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Predictive value of a constructed artificial neural network model for microvascular invasion in hepatocellular carcinoma:A retrospective study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 88-100页

作者： Hai-Yang Nong Yong-Yi Cen Shan-jin Lu Rui-Sui Huang Qiong Chen li-Feng Huang Jian-Ning Huang Xue Wei Man-Rong liu lin li Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youiiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Microvascular invasion(MVI)is a significant risk factor for recurrence and metastasis following hepatocellular carcinoma(HCC)***,there is a paucity of preoperative evaluation approaches for *** To investigate the predictive value of texture features and radiological signs based on multiparametric magnetic resonance imaging in the non-invasive preoperative prediction of MVI in *** Clinical data from 97 HCC patients were retrospectively collected from January 2019 to July 2022 at our *** were classified into two groups:MVI-positive(n=57)and MVI-negative(n=40),based on postoperative pathological *** correlation between relevant radiological signs and MVI status was ***4.6 software and the mutual information method were employed to identify the top 10 dominant texture features,which were combined with radiological signs to construct artificial neural network(ANN)models for MVI *** predictive performance of the ANN models was evaluated using area under the curve,sensitivity,and *** models with relatively high predictive performance were screened using the DeLong test,and the regression model of multilayer feedforward ANN with backpropagation and error backpropagation learning method was used to evaluate the models’*** The absence of a pseudocapsule,an incomplete pseudocapsule,and the presence of tumor blood vessels were identified as independent predictors of HCC *** ANN model constructed using the dominant features of the combined group(pseudocapsule status+tumor blood vessels+arterial phase+venous phase)demonstrated the best predictive performance for MVI status and was found to be automated,highly operable,and very *** The ANN model constructed using the dominant features of the combined group can be recommended as a noninvasive method for preoperative prediction of HCC MVI status.

关键词： Hepatocellular carcinoma Texture analysis Magnetic resonance imaging Microvascular invasion Pseudocapsule Tumor blood vessels

Association between autoimmune gastritis and gastric polyps:Clinical characteristics and risk factors

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 73-87页

作者： jing-Zheng jin Xiao liang Shu-Peng liu Rui-Lan Wang Qing-Wei Zhang Yu-Feng Shen Xiao-Bo li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai 200001China Division of Gastroenterology and Hepatology Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Sichuan Armed Police Corps HospitalLeshan 610041Sichuan ProvinceChina Division of Gastroenterology and Hepatology NHC Key Laboratory of Digestive DiseasesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Gastroenterology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive DiseasesShanghai 200127China

BACKGROUND The relationship between autoimmune gastritis(AIG)and gastric polyps(GPs)is not well *** To explore the clinical characteristics and risk factors of AIG with GPs in *** This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July *** collected clinical,biochemical,serological,and demographic data were of each *** regression analyses,both multivariate and univariate,were conducted to pinpoint independent risk factors for GPs in patients with AIG *** operating characteristic curves were utilized to establish the optimal cutoff values,sensitivity,and specificity of these risk factors for predicting GPs in patients with *** Patients with GPs had a higher median age than those without GPs[61(52.25-69)years vs 58(47-66)years,P=0.006].The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs[91.9(34.2-138.9)pmol/mL vs 60.9(12.6-98.4)pmol/mL,Plike cells hyperplasia(OR=3.116,Plike cells hyperplasia are significant risk factor for the development of GPs in patients with *** gastrin-17 levels may also play a role in this *** findings suggest potential targets for further research and therapeutic intervention in managing GPs in patients with AIG.

关键词： Autoimmune gastritis Gastric polyps Neuroendocrine tumor Risk factors Nomogram

含手性碳原子化合物环状结构及Fischer投影式R/S构型快速判定方法

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吉林师范大学学报（自然科学版） 1989年第4期20卷 62-65页

作者：金向军梅泽民李小平白城师范专科学校

本文对环状有机化合物,通过研究其环平面以及平面上下基团的位置顺序关系,确定出一种简单、迅速判定其R/S构型的方法,而且稍加变化,即可应用于Fischer投影式构型的判断。

关键词：优化基团孤线方向手性碳

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提高浅冷回收装置轻烃收率的技术研究

化学工程师 2005年第11期19卷 48-50页

作者：金丽梅王选庆黑龙江八一农垦大学黑龙江大庆163312 大庆油田测试技术分公司第七大队黑龙江大庆163412

本文以大庆油田某套浅冷回收装置为对象,通过模拟计算研究了温度、压力对轻烃收率的影响,分析装置所存在的问题,提出了具体的工艺技术改造措施。结果表明:在对原装置不作重大改造的前提下,通过回收外输干气冷量,增加水冷设备等,轻烃收... 详细信息

本文以大庆油田某套浅冷回收装置为对象,通过模拟计算研究了温度、压力对轻烃收率的影响,分析装置所存在的问题,提出了具体的工艺技术改造措施。结果表明:在对原装置不作重大改造的前提下,通过回收外输干气冷量,增加水冷设备等,轻烃收率大幅提高,丙烷收率增加了17％,改造方案合理。

关键词：工艺参数浅冷轻烃收率改进措施

人乳恒牙牙髓组织中P2X_3受体mRNA的表达研究

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牙体牙髓牙周病学杂志 2015年第3期25卷 133-136页

作者：金丽梅赵玉梅齐颖俞芳同济大学口腔医学院儿童口腔医学教研室口腔生物医学及转化医学实验室上海200072

目的:探讨乳牙和恒牙牙髓组织中P2X3受体的差异及与炎症引发的牙齿疼痛的关系。方法:选择14个正常恒牙、10个正常乳牙及疼痛乳恒牙各12个的牙髓组织为实验对象,用基质金属蛋白酶-9(MMP-9)来显示牙髓的炎症状态;采用荧光定量PCR方法检测... 详细信息

目的:探讨乳牙和恒牙牙髓组织中P2X3受体的差异及与炎症引发的牙齿疼痛的关系。方法:选择14个正常恒牙、10个正常乳牙及疼痛乳恒牙各12个的牙髓组织为实验对象,用基质金属蛋白酶-9(MMP-9)来显示牙髓的炎症状态;采用荧光定量PCR方法检测并比较人正常与疼痛乳恒牙牙髓组织中P2X3受体mRNA的表达水平。结果:恒牙疼痛组与正常组中P2X3受体mRNA的表达水平无明显差异(P>0.05),乳牙疼痛组中P2X3受体的表达较正常组增强(P<0.05),而乳牙正常组与疼痛组中P2X3受体的表达水平均分别高于恒牙正常组和疼痛组(P<0.05)。结论:P2X3受体可能参与乳牙牙髓炎疼痛的发生。

关键词： P2X3 受体恒牙乳牙牙髓组织疼痛

职业技能竞赛对技术专业课程教学改革的启示——以高职中药制药专业为例

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辽宁高职学报 2013年第5期15卷 29-30页

作者：赵亚丽王玲波靳丽梅黑龙江农业经济职业学院黑龙江牡丹江157041

高职学生参加职业技能竞赛能够锻炼技能,促进就业。通过竞赛,赛出水平,发现问题,找出差距,获得提升,最终达到提高学生专业技能水平的目的。同时竞赛也为调整人才培养方案、检验教学效果和提高教学水平创造了条件。

关键词：职业技能竞赛中药制药技术课程教学改革

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pH对费氏丙酸杆菌细菌素抑菌性的影响

食品研究与开发 2016年第16期37卷 175-178页

作者：郑丽雪郭晨谢建松唐亚进王立梅齐斌常熟理工学院生物与食品工程学院江苏常熟215500 苏州市食品生物技术重点实验室江苏常熟215500

以实验室保存的一株费氏丙酸杆菌CS1420(Propionibacterium freudenreichii CS1420)为试验菌株。首先考察了不同初始pH下对其发酵产细菌素的影响。结果表明:以大肠杆菌ATCC25922为指示菌,当培养基初始pH为6.0时,细菌素抑菌效果最好;以Sa... 详细信息

以实验室保存的一株费氏丙酸杆菌CS1420(Propionibacterium freudenreichii CS1420)为试验菌株。首先考察了不同初始pH下对其发酵产细菌素的影响。结果表明:以大肠杆菌ATCC25922为指示菌,当培养基初始pH为6.0时,细菌素抑菌效果最好;以Saccharomyces cerevisiae 2-10515为指示菌,当培养基初始pH为5.5时,细菌素抑菌效果最好。然后用丙酸调节细菌素粗提物的pH进行抑菌试验,结果表明,pH对粗提得到的细菌素抑菌性影响很大,当用丙酸将细菌素溶液的pH调至5.5时,细菌素的抑菌活性有显著提高。

关键词：费氏丙酸杆菌 pH 细菌素抑菌性