event was related with treatment.Conclusion:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry No.Chi CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

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Diagnostic performance of intravascular ultrasound-based fractional flow reserve in evaluating of intermediate left main stenosis

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Journal of Geriatric Cardiology 2024年第1期21卷 34-43页

作者： Yong-Gang SUI Cheng YANG Chang-Dong GUAN Yan-Lu XU Na-Qiong WU Wei-Xian YANG Yong-Jian WU Ke-Fei DOU Yue-jin YANG Shu-Bin QIAO Wei YU Bo XU sheng-Xian TU Jie QIAN Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Catheterization Laboratories Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Biomedical Instrument Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina National Clinical Research Center for Cardiovascular Diseases BeijingChina

BACKGROUND The recently introduced ultrasonic flow ratio(UFR),is a novel fast computational method to derive fractional flow reserve(FFR)from intravascular ultrasound(IVUS)images.In the present study,we evaluate the diagnostic performance of UFR in patients with intermediate left main(LM)stenosis.METHODS This is a prospective,single center study enrolling consecutive patients with presence of intermediated LM lesions(diameter stenosis of 30%-80%by visual estimation)underwent IVUS and FFR measurement.An independent core laboratory assessed offline UFR and IVUS-derived minimal lumen area(MLA)in a blinded fashion.RESULTS Both UFR and FFR were successfully achieved in 41 LM patients(mean age,62.0±9.9 years,46.3%diabetes).An acceptable correlation between UFR and FFR was identified(r=0.688,Phe area under the curve(AUC)in diagnosis of physiologically significant coronary stenosis for UFR was 0.94(95%CI:0.87-1.01),which was significantly higher than angiographic identified stenosis>50%(AUC=0.66,Pher than IVUS-derived MLA(AUC=0.82;P=0.09).Patient level diagnostic accuracy,sensitivity and specificity for UFR to identify FFR≤0.80 was 82.9%(95%CI:70.2-95.7),93.1%(95%CI:82.2-100.0),58.3%(95%CI:26.3-90.4),respectively.CONCLUSION In patients with intermediate LM diseases,UFR was proved to be associated with acceptable correlation and high accuracy with pressure wire-based FFR as standard reference.The present study supports the use of UFR for functional evaluation of intermediate LM stenosis.

关键词： stenosis flow fractional

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习近平总书记关于加强和改进民族工作的重要思想的多维阐释

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新疆大学学报（哲学社会科学版） 2024年第2期52卷 1-11页

作者：陈胜锦华南理工大学马克思主义学院广东广州510641

作为马克思主义民族理论中国化时代化的智慧结晶,习近平总书记关于加强和改进民族工作的重要思想为做好新时代民族工作提供了根本遵循。经典马克思主义镶嵌的民族基本观点、中华优秀传统文化内蕴的民族治理智慧以及革命、建设、改革各... 详细信息

作为马克思主义民族理论中国化时代化的智慧结晶,习近平总书记关于加强和改进民族工作的重要思想为做好新时代民族工作提供了根本遵循。经典马克思主义镶嵌的民族基本观点、中华优秀传统文化内蕴的民族治理智慧以及革命、建设、改革各历史时期党的主要领导人民族工作的理论与实践分别构成了习近平总书记关于加强和改进民族工作的重要思想出场的理论逻辑、文化逻辑和历史逻辑。明确了民族工作的战略定位、廓清了民族工作的价值旨归、提出了民族工作的建设理路是习近平总书记关于加强和改进民族工作的重要思想内容布展的系统性阐发。多维致思习近平总书记关于加强和改进民族工作的重要思想对做好新时代民族工作有着深刻的现实启示:坚持中国共产党的全面领导,筑牢民族工作的政治基石;殚精竭虑发展民族地区经济,夯实民族工作的物质基础;坚持和完善民族区域自治制度,构稳民族工作的制度基座。

关键词：习近平中国共产党民族工作民族地区铸牢中华民族共同体意识

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Opportunities for production and property research of neutron-rich nuclei around N=126 at HIAF

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Nuclear Science and Techniques 2024年第6期35卷 101-113页

作者： Shao-Bo Ma Li-Na sheng Xue-heng Zhang Shi-Tao Wang Kai-Long Wang Chun-Wang Ma Hool-jin Ong Zhi-Yu Sun Shu-Wen Tang Yu-Hong Yu Xin-Tong Du Xiao-Bao Wei Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Beijing 100049China College of Physics Henan Normal UniversityXinxiang 453007China Institute of Nuclear Science and Technology Henan Academy of ScienceZhengzhou 450046China Joint-Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsLanzhou 730000China Research Center for Nuclear Physics Osaka UniversityOsaka 567-0047Japan RIKEN Nishina Center Saitama 351-0198Japan Northwest Normal University Lanzhou 730070China

The study of nuclide production and its properties in the N=126 neutron-rich region is prevalent in nuclear physics and astrophysics research.The upcoming High-energy FRagment Separator(HFRS)at the High-Intensity heavy-ion Accelerator Facility(HIAF),an in-flight separator at relativistic energies,is characterized by high beam intensity,large ion-optical acceptance,high magnetic rigidity,and high momentum resolution power.This provides an opportunity to study the production and properties of neutron-rich nuclei around N=126.In this paper,an experimental scheme is proposed to produce neutron-rich nuclei around N=126 and simultaneously measure their mass and lifetime based on the HFRS separator;the feasibility of this scheme is evaluated through simulations.The results show that under the high-resolution optical mode,many new neutron-rich nuclei approaching the r-process abundance peak around A=195 can be produced for the first time,and many nuclei with unknown masses and lifetimes can be produced with high statistics.Using the time-of-flight corrected by the measured dispersive position and energy loss information,the cocktails produced from 208 Pb fragmentation can be unambiguously identified.Moreover,the masses of some neutron-rich nuclei near N=126 can be measured with high precision using the time-of-flight magnetic rigidity technique.This indicates that the HIAF-HFRS facility has the potential for the production and property research of neutron-rich nuclei around N=126,which is of great significance for expanding the chart of nuclides,developing nuclear theories,and understanding the origin of heavy elements in the universe.

关键词： HFRS Fragmentation Neutron-rich nuclei around N=126 Mass measurement Lifetime

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CD4^(-)CD56^(+)母细胞性浆细胞样树突细胞肿瘤的临床特征

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中国实验血液学杂志 2024年第2期32卷 588-594页

作者：何合胜魏元凤季新悦徐又海杨玉琼靳小可皖南医学院第一附属医院血液科安徽芜湖241001

目的:探讨CD4^(-)CD56^(+)母细胞性浆细胞样树突细胞肿瘤患者的临床表现、病理特点、免疫表型、诊治经过及预后,以提高对此类罕见疾病的认识。方法:对本院就诊的两例CD4^(-)CD56^(+)母细胞性浆细胞样树突细胞肿瘤患者的临床资料、实验... 详细信息

目的:探讨CD4^(-)CD56^(+)母细胞性浆细胞样树突细胞肿瘤患者的临床表现、病理特点、免疫表型、诊治经过及预后,以提高对此类罕见疾病的认识。方法:对本院就诊的两例CD4^(-)CD56^(+)母细胞性浆细胞样树突细胞肿瘤患者的临床资料、实验室资料、治疗方案进行回顾性分析。结果:两例患者均为老年男性,肿瘤累及皮肤、骨髓、淋巴结等部位,皮肤病理显示,CD56、CD123均为阳性,而CD4、CD34、TdT、CD3、CD20、MPO、EBER均为阴性。骨髓流式细胞检测结果显示,CD56、CD123、CD304均为阳性,而髓系、淋系特异性免疫标志均为阴性。两例患者初始对急性淋巴细胞白血病或淋巴瘤样化疗方案非常敏感,但短期内复发,生存期分别为36、4个月。结论:CD4^(-)CD56^(+)母细胞性浆细胞样树突细胞肿瘤罕见,该病容易误诊且预后差,应优先采用急性淋巴细胞白血病或淋巴瘤样的治疗方案改善不良预后。

关键词：母细胞性浆细胞样树突细胞肿瘤诊断治疗临床病理

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Serum inflammatory markers in children with Mycoplasma pneumoniae pneumonia and their predictive value for mycoplasma severity

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World Journal of Clinical Cases 2024年第22期12卷 4940-4946页

作者： Li-Ping Wang Zhong-Hua Hu Jun-sheng Jiang Jie jin Department of Pediatrics The First People's Hospital of Linping DistrictHangzhou 310000Zhejiang ProvinceChina Department of Pediatrics Changzhou Children HospitalChangzhou 213100Jiangsu ProvinceChina

BACKGROUND Mycoplasma pneumoniae pneumonia(MPP)significantly impacts pediatric health,necessitating markers for early severe disease identification.AIM To investigate the correlation between serum inflammatory marker and the severity of MPP in children.METHODS A prospective study was carried out from January 2023 to November 2023.A total of 160 children with MPP who underwent treatment were selected:80 had severe MPP and 80 had mild MPP.Clinical and laboratory data were collected at the time of hospital admission and during hospitalization.Receiver operating characteristic curves were utilized to assess the diagnostic and prognostic for severe MPP.RESULTS Fever duration and length of hospitalization in pediatric patients with severe MPP exceeded those with mild MPP.The incidence of pleural effusion,lung consolidation,and bronchopneumonia on imaging was markedly elevated in the severe MPP cohort compared to the mild MPP cohort.In contrast to the mild cohort,there was a notable increase in C-reactive protein(CRP),procalcitonin(PCT),erythrocyte sedimentation rate,lactic dehydrogenase,D-dimer,and inflammatory cytokines[interleukin(IL)-6,IL-8,IL-10 and tumor necrosis factor(TNF)-α]in the severe MPP group were significantly higher.CONCLUSION Serum inflammatory markers(CRP,PCT,IL-6,D-dimer,IL-10 and TNF-α)were considered as predictors in children with severe MPP.

关键词： Cytokine Mycoplasma pneumoniae pneumonia Children,Community-acquired pneumonia levels Interleukin-6 D-dimer

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基于二阶统计特性的方向向量估计算法的DOA估计

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电子与信息学报 2024年第2期46卷 697-704页

作者：侯进盛尧宝张波西南交通大学信息科学与技术学院智能感知智慧运维实验室成都611756

为了减小天线阵流形误差对波达方向(DOA)估计结果的影响,以及克服基于传统盲源分离算法的DOA估计算法不能应用于少通道测向设备的不足,提出一种基于2阶统计特性的方向向量估计算法的DOA估计算法。首先,根据确定性最大似然(DML)估计算法... 详细信息

为了减小天线阵流形误差对波达方向(DOA)估计结果的影响,以及克服基于传统盲源分离算法的DOA估计算法不能应用于少通道测向设备的不足,提出一种基于2阶统计特性的方向向量估计算法的DOA估计算法。首先,根据确定性最大似然(DML)估计算法谱函数的特征,构造关于协方差矩阵的酉约束下的优化问题;然后,通过优化该问题获得各个单信号的实际方向向量;最后,将各个单信号的实际方向向量输入到空间谱算法中实现DOA估计。由于将多信号的DOA估计转化为多个单信号的DOA估计,因此在天线阵列流形存在误差时,所提算法比传统的DOA方法具有更好的DOA估计性能。由于所提算法仅需使用协方差矩阵,因此所提算法可应用于少通道测向设备。由仿真实验结果可知,在阵列流形存在误差以及测向设备为少通道测向设备时,与传统DOA方法相比,所提算法的DOA估计的准确度、抗扰度以及分辨率更高。

关键词： DOA估计天线阵列流形误差盲源分离酉约束

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Revisiting the top-quark pair production at future e^(+)e^(−)colliders

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Chinese Physics C 2024年第4期48卷 82-88页

作者：马进王声权孙婷申建明吴兴刚 Department of Physics Guizhou Minzu UniversityGuiyang 550025China School of Physics and Electronics Hunan Provincial Key Laboratory of High-Energy Scale Physics and ApplicationsHunan UniversityChangsha 410082China Department of Physics Chongqing Key Laboratory for Strongly Coupled PhysicsChongqing UniversityChongqing 401331China

In this study,we reanalyze the top-quark pair production at next-to-next-to-leading order(NNLO)in quantum chromodynamics(QCD)at future e^(+)e^(−)colliders using the Principle of Maximum Conformality(PMC)method.The PMC renormalization scales inαs are determined by absorbing the non-conformalβterms by recursively using the Renormalization Group Equation(RGE).Unlike the conventional scale-setting method of fixing the scale at the center-of-mass energyμ_(r)=√s,the determined PMC scale Q_(⋆)is far smaller than the √sand increases with the √s,yielding the correct physical behavior for the top-quark pair production process.Moreover,the convergence of the pQCD series for the top-quark pair production is greatly improved owing to the elimination of the renormalon divergence.For a typical collision energy of √s=500 GeV,the PMC scale is Q_(⋆)=107 GeV;the QCD correction factor K for conventional results is K∼1+0.1244+0.0102+0.0012−0.0087−0.0011+0.0184−0.0086+0.0002+0.0061−0.0003,where the first error is caused by varying the scaleμr∈[√s/2,2√s]and the second error is from the top-quark massΔm_(t)=±0.7 GeV.After applying the PMC,the renormalization scale uncertainty is eliminated,and the QCD correction factor K is improved to K∼1+0.1507_(−0.0015)^(+0.0015)−0.0057_(−0.0000)^(+0.0001),where the error is from the top-quark massΔm_(t)=±0.7 GeV.The PMC improved predictions for the top-quark pair production are helpful for detailed studies of the properties of the top-quark at future e^(+)e^(−)colliders.

关键词： top-quark lepton colliders Renormalization Group Equation QCD correction

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新媒介何以“持续生长”:数字媒介生态视角下的数字可持续性

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编辑之友 2024年第1期32卷 92-99页

作者：金圣钧钟新中国人民大学新闻学院北京100872 中国人民大学新闻与社会发展研究中心北京100872

近年来,受到本土功能主义应用式传播研究风气的影响,相关研究对数字媒介生态理论维度和分析视角的革新、凝练和批判有所欠缺。文章在梳理对媒介生态学相关误读的基础上,探讨了从传统媒介生态学到数字媒介生态的进化机理与内涵变迁。在... 详细信息

近年来,受到本土功能主义应用式传播研究风气的影响,相关研究对数字媒介生态理论维度和分析视角的革新、凝练和批判有所欠缺。文章在梳理对媒介生态学相关误读的基础上,探讨了从传统媒介生态学到数字媒介生态的进化机理与内涵变迁。在此基础上,引入数字可持续性概念,从数字平台生态系统、数字媒介时间的生态学层面和数字保存、数字共享的传播层面解读数字可持续性的内涵和发展方向,关注在媒介生态变迁中如何延长数字寿命等问题。文章认为,数字媒介运作中物质与非物质、人类与非人类等因素如何在特定语境中通过组合实现持续性生长,是研究数字媒介生态时需长久关注的问题。

关键词：数字媒介生态数字可持续性媒介生态学数字化传播媒介技术

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