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Role of kaempferol to increase bioavailability and pharmacokinetics of nifedipine in rats

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Chinese Journal of Natural Medicines 2019年第9期17卷 690-697页

作者： PARK Ji-Won CHOI jin-seok Hazardous Substances Analysis Division Gwangju Regional Office of Food and Drug SafetyGwangju 61012Republic of Korea Department of Medical Management Chodang UniversityJeollanam-do 58530Republic of Korea

Herein,the purpose of this study is to evaluate the effects of kaempferol on bioavailability and pharmacokinetics of nifedipine and its metabolite dehydronifedipine in *** experimental design is based on with or without kaempferol in the oral and intravenous administration of nifedipine in ***,the pharmacokinetic parameters including nifedipine and dehydronifedipine were evaluated in *** in vitro studies of kaempferol were investigated on P-glycoprotein(P-gp)and cytochrome P450(CYP)3A4 *** reduced a 50%inhibitory concentration(IC50)of 8.6μmol·L-1 on CYP3A4 enzyme ***,kaempferol clearly improved the cell internalization of rhodamine-123 in MCF-7/ADR cells overexpressing *** on increased concentrations of kaempferol,the areas under the plasma concentration–time curve(AUC0-∞)and the peak concentration(Cmax)of nifedipine were increased after oral and intravenous ***,the absolute bioavailability(AB)and relative bioavailability(RB)of nifedipine in the presence of kaempferol was significantly higher than those of the control group after oral and intravenous *** of bioavailability of nifedipine by kaempferol may be mainly because of the inhibition of the P-gp-mediated efflux transporter in the small intestine and CYP3A4-mediated metabolism in the small intestine or liver,or both.

关键词： Nifedipine Kaempferol CYP3A4 P-gp Pharmacokinetics Bioavailability

Effects of methotrexate on collagen-induced arthritis in male Wistar rats

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The Journal of Biomedical Research 2019年第4期33卷 244-249页

作者： jin seok Kang Department of Biomedical Laboratory Science Namseoul University

To evaluate the effect of methotrexate on collagen-induced arthritis,micro-computed tomography(micro-CT)and histopathological analyses were used in male Wistar *** were divided randomly into three *** 1 was treated with 0.9% saline,and groups 2 and 3 were boosted with type II *** day 21 to 42,groups 1 and 2 were orally treated with 0.9% saline and group 3 was orally treated with 1.5 mg/kg *** rats were sacrificed at day 42 after the first collagen ***-CT analyses showed bony parameters,such as bone volume and trabecular number,were decreased in group 2 compared to group 1,and these parameters were recovered in group *** examination and pathological parameter scoring showed that the knee joints of rats in group 2 had severe joint destruction,showing cartilage and bone erosion,enlarged cavities with inflammatory cell infiltration and activation of synovial *** contrast,these changes were reduced in group *** together,methotrexate treatment showed therapeutic potential in male rat collageninduced arthritis model,and micro-CT analysis and histopathological tools could be integrated to assess the quantification/qualification of arthritic lesions.

关键词： arthritis rat collagen micro-computed tomography histopathology

Association of the neutrophil-to-lymphocyte ratio and prostate cancer detection rates in patients via contemporary multi-core prostate biopsy

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Asian Journal of Andrology 2016年第6期18卷 937-941页

作者： Jong jin oh ohsung Kwon Jung Keun Lee seok-Soo Byun Sang Eun Lee Sangchul Lee Sung Kyu Hong Department of Urology Seoul National University Bundang Hospital Seongnam Korea.

The aim of this study was to determine whether the neutrophil-to-lymphocyte ratio （NLR）, a measure of the systemic inflammatory response is associated with the overall prostate cancer detection rate in men who underwent contemporary multi （〉12）-core transrectal ultrasound （TRUS） biopsy. We reviewed the records of 3913 patients with initial prostate-specific antigen （PSA） levels ranging from 4 to 10 ng ml^-1 who underwent TRUS-guided prostate biopsy between April 2006 and May 2014. NLR was calculated by prebiopsy neutrophil and lymphocyte counts. We excluded patients who had evidence of acute prostatitis, a history of prostate surgery, and any systemic inflammatory disease. A multivariate logistic regression model was used to analyze prostate cancer detection. After adjusting for confounding factors, predictive values were determined according to the receiver operating characteristic-derived area under the curve, both including and excluding the NLR variable. In univariate analyses, NLR was a significant predictor of prostate cancer detection （P 〈 0.001）. In multivariate analyses, a higher NLR was significantly associated with prostate cancer detection after adjusting for other factors （OR = 1.372, P = 0.038）. The addition of NLR increased the accuracy from 0.712 to 0,725 （P = 0.005） in the multivariate model for prostate cancer detection. NLR may be a potentially useful clinical marker in the detection of prostate cancer among men with a PSA level in the 4-10 ng ml^-1 range. These findings are derived from a retrospective analysis and should be validated in larger populations through prospective studies.

关键词： inflammation lymphocyte neutrophil prostate biopsy prostate cancer

Prevalence and prognosis of acute pancreatitis in critically ill patients with COVID-19

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 399-402页

作者： Dongju Kang SuHo Park Changkyo oh Yujin Kim jinBae Kim SangHoon Park Myung seok Lee JaeKeun Park Department of Internal Medicine Kangnam Sacred Heart HospitalHallym University College of MedicineSeoul 07441Korea

Background:Coronavirus disease 2019(COVID-19)is a global pandemic *** addition to the well-known respiratory and fever symptoms,gastrointestinal symptoms have also been *** study aimed to evaluate the prevalence and prognosis of patients with COVID-19 infection complicated with acute pancreatitis in intensive care unit(ICU).Methods:This was a retrospective observational cohort study,and patients aged 18 years or older,ad-mitted into the ICU in a single tertiary center from January 1,2020,to April 30,2022 were *** were identified by electronic medical records and reviewed *** primary outcome was the prevalence of acute pancreatitis among ICU patients with *** secondary outcomes were the length of hospital stay,need for mechanical ventilation(MV),need for continuous renal replacement therapy(CRRT),and in-hospital ***:A total of 4133 patients,admitted into the ICU,were *** these patients,389 were infected by COVID-19,and 86 were diagnosed with acute ***-19 positive patients were more likely to present with acute pancreatitis than COVID-19 negative patients(odds ratio=5.42,95%confidence interval:2.35-6.58,P<0.01).However,the length of hospital stay,need for MV,need for CRRT,and in-hospital mortality were not significantly different between acute pancreatitis patients with and without COVID-19 ***:Severe COVID-19 infections may cause acute pancreas damage in critically ill ***-ever,the prognosis may not differ between acute pancreatitis patients with and without COVID-19 infec-tion.

关键词： Acute pancreatitis COVID-19 Coronavirus infections Intensive care unit

Adaptive Electrospinning System Based on Reinforcement Learning for Uniform‑Thickness Nanofiber Air Filters

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Advanced Fiber Materials 2023年第2期5卷 617-631页

作者： seok Hyeon Hwang jin Yeong Song Hyun Il Ryu Jae Hee oh Seungwook Lee Donggeun Lee Dong Yong Park Sang Min Park School of Mechanical Engineering Pusan National University63‑2 Busan University‑roGeumjeong‑guBusan 46241South Korea Smart Manufacturing Technology R&D Group Korea Institute of Industrial Technology320 Techno Sunhwan‑roYuga‑eupDalseong‑gunDaegu 42994Republic of Korea

Electrospinning is a simple and versatile method to produce nanofiber ***,owing to bending instability that occurs during the electrospinning process,electrospinning has frequently produced a non-uniform-thickness nanofiber filter,which deteriorates its air ***,an adaptive electrospinning system based on reinforcement learning(E-RL)was developed to produce uniform-thickness nanofiber *** E-RL accomplished a real-time thickness measurement of an electrospun nanofiber filter by measuring the transmitted light through the nanofiber filter using a camera placed at the bottom of the collector and converting it into thickness using the Beer–Lambert *** on the measured thickness,the E-RL detected the non-uniformity of the nanofiber filter thickness and manipulated the movable collector to alleviate the non-uniformity of the thickness by a pre-trained reinforcement learning(RL)*** the training of the RL algo-rithm,the nanofiber production simulation software based on the empirical model of the deposition of the nanofiber filter was developed,and the training process of the RL algorithm was repeated until the optimal policy was *** the training process with the simulation software,the trained model was transferred to the adaptive electrospinning *** the movement of the collector under the optimal strategy of RL algorithm,the non-uniformity of such nanofiber filters was significantly reduced by approximately five times in standard deviation and error for both simulation and *** finding has great potential in improving the reliability of electrospinning process and nanofiber filters used in research and industrial fields such as environment,energy,and biomedicine.

关键词： Electrospinning Nanofiber filter Uniform thickness Reinforcement learning Deep Q-network

Risk prediction platform for pancreatic fistula after pancreatoduodenectomy using artificial intelligence

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World Journal of Gastroenterology 2020年第30期26卷 4453-4464页

作者： In Woong Han Kyeongwon Cho Youngju Ryu Sang Hyun Shin jin seok Heo Dong Wook Choi Myung jin Chung oh Chul Kwon Baek Hwan Cho Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Medical Artificial Intelligence Research Center Department of Medical Device Management and ResearchSAIHSTSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Radiology Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Artificial Intelligence Research Center Medical DataBase IncorporatedSeoul 06048South Korea

BACKGROUND Despite advancements in operative technique and improvements in postoperative managements,postoperative pancreatic fistula(POPF)is a life-threatening complication following pancreatoduodenectomy(PD).There are some reports to predict POPF preoperatively or intraoperatively,but the accuracy of those is *** intelligence(AI)technology is being actively used in the medical field,but few studies have reported applying it to outcomes after *** To develop a risk prediction platform for POPF using an AI *** Medical records were reviewed from 1769 patients at Samsung Medical Center who underwent PD from 2007 to 2016.A total of 38 variables were inserted into AI-driven *** algorithms tested to make the risk prediction platform were random forest(RF)and a neural network(NN)with or without recursive feature elimination(RFE).The median imputation method was used for missing *** area under the curve(AUC)was calculated to examine the discriminative power of algorithm for POPF *** The number of POPFs was 221(12.5%)according to the International Study Group of Pancreatic Fistula definition *** median imputation,AUCs using 38 variables were 0.68±0.02 with RF and 0.71±0.02 with *** maximal AUC using NN with RFE was *** risk factors for POPF were identified by AI algorithm:Pancreatic duct diameter,body mass index,preoperative serum albumin,lipase level,amount of intraoperative fluid infusion,age,platelet count,extrapancreatic location of tumor,combined venous resection,co-existing pancreatitis,neoadjuvant radiotherapy,American Society of Anesthesiologists’score,sex,soft texture of the pancreas,underlying heart disease,and preoperative endoscopic biliary *** developed a web-based POPF prediction platform,and this application is freely available at http://*** This study is the first to predict POPF with multiple risk factors using *** platform is reli

关键词： Postoperative pancreatic fistula Pancreatoduodenectomy Neural networks Recursive feature elimination

Clinicopathologic significance of expression of nuclear factor-kB RelA and its target gene products in gastric cancer patients

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World Journal of Gastroenterology 2012年第34期18卷 4744-4750页

作者： Hyuk-Chan Kwon Sung-Hyun Kim Sung Yong oh Suee Lee Ji Hyun Lee jin seok Jang Min Chan Kim Ki Han Kim Su-jin Kim Seong-Geun Kim Hyo-jin Kim Department of Internal Medicine Dong-A University College of MedicineBusan 602-715South Korea Department of Surgery Dong-A University College of MedicineBusan 602-715South Korea Department of Pathology Dong-A University College of MedicineBusan 602-715South Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan HospitalBusan 602-715South Korea

AIM:To assess the prognostic significance of nuclear factor-kB (NF-kB) and its target genes in gastric cancer. METHODS:The tumor tissues of 115 patients with gastric cancer were immunohistochemically evaluated using monoclonal antibodies against NF-kB RelA. Preoperative serum levels of vascular endothelial growth factor (VEGF), interleukin-6 (IL-6) were assessed via enzyme-linked immuno-sorbent assay. C-reactive protein (CRP) and serum amyloid A (SAA) were measured via immunotrubidimetry. RESULTS:Positive rate of NF-kB RelA was 42.6%. NF-kB RelA expression in tumor tissues was also related to serum levels of IL-6 (P = 0.044) and CRP (P = 0.010). IL-6, SAA, CRP were related to depth of invasion, VEGF and SAA were correlated with lymph node metastasis. IL-6, VEGF, SAA and CRP were related to the stage. Univariate analysis demonstrated that immunostaining of NF-kB RelA, levels of IL-6, VEGF, SAA were significantly related with both disease free survival and over-all survival (OS). Multivariate analysis verified that NF-kB RelA [hazard ratio (HR): 3.40, P = 0.024] and SAA (HR: 3.39, P = 0.045) were independently associated with OS. CONCLUSION: Increased expression of NF-kB RelA and high levels of serum SAA were associated with poor OS in gastric cancer patients.

关键词： Nuclear factor-κB Vascular endothelial grow-th factor Interleukin-6 C-reactive protein Serum amy-loid A Stomach Carcinoma

Simulation of Suspended Sediment in the Yellow and East China Seas

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China Ocean Engineering 2005年第2期19卷 235-250页

作者： CHOI Byung-Ho MUN Jong-Yoon KO jin-seok YUK jin-Hee Department of Civil and Environmental Engineering Sungkyunkwan University Suwon 440-746 KoreaKorea Ocean Science and Engineering Corporation 175-9 Huam-dong Yongsan-gu Seoul 140-901 KoreaHyein Engineering and Construction Co. Ltd. 150-057 761 Shingil 7 dong Yungdungpogu Seoul KoreaDepartment of Civil and Environmental Engineering Sungkyunkwan University Suwon 440-746 Korea

Described is an initial attempt to simulate the suspended sediment dynamics relating to tidal and wave forcing during summertime in June 1980 and August 1981 for the Yellow and East China Seas continental shelf. The cohesive/non-cohesive sediment resuspension and movement generated by the interaction between current and wave are modeled by use of ECOMSED and WAM Cycle 4. Model results are compared with observations in US-China Marine Sedimentation Dynamics Program performed for 1980-81 at off the Changjiang estuary. The main features of simulations show that suspended sediment concentrations during the summer decreased markedly offshore as observed during the simulation periods. As for some discrepancies for the mouth of the estuary with high river discharges, i.e., the Changjiang River, the model did not properly reproduce the over-mixing situation in the summer; thus distinct vertical concentration variation in this local region is not agreeable with observation. However, general dispersal patterns of suspended sediment movement seem to be agreeably reproduced for the nearshore shallow region. Some of the procedures of simulation and results are presented and discussed.

关键词： Yellow Sea East China Sea sediment transport model time slice experiment sediment concentration

Clinicopathological significance of altered Notch signaling in extrahepatic cholangiocarcinoma and gallbladder carcinoma

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World Journal of Gastroenterology 2011年第35期17卷 4023-4030页

作者： Hyun Ah Yoon Myung Hwan Noh Byung Geun Kim Ji Sun Han jin seok Jang seok Ryeol Choi jin Sook Jeong jin Ho Chun Department of Gastroenterology Dong-A University Hospital3-1Dong dae shindongSeo-guBusan 602-715South Korea Department of Pathology Dong-A University Hospital3-1Dong dae shin-dongSeo-guBusan 602-715 South Korea Department of Preventive Medicine Inje University HospitalGae gum 2-dongBusanjinguBusan 614-735 South Korea

AIM:To investigate the role and clinicopathological significance of aberrant expression of Notch receptors and Delta-like ligand-4 (DLL4) in extrahepatic cholangiocarcinoma and gallbladder ***:One hundred and ten patients had surgically resected extrahepatic cholangiocarcinoma (CC) and gallbladder carcinoma specimens examined by immunohistochemistry of available paraffin *** was performed using anti-Notch receptors 1-4 and anti-DLL4 *** scored the immunopositivity of Notch receptors and DLL4 expression by percentage of positive tumor cells with cytoplasmic expression and intensity of *** nuclear localization was ***-logical parameters and survival data were compared with the expression of Notch receptors 1-4 and ***:Notch receptor proteins showed in the cytoplasm with or without nuclear expression in cancer cells,as well as showing weak cytoplasmic expression in non-neoplastic *** semiquantitative evaluation,positive immunostaining of Notch receptor 1 was detected in 96 cases (87.3%),Notch receptor 2 in 97 (88.2%),Notch receptor 3 in 97 (88.2%),Notch receptor 4 in 103 (93.6),and DLL4 in 84 (76.4%).In addition,coex- istent nuclear localization was noted [Notch receptor 1;18 cases (18.8%),Notch receptor 2;40 (41.2%),Notch receptor 3;32 (33.0%),Notch receptor 4;99 (96.1%),DLL4;48 (57.1%)].Notch receptor 1 expression was correlated with advanced tumor,node,metastasis (TNM) stage (P=0.043),Notch receptor 3 with advanced T stage (P=0.017),tendency to express in cases with nodal metastasis (P=0.065) and advanced TNM stage (P=0.052).DLL4 expression tended to be related to less histological differentiation (P=0.095).Coexistent nuclear localization of Notch receptor 3 was related to no nodal metastasis (P=0.027) and Notch receptor 4 with less histological differentiation (P=0.036),while DLL4 tended to be related inversely with T stage (P=0.053).Coexistent nuclear localizatio

关键词： Notch receptors Delta-like ligand-4 Cholangio-carcinoma Gallbladder carcinoma Immunohistochemistry