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A meta-regression evaluating the effectiveness and prognostic factors of oral phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction

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Asian Journal of Andrology 2016年第1期18卷 60-65页

作者： jin-qiu yuan Chen Mao Zu-Yao Yang Xiao-Hong Fu Samuel Y Wong jin-Ling Tang Division of Epidemiology School of Public Health and Primary Care The Chinese University of Hang Kong Hang Kong China Shenzhen Municipal Key Laboratory for Health Risk Analysis Shenzhen Research Institute of The Chinese University of Hang Kong Shenzhen 518055 China Department of Community and Family Medicine The Chinese University of Hang Kong Hang Kong China

The effectiveness of phosphodiesterase type 5 inhibitors （PDE5-1s） for erectile dysfunction （ED） varies considerably among trials, but available studies investigating the factors that affect the effectiveness are few and findings are not consistent. A systematic search was performed in PubMed, Cochrane Library, and EMBASE to identify randomized controlled trials comparing PDE5-1s with placebo for the treatment of ED. The methodological quality of included studies was assessed by the Cochrane Collaboration＇s tool for assessing risk of bias. The associations between prespecified study-level factors and effectiveness were tested by a random effects meta-regression model. This study included 93 trials with 26 139 patients. When all PDE5-1s were grouped together, Caucasian ethnicity was associated with 15.636% （95% confidence interval [CI]： 0.858% to 32.579%） increase in risk ratio （RR） for Global Assessment Questionnaire question-1 （GAQ-1）, and 1.473 （95% CI： 0.406 to 2.338） score increase in mean difference （MD） for posttreatment International Index of Erectile Function-Erectile Function domain score （IIEF-EF）, compared to Asian ethnicity. A one-score increase in baseline IIEF-EF was associated with -5.635% （95% CI： -9.120% to -2.017%） reduction in RR for GAQ-1, and -0.229 （95% CI： -0.425 to -0.042） score decrease in MD for posttreatment IIEF-EF. In conclusion, PDE5-1s are more effective in Caucasians than Asians, and in patients with more severe ED.

关键词： erectile dysfunction meta-regression phosphodiesterase type 5 inhibitors systematic review

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Research Progress in the Fabrication of Covalent Organic Framework Membranes for Chemical Separations

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Chinese Journal of Polymer Science 2024年第2期42卷 141-158,I0005页

作者： Cui-Ting Ding jin-qiu yuan Meng-Ying Xie Qing-yuan Liu Zeng-Guang Yao Shi-Yu Zhang Run-Nan Zhang Hong Wu Zhong-Yi Jiang Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China Zhejiang Institute of Tianjin University NingboZhejiang315201China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China Tianjin Key Laboratory of Membrane Science and Desalination Technology Tianjin UniversityTianjin300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou350207China

Membrane technology has become one of the most promising separation technologies for its energy saving, high separation efficiency, environmental friendliness, and economic feasibility. Covalent organic frameworks(COFs) with intrinsically high porosity, controllable pore size, uniform pore size distribution and long-range ordered channel structure, have emerged as next-generation materials to fabricate advanced separation membranes. This feature article summarizes some latest studies in the development of pure COF membranes in our lab, including their fabrication and applications in chemical separations. Finally, current challenges facing high-performance COF separation membranes are discussed.

关键词： Covalent organic frameworks Covalent organic framework membranes Water treatment Organic solvent nanofiltration Gas separation

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Fuzzy Comprehensive Evaluation for Decision Making of Water Saving Irrigation System

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Wuhan University Journal of Natural Sciences 2003年第03A期8卷 837-841页

作者： Luo jin\|yao, qiu yuan\|feng College of Water Resources and Hydropower Engineering , Wuhan University, Wuhan 430072, Hubei, China Wuhan University College of Water Resources and Hydropower Engineering Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***)

A model of fuzzy comprehensive evaluation for water saving irrigation system (WSIS) decision making is proposed based on establishing an index system affected by six kinds of basic factors including qualitative and quantitative indexes. The object function of WSIS is set up by using the concept of fuzzy membership degree, it is to transform characteristic vector matrix into unify membership matrix and extending the least square method to the least of weighted distance square. The optimum weighted membership degree and the inferior weighted membership degree are used to solve the object function. This method effective solves the problem of classify for fuzzy attributive indexes and the problem of optimum for the set of different attributive indexes. A case study shows that the fuzzy comprehensive evaluation model is reasonable and effective in decision making for water saving irrigation system planning.

关键词： water saving irrigation system (WSIS) decision making fuzzy comprehensive evaluation (FCE) index system fuzzy membership degree

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福州市垂直绿化植物的选择与配置研究

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福建林业科技 2007年第1期34卷 228-230,239页

作者：丘进渊福建农林大学林学院福建福州350002

通过对福州市垂直绿化植物的调查,从城市垂直绿化的应用范围和垂直绿化植物的种类出发,阐述了福州市垂直绿化现状,研讨了福州市垂直绿化植物的选择与合理配置,并提出垂直绿化新技术,从而为福州市今后的绿化提供科学依据。

关键词：福州垂直绿化选择与配置

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Associations between serum uric acid and hepatobiliary-pancreatic cancer:A cohort study

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World Journal of Gastroenterology 2020年第44期26卷 7061-7075页

作者： Chong-Fei Huang Jun-Jun Huang Ning-Ning Mi Yan-Yan Lin Qiang-Sheng He Ya-Wen Lu Ping Yue Bing Bai jin-Duo Zhang Chao Zhang Teng Cai Wen-Kang Fu Long Gao Xun Li jin-qiu yuan Wen-Bo Meng The First Clinical Medical School Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Special Minimally Invasive Surgery Department The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Institute of Genetics School of Basic Medical SciencesLanzhou UniversityLanzhou 730000Gansu ProvinceChina Gansu Province Institute of Hepatopancreatobiliary Lanzhou 730000Gansu ProvinceChina Gansu Province Key Laboratory Biotherapy and Regenerative Medicine Lanzhou 730000Gansu ProvinceChina Scientific Research and Planning Department The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Clinical Research Center and Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107Guangdong ProvinceChina The Fifth Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Uric acid is the end product of purine *** studies have found that serum uric acid(SUA)levels are associated with the total cancer ***,due to the dual effect of uric acid on cancer,the relationship between the SUA levels and most specific-site cancer remains *** To investigate the associations between the SUA levels and incidence of hepatobiliary-pancreatic *** In this prospective cohort study,444462 participants free of cancer from the UK Biobank were *** SUA levels were measured at baseline,and the incidence of hepatobiliary-pancreatic cancer was determined by contacting the cancer *** hazard ratios(HRs)and 95%confidence intervals(CIs)between the SUA levels and hepatobiliary-pancreatic cancer were investigated using multiple adjusted Cox regression models adjusted for potential *** In total,920 participants developed liver,gallbladder,biliary tract or pancreatic cancer during a median of 6.6 yrs of *** found that the HR of pancreatic cancer in the highest SUA group was 1.77(95%CI:1.29-2.42)compared with that in the lowest *** stratifying by gender,we further found that SUA was associated with an increased risk of pancreatic cancer only among the females(highest quartile vs lowest quartile HR 2.04,95%CI:1.35-3.08).Among the males,the SUA levels were positively associated with the gallbladder cancer risk(highest quartile vs lowest quartile HR 3.09,95%CI:1.28-7.46),but a U-shaped association with the liver cancer risk was observed(P-nonlinear=0.03).CONCLUSION SUA is likely to have gender-specific effects on hepatobiliary-pancreatic *** SUA levels are a risk factor for pancreatic cancer in females and gallbladder cancer in males.A U-shaped association with the liver cancer risk was identified.

关键词： Uric acid Liver neoplasms Pancreatic neoplasms Gallbladder neoplasms Biliary tract neoplasms Cohort studies

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基于知识原型网络的小样本多功能雷达工作模式识别

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电子学报 2022年第6期50卷 1344-1350页

作者：利强张伟金秋园姚欣电子科技大学信息与通信工程学院四川成都611731 鹏城实验室广东深圳518055 电子信息控制重点实验室四川成都610036

在认知电子战中,对多功能雷达工作模式的识别是至关重要的一个环节.在实际中,由于多功能雷达工作模式的多样性、隐藏性,能侦收到的不同工作模式脉冲样本数可能较少.因此,如何在少量样本条件下,准确识别多功能雷达的工作模式,对雷达对抗... 详细信息

在认知电子战中,对多功能雷达工作模式的识别是至关重要的一个环节.在实际中,由于多功能雷达工作模式的多样性、隐藏性,能侦收到的不同工作模式脉冲样本数可能较少.因此,如何在少量样本条件下,准确识别多功能雷达的工作模式,对雷达对抗具有重要意义.针对此问题,本文提出了一种将模式先验知识与原型网络相融合的识别方法.该方法的核心是将雷达工作模式先验知识进行编码映射,并融入原型网络训练,实现知识在网络模型中的内嵌,以在少量训练样本条件下获得更好的识别性能.仿真结果表明,融入了先验知识的原型网络与不使用先验知识的原型网络、SVM分类器相比,识别准确率分别提升了2.9%和10.5%.

关键词：小样本雷达模式识别原型网络先验知识融合

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江苏省碳排放效率时空格局及驱动因素

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地域研究与开发 2018年第4期37卷 144-149页

作者：金娜仇方道袁荷江苏师范大学地理测绘与城乡规划学院江苏徐州221116

采用SBM模型、ESDA与GWR等方法,以县域为研究单元,分析2002—2015年江苏碳排放效率空间格局及驱动因素。结果表明:江苏碳排放效率区域差异呈先增后减变化趋势,空间上呈南高北低格局;研究期内江苏碳排放效率的分布呈显著的空间正相关集聚... 详细信息

采用SBM模型、ESDA与GWR等方法,以县域为研究单元,分析2002—2015年江苏碳排放效率空间格局及驱动因素。结果表明:江苏碳排放效率区域差异呈先增后减变化趋势,空间上呈南高北低格局;研究期内江苏碳排放效率的分布呈显著的空间正相关集聚,形成以昆山、南京市区以及无锡市区为核心的三大热点区和以泗阳—宿迁市区—沭阳为中心的冷点区并向外扩散的空间俱乐部;城镇化水平对江苏省碳排放效率空间差异的影响逐步增强,技术创新影响作用逐步凸显,能源消耗强度对碳排放效率空间差异影响程度呈增强趋势。

关键词：碳排放效率时空格局 SBM模型 GWR模型江苏省

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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue jin Yusong yuan Bo Ma Wenyong Xie Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan Yu jing Wu Guang Yin Fan‑Zhen Jiao Zhong‑Zhen Yu jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： Ruiqi qiu Mingzhu Yang Xiuxiu jin jingyang Liu Weiping Wang Xiaoli Zhang jinfeng Han Bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

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