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Genetic polymorphism of MCP-1-2518,IL-8-251 and susceptibility to acute pancreatitis:A pilot study in population of Suzhou,China

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World Journal of Gastroenterology 2008年第37期14卷 5744-5748页

作者： Wei-Chang Chen jin-shan nie Department of Gastroenterology the FirstAffiliated Hospital Suzhou University Suzhou 215006 JiangsuProvince China Department of Gastroenterology TaicangHospital the Affiliated Hospital of Suzhou University Taicang215400 Jiangsu Province China

AIM： To study the relationship between MCP-1-2518A/ G, IL-8-251A/T polymorphism and acute pancreatitis （AP） in the Han population of Suzhou, China. METHODS： A case-control study was conducted to compare the distribution of genotype and genetic frequency of MCP-1-2518A/G, IL-8-251A/T gene polymorphism among AP （n = 101）, including mild AP （n = 78） and severe AP （n = 23） and control healthy individuals （n = 120） with polymerase chain reaction- restriction fragment length polymorphism （PCR-RFLP） and DNA sequencing, and analyze the relationship between the MCP-1-2518A/G, IL-8-251A/T gene polymorphism and the susceptibility to AP. RESULTS： Significant differences were found in the distribution of genotype of MCP-1-2518A/G between the healthy control group and mild AP group （χ^2 = 32.015, P 〈 0.001）, the same was evident between the healthy control group and severe AP group （χ^2 = 12.932, P 〈 0.05） in Suzhou. However, no difference of genotypic distribution was noted between MAP and SAP （Z2 = 0.006, P = 0.997）. The genetic frequencies of G allele in mild AP were 72.4% （113/156） and 76.1% （35/46） in severe AP, both were higher than the controls, 47.1% （113/240）（χ^2 = 24.804; P 〈 0.001, and 4,2 = 13：005; P 〈 0.001）, but no difference was found between severe AP and mild AP （χ^2 = 0.242, P = 0.623）. No difference was found in the distribution of genotype of IL-8-251A/T between the healthy control group and AP group neither in the frequency of A and T allele. CONCLUSION： The MCP-1-2518 AA genotype of the population in Suzhou may be a protective genotype of AP, while one with higher frequency of G allele is more likely to suffer from pancreatitis. But the genotype of AA and the frequency of G allele could not predict the risk of severe AP. No correlation is found between the IL-8-251 polymorphism and the liability of AP.

关键词： Acute pancreatitis MCP-1 DNA IL-8 DNA Polymorphism

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A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi Liu Jianye Xie Runxue Zhou jin Deng Weihong nie Shuwei Sun Haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

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Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys: A First-principles Study

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 246-257页

作者： ZHANG Jian nie Wei HUANG jin ZHU Ke LIU Ruxia ZHANG Ruizhi LUO Guoqiang SHEN Qiang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermodynamic properties of W-Ti alloys(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloys)were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W_(8)Ti_(8) are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

关键词： first-principles mechanical properties thermodynamic properties tungsten-titanium alloys

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Quantum Teleportation Through a Two-Qubit Heisenberg XXZ Chain

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Communications in Theoretical Physics 2008年第6期49卷 1435-1438页

作者： GUO jin-Liang nie jing SONG He-shan School of Physics and Optoelectronic Technology Dalian University of Technology Dalian 116024 China

We consider a two-qubit Heisenberg XXZ chain as a resource for quantum teleportation via the standard teleportation protocol To. The effects of anisotropic on teleportation fidelity and entanglement are studied in detail. We find anisotropic not only improves the criticM temperature Tc and criticM magnetic field Bc, beyond which quantum teleportation is inferior to classicM communication protocol, but also enhances the fidelity for fixed magnetic field B and temperature T. For entanglement teleportation, the effects of magnetic field on average fidelity and output entanglement are studied.

关键词： thermal entanglement negativity two-qubit Heisenberg XXZ chain

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Influence of Isotope Effects on Product Polarizations of N(~2D)+D_2, N(~2D)+H_2 and N(~2D)+HD Reactive Systems

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Chemical Research in Chinese Universities 2012年第5期28卷 897-902页

作者： nie shan-shan CHU Tian-shu State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023P.R.China Institute for Computational Sciences and Engineering Laboratory of New Fiber Materials and Modern Textilethe Growing Base for State Key LaboratoryQingdao UniversityQingdao 266071P.R.China

To figure out the influence of isotope effect on product polarizations of the N（2D）＋D2 reactive system and its isotope variants, quasi-classical trajectory（QCT） calculation was performed on Ho＇s potential energy surface（PES） of 2A″ state. Product polarizations such as product distributions of P（θr）, P（φr） and P（θr,φr）, as well as the generalized polarization-dependent differential cross sections（PDDCSs） were discussed and compared in detail among the four product channels of the title reactions. Both the intermolecular and intramolecular isotope effects were proved to be influential on product polarizations.

关键词： Isotope effect Product polarization Quasi-classical trajectory calculation Potential energy surface

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Effect of Precipitated Phases on Corrosion of Mg95.8Gd3Zn1Zr0.2 Alloy with Long-Period Stacking Ordered Structure

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Acta Metallurgica Sinica(English Letters) 2016年第1期29卷 32-38页

作者： Xi-Mei zong Dan Wang Wei Liu Kai-Bo nie Chun-Xiang Xu jin-shan Zhang College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 China shanxi Key Laboratory of Advanced Magnesium-Based Materials Taiyuan 030024 China Department of Chemistry Taiyuan Normal UniversityTaiyuan 030031 China

The microstructure of the precipitated phases of ***3Zn1Zro.2 alloys with long-period stacking ordered structure before and after heat treatment is discussed. The corrosion properties of the as-cast （F）, solid-solution （T4） and aging-treated （T6） alloys in 1% NaC1 solution are studied. The hydrogen evolution and electrochemical measurements display that the as-cast ***3Zn1Zro.2 alloy with the continuous network eutectic phase exhibits the greatest corrosion resistance, while T6 sample with some needle-like phases and the particle phases is the worst among the three alloys. It is proposed to be mainly related to the amount, composition, microstructure and distribution of the precipitated phases.

关键词： Mg-Gd-Zn Corrosion properties Long-period stacking ordered (LPSO) Microstructure

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Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys:A First-principles Study

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期 246-257页

作者：张建 nie Wei HUANG jin ZHU Ke LIU Ruxia 张睿智 LUO Guoqiang SHEN Qiang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Institute for Carbon Neutrality University of Science and Technology Beijing

The mechanical and thermodynamic properties of W-Ti alloys (including W15Ti1,W14Ti2,W12Ti4and W8Ti8alloys) were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W8Ti8are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

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Analysis for MIMO correlated frequency-selective channel in the presence of interference

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Journal of Systems Engineering and Electronics 2008年第4期19卷 679-682页

作者： Xiao Hailin nie Zaiping Li Xin Ouyang shan School of Information and Communication Guilin Univ. of Electronic Technology Guilin 541004 P. R. China School of Electronic Engineering Univ. of Electronic Science and Technology of China Chengdu 610054 P. R. China

The space time spreading, superimposed training sequences, and space-time coding are used to present a multiple input and multiple output （MIMO） systems model, and a closed-form of average error probability upper bound expression for MIMO correlated frequency-selective channel in the presence of interference （co-channel interference and jamming signals） is derived. Moreover, the correlation at both ends of the wireless link that can be incorporated equivalently into correlation at the transmit end is also derived, which is significant to analyze space-time link algorithm of MIMO systems.

关键词： average error probability upper bound Chernoff bound space time spreading space time coding

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Capacity analysis of high-rank line-of-sight MIMO channels

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Journal of Systems Engineering and Electronics 2009年第4期20卷 706-710页

作者： Xiao Hailin Ouyang shan nie Zaiping Zhao Feng School of Information and Communications Guilin Univ. of Electronic Technology Guilin 541004 P. R. China School of Electronic engineering Univ. of Electronic Science and Technology of china Chengdu 610054 P. R. China

Matrix perturbation theory is utilized to investigate high-rank line of sight multiple input multiple output channels in a microwave relay system. The upper and lower bounds of channel capacity are derived based on space time block codes technique and singular values decomposition. A useful constraint for designing LOS MIMO channels is developed by the use of the condition number of the MIMO channel matrix. The theoretical analysis of channel capacity is confirmed by the simulation. The results show that the proposed method is able to give a physical explanation of the high-rank LOS MIMO channel matrix characteristics.

关键词： MIMO channel matrix perturbation theory condition number space time block code

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Progress in Mechanism of Astragalus membranaceus and Its Chemical Constituents on Multiple Sclerosis

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Chinese Journal of Integrative Medicine 2023年第1期29卷 89-95页

作者： PENG Yong DENG Xiang YANG shan-shan nie Wei TANG Yan-dan Department of Neurology Affiliated First Hospital of Hunan Traditional Chinese Medical CollegeZhuzhouHunan Province412000China

The primary chemical components of Astragalus membranaceus include polysaccharides,saponins,flavonoids,and amino *** studies have shown that Astragalus membranaceus has multiple functions,including improving immune function and exerting antioxidative,anti-radiation,anti-tumor,antibacterial,antiviral,and hormone-like *** membranaceus and its extracts are widely used in clinical practice because they have obvious therapeutic effects against various autoimmune diseases and relatively less adverse *** sclerosis(MS)is an autoimmune disease of central nervous system(CNS),which mainly caused by immune disorder that leads to inflammatory demyelination,inflammatory cell infiltration,and axonal degeneration in the *** this review,the authors analyzed the clinical manifestations of MS and experimental autoimmune encephalomyelitis(EAE)and focused on the efficacy of Astragalus membranaceus and its chemical components in the treatment of MS/EAE.

关键词： Astragalus membranaceus chemical components multiple sclerosis experimental autoimmune encephalomyelitis immunoregulation

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