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World Journal of Gastroenterology 2014年第35期20卷 12687-12690页

作者： Ji Eun Kim Tae-Geun Gweon Chang Dong Yeo Young-seok Cho Gi Jun Kim Jae Young Kim Jong Wook Kim Hyunho Kim Hye Won Lee Taeseok Lim Hyoju Ham Hyun jin oh Yeongbok Lee Jaeho Byeon Sung Soo Park Department of Internal Medicine Seoul St Mary’s hospitalThe Catholic University of KoreaCollege of Medicine Division of Gastroenterology Department of Internal MedicineSeoul St.Mary’s HospitalThe Catholic University of KoreaCollege of Medicine Division of Pulmonology Department of Internal MedicineUijeongbu St.Mary’s HospitalThe Catholic University of KoreaCollege of Medicine Division of Gastroenterology Department of Internal MedicineUijeongbu St.Mary’s HospitalThe Catholic University of KoreaCollege of Medicine

Acute respiratory distress syndrome is a life-threatening disorder caused mainly by *** difficile infection(CDI)is a common nosocomial diarrheal *** of normal intestinal flora by antibiotics is the main risk factor for *** use of broadspectrum antibiotics for serious medical conditions can make it difficult to treat CDI complicated by acute respiratory distress *** microbiota transplantation is a highly effective treatment in patients with refractory *** we report on a patient with refractory CDI and acute respiratory distress syndrome caused by pneumonia who was treated with fecal microbiota transplantation.

关键词： Clostridium difficile infection Acute respiratory distress syndrome Fecal microbiota transplantation

Assessment of disease activity by fecal immunochemical test in ulcerative colitis

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World Journal of Gastroenterology 2016年第48期22卷 10617-10624页

作者： Dae Gon Ryu Hyung Wook Kim Su Bum Park Dae Hwan Kang Cheol Woong Choi Su jin Kim Hyeong seok Nam Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital

AIM To evaluate the efficacy of quantitative fecal immunochemical test(FIT) as biomarker of disease activity in ulcerative colitis(UC).METHODS Between February 2013 and November 2014, a total of 82 FIT results, obtained in conjunction with colonoscopies, were retrospectivelyevaluated for 63 patients with UC. The efficacy of FIT for evaluation of disease activity was compared to colonoscopic findings. Quantitative fecal blood with automated equipment examined from collected feces. Endoscopic disease severity were assessed using the Mayo endoscopic subscore(MES) classification. The extent of disease were classified by proctitis(E1), left sided colitis(E2), and extensive colitis(E3). Clinical activity were subgrouped by remission or *** All of 21 patients with MES 0 had negative FIT( 134.89 ng/m L. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and accuracy of negative FIT about mucosal healing were 73.33%, 81.82%, 91.49%, 51.43% and 73.17%, respectively. The sensitivity, specificity, PPV, NPV and accuracy of predictive value of positive FIT(cutoff value > 100 ng/mL) about active disease status were 45.45%, 93.33%, 71.43%, 82.35%and 26.83%, respectively. Among patients with clinical remission, FIT was negative in 31(81.6%) of 38 cases, with a mean fecal hemoglobin concentration of 6.12 ng/mL(range, negative to 80.9 ng/mL) for this group of patients. Among patients with clinical active disease, FIT was negative in 16(36.4%) out of 44 cases, with a mean fecal hemoglobin concentration > 167.4 ng/mL for this group of patients. FIT was positively correlated with endoscopic activity(r = 0.626, P < 0.01) and clinical activity(r = 0.496, P < 0.01). But, FIT did not correlate with the extent of disease(r =-0.047, P = 0.676)CONCLUSION Quantitative FIT can be a non-invasive and effective biomarker for evaluation of clinical and endoscopic activity in UC, but not

关键词： Ulcerative colitis Fecal immunochemical test Mayo endoscopic subscore Biomarker Disease activity

Is endoscopic ultrasonography essential for endoscopic resection of small rectal neuroendocrine tumors?

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World Journal of Gastroenterology 2017年第11期23卷 2037-2043页

作者： Su Bum Park Dong Jun Kim Hyung Wook Kim Cheol Woong Choi Dae Hwan Kang Su jin Kim Hyeong seok Nam Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanGyeongsangnam-do 626-770South Korea

AIM To evaluate the importance of endoscopic ultrasonography(EUS) for small(≤ 10 mm) rectal neuroendocrine tumor(NET) *** Patients in whom rectal NETs were diagnosed by endoscopic resection(ER) at the Pusan National University Yangsan Hospital between 2008 and 2014 were included in this study. A total of 120 small rectal NETs in 118 patients were included in this study. Histologic features and clinical outcomes were analyzed, and the findings of endoscopy, EUS and histology were compared. RESULTS The size measured by endoscopy was not significantly different from that measured by EUS and histology(r = 0.914 and r = 0.727 respectively). Accuracy for the depth of invasion was 92.5% with EUS. No patients showed invasion of the muscularis propria or metastasis to the regional lymph nodes. All rectal NETswere classified as grade 1 and demonstrated an L-cell phenotype. Mean follow-up duration was 407.54 ± 374.16 d. No patients had local or distant metastasis during the follow-up periods. CONCLUSION EUS is not essential for ER in the patient with small rectal NETs because of the prominent morphology and benign behavior.

关键词： Neuroendocrine tumor Small Rectal Endoscopic ultrasonography Histology Endoscopy

Efficacy and safety of limited endoscopic sphincterotomy before self-expandable metal stent insertion for malignant biliary obstruction

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World Journal of Gastroenterology 2017年第9期23卷 1627-1636页

作者： Hyeong seok Nam Dae Hwan Kang Hyung Wook Kim Cheol Woong Choi Su Bum Park Su jin Kim Dae Gon Ryu Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsan-siGyeongsangnam-do 50612South Korea

To evaluate the safety and efficacy of limited endoscopic sphincterotomy (ES) before placement of self-expandable metal stent (SEMS).METHODSThis was a retrospective analysis of 244 consecutive patients with unresectable malignant biliary obstruction, who underwent placement of SEMSs following limited ES from December 2008 to February 2015. The diagnosis of malignant biliary obstruction and assessment of patient eligibility for the study was established by a combination of clinical findings, laboratory investigations, imaging and pathological results. All patients were monitored in the hospital for at least 24 h following endoscopic retrograde cholangio pancreatography (ERCP). The incidence of immediate or early post-ERCP complications such as post-ERCP pancreatitis (PEP) and bleeding related to limited ES were considered as primary outcomes. Also, characteristics and complications according to the cancer type were *** the 244 patients included, the underlying diagnosis was cholangiocarcinoma in 118 patients, pancreatic cancer in 79, and non-pancreatic or non-biliary malignancies in the remaining 47 patients. Early post-ERCP complications occurred in 9 patients (3.7%), with PEP in 7 patients (2.9%; mild, 6; moderate, 1) and mild bleeding in 2 patients (0.8%). There was no significant association between the incidence of post-ERCP complications and the type of malignancy (cholangiocarcinoma vs pancreatic cancer vs others, P = 0.696) or the type of SEMS used (uncovered vs covered, P = 1.000). Patients who had more than one SEMS placed at the first instance were at a significantly higher risk of post-ERCP complications (one SEMS vs two SEMS, P = 0.031). No other factors were predictive of post-ERCP *** ES is feasible and safe, and effectively facilitates the placement of SEMS, without any significant risk of PEP or severe bleeding.

关键词： Endoscopic sphincterotomy Endoscopic retrograde cholangio pancreatography Complications Pancreatitis Bleeding Cholestasis Self-expandable metal stent

Electronically coupled layered double hydroxide/MXene quantum dot metallic hybrids for high-performance flexible zinc–air batteries

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InfoMat 2021年第10期3卷 1134-1144页

作者： Xiaotong Han Nannan Li Peixun Xiong Min Gyu Jung Yingbo Kang Qingyun Dou Qing Liu jin Yong Lee Ho seok Park School of Chemical Engineering Sungkyunkwan University(SKKU)SuwonRepublic of Korea Department of Chemistry Institute of Basic ScienceSungkyunkwan UniversitySuwonRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

Precise control of the local electronic structure and properties of electrocatalysts is important for enhancing the multifunctionality and durability of electrocatalysts and for correlating the structure/chemistry with the catalytic ***,we report electronically coupled metallic hybrids of NiFe layered double hydroxide nanosheet/Ti3C2 MXene quantum dots deposited on a nitrogen-doped graphene surface(LDH/MQD/NG)for high-performance flexible Zn-air batteries(ZABs).As verified from the Mott-Schottky and Nyquist plots,as well as spectroscopic,electrochemical,and computational analyses,the electronic and chemical coupling of LDH/MQD/NG modulates the local electronic and surface structure of the active LDH to provide metallic conductivity and abundant active sites,leading to significantly improved bifunctional activity and electrocatalytic *** rechargeable ZABs with LDH/MQD/NG hybrids are superior to the previous LDH-based ZABs,demonstrating a high power density(113.8 mW cm^(-2))and excellent cycle stability(150 h at 5 mA cm^(-2)).Moreover,the corresponding quasi solid-state ZABs are completely flexible and practical,affording a high power density of 57.6 mW cm^(-2)even in the bent state,and in real-life operation of tandem cells for powering various electronic devices.

关键词： 2D quantum dots flexible battery metallic hybrids oxygen electrochemistry Zn-air battery

Bacterial peptide deformylase inhibitor PMT analogs inhibit cancer cell growth by interacting with human peptide deformylase

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Chinese Science Bulletin 2014年第32期59卷 4274-4282页

作者： Won-Je Kim Woo Sung Son Kyoung-seok Ryu Seung-Kyu Lee Kwang-Hyun Choi Jong-Sun Lee Bong-jin Lee College of Pharmacy Seoul National University Seoul 151-742Korea College of Pharmacy CHA University SeongnamGyeonggi-do 487-010 Korea Division of Magnetic Resonance Korea Basic Science InstituteOchang Campus Seoul Chungcheongbuk-Do 363-883 Korea Promeditech Ltd Seoul National University Seoul 151-742Korea

Potent inhibitors of human peptide deformylase(HsPDF)were screened using known PMT analog inhibitors of bacterial peptide ***-three species of PMT analogs that are non-peptidyl bacterial PDF inhibitors like actinonin were selected using virtual screening *** species out of 43 that could bind to HsPDF were selected and their antitumor activities were *** them,four species(PMT-172,PMT-173,PMT-199,and PMT-201)showed excellent growth inhibition of cancer cell in the MTT ***-PMT binding was confirmed through a1H-CPMG-T2filter NMR experiment leading to a significant change in peak intensity for PMT-172 and *** results suggest that PMT analogs could possibly interact with HsPDF and be a novel anticancer drug candidate.

关键词：相互作用抑制剂类似物 PMT 癌细胞类肽细胞生长细菌

Dissecting microRNA-mediated regulation of stemness,reprogramming,and pluripotency

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Cell Regeneration 2016年第1期5卷 12-21页

作者： Young jin Lee Suresh Ramakrishna Himanshu Chauhan Won Sun Park seok-Ho Hong Kye-Seong Kim iDream Research Center MizMedi Women’s HospitalSeoul 07639South Korea Department of Biomedical Science Graduate School of Biomedical Science and EngineeringHanyang University222 Wangsimni-roSeongdong-guSeoul 04763South Korea College of Medicine Hanyang UniversitySeoulSouth Korea Uppsala University 75236 UppsalaSweden Department of Physiology School of MedicineKangwon National UniversityChuncheon 24341South Korea Department of Internal Medicine School of MedicineKangwon National University1 Kangwondaehak-gilChuncheon-siGangwon-do 24341South Korea Stem Cell Institute Kangwon National UniversityChuncheon 24341South Korea

Increasing evidence indicates that microRNAs(miRNAs),endogenous short non-coding RNAs 19–24 nucleotides in length,play key regulatory roles in various biological events at the post-transcriptional *** stem cells(ESCs)represent a valuable tool for disease modeling,drug discovery,developmental studies,and potential cell-based therapies in regenerative medicine due to their unlimited self-renewal and ***,remarkable progress has been made in recent decades toward understanding the expression and functions of specific miRNAs in the establishment and maintenance of ***,we summarize the recent knowledge regarding the regulatory roles of miRNAs in self-renewal of pluripotent ESCs and during cellular reprogramming,as well as the potential role of miRNAs in two distinct pluripotent states(naïve and primed).

关键词： miRNAs Embryonic stem cells Pluripotency Reprogramming Self-renewal

Tenofovir rescue therapy for chronic hepatitis B patients after multiple treatment failures

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World Journal of Gastroenterology 2012年第47期18卷 6996-7002页

作者： Yu jin Kim Dong Hyun Sinn Geum-Youn Gwak Moon seok Choi Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Joon Hyeok Lee Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135-710South Korea

AIM:To evaluate the efficacy and safety of tenofovir disoproxil fumarate(TDF) for chronic hepatitis B(CHB) patients after multiple ***:A total of 29 CHB patients who had a suboptimal response or developed resistance to two or more previous nucleoside/nucleotide analogue(NA) treatments were *** subjects were treated with TDF alone(n = 13) or in combination with lamivudine(LAM,n = 12) or entecavir(ETV,n = 4) for ≥ 6 *** virologic response(CVR) was defined as an achievement of serum hepatitis B virus(HBV) DNA level ≤ 60 IU/mL by real-time polymerase chain reaction method during *** assessment was based on serum creatinine and phosphorus *** patients had histories of LAM and adefovir dipivoxil(ADV) treatment and 18 patients were exposed to LAM,ADV,and ***-seven patients(93.1%) were hepatitis B e antigen(HBeAg) positive and the mean value of the baseline serum HBV DNA level was 5.5 log IU/mL ± 1.7 log IU/*** median treatment duration was 16 mo(range 7 to 29 mo).RESULTS:All the patients had been treated with LAM and developed genotypic and phenotypic resistance to *** to ADV was present in 7 patients and 10 subjects had a resistance to *** patient had a resistance to both ADV and *** cumulative probabilities of CVR at 12 and 24 mo of TDF containing treatment regimen calculated by the Kaplan Meier method were 86.2% and 96.6%,*** one patient failed to achieve CVR,serum HBV DNA level decreased by 3.9 log IU/mL from the baseline and the last serum HBV DNA level during treatment was 85 IU/mL,achieving near *** patients in this study showed viral breakthrough or primary non-response during the follow-up *** cumulative probability of HBeAg clearance in the 27 HBeAg positive patients was 7.4%,12%,and 27% at 6,12,and 18 mo of treatment,*** efficacy of TDF containing regimen was not statistically different according to the presence of specific HBV mutatio

关键词： Tenofovir Chronic hepatitis B Treatment failure

Strong contact coupling of neuronal growth cones with height-controlled vertical silicon nanocolumns

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Nano Research 2018年第5期11卷 2532-2543页

作者： Seong-Min Kim Seyeong Lee Dongyoon Kim Dong-Hee Kang Kisuk Yang Seung-Woo Cho jin seok Lee Insung S. Choi Kyungtae Kang Myung-Han Yoon School of Materials Science and Engineering Gwangju Institute of Science and Technology Gwongju 61005 Republic of Korea Department of Biotechnology Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 Republic of Korea Department of Chemistry Sookmyung Women's University Seoul 04310 Republic of Korea Center for Cell-Encapsulation Research Department of Chemistry KAIST Daejeon 34141 Republic of Korea Department of Applied Chemistry Kyung Hee University Yongin Gyeonggi 17104 Republic of Korea

In this study, we report that height-controlled vertically etched silicon nano- column arrays （vSNAs） induce strong growth cone-to-substrate coupling and accelerate in vitro neurite development while preserving the essential features of initial neurite formation. Large-scale preparation of vSNAs with flat head morphology enabled the generation of well-controlled topographical stimulation without cellular impalement. A systematic analysis on topography- induced variations on cellular morphology and cytoskeletal dynamics was conducted. In addition, neurite development on the grid-patterned vSNAs exhibited preferential adhesion to the nanostructured region and outgrowth directionality. The arrangement of cytoskeletal proteins and the expression of a focal adhesion complex indicated that a strong coupling existed between the underlying nanocolumns and growth cones. Furthermore, the height-controlled nanocolumn substrates differentially modulated neurite polarization and elongation. Our findings provide an important insight into neuron-nanotopography interactions and their role in cell adhesion and neurite development.

关键词： vertical silicon nanostructures metal-assisted chemical etching primary hippocampal neurons neurite outgrowth cytoskeletal dynamics

Interactions between Transmembrane Helices within Monomers of the Aquaporin AtPIP2;1 Play a Crucial Role in Tetramer Formation

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Molecular Plant 2016年第7期9卷 1004-1017页

作者： Yun-Joo Yoo Hyun Kyung Lee Wonhee Han Dae Heon Kim Myoung Hui Lee Jouhyun Jeon Dong Wook Lee Junho Lee Yongjik Lee Juhun Lee jin seok Kim Yunje Cho jin-Kwan Han Inhwan Hwang School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology Pohang 790-784 Korea Department of Life Sciences Pohang University of Science and Technology Pohang 790-784 Korea Department of Biology Sunchon National University Sunchon 57922 Korea Division of Integrative Biosciences and Biotechnology Pohang University of Science and Technology Pohang 790-784 Korea

Aquaporin （AQP） is a water channel protein found in various subcellular membranes of both prokaryotic and eukaryotic cells. The physiological functions of AQPs have been elucidated in many organisms. However, understanding their biogenesis remains elusive, particularly regarding how they assemble into tetramers. Here, we investigated the amino acid residues involved in the tetramer formation of the Arabidopsis plasma membrane AQP AtPIP2;1 using extensive amino acid substitution mutagenesis. The mutant proteins V41A/ E44A, F51A/L52A, F87A/191A, F92A/193A, V95A/Y96A, and H216A/L217A, harboring alanine substitutions in the transmembrane （TM） helices of AtPIP2;1 polymerized into multiple oligomeric complexes with a vari- able number of subunits greater than four. Moreover, these mutant proteins failed to traffic to the plasma membrane, instead of accumulating in the endoplasmic reticulum （ER）. Structure-based modeling revealed that these residues are largely involved in interactions between TM helices within monomers. These results suggest that inter-TM interactions occurring both within and between monomers play crucial roles in tetramer formation in the AtPIP2;1 complex. Moreover, the assembly of AtPIP2;1 tetramers is critical for their trafficking from the ER to the plasma membrane, as well as water permeability.

关键词： aquaporin AtPIP2 tetramer formation interaction between transmembrane helices