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Calcification-associated molecular traits and therapeutic strategies in hormone receptor-positive HER2-negative breast cancer

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Cancer Biology & Medicine 2024年第5期21卷 400-415页

作者： Yuwei Li Yuzheng Xu Caijin lin Xi jin Ding Ma Zhiming Shao Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

Objective:Mammographic calcifications are a common feature of breast cancer,but their molecular characteristics and treatment implications in hormone receptor-positive(HR+)/human epidermal growth factor receptor 2-negative(HER2−)breast cancer remain ***:We retrospectively collected mammography records of an HR+/HER2−breast cancer cohort(n=316)with matched clinicopathological,genomic,transcriptomic,and metabolomic *** the basis of mammographic images,we grouped tumors by calcification status into calcification-negative tumors,tumors with probably benign calcifications,tumors with calcification of lowmoderate suspicion for maligancy and tumors with calcification of high suspicion for *** then explored the molecular characteristics associated with each calcification status across multiple ***:Among the different statuses,tumors with probably benign calcifications exhibited elevated hormone receptor immunohistochemical staining scores,estrogen receptor(ER)pathway activation,lipid metabolism,and sensitivity to endocrine *** with calcifications of high suspicion for malignancy had relatively larger tumor sizes,elevated lymph node metastasis incidence,Ki-67 staining scores,genomic instability,cell cycle pathway activation,and may benefit from cyclin-dependent kinase 4 and 6(CDK4/6)***:Our research established links between tumor calcifications and molecular features,thus proposing potential precision treatment strategies for HR+/HER2−breast cancer.

关键词： HR+/HER2−breast cancer mammographic calcifications molecular features precision treatment

Lithium polysulfide solvation and speciation in the aprotic lithium-sulfur batteries

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Particuology 2024年第6期89卷 238-245页

作者： jinhao Zhang Qingshan Fu Peng Li Ruibo linghu Xiaozhong Fan Haibin lin Juncao Bian Songbai Han Gengzhi Sun long Kong Frontiers Science Center for Flexible Electronics and Xi’an Institute of Flexible Electronics Northwestern Polytechnical UniversityXi’an710129China China Automotive Innovation Corporation Nanjing211100China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen518055China Institute of Advanced Materials Nanjing Tech UniversityNanjing211816China

Fingerprinting sulfur speciation in aprotic electrolytes is a key to understand fundamental chemistry and design well-performing lithium–sulfur(Li–S)*** polysulfide(LiPS)dissolution and deposition in ether-based electrolytes during redox reactions have been probed and established by spectroscopy and ***,detailed LiPS structure and solvation properties influenced by conventional and newly developed electrolytes remain elusive,which exert fundamental challenges and practical difficulties in decoupling battery performance from electrolyte *** perspective aims to provide timely information to uncover underlying mechanisms that rein in sulfur speciation by considering the charge density of LiPSs and the coordination strength of solvents/*** discussion starts with unlocking the baseline electrolyte formulation to investigate its role in LiPS formation and *** that,the term coordination strength is used instead of donor number and dielectric constant to describe interactions between solvents and LiPSs and to reveal LiPS structure *** work is expected to encourage the discovery of new electrolyte working mechanisms to develop energy-dense and power-intensive Li–S batteries.

关键词： Sulfur speciation Redox kinetics Coordination strength Solvation chemistry Lithium-sulfur batteries

Amelanotic primary cervical malignant melanoma:A case report and review of literature

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World Journal of Clinical Oncology 2024年第7期15卷 953-960页

作者： jin-lin Duan jing Yang Yong-long Zhang Wen-Tao Huang Department of Pathology The Affiliated Tongren HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200332China Laboratory of Targeted Therapy and Precision Medicine Department of Clinical LaboratoryShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

BACKGROUND Primary malignant melanoma of the cervix(PMMC)is an extremely rare disease that originates from primary cervical malignant melanoma and frequently re-presents a challenge in disease diagnosis due to unclarified clinical and histo-logical presentations,particularly those without *** SUMMARY Here,we report a case of amelanotic PMMC,with a history of breast cancer and thyroid *** patient was finally diagnosed by immunohistochemical staining and staged as IB2 based on the International Federation of Gynecology and Obstetrics with reference to National Comprehensive Cancer Network guide-lines and was treated with radical hysterectomy,bilateral salpingo-oophorectomy and pelvic *** then received combination therapy consisting of immunotherapy with tislelizumab and radiofrequency *** has remained free of disease for more than 1 *** The differential diagnosis process reenforced the notion that immunohisto-chemical staining is the most reliable approach for amelanotic PMMC *** to the lack of established therapeutic guidelines,empirical information from limited available studies does not provide the rationale for treatment-decision *** integrating'omics'technologies and patient-derived xenografts or mini-patient-derived xenograft models this will help to identify selective thera-peutic window(s)and screen the appropriate therapeutics for targeted therapies,immune checkpoint blockade or combination therapy strategies effectively and precisely that will ultimately improve patient survival.

关键词： Primary cervical malignant melanoma MelanA Immunotherapy Patient management Case report

Enhancing photoresponsiveness of metal-organic polyhedra by modifying microenvironment

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Nano Research 2024年第6期17卷 5712-5717页

作者： long Zheng Peng Tan Qian Song Sheng-Tao Wang Min Li Xiao-Qin Liu lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

Photoresponsiveness of materials is critical to their tunability and efficiency in terminal *** metal-organic polyhedra(PMOPs)feature intrinsic pores and remote controllability,but aggregation of PMOPs in solid state hampers their photoresponsiveness ***,we report the construction of a new PMOP(Cu_(24)(C_(16)H_(12)N_(2)O_(4))_(12)(C_(18)H_(22)O_(5))12,denoted as MOP-PR-LA),where long alkyl(LA)chains act as the intermolecular poles,propping against adjacent PMOP molecules to create individual microenvironment benefiting the isomerization of photoresponsive(PR)*** ultraviolet(UV)-and visible-light irradiation,MOP-PR-LA is much easier to isomerize than the counterpart MOP-PR without *** propylene adsorption,MOP-PR has a low change of adsorption capacity(9.9%),while that of MOP-PR-LA reaches 58.6%.Density functional theory calculations revealed that PR in the cis state has a negative effect on adsorption,while the trans state of PR favors *** work might open an avenue for the construction of photoresponsive materials with high responsiveness and controllability.

关键词： photoresponsive adsorption metal-organic polyhedra azobenzene long alkyl chains propylene capture

Spin effect on redox acceleration and regioselectivity in Fe-catalyzed alkyne hydrosilylation

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National Science Review 2024年第2期11卷 155-167页

作者： Peng He Meng-Yang Hu jin-Hong Li Tian-Zhang Qiao Yi-lin Lu Shou-Fei Zhu Frontiers Science Center for New Organic Matter State Key Laboratory and Institute of Elemento-Organic Chemistry Nankai University

Iron catalysts are ideal transition metal catalysts because of the Earths abundant, cheap, biocompatible features of iron salts. Iron catalysts often have unique open-shell structures that easily undergo spin crossover in chemical transformations, a feature rarely found in noble metal catalysts. Unfortunately, little is known currently about how the open-shell structure and spin crossover affect the reactivity and selectivity of iron catalysts, which makes the development of iron catalysts a low efficient trial-and-error program. In this paper, a combination of experiments and theoretical calculations revealed that the iron-catalyzed hydrosilylation of alkynes is typical spin-crossover catalysis. Deep insight into the electronic structures of a set of well-defined open-shell active formal Fe(0) catalysts revealed that the spin-delocalization between the iron center and the 1,10-phenanthroline ligand effectively regulates the iron center's spin and oxidation state to meet the opposite electrostatic requirements of oxidative addition and reductive elimination, respectively,and the spin crossover is essential for this electron transfer process. The triplet transition state was essential for achieving high regioselectivity through tuning the nonbonding interactions. These findings provide an important reference for understanding the effect of catalyst spin state on reaction. It is inspiring for the development of iron catalysts and other Earth-abundant metal catalysts, especially from the point of view of ligand development.

关键词： spin effect spin-delocalization spin crossover iron-catalysis alkyne hydrosilylation

Recent advances in quantifying the inactive lithium and failure mechanism of Li anodes in rechargeable lithium metal batteries

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Journal of Energy Chemistry 2024年第9期96卷 226-248页

作者： Mingming Tao Junning Chen Hongxin lin Yingao Zhou Danhui Zhao Peizhao Shan Yanting jin Yong Yang State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materialsnd Department of ChemistryCollege of Chemistrynd Chemical EngineeringTan Kah Kee Innovation Laboratory(IKKEM)Xiamen UniversityXiamen 361005FujianChina School of Engineering Westlake UniversityHangzhou 310024ZhejiangChina School of Energy Research Xiamen UniversityXiamen 361005FujianChina

Lithium metal is considered as the ultimate anode material for the next generation of high-energy density ***,non-uniform lithium dendrite growth,serious electrolyte consumption,and significant volume changes during lithium deposition/stripping processes lead to sustained accumulation of inactive lithium and poor cycling *** the formation and evolution of inactive lithium under different conditions and fully evaluating the complex failure modes are the key issues in this challenging *** article comprehensively reviews recent research progress on the quantification of formation and evolution of inactive lithium detected by different quantitative techniques in rechargeable lithium metal *** key research challenges such as failure mechanism,modification strategies and operando characterization of lithium metal anodes are systematically summarized and *** review provides a new angle of view to understand failure mechanism of lithium metal anodes and inspiration and guidance for the future development of rechargeable lithium metal batteries.

关键词： Lithium metal anodes Inactive lithium Quantitative technique Failure mechanism

A newly proposed heatstroke-induced coagulopathy score in patients with heat illness: A multicenter retrospective study in China

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Chinese Journal of Traumatology 2024年第2期27卷 83-90页

作者： Qing-Wei lin lin-Cui Zhong long-Ping He Qing-Bo Zeng Wei Zhang Qing Song jing-Chun Song Department of Critical Care Medicine The 908th Hospital of Chinese PLA Logistic Support ForcesNanchang360104Jiangsu ProvinceChina Department of Emergency Medicine The 900th Hospital of Chinese PLA Logistic Support ForcesFuzhou350000China Department of Critical Care Medicine Hainan Hospital of Chinese PLA General HospitalSanya572013Hainan ProvinceChina

Purpose:In patients with heatstroke, disseminated intravascular coagulation (DIC) is associated with greater risk of in-hospital mortality. However, time-consuming assays or a complex diagnostic system may delay immediate treatment. Therefore, the present study proposes a new heatstroke-induced coagulopathy (HIC) score in patients with heat illness as an early warning indicator for ***:This retrospective study enrolled patients with heat illness in 24 Chinese hospitals from March 2021 to May 2022. Patients under 18 years old, with a congenital clotting disorder or liver disease, or using anticoagulants were excluded. Data were collected on demographic characteristics, routine blood tests, conventional coagulation assays and biochemical indexes. The risk factors related to coagulation function in heatstroke were identified by regression analysis, and used to construct a scoring system for HIC. The data of patients who met the diagnostic criteria for HIC and International Society on Thrombosis and Haemostasis defined-DIC were analyzed. All statistical analyses were performed using SPSS ***:The final analysis included 302 patients with heat illness, of whom 131 (43.4%) suffered from heatstroke, including 7 death (5.3%). Core temperature (OR = 1.681, 95% CI 1.291 - 2.189, p < 0.001), prothrombin time (OR = 1.427, 95% CI 1.175 - 1.733, p < 0.001) and D-dimer (OR = 1.242, 95% CI 1.049 - 1.471, p = 0.012) were independent risk factors for heatstroke, and therefore used to construct an HIC scoring system because of their close relation with abnormal coagulation. A total score ≥ 3 indicated HIC, and HIC scores correlated with the score for International Society of Thrombosis and Hemostasis-DIC (r = 0.8848, p < 0.001). The incidence of HIC (27.5%) was higher than that of DIC (11.2%) in all of 131 heatstroke patients. Meanwhile, the mortality rate of HIC (19.4%) was lower than that of DIC (46.7%). When HIC developed into DIC, parameters of coagulation dysfunct

关键词： Heat illness Heatstroke Coagulation disorders Diagnosis Disseminated intravascular coagulation

Catalytic transformation of 4-nitrophenol into 4-aminophenol over ZnO nanowire array-decorated Cu nanoparticles

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Green Chemical Engineering 2024年第2期5卷 205-212页

作者： Anlin Feng Chaoyu lin Huiqin Zhou Weihong jin Yidong Hu Dongyang Li Qingyang Li Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou510632China School of Chemical Engineering and Technology Hebei University of TechnologyTianjin300401China Department of Chemical and Materials Engineering University of AlbertaEdmontonT6G 2H5Canada

To realize economical and effective removal of hazardous 4-nitrophenol from the environment,we developed an easily recyclable ZnO nanowire array decorated with Cu *** salix argyracea-shaped structure not only provides a platform to achieve stable and good dispersion of Cu nanoparticles,but also offers a great deal of catalytically active *** density functional theory calculations reveal that ZnO and Cu have a very beneficial synergistic effect on their catalytic *** synergy is ascribed to the electronic localization occurring at ZnO/Cu interface,which helps improve Cu nanoparticle’s ability to adsorb electro-negatively 4-nitrophenolate ions and to capture hydrogen radicals,thereby accelerating the hydrogen transfer from metal hydride complex to *** from these characteristics,it exhibits high efficiency and reusability towards the catalytic reduction of waste 4-nitrophenol to valuable 4-aminophenol with a rate constant of 43.02×10^(-3)s^(-1)and an average conversion of 96.5%in 90 s during 10 *** activity is superior to that of most reported noble-or non-noble-metal powder,bulk,coating,and array catalysts,indicating its competitive advantages in cost and efficiency,as well as enticing application prospects.

关键词： ZnO nanowire Cu nanoparticle Nano-heterojunction 4-Nitrophenol catalytic reduction Density functional theory

In situ tracking of the lithiation and sodiation process of disodium terephthalate as anodes for rechargeable batteries by Raman spectroscopy

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Nano Research 2024年第1期17卷 245-252页

作者： Xiu-Mei lin Chong Han Xin-Tao Yang Jia-Sheng lin Wei-Qiang Yang Hong-Xu Guo Yao-Hui Wang jin-Chao Dong Jian-Feng Li Department of Chemistry and Environment Science Fujian Province University Key Laboratory of Analytical ScienceMinnan Normal UniversityZhangzhou 363000China College of Energy College of Chemistry and Chemical EngineeringCollege of MaterialsState Key Laboratory of Physical Chemistry of Solid SurfacesiChEMXiamen UniversityXiamen 361005China Institute of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China

Organic compounds represent an appealing group of electrode materials for rechargeable batteries due to their merits of biomass,sustainability,environmental friendliness,and *** terephthalate(Na_(2)C_(8)H_(4)O_(4),Na_(2)TP),an organic salt with a theoretical capacity of 255 mAh·g^(-1),is electroactive towards both lithium and ***,its electrochemical energy storage(EES)process has not been directly observed via in situ characterization techniques and the underlying mechanisms are still under ***,in situ Raman spectroscopy was employed to track the de/lithiation and de/sodiation processes of *** appearance and then disappearance of the–COOLi Raman band at 1625 cm^(-1) during the de/lithiation,and the increase and then decrease of the–COONa Raman band at 1615 cm^(-1) during the de/sodiation processes of Na2TP elucidate the one-step with the 2Li+or 2Na+transfer *** also found that the inferior cycling stability of Na2TP as an anode for sodium-ion batteries(SIBs)than lithium-ion batteries(LIBs)could be due to the larger ion radium of Na+than Li+,which results in larger steric resistance and polarization during *** Na2TP,therefore,shows greater changes in spectra during de/sodiation than de/*** expect that our findings could provide a reference for the rational design of organic compounds for EES.

关键词： disodium terephthalate(Na_(2)C_(8)H_(4)O_(4) Na2TP) in situ Raman spectroscopy de/lithiation de/sodiation mechanisms