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5’tiRNA-Pro-TGG,a novel tRNA halve,promotes oncogenesis in sessile serrated lesions and serrated pathway of colorectal cancer

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World Journal of Gastrointestinal Oncology 2023年第6期15卷 1005-1018页

作者： Xin-Yuan Wang Yu-Jie Zhou Hai-Ying chen jin-nan chen Shan-Shan chen Hui-Min chen Xiao-Bo Li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200000China Department of Spleen and Stomach and Rheumatology Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Transfer RNA(tRNA)-derived small RNAs(tsRNAs)are small fragments that form when tRNAs *** halves(tiRNAs),a subcategory of tsRNA,are involved in the oncogenic processes of many ***,their specific role in sessile serrated lesions(SSLs),a precancerous lesion often observed in the colon,has not yet been *** To identify SSL-related tiRNAs and their potential role in the development of SSLs and serrated pathway of colorectal cancer(CRC).METHODS Small-RNA sequencing was conducted in paired SSLs and their adjacent normal control(NC)*** expression levels of five SSL-related tiRNAs were validated by q-polymerase chain *** counting kit-8 and wound healing assays were performed to detect cell proliferation and *** target genes and sites of tiRNA-1:33-Pro-TGG-1(5′tiRNA-Pro-TGG)were predicted by TargetScan and miRanda ***-associated and immune-related pathways were analyzed by single-sample gene set enrichment *** analyses were performed to establish the roles of 5′tiRNA-Pro-TGG based on the target *** In total,we found 52 upregulated tsRNAs and 28 downregulated tsRNAs in SSLs compared to *** expression levels of tiRNA-1:33-Gly-CCC-2,tiRNA-1:33-Pro-TGG-1,and tiRNA-1:34-Thr-TGT-4-M25′tiRNAs were higher in SSLs than those in NC,while that of 5′tiRNA-Pro-TGG was associated with the size of *** was demonstrated that 5′tiRNAPro-TGG promoted cell proliferation and migration of RKO cell in ***,heparanase 2(HPSE2)was identified as a potential target gene of 5′*** lower expression was associated with a worse prognosis in ***,lower expression of HPSE2 was observed in SSLs compared to normal controls or conventional adenomas and in BRAF-mutant CRC compared to BRAF-wild *** analyses revealed that its low expression was associated with a low interferonγresponse and also with many metabolic pathways such as riboflavin,retinol,and cy

关键词： Noncoding RNA tRNA halves Sessile serrated lesions Colon cancer Serrated pathway

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Effect of 211At treating pollen and stigma on generative cells and seed setting of rice

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Nuclear Science and Techniques 1998年第3期 45-47页

作者： jin Jian nan 1, chen Fang 2, Mo Shang Wu 1, Liu Ning 1, Zhang Yi Zheng 2, Gao Mao Guo 2, Zhou Mao Lun 1 and Zhang Shu Yuan 1 ( 1Institute of Nuclear Science and Technology, 2Department of Biology, Sichuan Union University,

１ＩｎｔｒｏｄｕｃｔｉｏｎＴｒａｄｉｔｉｏｎａｌγｒａｙｉｓｓｔｉｌｕｓｅｄａｓａｍａｉｎｍｕｔａｇｅｎｉｃｓｏｕｒｃｅｆｏｒｔｈｅｒａｄｉａｔｉｏｎｉｎｄｕｃｅｄｍｕｔａｔｉｏｎｒｅｓｅａｒｃｈｉｎｐｌａｎｔ... 详细信息

１ＩｎｔｒｏｄｕｃｔｉｏｎＴｒａｄｉｔｉｏｎａｌγｒａｙｉｓｓｔｉｌｕｓｅｄａｓａｍａｉｎｍｕｔａｇｅｎｉｃｓｏｕｒｃｅｆｏｒｔｈｅｒａｄｉａｔｉｏｎｉｎｄｕｃｅｄｍｕｔａｔｉｏｎｒｅｓｅａｒｃｈｉｎｐｌａｎｔｓ．Ｉｎｔｈｅｍｅａｎｔｉｍｅ，ｔ...

关键词： At Rice Generative cells Seed setting rate Induced variation

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Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali chen Yiyong Wei jin Liu Tao Zhu cheng Zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

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Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： jin-Hui chen Zuo-Tang Liang Yu-Gang Ma Xin-Li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

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扩弓和Ⅱ类牵引矫治成人安氏Ⅱ类2分类错

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实用口腔医学杂志 2004年第6期20卷 707-710页

作者：金作林陈楠王海雪西安第四军医大学口腔医学院 710032

目的 :应用扩大上 /下颌牙弓和Ⅱ类牵引方法矫治成人安氏Ⅱ类 2分类错牙合 ,观察并比较矫治前后硬组织X线头影测量以及模型的变化。方法 :选取临床矫治的安氏Ⅱ类 2分类错牙合成人病例 15例 ,矫治采用非拔牙矫治的扩大上 /下颌牙弓以及... 详细信息

目的 :应用扩大上 /下颌牙弓和Ⅱ类牵引方法矫治成人安氏Ⅱ类 2分类错牙合 ,观察并比较矫治前后硬组织X线头影测量以及模型的变化。方法 :选取临床矫治的安氏Ⅱ类 2分类错牙合成人病例 15例 ,矫治采用非拔牙矫治的扩大上 /下颌牙弓以及Ⅱ类牵引的方法 ,测量矫治前后X线头影测量和模型测量的变化并比较。结果 :头影测量治疗前后上颌骨矢状方向和垂直方向变化不明显 ,下颌骨矢状方向SNB平均增加 2 .5° ,垂直方向下颌平面角平均增加了 2 .7° ,下前面高平均增加了 11.8mm ,上下切牙明显唇倾 ,下颌磨牙明显近移 ;模型测量治疗前后覆牙合明显减小 ,上下颌尖牙间、前磨牙间和上颌磨牙间宽度明显增加 ,下颌磨牙增加不明显。下颌尖牙和磨牙平均近移 4.1mm和 3 .6mm。磨牙关系由Ⅱ类变为I类。结论 :成人安氏Ⅱ类 2分类错牙合可以通过扩大上 /下颌牙弓和II类牵引方法矫治。

关键词：扩大上/下牙弓 Ⅱ类牵引成人安氏Ⅱ类2分类错(hé)

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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke Feng chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian Xiang Lu Qiu Xiaohan chen Yinkun Zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu Dan Xiao Zhaoyu jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

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Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： jin-Fang Wu Yi-Sheng chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

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聚酰亚胺纤维化学镀镍–磷及其性能

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电镀与涂饰 2017年第1期36卷 16-20页

作者：李爽邵惠奇蒋金华陈南梁东华大学纤维材料改性国家重点实验室纺织学院上海201620

在聚酰亚胺(PI)纤维表面化学镀镍–磷合金镀层。采用场发射扫描电子显微镜、能谱仪、X射线衍射仪、微电阻测试仪等表征了其微观形貌、成分、物相组成和导电性。分别通过铜盐加速乙酸盐雾(CASS)试验和冷热循环试验对镍–磷镀层的耐蚀性... 详细信息

在聚酰亚胺(PI)纤维表面化学镀镍–磷合金镀层。采用场发射扫描电子显微镜、能谱仪、X射线衍射仪、微电阻测试仪等表征了其微观形貌、成分、物相组成和导电性。分别通过铜盐加速乙酸盐雾(CASS)试验和冷热循环试验对镍–磷镀层的耐蚀性和结合力进行评判。结果表明:聚酰亚胺纤维化学镀镍–磷后,表面沉积了一层均匀、致密的镍–磷合金镀层,其中镍和磷的质量分数分别为88.32%和8.41%,厚度约为2μm。镀层与纤维结合良好,导电性和耐蚀性优异。

关键词：聚酰亚胺纤维化学镀镍-磷合金表面形貌导电性耐蚀性结合力

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植保无人机作业质量提升方法

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现代农业科技 2017年第13期 140-141,143页

作者：雷楠金晨钟李静波湖南人文科技学院湖南农田杂草防控技术与应用协同创新中心湖南娄底417000

植保无人机具有较高的灵活性和施药效率,省工、省力、节约人力成本,近年来受到高度重视。无人机作业质量需要考虑作业环境、作业条件、作业参数、药液配方、药液浓度、无人机参数等因素。选择合适的无人机作业条件和参数以及合理的药液... 详细信息

植保无人机具有较高的灵活性和施药效率,省工、省力、节约人力成本,近年来受到高度重视。无人机作业质量需要考虑作业环境、作业条件、作业参数、药液配方、药液浓度、无人机参数等因素。选择合适的无人机作业条件和参数以及合理的药液,结合现代精准农业技术优化无人机性能,可提高植保无人机的作业质量,促进植保无人机的发展。

关键词：植保无人机作业参数作业质量性能优化

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