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Ultrasound Elastography of Ethanol-induced Hepatic Lesions:In Vitro Study

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Chinese Medical Sciences Journal 2009年第2期24卷 81-85页

作者： Li-gang Cui jin-hua Shao jin-rui wang jing Bai Yi-zhuo Zhang Department of Diagnostic Ultrasound Peking University Third Hospital Beijing 100083 China Department of Biomedical Engineering School of Medicine Tsinghua University Beijing 100084 China Department of Diagnostic Ultrasound Beijing Shijitan Hospital Beijing 100038 China

Objective To study the value of ultrasound elastography in evaluation of ethanol-induced lesions of liver. Methods Alcohol with a dose of 2 ml was injected into a fresh porcine liver under ultrasound guidance to create stiff necrosis. Then freehand elastography of the lesion from the identical scan plane was obtained with SONOLINE Antares system using VF10-5 probe at about every 30 seconds till 6 minutes later. The original high quality radiofrequency data were acquired through an ultrasound research interface which was provided by the ultrasound system. Then, corresponding elastograms were produced offline using cross-correlation technique and compared with gross pathology findings. Results Gray-scale sonogram showed a hyperechoic area with acoustic shadow below appeared immediately after alcohol injection. The hyperechoic area tended to be diffuse and its boundary to be illegible with time. On the contrary, the ethanol-induced lesion in elastogram appeared as a low swain hard region surrounded by high strain soft hepatic tissues, with clear but irregular boundaries. Sequential elastograms with the sketched lesion boundaries showed that the lesion area increased in the first 3 minutes after ethanol injection, and then reached a plateau which corresponding to gross specimen. Conclusion Ultrasound elastography is capable of detecting and evaluating the diffusion of ethanol-induced hepatic lesion, and more sensitive and accurate than routine sonography.

关键词： elastography ultrasound hepatic cirrhosis ethanol

Quantitative Assessment of Hepatic Fibrosis by Contrast-enhanced Ultrasonography

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Chinese Medical Sciences Journal 2011年第4期26卷 208-215页

作者： Ming-bo Zhang En-ze Qux En-ze Qu Ji-Bin Liu jin-rui wang Department of Ultrasound Peking University Third Hospital Beijing 100191 China Inner Mongolia Institute of Ultrasound Erdos 017000 China

Objective To explore the contrast-enhanced ultrasonographic features for quantitative assessment of hepatic fibrosis. Methods 86 patients with chronic viral hepatitis B were enrolled in this study from March 2007 to August 2009. The patients were classified into 5 groups (S0-S4) according to fibrosis stage evaluated with ultrasound guided liver biopsy. New contrast-enhanced ultrasonography (CEUS) features including area under the time-intensity curve (TIC) of portal venous phase/hepatic arterial phase (Qp/Qa) and intensity of portal venous phase/hepatic arterial phase (Ip/Ia) were used to detect the blood supply ratio (portal vein/hepatic artery) in each group. Arrival time of portal vein trunk (Tp) and decreasing rate of TIC (β ) were also analyzed. Results Qp/Qa and Ip/Ia decreased from S0 to S4, while Tp and β increased. These 4 features were significantly correlated with the degree of fibrosis (P<0.001) and were significantly different among the five groups (P<0.001). Sensitivity and specificity of Ip/Ia were 80% and 86% for groups ≥S1, 75% and 86% for groups ≥ S2, 71% and 84% for groups ≥ S3, and 76% and 80% for group S4, respectively. Sensitivity and specificity of Qp/Qa were 70% and 88% for groups ≥ S1, 80% and 76% for groups ≥ S2, 74% and 70% for groups ≥ S3, and 81% and 95% for group S4, respectively. Conclusion Ip/Ia and Qp/Qa could be adopted as reliable, non-invasive features for quantitative assessment of hepatic fibrosis.

关键词： hepatic fibrosis contrast-enhanced ultrasonography quantitative non- invasive

PREPARATION OF POLYELECTROLYTE MULTILAYER COATED MICROBUBBLES FOR USE AS ULTRASOUND CONTRAST AGENT

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Chinese Medical Sciences Journal 2008年第2期23卷 103-107页

作者： Zhan-wen Xing Heng-te Ke Shao-qin Liu Zhi-fei Dai jin-rui wang Ji-bin Liu Nanomedicine and Biosensor Laboratory Bio-X Center Harbin Institute of Technology Harbin 150080 Department of Ultrasonography Third Hospital Peking University Beijing 100083 Ultrasound Research and Education Institute Thomas Jefferson University Hospital Philadelphia 19107 USA

Objeelive To prepare and characterize polyelectrolyte multilayer film coated microbubbles for use as ultrasound contrast agent （UCA） and evaluate its effects in ultrasonic imaging on normal rabbit＇s fiver parenchyma. Methods Perfluorocarbon （PFC）-containing microbubbles （ST68-PFC） were prepared by sonication based on suffactant （ Span 60 and Tween 80）. Subsequently, the resulting ST68-PFC microbubbles were coated using oppositely charged polyelectrolytes by microbubble-templated layer-by-layer self-assembly technique via electrostatic interaction. The enhancement effects in ultrasonic imaging on normal rabbit＇s liver parenchyma were assessed. Results The obtained microbubbles exhibited a narrow size distribution. The polyelectrolytes were successfully assembled onto the surface of ST68-PFC microbubbles. In vivo experiment showed that polyelectrolyte multilayer film coated UCA effectively enhanced the imaging of rabbit＇s liver parenchyma. Conclusions The novel microbubbles UCA coated with polyelectrolyte multilayer, when enabled more function, has no obvious difference in enhancement effects compared with the pre-modified microbubbles. The polymers with chemically active groups （ such as amino group and carboxyl group） can be used as the outermost layer for attachment of targeting ligands onto microbubbles, allowing selective targeting of the microbubbles to combine with desired sites.

关键词： microbubbles ultrasound contrast agent layer-by-layer self-assembly technique polyelectrolyte

TWO DIMENSIONAL PROPERTIES OF REVERSED DUCKWEED AMPHIPHILIC POLYMER

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Chinese Chemical Letters 1993年第10期4卷 939-940页

作者： jin wang rui Feng ZHANG Yue Xia LIANG Jia Cong SHEN Department of Chemistry,JiLin University Changchun 130023

The surface pressure-Area isotherms of Reversed Duckweed amphiphili polymer were examined in view of their chemical structure and two- dimentional properties of polymer monolayer were studied.

关键词： Poly TWO DIMENSIONAL PROPERTIES OF REVERSED DUCKWEED AMPHIPHILIC POLYMER

Effects of light curing modes and ethanol-wet bonding on dentin bonding properties

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第9期17卷 703-711页

作者： Mu-zi LI jin-rui wang Hong LIU Xia wang Kang GAN Xiu-ju LIU De-li NIU Xiao-qing SONG School and Hospital of Stomatology Jilin UniversityChangchun 130021China Jilin Provincial Key Laboratory of Tooth Development and Remodeling Changchun 130021China

Objective： This study explored the effects of different light curing modes and ethanol-wet bonding on dentin bonding strength and durability. Methods： A total of 54 molars were randomly divided into three groups： Single Bond 2, Gluma Comfort Bond, and N-Bond. Based on the three light-curing modes and presence or absence of eth- anol pretreatment, the samples were assigned to six subgroups： high-light mode, ethanol pretreatment＋high-light mode, soft-start mode, ethanol pretreatment＋soft-start mode, standard mode, and ethanol pretreatment＋standard mode. All samples were bonded with resin based on the experimental groups. After 24 h and 6 months of water storage, a universal testing machine was used to measure microtensile bond strength. Scanning electron microscopy （SEM） was applied to observe mixed layer morphology. Results： The 24-h and 6-month microtensile bond strengths of the ethanol pretreatment groups were significantly higher than those of the non-ethanol pretreatment groups at the same light modes （P〈0.05）. With or without ethanol pretreatment, the microtensile bond strengths of the high-light modes were significantly lower than those of the soft-start modes and standard modes （P〈0.05）. The microtensile bond strengths of samples from the 6-month water storage group significantly decreased compared with those of samples from the 24-h water storage group （P〈0.05）. The soft-start groups and standard groups formed better mixed layers than the high-light mode groups, whereas the ethanol pretreatment groups formed more uniform mixed layers than those without ethanol pretreatment. Conclusions： Ethanol-wet bonding technique, soft-start, and standard modes could improve dentin bonding properties.

关键词： Light curing mode Soft-start Ethanol-wet bonding Scanning electron microscopy (SEM) Bondingstrength

Risk factor analysis and clinical decision tree model construction for diabetic retinopathy in Western China

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World Journal of Diabetes 2022年第11期13卷 986-1000页

作者： Yuan-Yuan Zhou Tai-Cheng Zhou Nan Chen Guo-Zhong Zhou Hong-Jian Zhou Xing-Dong Li jin-rui wang Chao-Fang Bai Rong Long Yu-Xin Xiong Ying Yang Department of Endocrinology and Metabolism The Sixth Affiliated Hospital of Kunming Medical UniversityThe People’s Hospital of Yuxi CityYuxi 653100Yunnan ProvinceChina Department of Endocrinology and Metabolism Affiliated Hospital of Yunnan UniversityThe Second People’s Hospital of Yunnan ProvinceKunming 650021Yunnan ProvinceChina Department of Endocrinology and Metabolism The Frist People’s Hospital of Anning CityAnning City 650300Yunnan ProvinceChina

BACKGROUND Diabetic retinopathy(DR)is the driving force of blindness in patients with type 2 diabetes mellitus(T2DM).DR has a high prevalence and lacks effective therapeutic strategies,underscoring the need for early prevention and *** province,located in the southwest plateau of China,has a high prevalence of DR and an underdeveloped *** To build a clinical prediction model that will enable early prevention and treatment of *** In this cross-sectional study,1654 Han population with T2DM were divided into groups without(n=826)and with DR(n=828)based on fundus *** DR group was further subdivided into non-proliferative DR(n=403)and proliferative DR(n=425)groups.A univariate analysis and logistic regression analysis were conducted and a clinical decision tree model was *** Diabetes duration≥10 years,female sex,standing-or supine systolic blood pressure(SBP)≥140 mmHg,and cholesterol≥6.22 mmol/L were risk factors for DR in logistic regression analysis(odds ratio=2.118,1.520,1.417,1.881,and 1.591,respectively).A greater severity of chronic kidney disease(CKD)or hemoglobin A 1c increased the risk of DR in patients with *** the decision tree model,diabetes duration was the primary risk factor affecting the occurrence of DR in patients with T2DM,followed by CKD stage,supine SBP,standing SBP,and body mass index(BMI).DR classification outcomes were obtained by evaluating standing SBP or BMI according to the CKD stage for diabetes duration<10 years and by evaluating CKD stage according to the supine SBP for diabetes duration≥10 *** Based on the simple and intuitive decision tree model constructed in this study,DR classification outcomes were easily obtained by evaluating diabetes duration,CKD stage,supine or standing SBP,and BMI.

关键词： Diabetic retinopathy Type 2 diabetes Western China Decision tree

Detection of Epstein-Barr virus infection subtype in patients with multiple sclerosis by indirect immunofluorescence assay

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Neuroimmunology and Neuroinflammation 2014年第1期1卷 24-28页

作者： Shan-Chao Zhang Lei Liu rui-jin wang Hou-Zhen Tuo Yan-Jun Guo Li Yi De-Xin wang Jia-Wei wang Department of Neurology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Neurology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Aim:The aim was to investigate the infectious conditions of Epstein-Barr virus(EBV)in patients with multiple sclerosis(MS).Methods:Cerebrospinal fluid(CSF)of 20 patients with MS and 20 with other neurological diseases(OND)were tested with indirect immunofluorescence for anti-EBV capsid antigen(EBV-CA)immunoglobulin G(IgG),IgG affinity for anti-EBV-CA,anti-EBV-CA immunoglobulin M(IgM),anti-EBV early antigen(EBV-EA)IgG and anti-EBV nuclear antigen(EBNA)*** to the pattern of antibodies in CSF,infection rates of acute,chronic,primary,recurrent,and past infections were analyzed in the two groups of ***:There were no significant differences in anti-EBV-CA,anti-EBC-EA,and anti-EBNA antigen IgG in CSF between MS and OND patients(P>0.05).The positive rate of low affinity for anti-EBV-CA IgG in MS patients was significantly higher than that for OND patients(75%vs.40%,P<0.05).Furthermore,significant differences in the positive rate of anti-EBV-CA IgM were found between MS and OND patients(70%vs.25%,P<0.05).Of the MS patients,75%were in an EBV acute infection state compared with 40%of OND patients(P<0.05).Conclusion:Acute infection of EBV closely correlates with the occurrence of MS.

关键词： Epstein-Barr virus fluorescent antibody technique herpes virus 4 multiple sclerosis

Development of a Chinese land data assimilation system:its progress and prospects

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Progress in Natural Science:Materials International 2007年第8期17卷 881-892页

作者： Li Xin~(1**) Huang Chunlin~1 Che Tao~1 jin rui~1 wang Shugong~l wang Jiemin~1 Gao Feng~1 Zhang Shuwen~2 Qiu Chongjian~2 wang Chenghai~2 (1.Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,Lanzhou 730000,China 2.College of Atmospheric Sciences,Lanzhou University,Lanzhou 730000,China) Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China College of Atmospheric Sciences Lanzhou University Lanzhou 730000 China

The objective of land data assimilation is to merge multi-source observations into the dynamics of land surface model for improving the estimation of land surface *** have developed a land data assimilation system for China's land *** this sys- tem,the Common Land Model and Simple Biosphere Model 2 are used to simulate land surface *** radiative transfer models of thawed and frozen soil,snow,lake,and vegetation are used as observation operators to transfer model predictions into estimated bright- ness temperatures.A Monte-Carlo based sequential filter,the ensemble Kalman filter,is implemented as data assimilation method to inte- grate modeling and *** system is capable of assimilating passive microwave remotely sensed data such as special sensor mi- crowave/imager (SSM/I),TRMM microwave imager (TMI),and advanced microwave scanning radiometer enhanced for EOS (AMSR- E) and the conventional in situ measurements of soil and snow.A spatiotemporally consistent assimilated dataset for soil moisture,soil temperature,snow and frozen soil,with a spatial resolution of 0.25 degree and temporal resolution of one hour,has been *** paper introduces the development of Chinese land data assimilation system and the progress made on data assimilation algorithms,land sur- face modeling,microwave remote sensing of land surface hydrological variables,and the preparation of atmospheric forcing *** dis- tinct characteristics and challenges of developing land data assimilation system and the perspectives for future development are also dis- cussed.

关键词： land data assimilation land surface model passive microwave remote sensing Kalman filter

含乌头碱中成药临床安全用药风险评估量表的构建与验证

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中国中药杂志 2018年第2期43卷 222-226页

作者：金锐王宇光张冰首都医科大学附属北京世纪坛医院北京100038 北京中医药大学第三附属医院北京100029 北京中医药大学中药学院北京100029

含乌头碱中成药是临床安全合理用药的重点,此类药品多含有川乌、草乌附子或雪上一枝蒿,以祛风除湿或温中补阳为功效,需要严格遵照适应症和用法用量使用。但此类药品种类繁多,不仅部分中西医师对于药品性效特征不了解,而且还时常存在多... 详细信息

含乌头碱中成药是临床安全合理用药的重点,此类药品多含有川乌、草乌附子或雪上一枝蒿,以祛风除湿或温中补阳为功效,需要严格遵照适应症和用法用量使用。但此类药品种类繁多,不仅部分中西医师对于药品性效特征不了解,而且还时常存在多科室联合用药的情况,增加了乌头碱中毒的风险。该文在前期研究基础上,将近2年的含毒中成药处方点评和用药宣教工作经验提炼为＂辨证-辨量-辨毒＂3个核心要素,并采用客观化、标准化的评价方式,以虎力散胶囊和祛风止痛胶囊为例,构建包含3类9项36个指标的风险评估数字量表,实现对于含乌头碱中成药治疗方案的治疗风险预估和治疗现状评估。以现有上述中成药的不良反应案例报道的验证显示,该风险评估量表可以提示药物治疗方案的风险,标识药物治疗现状的风险等级。为科学、客观地评价含毒中成药的临床用药安全性提供了方法学范例,也有助于不熟悉中医药理论的医师和药师快速掌握含毒中成药合理使用的关键环节和风险防范。

关键词：中成药安全性评价数学量表乌头碱虎力散胶囊祛风止痛胶囊