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Imprvoing the solubility of Rivaroxaban via nanocrystallizion

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Imprvoing the solubility of Rivaroxaban via nanocrystallizio...

Attention deficit hyperactivity disorder in children with epilepsy:a multicenter cross-sectional analysis in China

中国晶体学会第六届学术年会暨会员代表大会——第六届全国晶型药物研发技术学术研讨会

作者： jin-mei li Jia-mei Chen Tong-Bu Lu School of Pharmaceutical Sciences Sun Yat-Sen University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry and Chemical EngineeringSun Yat-Sen University

we described a Rivaroxaban(RIV) nanocrystal for overcoming poor solubility here. The results showed that using dissocubes method with polxamer 188、Hydroxy Propyl Methyl Cellulose(HPMC) E9 and Sodium Dodecyl Sulfonate(SDS) as stabilizers, mannitol as freeze-drying protective additive, RIV nanocrystal was produced quickly, the average size of nanocrystal was 186.6±10.0 nm and the zeta potential was 27.03±2.33 mV. The X-ray powder diffraction(XRPD) and differential scanning calorimetry(DSC) analysis verified that the crystalline state of RIV was not transformed after nanocrystallizion. In simulated intestinal fluid(pH 6.8) and simulated gastric fluid(pH 1.2), apparent solubility values of rivaroxaban both are higher than those of the physical mixture and rivaroxaban powder, indicating the solubility of rivaroxaban can be improved by nanocrystallization. It was stable for at least 1 month at 4℃. The pharmacokinetic test in rats indicated that the area under plasma concentration-time curve(AUC) value of RIV nanosuspension(0.552 mg/L·h) was about 4.8-fold higher than that of RIV solution(0.113 mg/L·h). In summary, rivaroxaban nanocrystals are a potential oral delivery system to improve rivaroxaban’s poor dissolution and its oral bioavailability.

关键词： Nanocrystal Rivaroxaban Dissolution Bioavailability

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World Journal of Pediatrics 2024年第10期20卷 1070-1078页

作者： Gang Pan Ying Han Tian-Cheng Wang Zi-Yi Chen Xiang-Qing Wang Hong-Bin Sun Yong-Hong liu Qun Wang Wei-Hong lin jin-mei li Shui-Zhen Zhou Yue-Hua Zhang Department of Neurology Children’s Hospital of Fudan University399 Wan Yuan RoadMinhang DistrictShanghaiChina Department of Pediatrics Peking University First HospitalBeijingChina Department of Neurology Lanzhou University Second HospitalLanzhouChina Department of Neurology The First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina Department of Neurology The First Medical Center of Chinese PLA General HospitalBeijingChina Department of Neurology Sichuan Provincial People HospitalChengduChina Department of Neurology Xijing HospitalFourth Military Medical UniversityXi’anChina Department of Neurology Beijing Tiantan HospitalCaptial Medical UniversityBeijingChina Department of Neurology The First Hospital of Jilin UniversityChangchunChina Department of Neurology Sichuan University West China HospitalChengduChina

Background The diagnosis and treatment of attention deficit hyperactivity disorder(ADHD)comorbid with epilepsy have been insufficiently addressed in *** conducted a study in China to investigate the current status,diagnosis,and treatment of ADHD in children to further our understanding of ADHD comorbid with epilepsy,strengthen its management,and improve patients’quality of *** We carried out a multicenter cross-sectional survey of children with epilepsy across China between March 2022 and August *** screened all patients for ADHD and compared various demographic and clinical factors between children with and without ADHD,including gender,age,age at epilepsy onset,duration of epilepsy,seizure types,seizure frequency,presence of epileptiform discharges,and treatment *** objective was to explore any possible associations between these characteristics and the prevalence of *** Overall,395 epilepsy patients aged 6–18 years were *** age at seizure onset and duration of epilepsy ranged from 0.1–18 to 0.5–15 years,*** onset seizures were observed in 212(53.6%)patients,while 293(76.3%)patients had epileptiform interictal electroencephalogram(EEG)*** the 370 patients treated with anti-seizure medications,200(54.1%)had *** 189(47.8%)patients had ADHD,only 31 received treatment for it,with the inattentive subtype being the most *** was more common in children undergoing polytherapy compared to those on ***,poor seizure control and the presence of epileptiform interictal EEG abnormalities may be associated with a higher prevalence of *** While the prevalence of ADHD was higher in children with epilepsy than in normal children,the treatment rate was notably *** highlights the need to give more importance to the diagnosis and treatment of ADHD in children with epilepsy.

关键词： Attention deficit hyperactivity disorder Children China Epilepsy Electroencephalogram

CD56^brightCD25^＋ NK cells are preferentially recruited to the maternal/fetal interface in early human pregnancy

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Cellular & Molecular Immunology 2015年第1期12卷 77-86页

作者： Yu Tao Yan-Hong li Hai-Lan Piao Wen-Jie Zhou Di Zhang Qiang Fu Song-Cun Wang Da-jin li mei-Rong Du Laboratory for Reproductive Immunology Hospital and Institute of Obstetrics and Gynecology Fudan University Shanghai Medical College Shanghai KeyLaboratory of Female Reproductive Endocrine Related Diseases Shanghai China

Decidual natural killer （dNK） cells are believed to be critical for maintaining maternal/fetal tolerance and regulating placental vascular remodeling based upon their abundance and unique phenotype during early pregnancy. However, the mechanism for how the dNK cells play such important roles in successful pregnancy remains undefined. Here, we identified a subtype of dNK cells characterized as having a CD3-CD56^brightCD25^＋ phenotype. We found that CD56^brightCD25^＋ NK cells preferentially localize to the maternal/fetal interface during early human pregnancy. CD25^＋ dNK cells account for approximately 75% of CD25-expressing decidual immune cells （DICs）. However, less than 5% of CD25-positive peripheral blood mononuclear cells are CD25^＋ NK cells. Furthermore, CD25^＋ and CD25^- dNK cells exhibit distinct phenotypes： CD25^＋ dNK cells display a more activated phenotype and greater cytokine-secreting capacity. Interestingly, coculture of peripheral NK （pNK） cells with primary trophoblasts upregulates the percentage of CD25-expressing pNK cells, resulting in increased expression of activation markers and cytokine production by pNK cells. In addition, we demonstrated that the CXCL12/CXCR4 axis is crucial for the recruitment of CD25^＋ dNK cells and contributes to the accumulation of CD3^-CD56^brightCD25^＋ dNK cells at the maternal/fetal interface. Thus, our data reveal that the crosstalk between trophoblasts and pNK cells leads to the accumulation of CD3^-CD56^brightCD25^＋ dNK cells, which exert a regulating effect at the maternal/fetal interface.

关键词： CXCL12/CXCR4 CD3^-CD56^brightCD25^+ N K cells maternal/fetal interface trophoblasts

Experimental Synthesis of Strained Monolayer Silver Arsenide on Ag(111)Substrates

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Chinese Physics Letters 2020年第6期37卷 111-114页

作者： Shuai Zhang Yang Song Hang li jin-mei li Kai Qian Chen liu Jia-Ou Wang Tian Qian Yu-Yang Zhang Jian-Chen Lu Hong Ding Xiao lin jinbo Pan Shi-Xuan Du Hong-Jun Gao Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100190China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China Kunming University of Science and Technology Kunming 650500China

Two-dimensional(2 D)materials are playing more and more important roles in both basic sciences and industrial *** 2 D materials,strain could tune the properties and enlarge *** the growth of 2 D materials on substrates is often accompanied by strain,the interaction between 2 D materials and substrates is worthy of careful *** we demonstrate the fabrication of strained monolayer silver arsenide(AgAs)on Ag(111)by molecular beam epitaxy,which shows one-dimensional stripe structures arising from uniaxial *** atomic geometric structure and electronic band structure are investigated by low energy electron diffraction,scanning tunneling microscopy,x-ray photoelectron spectroscopy,angle-resolved photoemission spectroscopy and first-principle *** AgAs synthesized on Ag(111)provides a platform to study the physical properties of strained 2 D materials.

关键词： materials. strained silver

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中国会展业时空分布特征

经济地理 2014年第8期34卷 96-102页

作者：杨欣金李梅浙江工商大学旅游与城市管理学院中国浙江杭州310018

从时空思维视角对我国会展业的空间集聚及时间分布特征进行研究,以"E展网"这一中文网页作为研究样本,对2011年1月—2013年12月期间的展会数量、场馆、展览面积、类型等数据进行收集和统计,采用地理集中指数等相关指数,并结合SPSS17.0和A... 详细信息

从时空思维视角对我国会展业的空间集聚及时间分布特征进行研究,以"E展网"这一中文网页作为研究样本,对2011年1月—2013年12月期间的展会数量、场馆、展览面积、类型等数据进行收集和统计,采用地理集中指数等相关指数,并结合SPSS17.0和ArcGIS软件对各地区会展的时空分布特点进行分析。研究发现,会展业在全国范围内存在区域、季节、类型集聚程度不平衡的发展状况,且这些差异与各省市的经济发展水平、场馆建设情况、各地区的季节气候特征以及参展产品属性等因素之间有关联。

关键词：会展业时空分布集聚程度场馆中国

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai li Zhen Ma jin-Hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

Epitaxial fabrication of monolayer copper arsenide on Cu(111)

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Chinese Physics B 2020年第7期29卷 194-198页

作者： Shuai Zhang Yang Song jin mei li Zhenyu Wang Chen liu Jia-Ou Wang Lei Gao Jian-Chen Lu Yu Yang Zhang Xiao lin jinbo Pan Shi Xuan Du Hong-Jun Gao Institute of Physics&University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100190China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100190China Kunming University of Science and Technology Kunming 650500China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China

We report the epitaxial growth of monolayer copper arsenide(CuAs)with a honeycomb lattice on Cu(111)by molecular beam epitaxy(MBE).Scanning tunneling microscopy(STM),low energy electron diffraction(LEED),x-ray photoelectron spectroscopy(XPS),and density functional theory(DFT)verify the√3×√3 superlattice of monolayer CuAs on Cu(111)***-resolved photoemission spectroscopy(ARPES)measurements together with DFT calculations demonstrate the electronic band structures of monolayer CuAs and reveal its metallic *** calculations show that charge transfer from Cu(111)substrate to monolayer CuAs lifts the Fermi level and tunes the band structure of the monolayer *** high-quality epitaxial monolayer CuAs with potential tunable band gap holds promise on the applications in nano-electronic devices.

关键词： copper arsenide(CuAs) band structure scanning tunneling microscopy(STM)

Maternal and fetal death associated with acute pancreatitis during pregnancy:A case report

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World Journal of Clinical Cases 2025年第10期13卷 53-58页

作者： jin li Qing-Yan Zhang mei-Hong Zhang Shan-Yun Jiang Department of Anesthesiology Kaihua County People’s HospitalQuzhou 324300Zhejiang ProvinceChina Center for Clinical Inspection and Quarantine Kaihua County Center for Clinical Inspection and QuarantineQuzhou 324300Zhejiang ProvinceChina

BACKGROUND Acute pancreatitis in pregnancy is a rare but serious condition that can lead to high maternal mortality and fetal *** of pregnancy complicated by severe acute pancreatitis,particularly with subsequent respiratory and cardiac arrest,are rarely *** SUMMARY We present the case of a 35-year-old woman,at 36+5 weeks of gestation,who presented with paroxysmal epigastric pain accompanied by low back pain,nausea,and *** to the clinical symptoms,B-ultrasound imaging and biochemical indicators,the patient was diagnosed with acute pancreatitis and initially managed ***,3 hours after admission,the patient experienced respiratory and cardiac arrest,and the fetus *** this case,the adverse outcomes occurred due to the lack of aggressive fluid resuscitation and an active surgical *** Implementing aggressive fluid resuscitation to sustain tissue perfusion,alongside the proactive evaluation of pharmacological agents that suppress gastric acid secretion and inhibit pancreatic enzyme activity,may be beneficial in mitigating the risk of a severely adverse *** management of acute pancreatitis during pregnancy requires careful timing of surgical intervention,a thorough evaluation of the risks and benefits regarding the continuation or termination of pregnancy,and a focus on safeguarding both maternal and fetal health.

关键词： Severe acute pancreatitis Pregnancy Cardiac arrest Fetal death Case report

双歧杆菌对内毒素损伤幼年大鼠抗氧化作用的影响

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世界华人消化杂志 2006年第29期14卷 2844-2848页

作者：王玮李金梅马文旭孙梅中国医科大学附属第二临床学院儿科辽宁省沈阳市110004 鸡西矿业集团总医院儿科黑龙江省鸡西市158100 大庆油田总医院儿科黑龙江省大庆市163001

目的：探讨内毒素损伤时幼年大鼠体内超氧化物歧化酶(SOD)的变化及双歧杆茵的保护作用．方法：ip内毒素制造内毒素损伤动物模型(模型组,E组),治疗组(T组)提前7d给予双歧杆茵灌胃,同时设对照组(C组,ip生理盐水)和治疗对照组(Tc组,ip内毒... 详细信息

目的：探讨内毒素损伤时幼年大鼠体内超氧化物歧化酶(SOD)的变化及双歧杆茵的保护作用．方法：ip内毒素制造内毒素损伤动物模型(模型组,E组),治疗组(T组)提前7d给予双歧杆茵灌胃,同时设对照组(C组,ip生理盐水)和治疗对照组(Tc组,ip内毒素同时提前7d给予生理盐水灌胃),于不同时间点处死后观察大体及光镜下肠组织损伤变化,同时检测血清和肠组织中SOD的活性．结果：双歧杆茵治疗组大鼠萎靡、食欲差、腹胀、腹泻、肠组织的充血水肿及肠管扩张情况均比模型组轻,HE染色光镜下可见肠绒毛损伤修复时间提前．治疗组血清SOD活性6 h(2158．10±219．04),12 h(2295．96±247．38)和24 h(2416．48±197．21)比模型组高(1644．66±240．38,2016．40±147．03,2108．42±225．55,P＜0．05)：治疗组回肠组织SOD活性6 h (7604．69±662．80),12 h(7573．85±780．66)比模型组高(6805．36±741．98,6723．51±614．62,P＜0．05)．结论：双歧杆菌能减轻由内毒素损伤引起的幼年大鼠的肠组织改变,SOD活性增高进而抑制脂质过氧化损伤可能是其作用机制之一．

关键词：双歧杆菌内毒素抗氧化作用超氧化物歧化酶幼年大鼠