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Nano-selenium alleviates cadmium-induced cerebellar injury by activating metal regulatory transcription factor 1 mediated metal response

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Animal Nutrition 2022年第4期11卷 402-412页

作者： Shao-Shuai Bi Milton Talukder Hai-Tao jin Mei-Wei Lv jing Ge Cong Zhang Jin-Long Li College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China College of Biotechnology and Pharmaceutical Engineering of West Anhui University Lu’an 237012China Department of Physiology and Pharmacology Faculty of Animal Science and Veterinary MedicinePatuakhali Science and Technology UniversityBarishal8210Bangladesh Quality and Safety Institute of Agricultural Products Heilongjiang Academy of Agricultural SciencesHarbin 150010China College of Veterinary Medicine Henan Agricultural UniversityZhengzhou 450002China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Northeast Agricultural UniversityHarbin 150030China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine Northeast Agricultural UniversityHarbin 150030China

This study aims to investigate the role of metal regulatory transcription factor 1(MTF1)-mediated metal response in cadmium(Cd)-induced cerebellar injury,and to evaluate the antagonistic effects of nanoselenium(Nano-Se)against Cd toxicity.A total of 80 chicks(1 d old,male,Hy-line Variety White)were randomly allocated to 4 treatment groups for 3 months:the control group(fed with a basic diet,n=20),the Nano-Se group(basic diet with 1 mg/kg nano-Se 1 mg/kg Nano-Se in basic diet,n=20),the NanoSe+Cd group(basic diet with 1 mg/kg Nano-Se and 140 mg/kg Cd Cl_(2),n=20)and the Cd group(basic diet with 140 mg/kg Cd Cl_(2),n=20).The results of the experiment showed that the Purkinje cells were significantly decreased with their degradation and indistinct nucleoli after Cd exposure.Moreover,exposure to Cd caused a significant accumulation of Cd and cupper.However,the contents of Se,iron,and zinc were decreased,thereby disturbing the metal homeostasis in the cerebellum.The Cd exposure also resulted in high levels of malondialdehyde(MDA)and down regulation of selenoprotein transcriptome.Furthermore,the expressions of MTF1,metallothionein 1(MT1),MT2,zinc transporter 3(ZNT3),ZNT5,ZNT10,zrt,irt-like protein 8(ZIP8),ZIP10,transferrin(TF),ferroportin 1(FPN1),ATPase copper transporting beta(ATP7B),and copper uptake protein 1(CTR1)were inhibited by Cd exposure.However,all these changes were significantly alleviated by the supplementation of Nano-Se.This study proved that Cd could disorder metal homeostasis and induce oxidative stress,whereas Nano-Se could relieve all these negative effects caused by Cd via activating the MTF1-mediated metal response in the cerebellum of chicken.

关键词： Nano-selenium Cadmium Selenoprotein transcriptome MTF1-mediated metal response Cerebellar injury

ReCSA:a dedicated sort accelerator using ReRAM-based content addressable memory

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中国计算机科学前沿:英文版 2023年第2期17卷 1-13页

作者： Huize li Hai jin long ZHENG Yu HUANG Xiaofei liAO National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabClusters and Grid Computing LabSchool of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

With the increasing amount of data,there is an urgent need for efficient sorting algorithms to process large data sets.Hardware sorting algorithms have attracted much attention because they can take advantage of different hardware's parallelism.But the traditional hardware sort accelerators suffer“memory wall”problems since their multiple rounds of data transmission between the memory and the processor.In this paper,we utilize the in-situ processing ability of the ReRAM crossbar to design a new ReCAM array that can process the matrix-vector multiplication operation and the vector-scalar comparison in the same array simultaneously.Using this designed ReCAM array,we present ReCSA,which is the first dedicated ReCAM-based sort accelerator.Besides hardware designs,we also develop algorithms to maximize memory utilization and minimize memory exchanges to improve sorting performance.The sorting algorithm in ReCSA can process various data types,such as integer,float,double,and strings.We also present experiments to evaluate the performance and energy efficiency against the state-of-the-art sort accelerators.The experimental results show that ReCSA has 90.92×,46.13×,27.38×,84.57×,and 3.36×speedups against CPU-,GPU-,FPGA-,NDP-,and PIM-based platforms when processing numeric data sets.ReCSA also has 24.82×,32.94×,and 18.22×performance improvement when processing string data sets compared with CPU-,GPU-,and FPGA-based platforms.

关键词： ReCAM parallel sorting architecture design processing-in-memory

Non-targeted metabolomics reveals the stress response of a cellulase-containing penicillium to uranium

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Journal of Environmental Sciences 2022年第10期34卷 9-17页

作者： li Zhang Jie li jin-long Lai Xu Yang Yu Zhang Xue-gang Luo School of life Science and Engineering Southwest University of Science and TechnologyMianyang 621010China Engineering Research Center of Biomass Materials Ministry of Education ofSWUSTMianyang 621010China

Human industrial activities have caused environmental uranium(U) pollution, resulting in uranium(Ⅵ) had radiotoxicity and chemical toxicity. Here, a cellulase-producing Penicillium fungus was screened and characterized by X-ray fluorescence(XRF), and Fourier transform infrared reflection(FT-IR), as well as by GC/MS metabolomics analysis, to study the response to uranium(Ⅵ) stress. The biomass of Penicillium decreased after exposure to 100 mg/L U.Uranium combined with carboxyl groups, amino groups, and phosphate groups to form uranium mineralized deposits on the surface of this fungal strain. The α-activity concentration of uranium in the strain was 2.57×10^(6)Bq/kg, and the β-activity concentration was 2.27×10^(5)Bq/kg. Metabolomics analysis identified 118 different metabolites, as well as metabolic disruption of organic acids and derivatives. Further analysis showed that uranium significantly affected the metabolism of 9 amino acids in Penicillium. These amino acids were related to the TCA cycle and ABC transporter. At the same time, uranium exhibited nucleotide metabolism toxicity to Penicillium. This study provides an in-depth understanding of the uranium tolerance mechanism of Penicillium and provides a theoretical basis for Penicillium to degrade hyper-enriched plants.

关键词： Penicillium Uranium Metabolomics Amino acid Nucleic acid

Network Pharmacology and in vitro Experimental Veriflcation on Intervention of Quercetin, Present in Chinese Medicine Yishen Qutong Granules, on Esophageal Cancer

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Chinese Journal of Integrative Medicine 2023年第3期29卷 233-243页

作者： li Jie CHANG jin-yuan JIANG Zheng-long YIN Yu-kun CHEN Jia-yang jin Wei li Hao FENG li National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing(100021)China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing(100029)China

Objective: To explore the potential mechanism of Yishen Qutong Granules(YSQTG) for the treatment of esophageal cancer using network pharmacology and experimental research. Methods: The effective components and molecular mechanism of YSQTG in treating esophageal cancer were expounded based on network pharmacology and molecular docking. The key compound was identified by high-performance liquid chromatography and mass spectrometry(HPLC-MS) to verify the malignant phenotype of the key compounds in the treatment of esophageal cancer. Then, the interaction proteins of key compounds were screened by pull-down assay combined with mass spectrometry. RNA-seq was used to screen the differential genes in the treatment of esophageal cancer by key compounds, and the potential mechanism of key compounds on the main therapeutic targets was verified. Results: Totally 76 effective compounds of YSQTG were found, as well as 309 related targets, and 102 drug and disease interaction targets. The drug-compound-target network of YSQTG was constructed, suggesting that quercetin, luteolin, wogonin, kaempferol and baicalein may be the most important compounds, while quercetin had higher degree value and degree centrality, which might be the key compound in YSQTG. The HPLC-MS results also showed the stable presence of quercetin in YSQTG. By establishing a protein interaction network, the main therapeutic targets of YSQTG in treating esophageal cancer were Jun proto-oncogene, interleukin-6, tumor necrosis factor, and RELA proto-oncogene. The results of cell function experiments in vitro showed that quercetin could inhibit proliferation, invasion, and clonal formation of esophageal carcinoma cells. Quercetin mainly affected the biological processes of esophageal cancer cells, such as proliferation, cell cycle, and cell metastasis. A total of 357 quercetin interacting proteins were screened, and 531 genes were significantly changed. Further pathway enrichment analysis showed that quercetin mainly affects the metabolic pathway, MAPK signaling

关键词： network pharmacology esophageal cancer Yishen Qutong Granule Chinese medicine quercetin nuclear factor kappa B

Sichuan hot-spring snakes imperiled:reason,situation,and protection

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Zoological Research 2022年第1期43卷 95-97页

作者： jin-long Ren Chaochao Yan Zhong-liang Peng Jia-Tang li Chengdu Institute of Biology Chinese Academy of SciencesChengduSichuan 610040China University of Chinese Academy of Sciences Beijing 100049China Mangkang Ecological Station Xizang Ecological Safety Monitor NetworkChangduXizang 854500China

The Sichuan hot-spring snake(Thermophis zhaoermii)is a rare and endemic species found at high elevations in the Hengduan Mountains of China.Recent species-specific investigations showed that the Sichuan hot-spring snake is still restricted to geothermal zones at elevations higher than 3000 m a.s.l.The species also remains at risk of extinction,with the effective population size showing continual decline over the past one million years based on coalescent inference from genome-level single nucleotide polymorphism(SNP)data.We propose several approaches for protecting Sichuan hot-spring snake populations and their habitat.

关键词： spring snake extinction

Enhancing li cycling coulombic efficiency while mitigating “shuttle effect” of li-S battery through sustained release of liNO_(3)

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Journal of Energy Chemistry 2023年第9期84卷 22-29页

作者： Qi jin Kaixin Zhao lili Wu Lu li long Kong Xitian Zhang Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025HeilongjiangChina Frontiers Science Center for Flexible Electronics and Xi’an Institute of Flexible Electronics(IFE) Northwestern Polytechnical UniversityXi’an 710129ShaanxiChina

In practical lithium-sulfur batteries(LSBs),the shuttle effect and li cycling coulombic efficiency(CE) are strongly affected by the physicochemical properties of solid electrolyte interphase(SEI).liNO_(3) is widely used as an additive in electrolytes to build a high-quality SEI,but its self-sacrificial nature limits the ability to mitigate the shuttle effect and stabilize li anode during long-term cycling.To counteract liNO_(3) consumption during long-term cycling without using a high initial concentration,inspired by sustainedrelease drugs,we encapsulated liNO_(3) in lithiated Nafion polymer and added an electrolyte co-solvent(1,1,2,2-tetrafluoroethylene 2,2,2-trifluoromethyl ether) with poor liNO_(3) solubility to construct highquality and durable F-and N-rich SEI.Theoretical calculations,experiments,multiphysics simulations,and in-situ observations confirmed that the F-and N-rich SEI can modulate lithium deposition behavior and allow persistent repair of SEI during prolonged cycling.Hence,the F-and N-rich SEI improves the li anode cycling CE to 99.63% and alleviates the shuttle effect during long-term cycling.The lithium anode with sustainable F-and N-rich SEI shows a stable li plating/stripping over 2000 h at 1 mA cm^(-2).As expected,li‖S full cells with this SEI achieved a long lifespan of 250 cycles,far exceeding cells with a routine SEI.The li‖S pouch cell based on F-and N-rich SEI also can achieve a high energy density of about300 Wh kg^(-1) at initial cycles.This strategy provides a novel design for high-quality and durable SEls in LSBs and may also be extendable to other alkali metal batteries.

关键词： lithium-sulfur battery Solid electrolyte interphase liNO_(3) Coulombic efficiency Shuttle effect

Biodegradable magnesium-matrix composites:A review

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International Journal of Minerals,Metallurgy and Materials 2020年第6期27卷 724-744页

作者： jin-long Su Jie Teng Zi-li Xu Yuan li College of Materials Science and Engineering Hunan UniversityChangsha 410082China The First Affiliated Hospital Hunan Normal UniversityChangsha 410006China

Biodegradable magnesium alloys as new biomedical implant materials have been extensively studied because of their notable biodegradability over traditional bio-inert metals.However,the extreme degradation rate of pure magnesium leads to the loss of its mechanical integrity before the tissue recovers completely.The solutions to this challenge are as follows:(1)purification,(2)alloying,(3)surface modification,and(4)biodegradable magnesium-matrix composites(BMMCs)synthesis.Owing to the tunability of mechanical properties,the adjustability of degradation rate,and the improvement of biocompatibility,BMMCs reinforced with bioactive reinforcements have promising applications as a new generation of biomedical implants.In this review,the processing methods,Mg matrix,and reinforcement phases of BMMCs are discussed.Moreover,the review comprehensively discusses various BMMCs synthesized thus far,aiming to show the governing aspects of the achieved mechanical properties,corrosion behavior,and biocompatibility.Finally,this paper also discusses the research direction and further development areas for these materials.

关键词： magnesium-matrix composites biomaterials mechanical properties corrosion behavior

Simulation on venting process and valve opening control method for gas trunk pipelines

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Petroleum Science 2022年第6期19卷 3016-3028页

作者： li-li Zuo An-Tai jin Qian Chen Qin-long Dong Yuan-Xin li Si-Rui Zhao National Engineering Laboratory for Pipeline Safety/Beijing Key Laboratory of Urban Oil and Gas Distribution Technology China University of Petroleum(Beijing)Beijing102249China Petro China Planning&Engineering Institute Beijing100083China National Petroleum and Natural Gas Pipe Network Group Beijing Pipeline Co. Ltd.Beijing100101China

Determining the venting time of a gas trunk pipeline segment provides an important basis for formulating an emergency plan in the advent of unexpected accidents.As the natural gas venting process corresponds to the transient flow,it is necessary to establish a transient hydraulic-thermal simulation model in order to determine the venting time.In this paper,based on two kinds of venting scenarios in which there is only one venting point in the venting system of a gas trunk pipeline segment—namely,where the venting point is either at one of the two ends or at the junction of two gas trunk pipeline segments—transient hydraulic-thermal simulation models are established.The models consist of gas flow governing equations,the gas state equation,gas physical property equations,initial conditions,and appropriate boundary conditions.The implicit central difference method is used to discretize the gas flow partial differential equations,and the trust-region-dogleg algorithm is used to solve the equations corresponding to each time step,in order to dynamically simulate the whole venting process.The judgment condition for the end of the venting process is that the average pressure of gas trunk pipeline segment is less than 0.11 MPa(actual pressure).Comparing the simulation results of the proposed model with those of the OLGA software and real operational data,we find that the venting time error is less than 10%.On this basis,a venting valve opening control principle is proposed,which prevents the venting noise from exceeded the specified noise value(85 d B)in the venting design of domestic gas pipeline projects.The established calculation model for venting time(dynamic simulation model)for a gas trunk pipeline segment and the proposed opening control principle of venting valve provide reference for the optimal operation of gas pipeline venting systems.

关键词： Gas pipeline Venting time Transient simulation Implicit central difference method Valve Opening Control Method

Controllable Synthesis of a Well-defined Polypropylene grafted Silica Nanoparticles and Its Effect on Crystallization Behavior of Polypropylene

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Chinese Journal of Polymer Science 2022年第11期40卷 1411-1421页

作者： Wei-long Ju Shao-Fan li Yun-Lan Su Du-jin Wang Key Laboratory of Engineering Plastics Beijing National Laboratory for Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

Well-defined polypropylene grafted silica nanoparticles(PP-g-SiO_(2))were prepared through the reaction of maleic anhydride grafted polypropylene(PP-g-MAH)with amino-functionalized silica(SiO_(2)-NH_(2))by the'grafting-to'method.The grafting density of PP-g-SiO_(2) is found to be controlled by the concentration of silane coupling agent 3-[2-(2-aminoethylamino)ethyl amino]propyl trimethoxy silane(TAMS).The maximum grafting density of grafted PP-g-MAH chains with molecular weight of 9100 g/mol could reach 0.34 chains/nm~2,when the critical concentration of TAMS was 0.0194 mol/L.The critical concentration of TAMS can be explained by the maximum amounts of primary amino groups,which can totally react with PP-g-MAH on the surface of SiO_(2)-NH_(2),when the silane monolayer is formed.The synthesized PP-g-SiO_(2)with different molecular weights was mixed with PP by solution mixing to form a series of nanocomposites.The crystallization temperature(T_(c))of nanocomposites increased significantly with the particle loading.The PP-g-SiO_(2) with high molecular weight of grafted chains exhibits a high nucleation ability at 1 wt%nanoparticle loading in PP/PP-g-SiO_(2)nanocomposites.In summary,we provide an effective method to synthesize the well-defined PP-g-SiO_(2)with controlled grafting density,which shows excellent nucleation ability.

关键词： Polypropylene grafted silica nanoparticles Grafting density Grafting to Crystallization behavior