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Autophagy and apoptosis: rivals or mates?

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Chinese Journal of Cancer 2013年第3期32卷 103-105页

作者： Yan Cheng jin-ming yang Department of Pharmacology and The Penn State Hershey Cancer Institute The Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center HersheyPA 17033 USA.

Autophagy, a cellular process of "self-eating" by which intracellular components are degraded within the lysosome, is an evolutionarily conserved response to various stresses. Autophagy is associated with numerous patho-physiological conditions, and dysregulation of autophagy contributes to the pathogenesis of a variety of human diseases including cancer. Depending on context, activation of autophagy may promote either cell survival or death, two major events that determine pathological process of many illnesses. Importantly, the activity of autophagy is often associated with apoptosis, another critical cellular process determining cellular fate. A better understanding of biology of autophagy and its implication in human health and disorder, as well as the relationship between autophagy and apoptosis, has the potential of facilitating the development of autophagy -based therapeutic interventions for human diseases such as cancer.

关键词：细胞凋亡自噬人类疾病病理过程细胞内生理条件自体吞噬发病机制

Bismuth trichloride-catalyzed oxy-Michael addition of water and alcohol to α,β-unsaturated ketones

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Chinese Chemical Letters 2020年第5期31卷 1297-1300页

作者： Zhen Wu Xue-Xin Feng Qing-Dong Wang jin-jin Yun Weidong Rao jin-ming yang Zhi-Liang Shen School of Chemistry and Molecular Engineering Nanjing Tech UniversityNanjing 211816China School of Pharmacy Yancheng Teachers UniversityYancheng 224007China Jiangsu Key Laboratory of Biomass-based Green Fuels and Chemicals College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China

An efficient method was developed for the conjugate addition of water to various a,β-unsaturated ketones by using bismuth(Ⅲ)chlo ride as a *** reactions proceeded smoothly in the presence of a catalytic amount of BiCl3(20 mol%)in aqueous media to furnish a variety of synthetically usefulβ-hydroxyl ketones in moderate to good *** from water molecule,various alcohols could also be employed as nucleophiles to react withα,β-unsaturated ketones,leading toβ-alkoxyl ketones in modest to high *** addition,the mild reaction conditions also entailed the conjugate addition reactions to proceed with the tolerance to a range of functional groups.

关键词： Bismuth trichloride Water β-Hydroxyl carbonyl compound Michael addition Functional group tolerance

Experimental Study of Local Scour Around Four Piles Under Different Attack Angles and Gap Ratios

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China Ocean Engineering 2024年第4期38卷 612-624页

作者： LIU ming-ming TANG Guo-qiang jin Xin GENG Shao-yang School of Architecture and Engineering Liaocheng UniversityLiaocheng 252000China Water-Sediment Regulation and Sand Effective Utilization Special Laboratory of Shandong Provincial Education Department Liaocheng UniversityLiaocheng 252000China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China College of Electronic Engineering Chengdu University of Information TechnologyChengdu 610225China College of Energy Chengdu University of TechnologyChengdu 610059China

In an effort to investigate and quantify the patterns of local scour,researchers embarked on an in-depth study using a systematic experimental *** research focused on the effects of local scour around a set of four piles,each subjected to different hydromechanical *** particular,this study aimed to determine how different attack angles—the angles at which the water flow impinges on the piles,and gap ratios—the ratios of the spacing between the piles to their diameters,influence the extent and nature of scour.A comprehensive series of 35 carefully designed experiments were orchestrated,each designed to dissect the nuances in how the gap ratio and attack angle might contribute to changes in the local scour observed at the base of pile *** these experimental trials,a wealth of local scour data were collected to support the *** data included precise topographic profiles of the sediment bed around the pile groups,as well as detailed scour time histories showing the evolution of scour at strategic feature points throughout the test *** analysis of the experimental data provided interesting *** study revealed that the interplay between the gap ratio and the attack angle had a pronounced influence on the scouring dynamics of the pile *** of the key observations was that the initial phases of scour,particularly within the first hour of water flow exposure,were characterized by a sharp increase in the scour depth occurring immediately in front of the *** this initial rapid development,the scour depth transitioned to a more gradual change *** contrast,the scour topography around the piles continuously *** suggests that sediment displacement and the associated sculpting of the seabed around pile foundations are sustained and progressive processes,altering the underwater landscape over *** results of this empirical investigation have significant implications for the design and constructio

关键词： local scour piles gap ratio attack angle

Global Zero-relaxation Limit Problem of the Electro-diffusion Model Arising in Electro-Hydrodynamics

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 241-268页

作者： ming-hua yang Si-ming Huang jin-yi Sun Department of Mathematics Jiangxi University of Finance and EconomicsNanchang330032China School of Public Administration Guangdong University of Foreign StudiesGuangzhou510006China College of Mathematics and Statistics Northwest Normal UniversityLanzhou730070China

In this paper,we study a global zero-relaxation limit problem of the electro-diffusion model arising in electro-hydrodynamics which is the coupled Planck-Nernst-Poisson and Navier-Stokes *** is,the paper deals with a singular limit problem of{u^(∈)_(t)+u^(∈)·▽u^(∈)-Δu^(∈)+▽P^(∈)=Δφ^(∈)▽φ^(∈),in R^(3)×(0,∞),▽·u^(∈)=0,in R^(3)×(0,∞),n^(∈)_(t)+u^(∈)·▽n^(∈)-Δn^(∈)=-▽·(n^(∈)▽φ^(∈)),in R^(3)×(0,∞),ct+u^(∈)·▽c^(∈)-Δc^(∈)=▽·(c^(∈)▽φ^(∈)),in R^(3)×(0,∞),∈^(-1)φ^(∈)_(t)=Δφ^(∈)-n^(∈)+c^(∈),in R^(3)×(0,∞),(u^(∈),n^(∈),c^(∈),φ^(∈))|t=0=(u0,n0,c0,φ0),in R^(3) involving with a positive,large parameter^(∈).The present work show a case that(u^(∈),n^(∈),c^(∈))stabilizes to(u^(∞),n∞,c∞):=(u,n,c)uniformly with respect to the time variable as^(∈)→+∞with respect to the strong topology in a certain Fourier-Herz space.

关键词： fourier-Herz space littlewood-Paley decomposition stability limit dissipative system

Expression of nucleus accumbens-1 in colon cancer negatively modulates antitumor immunity

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World Journal of Gastrointestinal Oncology 2022年第12期14卷 2329-2339页

作者： Zhao-Hua Shen Wei-Wei Luo Xing-Cong Ren Xiao-Yan Wang jin-ming yang Department of Gastroenterology Third Xiangya HospitalCentral South UniversityChangsha 410013Hunan ProvinceChina Department of Cancer Biology and Toxicology University of Kentucky College of MedicineLexingtonMA 40506United States

BACKGROUND Nucleus accumbens-1(NAC-1)is highly expressed in a variety of tumors,including colon cancer,and is closely associated with tumor recurrence,metastasis,and *** To determine whether and how NAC-1 affects antitumor immunity in colon *** NAC-1-siRNA was transfected into RKO colon cancer cells to knock down NAC expression;tumor cells with or without knockdown of NAC-1 were treated with CD8+T cells to test their cytocidal *** level of the immune checkpoint programmed death receptor-1 ligand(PD-L1)in colon cancer cells with or without knockdown of NAC-1 was analyzed using Quantitative real-time polymerase chain reaction and Western blotting.A double luciferase reporter assay was used to examine the effects of NAC-1 on the transcription of *** bearing MC-38-OVA colon cancer cells expressing NAC-shRNA or controlshRNA were treated with OT-I mouse CD8+T cells to determine the tumor response to *** cells in the tumor tissues were analyzed using flow ***-1,PD-L1 and CD8+T cells in colon cancer specimens from patients were examined using immunohistochemistry *** Knockdown of NAC-1 expression in colon cancer cells significantly enhanced the cytocidal effect of CD8+T cells in cell culture *** sensitizing effect of NAC-1 knockdown on the antitumor action of cytotoxic CD8+T cells was recapitulated in a colon cancer xenograft animal ***,knockdown of NAC-1 in colon cancer cells decreased the expression of PD-L1 at both the mRNA and protein levels,and this effect could be rescued by transfection of an RNAi-resistant NAC-1 expression *** a reporter gene assay,transient expression of NAC-1 in colon cancer cells increased the promoter activity of PD-L1,indicating that NAC-1 regulates PD-L1 expression at the transcriptional *** addition,depletion of tumoral NAC-1 increased the number of CD8+T cells but decreased the number of suppressive myeloid-derived suppressor cells

关键词： Nucleus accumbens-1 Colon cancer Tumor immunity Programmed death receptor-1/programmed death receptor-1 ligand CD8+T cells

An efficient Bi/NH_4I-mediated addition reaction for the highly diastereoselective synthesis of homoallylic alcohols in aqueous media

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Chinese Chemical Letters 2020年第2期31卷 391-395页

作者： Zhen Wu Xue-Xin Feng Qing-Dong Wang Xuan-Yu Liu Weidong Rao jin-ming yang Zhi-Liang Shen School of Chemistry and Molecular Engineering Nanjing Tech UniversityNanjing 211816China School of Pharmacy Yancheng Teachers UniversityYancheng 224007China Jiangsu Key Laboratory of Biomass-based Green Fuels and Chemicals College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China

An efficient water-based bismuth-mediated addition reaction of carbonyl compound with cyclic allylic halide was *** reactions proceeded smoothly in aqueous DMF in the presence of ammonium iodide to afford the corresponding syn-homoallylic alcohols in moderate to good yields with excellent diastereoselectivities(>99:1 syn:anti).Reversal of product diastereoselectivity was observed when heteroaryl aldehyde possessing an adjacent chelating nitrogen atom was employed as substrate.

关键词： Bismuth Ammonium iodide Water Homoallylic alcohol Diastereoselectivity

Production induced fracture closure of deep shale gas well under thermo-hydro-mechanical conditions

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Petroleum Science 2024年第3期21卷 1796-1813页

作者： Shi-ming Wei yang Xia Yan jin Xu-yang Guo jing-Yu Zi Kai-Xuan Qiu Si-Yuan Chen College of Science China University of Petroleum(Beijing)Beijing102249China CNOOC Research Institute Ltd Beijing100028China The University of Hong Kong Hong Kong999077China

Deep shale gas reservoirs have geological characteristics of high temperature,high pressure,high stress,and inferior ability to pass through *** multi-stage fractured horizontal well is the key to exploiting the deep shale gas ***,during the production process,the effectiveness of the hydraulic fracture network decreases with the closure of fractures,which accelerates the decline of shale gas *** this paper,we addressed the problems of unclear fracture closure mechanisms and low accuracy of shale gas production prediction during deep shale gas *** we established the fluid—solid—heat coupled model coupling the deformation and fluid flow among the fracture surface,proppant and the shale *** the fluid—solid—heat coupled model was applied to the fracture network,it was well solved by our numerical method named discontinuous discrete fracture *** with the conventional discrete fracture method,the discontinuous discrete fracture method can describe the three-dimensional morphology of the fracture while considering the effect of the change of fracture surface permeation coefficient on the coupled fracture—matrix flow and describing the displacement discontinuity across the *** simulations revealed that the degree of fracture closure increases as the production time proceeds,and the degree of closure of the secondary fractures is higher than that of the primary *** creep and proppant embedment both increase the degree of fracture *** reduction in fracture surface permeability due to proppant embedment reduces the rate of fluid transfer between matrix and fracture,which has often been overlooked in the ***,it significantly impacts shale gas production,with calculations showing a 24.7%cumulative three-year yield *** study is helpful to understand the mechanism of hydraulic fracture ***,it provides the theoretical guidance for maintaining the long

关键词： Shalegas Fracture closure Fluid-solid-heat coupling Discontinuous discrete fracture

Even Search in a Promising Region for Constrained Multi-Objective Optimization

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 474-486页

作者： Fei ming Wenyin Gong Yaochu jin School of Computer Science China University of GeosciencesWuhan 430074China IEEE Faculty of Technology Bielefeld UniversityNorth Rhine-Westphalia 33619Germany School of Engineering Westlake UniversityHangzhou 310030China

In recent years, a large number of approaches to constrained multi-objective optimization problems(CMOPs) have been proposed, focusing on developing tweaked strategies and techniques for handling constraints. However, an overly finetuned strategy or technique might overfit some problem types,resulting in a lack of versatility. In this article, we propose a generic search strategy that performs an even search in a promising region. The promising region, determined by obtained feasible non-dominated solutions, possesses two general ***, the constrained Pareto front(CPF) is included in the promising region. Second, as the number of feasible solutions increases or the convergence performance(i.e., approximation to the CPF) of these solutions improves, the promising region shrinks. Then we develop a new strategy named even search,which utilizes the non-dominated solutions to accelerate convergence and escape from local optima, and the feasible solutions under a constraint relaxation condition to exploit and detect feasible regions. Finally, a diversity measure is adopted to make sure that the individuals in the population evenly cover the valuable areas in the promising region. Experimental results on 45 instances from four benchmark test suites and 14 real-world CMOPs have demonstrated that searching evenly in the promising region can achieve competitive performance and excellent versatility compared to 11 most state-of-the-art methods tailored for CMOPs.

关键词： Constrained multi-objective optimization even search evolutionary algorithms promising region real-world problems

Total Synthesis and Stereochemical Assignment of Talaroconvolutin A and Talarofuranone: Gram-scale Synthesis of Ferroptosis Inducer Talaroconvolutin A

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Chinese Journal of Chemistry 2024年第13期42卷 1509-1514页

作者： ming Yao Wei yang jing Li Chengyun Huang jin Fang Sulu Qin Shuzhi Liu Xiaolong yang School of Pharmaceutical Sciences South-Central Minzu UniversityWuhanHubei 430074China

The first total synthesis of talaroconvolutin A(1.1 g obtained)and talarofuranone has been achieved using accessible materials(12 steps,7.5%and 8.2%yields,respectively).Convergent routes involved intramolecular Diels-Alder reactions in two approaches for creating the decalin ***,an unprecedented DMP-mediated domino reaction resulted in the deoxy-tetramic acid *** syntheses not only establish the absolute configuration of talaroconvolutin A but also enable further collaborative studies of this typeofferroptosisinducers.

关键词： Natural products Aldehydes Total synthesis Domino reactions Biological activity Antitumor agents Ferroptosis Diels-Alder reaction Talaroconvolutin A