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Banxia Xiexin Decoction Alleviated Cerebral Glucose Metabolism Disorder by Regulating Intestinal Microbiota in APP/PS1 Mice

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Chinese Journal of Integrative Medicine 2024年第8期30卷 701-712页

作者： gao Chen-yan QIN gao-feng ZHENG ming-cui TIAN Mei-jing HE Yan-nan WANG Peng-wen Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Neurology Department Binzhou Medical University HospitalBinzhouShandong Province256603China

Objective To identify whether Banxia Xiexin Decoction(BXD)alleviates cerebral glucose metabolism disorder by intestinal microbiota regulation in APP/PS1 *** Forty-five 3-month-old male APP/PS1 mice were divided into 3 groups using a random number table(n=15 per group),including a model group(MG),a liraglutide group(LG)and a BXD group(BG).Fifteen 3-month-old male C57BL/6J wild-type mice were used as the control group(CG).Mice in the BG were administered BXD granules by gavage at a dose of 6 g/(kg·d)for 3 months,while mice in the LG were injected intraperitoneally once daily with Liraglutide Injection(25 nmol/kg)for 3 ***,liquid chromatography with tandem-mass spectrometry was used to analyze the active components of BXD granules and the medicated serum of ***,the cognitive deficits,Aβpathological change and synaptic plasticity markers,including synaptophysin(SYP)and postsynaptic density protein 95(PSD95),were measured in APP/PS1 *** glucose uptake was detected by micropositron emission *** microbial constituents were detected by 16S rRNA *** levels of intestinal glucagon-like peptide 1(GLP-1)and cerebral GLP-1 receptor(GLP-1R),as well as the phosphoinositide-3-kinase/protein kinase B/glycogen synthase kinase-3β(PI3K/Akt/GSK3β)insulin signaling pathway were determined by immunohistochemical(IHC)staining and Western blot analysis,*** BXD ameliorated cognitive deficits and Aβpathological features(P<0.01).The expressions of SYP and PSD95 in the BG were higher than those in the MG(P<0.01).Brain glucose uptake in the BG was higher than that in the MG(P<0.01).The intestinal microbial composition in the BG was partially *** levels of intestinal GLP-1 in the BG were higher than those in the MG(P<0.01).Compared with the MG,the expression levels of hippocampal GLP-1R,Akt,PI3K and p-PI3K in the BG were significantly increased(P<0.01),while the levels of GSK3βwere reduced(P<0.01).Conclusion BXD

关键词： Banxia Xiexin Decoction Alzheimer's disease intestinal microbiota glucagon-like peptide 1 cerebral insulin resistance phosphoinositide-3-kinase/proteinkinase B/glycogen synthase kinase-3β Chinese medicine

Dynamic access task scheduling of LEO constellation based on space-based distributed computing

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Journal of Systems Engineering and Electronics 2024年第4期35卷 842-854页

作者： LIU Wei jin Yifeng ZHANG Lei gao Zihe TAO Ying Institute of Telecommunication and Navigation Satellites China Academy of Space TechnologyBeijing 100094China Innovation Center of Satellite Communication System China National Space AdministrationBeijing 100094China

A dynamic multi-beam resource allocation algorithm for large low Earth orbit(LEO)constellation based on on-board distributed computing is proposed in this *** allocation is a combinatorial optimization process under a series of complex constraints,which is important for enhancing the matching between resources and requirements.A complex algorithm is not available because that the LEO on-board resources is *** proposed genetic algorithm(GA)based on two-dimen-sional individual model and uncorrelated single paternal inheri-tance method is designed to support distributed computation to enhance the feasibility of on-board application.A distributed system composed of eight embedded devices is built to verify the algorithm.A typical scenario is built in the system to evalu-ate the resource allocation process,algorithm mathematical model,trigger strategy,and distributed computation *** to the simulation and measurement results,the proposed algorithm can provide an allocation result for more than 1500 tasks in 14 s and the success rate is more than 91%in a typical *** response time is decreased by 40%com-pared with the conditional GA.

关键词： beam resource allocation distributed computing low Earth obbit(LEO)constellation spacecraft access task scheduling

Experimental and numerical study of combustion characteristics of ammonia-hydrogen-air swirling flame with/without secondary air injection

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Chinese Journal of Aeronautics 2024年第4期37卷 243-255页

作者： Chunyu LIU Chenhu gao Yue HUANG Hua jin Dan ZHAO Wenjiang XU Yancheng YOU School of Aerospace Engineering Xiamen UniversityXiamen 361005China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Mechanical Engineering University of CanterburyChristchurch 8041New Zealand

Ammonia (NH_(3)) is currently considered to be a potential carbon-free alternative fuel,and its large-scale use as such would certainly decrease greenhouse gas emissions and meet increasingly stringent emission *** the low flame propagation speed and high NO production of NH_(3) hinder its direct application as a renewable fuel,co-combustion of NH_(3)–H_(2)is an effective way to overcome these *** this study,the combustion characteristics of NH_(3)–H_(2)swirling flames under different equivalence ratios and H_2blending ratios conditions are both numerically and experimentally ***,the One-Dimensional (1D) laminar flame computation presents a comparison base and the Three-Dimensional (3D) numerical simulation yields detailed flame property ***,the high-speed camera takes instantaneous swirl flame images and the gas analyzer measures the NO emission at the exit plane of the flame *** and quantitative analysis is performed on the flame structure and NO emission for a series of NH_(3)–H_(2)swirl *** variation trends of the NO emission calculated using different techniques agree very *** quantitative results show that the NO emissions are much higher at lean equivalence ratios than those at rich equivalence ratios,and such difference is closely related to the combustion flame ***,it is shown that the utilization of secondary air injection can achieve a significant reduction in NO emissions at the exit of the combustion chamber at equivalence ratios less than or equal to 0.9.

关键词： Ammonia combustion Swirling flow NO emission characteristics Secondary combustion Chemical reaction mechanism

Recent advances and future prospects on Ni_(3)S_(2)-Based electrocatalysts for efficient alkaline water electrolysis

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Green Energy & Environment 2024年第4期9卷 659-683页

作者： Shiwen Wang Zhen Geng Songhu Bi Yuwei Wang Zijian gao Liming jin Cunman Zhang Clean Energy Automotive Engineering Center School of Automotive StudiesTongji UniversityShanghai201804China

Green hydrogen(H_(2))produced by renewable energy powered alkaline water electrolysis is a promising alternative to fossil fuels due to its high energy density with zero-carbon ***,efficient and economic H_(2) production by alkaline water electrolysis is hindered by the sluggish hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).Therefore,it is imperative to design and fabricate high-active and low-cost non-precious metal catalysts to improve the HER and OER performance,which affects the energy efficiency of alkaline water ***_(3)S_(2) with the heazlewoodite structure is a potential electrocatalyst with near-metal conductivity due to the Ni–Ni metal ***,the review comprehensively presents the recent progress of Ni_(3)S_(2)-based electrocatalysts for alkaline water ***,the HER and OER mechanisms,performance evaluation criteria,preparation methods,and strategies for performance improvement of Ni_(3)S_(2)-based electrocatalysts are *** challenges and perspectives are also analyzed.

关键词： Alkaline water electrolysis Hydrogen Electrocatalysts Ni_(3)S_(2)

Pathological and physiological functional cross-talks ofα-synuclein and tau in the central nervous system

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Neural Regeneration Research 2024年第4期19卷 855-862页

作者： mingyue jin Shengming Wang Xiaodie gao Zhenyou Zou Shinji Hirotsune Liyuan Sun Guangxi Key Laboratory of Brain and Cognitive Neuroscience Guilin Medical University Department of Genetic Disease Research Osaka Metropolitan University Graduate School of Medicine Department of Scientific Research Brain Hospital of Guangxi Zhuang Autonomous Region

α-Synuclein and tau are abundant multifunctional brain proteins that are mainly expressed in the presynaptic and axonal compartments of neurons,*** works have revealed that intracellular deposition ofα-synuclein and/or tau causes many neurodegenerative disorders,including Alzheimer’s disease and Parkinson’s *** intense investigation,the normal physiological functions and roles ofα-synuclein and tau are still unclear,owing to the fact that mice with knockout of either of these proteins do not present apparent ***,the co-occurrence ofα-synuclein and tau aggregates was found in post-mortem brains with synucleinopathies and tauopathies,some of which share similarities in clinical ***,the direct interaction ofα-synuclein with tau is considered to promote the fibrillization of each of the proteins in vitro and in *** the other hand,our recent findings have revealed thatα-synuclein and tau are cooperatively involved in brain development in a stage-dependent *** findings indicate strong cross-talk between the two proteins in physiology and *** this review,we provide a summary of the recent findings on the functional roles ofα-synuclein and tau in the physiological conditions and pathogenesis of neurodegenerative diseases.A deep understanding of the interplay betweenα-synuclein and tau in physiological and pathological conditions might provide novel targets for clinical diagnosis and therapeutic strategies to treat neurodegenerative diseases.

关键词： alpha-synuclein microtubule-associated protein neurodegenerative disease tau

Engineering g-C_(3)N_(4)based materials for advanced photocatalysis:Recent advances

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Green Energy & Environment 2024年第2期9卷 166-197页

作者： Xin-Lian Song Lei Chen Li-Jiao gao jin-Tao Ren Zhong-Yong Yuan National Institute for Advanced Materials School of Materials Science and EngineeringSmart Sensing Interdisciplinary Science CenterNankai UniversityTianjin300350China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin300071China

Photocatalysis driven by abundant yet intermittent solar energy has considerable potential in renewable energy generation and environmental *** outstanding electronic structure and physicochemical properties of graphitic carbon nitride(g-C_(3)N_(4)),together with unique metal-free characteristic,make them ideal candidates for advanced photocatalysts *** review summarizes the up-to-date advances on g-C_(3)N_(4)based photocatalysts from ingenious-design strategies and diversified photocatalytic ***,the advantages,fabrication methods and limitations of each design strategy are systemically *** order to deeply comprehend the inner connection of theory–structure–performance upon g-C_(3)N_(4)based photocatalysts,structure/composition designs,corresponding photocatalytic activities and reaction mechanisms are jointly discussed,associated with introducing their photocatalytic applications toward water splitting,carbon dioxide/nitrogen reduction and pollutants degradation,***,the current challenges and future perspectives for g-C_(3)N_(4)based materials for photocatalysis are briefly *** design strategies and limitations are also instructive for constructing g-C_(3)N_(4) based materials in other energy and environment-related applications.

关键词： Graphitic carbon nitride g-C_(3)N_(4) Design strategies Photocatalysis Photocatalysts Reaction mechanism

DCFNet:Discriminant Correlation Filters Network for Visual Tracking

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Journal of Computer Science & Technology 2024年第3期39卷 691-714页

作者：胡卫明王强高晋李兵 Stephen Maybank State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of Sciences Beijing 100190China Department of Computer Science and Information Systems Birkbeck CollegeLondon WC1E 7HXU.K.

CNN(convolutional neural network)based real time trackers usually do not carry out online network update in order to maintain rapid tracking *** inevitably influences the adaptability to changes in object *** filter based trackers can update the model parameters online in real *** this paper,we present an end-to-end lightweight network architecture,namely Discriminant Correlation Filter Network(DCFNet).A differentiable DCF(discriminant correlation filter)layer is incorporated into a Siamese network architecture in order to learn the convolutional features and the correlation filter *** correlation filter can be efficiently updated *** previous work,we introduced a joint scale-position space to the DCFNet,forming a scale DCFNet which carries out the predictions of object scale and position *** combine the scale DCFNet with the convolutional-deconvolutional network,learning both the high-level embedding space representations and the low-level fine-grained representations for *** adaptability of the fine-grained correlation analysis and the generalization capability of the semantic embedding are complementary for visual *** back-propagation is derived in the Fourier frequency domain throughout the entire work,preserving the efficiency of the *** evaluations on the OTB(Object Tracking Benchmark)and VOT(Visual Object Tracking Challenge)datasets demonstrate that the proposed trackers have fast speeds,while maintaining tracking accuracy.

关键词： correlation filter convolutional neural network(CNN) visual tracking

Efficient photocatalytic NADH regeneration with Rh-loaded Z-scheme mediator-free system

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Chinese Chemical Letters 2024年第2期35卷 496-500页

作者： Yi Zhou Yiling He ming gao Ningkai Ding Juying Lei Yanbo Zhou State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process East China University of Science and TechnologyShanghai 200237China National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery East China University of Science and TechnologyShanghai 200237China Shanghai Engineering Research Center for Multi-media Environmental Catalysis and Resource Utilization East China University of Science and TechnologyShanghai 200237China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Nicotinamide adenine dinucleotide(NADH)regeneration is necessary for the sustainable application of enzymatic *** Rh-based complex[Cp^(*)Rh(bpy)(H)]+has been widely used as an important mediator in NADH regeneration systems,but it is limited by complexity and high ***,a Z-scheme was constructed by loading Rh onto carbon nitride nanosheets/carbon nitride quantum dots(CN-CNQD).The resultant catalyst achieved a high yield of NADH in a mediator-free(M-free)system of 0.283 mmol L^(−1) g^(−1) min^(−1),which is 5.29 times that of pure *** enzyme introduction experiments confirmed that the enzyme active product 1,4-NADH could reach 34.21%selectivity in the M-free *** research revealed that the heterojunction between CNs and CNQDs improved the NADH regeneration activity in the traditional M-involved system,while Rh loading was proved to optimize the yield and selectivity of 1,4-NADH in M-free *** immobilized Rh shows more competitiveness than[Cp^(*)Rh(bpy)(H)]^(+).This study contributes to the construction of an M-free system for further application in greener,lower-cost enzymatic processes.

关键词： Photocatalysis NADH regeneration Mediator-free Carbon nitride Z-scheme

Construction of biomimetic proton transport channels in metal-organic framework

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Chinese Chemical Letters 2024年第3期35卷 513-517页

作者： Xiao-Min Li Junchao Jia Danting Yang Jiali jin Junkuo gao School of Materials Science and Engineering Institute of Functional Porous MaterialsZhejiang Sci-Tech UniversityHangzhou 310018China Zhejiang Key Laboratory of Pathophysiology School of Public HealthSchool of MedicineNingbo UniversityNingbo 315211China

Construction of proton transport channels in metal-organic frameworks(MOFs)with simple synthesis processes,high proton conductivities and good performance stabilities has been of great interest for proton exchange membrane fuel cell(PEMFC).Herein,we mimic the proton transport behavior of amino acid residues in bacteriorhodopsin,select UiO-66-COOH as the host,glycine and aspartic acid as the functional guest molecules,and then functionalize the MOF framework with amino acids to obtain biomimetic proton transport *** strategy endows UiO-66-COOH-Asp a high proton conductivity of 1.19×10^(-2)S/cm at 70℃and 98%RH,excellent cycle stability of performances and performance durability,which can be comparable to the reported MOFs-based proton ***,the proton conduction mechanism in UiO-66-COOH-Asp is elaborated in detail due to its visual structure,which is also one of the advantages of adopting MOFs as research platform,making it possible to optimize the structure-activity relationship of advanced ***,this strategy has clear objectives and simple synthesis,which has made certain contributions to both theoretical research and future industrial production of proton conductors.

关键词： MOF Amino acids Biomimetic proton transport channels Synergistic effect Proton conduction mechanism