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300 MPa grade highly ductile biodegradable Zn-2Cu-(0.2-0.8)Li alloys with novel ternary phases

Journal of Materials Science & Technology 2023年第26期157卷 234-245页

作者： Meng Cao Zhe Xue Zhao-Yong Lv Jin-Ling Sun Zhang-Zhi Shi Lu-Ning Wang Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advance Metals and MaterialsSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Orthopedics Department Peking University ShouGang HospitalBeijing 100144China Advanced Technology and Materials Co. Ltd.(AT&M)Beijing 100081China Liaocheng People’s Hospital Liaocheng Hospital Affiliated to Shandong First Medical UniversityLiaocheng 252000China

Although a few high-strength biodegradable Zn alloys with yield strengths(YSs)over 300 MPa in rolled state have been developed,their elongations(ELs)are generally less than 30%.This study developed rolled Zn-2Cu-x Li(x=0.2 wt.%,0.5 wt.%,0.8 wt.%)alloys with YSs of 316-335 MPa and ELs of 44%-61%.Three-dimensional atom probe(3DAP)and time of flight secondary ion mass spectrometry(TOF-SIMS)were employed to characterize Li distribution.Three kinds of Zn-Cu-Li ternary phases are identified,which are blockyε′-(Cu_(0.5),Li_(0.5))Zn 4,blockyβ′-(Li_(0.9),Cu_(0.1))Zn 4,and small roundγparticles with high Li content in the annealed state.Other identified phases are Zn,β-LiZn 4,andε-CuZn 4 phases.With the increase of Li content in the alloys,ε′phase with 6.50 at.%Cu transforms intoβ′phase with 2.12 at.%Cu,i.e.,the average level in the alloys.Withinε′phase,there exist nano-scale Li clusters andεphase,resulting inε′/εstructure.Dense Zn laths precipitate fromβ′phase,resulting inβ′/Zn lamellar structure.The lamel-lar structure is the matrix of Zn-2Cu-0.8Li and leads to near-isotropic plasticity.Electrochemistry tests show that degradation rates fall in the range of 153-196μm/year,which decrease with Li content.All the alloys exert positive effects on the growth of MC3T3-E1 cells with 10%extract.This research reveals how microstructure evolves in Zn-2Cu-x Li alloys,which lays the foundation for their future applications.

关键词： Biodegradable Zn alloys Zn-Cu-Li ternary phase Microstructure

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Recent advances in bacteriophage-based therapeutics:Insight into the post-antibiotic era

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Acta Pharmaceutica Sinica B 2022年第12期12卷 4348-4364页

作者： Hao ling Xinyu Lou Qiuhua Luo Zhonggui He Mengchi sun jin sun Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmacy The First Affiliated Hospital of China Medical UniversityShenyang 110001China

Antibiotic resistance is one of the biggest threats to global health, as it can make the treatment of bacterial infections in humans difficult owing to their high incidence rate, mortality, and treatment costs. Bacteriophage, which constitutes a type of virus that can kill bacteria, is a promising alternative strategy against antibiotic-resistant bacterial infections. Although bacteriophage therapy was first used nearly a century ago, its development came to a standstill after introducing the antibiotics. Nowadays, with the rise in antibiotic resistance, bacteriophage therapy is in the spotlight again.As bacteriophage therapy is safe and has significant anti-bacterial activity, some specific types of bacteriophages(such as bacteriophage phi X174 and Pyo bacteriophage complex liquid) entered into phase Ⅲ clinical trials. Herein, we review the key points of the antibiotic resistance crisis and illustrate the factors that support the renewal of bacteriophage applications. By summarizing recent state-of-the-art studies and clinical data on bacteriophage treatment, we introduced(i) the pharmacological mechanisms and advantages of antibacterial bacteriophages,(ii) bacteriophage preparations with clinical potential and bacteriophage-derived anti-bacterial treatment strategies, and(iii) bacteriophage therapeutics aimed at multiple infection types and infection-induced cancer treatments. Finally, we highlighted the challenges and critical perspectives of bacteriophage therapy for future clinical development.

关键词： Antibiotic resistance Bacteriophage therapy Bacteriophage preparations Bacteriophage-derived anti-bacterial treatment strategies

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Photo-triggered Intramolecular Radical Tandem Regioselective Alkylation/Cyclization of 1,6-Dienes with Redox-Active Esters Enabled by an EDA Complex

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Chinese Journal of Chemistry 2023年第1期41卷 37-42页

作者： Bin sun Lan ling Xiaohui Zhuang Lulu Yang Jieli Yin Can jin Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals Zhejiang University of TechnologyHangzhouZhejiang 310014China College of Pharmaceutical Sciences Zhejiang University of TechnologyHangzhouZhejiang 310014China

A photocatalyst-and metal-free radical tandem alkylation/cyclization between 1,6-dienes and redox-active esters has been devel-oped,affording a series of N-aryl pyrrolidine-2-ones in moderate to good yields.The transformation is driven by the formation of an electron-donor-acceptor(EDA)complex and a subsequent single electron transfer(SET)process.This photocatalyst-free protocol features excellent regioselectivity,mild conditions and broad substrate scope,providing a facile access to 3-alkyl-3,4-dimethyl-1-phe-nylpyrrolidin-2-one.

关键词： Alkylation Cyclization EDA Complex Pyrrolidone Photocatalysis

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Emerging nanomedicine and prodrug delivery strategies for the treatment of inflammatory bowel disease

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Chinese Chemical Letters 2022年第10期33卷 4449-4460页

作者： Mengchi sun Weiyue Ban Hao ling Xiang Yu Zhonggui He Qikun Jiang jin sun Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Huzhou Central Hospital Affiliated Huzhou HospitalZhejiang University School of MedicineAffiliated Central Hospital Huzhou UniversityHuzhou 110016China

Inflammatory bowel disease(IBD)is a chronic and recurrent disease of the gastrointestinal tract,mainly including Crohn's disease(CD)and ulcerative colitis(UC).However,current approaches against IBD do not precisely deliver drugs to the inflammatory site,which leads to life-long medication and serious side effects that can adversely impact patients’adherence.It is necessary to construct optimal drug delivery systems(DDSs)that can target drugs to the region of inflammation,thereby improve therapeutic efficacy and reduce side effects.With the burgeoning development of nanotechnology-based nanomedicines(NMs)and prodrug strategy,remarkable progresses in the treatment of IBD have been made in recent years.Herein,the latest advances are outlined at the intersection of IBD treatment and nanotherapeutics as well as prodrug therapy.First,the pathophysiological microenvironment of inflammatory sites of IBD is introduced in order to rationally design potential NMs and prodrugs.Second,the necessity of NMs for the IBD therapy is elaborated,and the representative nanotherapeutics via passive targeted and active targeted NMs developed to treat the IBD are overviewed.Furthermore,the emerging prodrug-based therapeutics are summarized,including 5-aminosalicylic acid-,amino acid-,and carbohydrate-conjugated prodrugs.Finally,the design considerations and perspectives of these NMs and prodrugs-driven IBD therapeutics in the clinical translation are spotlighted.

关键词： Inflammatory bowel disease(IBD) Nanotechnology-based nanomedicines(NMs) Prodrug strategy Pathophysiological microenvirnoment Passive targeted and active targeted NMs

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Biodegradable Zn-0.5Li alloy rib plate:Processing procedure development and in vitro performance evaluation

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Journal of Materials Science & Technology 2023年第10期141卷 245-256页

作者： Jin-Ling Sun Yun Feng Zhang-Zhi Shi Zhe Xue Meng Cao Sheng-Lian Yao Zhen Li Lu-Ning Wang Beijing Advanced Innovation Center for Materials Genome Engineering School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Department of Ophthalmology Beijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third HospitalBeijing 100191China Orthopedics Department Peking University ShouGang HospitalBeijing 100144China Advanced Technology and Materials Co. Ltd(AT&M)Beijing 100081China

Trauma kills more than four million people worldwide each year,with chest trauma accounting for 25%of these deaths.Rib fractures are the main manifestation of chest trauma.Biodegradable Zn alloys offer a new option to overcome clinical problems caused by permanent rib fracture internal fixation mate-rials,e.g.,long-term stress masking and secondary surgery.In this study,the fabrication procedure of biodegradable Zn-0.5Li alloy rib plates is successfully developed,which consists of casting,hot-warm rolling,cutting,and pressing sequentially.Biomechanical three-point bending performance of the Zn al-loy rib plates is comparable to that of commercial pure Ti rib plates,much higher than that of pure Zn rib plates.In addition,the Zn alloy exhibits the best antibacterial ability against E.coli and S.aureus among the three materials.Although the Zn alloy exhibits a weaker MC3T3 cytocompatibility than pure Ti,it is better than pure Zn.This study provides a foundation for the future development of various biodegrad-able Zn alloy rib plates.

关键词： Biodegradable Zn alloy rib plate Mechanical properties Corrosion behavior Biocompatibility Antibacterial ability

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Pure redox-sensitive paclitaxelemaleimide prodrug nanoparticles: Endogenous albumininduced size switching and improved antitumor efficiency

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Acta Pharmaceutica Sinica B 2021年第7期11卷 2048-2058页

作者： Xinyu Lou Dong Zhang Hao ling Zhonggui He jin sun Mengchi sun Dongchun Liu School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Jiangsu Hengrui Medicine Co. Ltd.Lianyungang Eco&Tech Development ZoneLianyungang 222047China

A commercial albumin-bound paclitaxel nano-formulation has been considered a gold standard against breast cancer.However,its application still restricted unfavorable pharmacokinetics and the immunogenicity of exogenous albumin carrier.Herein,we report an albumin-bound tumor redoxresponsive paclitaxel prodrugs nano-delivery strategy.Using diverse linkages(thioether bond and disulfide bond),paclitaxel(PTX)was conjugated with an albumin-binding maleimide(MAL)functional group.These pure PTX prodrugs could self-assemble to form uniform and spherical nanoparticles(NPs)in aqueous solution without any excipients.By immediately binding to blood circulating albumin after intravenous administration,NPs are rapidly disintegrated into small prodrug/albumin nanoaggregates in vivo,facilitating PTX prodrugs accumulation in the tumor region via albumin receptormediated active targeting.The tumor redox dual-responsive drug release property of prodrugs improves the selectivity of cytotoxicity between normal and cancer cells.Moreover,disulfide bond-containing prodrug/albumin nanoaggregates exhibit long circulation time and superior antitumor efficacy in vivo.This simple and facile strategy integrates the biomimetic characteristic of albumin,tumor redox-responsive on-demand drug release,and provides new opportunities for the development of the high-efficiency antitumor nanomedicines.

关键词： Paclitaxel Abraxane Redox-sensitive Disulfide bond Maleimide Prodrug-based nano-drug delivery systems Prodrug/albumin nanoaggregates Breast cancer treatment

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Cross-Band Spectrum Prediction Based on Deep Transfer Learning

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China Communications 2020年第2期17卷 66-80页

作者： Fandi Lin jin Chen Jiachen sun Guoru Ding ling Yu College of Communications Engineering Army Engineering University

Spectrum prediction is a promising technology to infer future spectrum state by exploiting inherent patterns of historical spectrum data.In practice,for a given spectrum band of interest,when facing relatively scarce historical data,spectrum prediction based on traditional learning methods does not work well.Thus,this paper proposes a cross-band spectrum prediction model based on transfer learning.Firstly,by analysing service activities and computing the distances between various frequency points based on Dynamic Time Warping,the similarity between spectrum bands has been verified.Next,the features,which mainly affect the performance of transfer learning in the crossband spectrum prediction,are explored by leveraging transfer component analysis.Then,the effectiveness of transfer learning for the cross-band spectrum prediction has been demonstrated.Further,experimental results with real-world spectrum data demonstrate that the performance of the proposed model is better than the state-of-theart models when the historical spectrum data is limited.

关键词： cross-band spectrum prediction deep transfer learning long short-term memory dynamic time warping transfer component analysis

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Mechanism of Wireless Power Transfer System Waveform Distortion Caused by Nonideal Gallium Nitride Transistor Characteristics

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Chinese Journal of Electrical Engineering 2021年第2期7卷 61-69页

作者： Shaoyu sun Jianshan Zhang Wengang Wu ling Xia Yufeng jin Shenzhen Graduate School Peking UniversityShenzhen 518055China Institute of Microelectronics Peking UniversityBeijing 100871China Shenzhen Hai Li Tech. Inc.Shenzhen 518129China

Gallium nitride(GaN)field-effect transistors have low ON resistance and switching losses in high-frequency(>MHz)resonant wireless power transfer systems.Nevertheless,their performance in the system is determined by their characteristics and operation mode.A particular operating mode in a 6.78-MHz magnetic resonant wireless transfer system that employs class-D GaN power amplifiers in the zero-voltage switching mode is studied.Two operation modes,the forward mode and the reverse mode,are investigated.The nonideal effect under the device-level dynamic resistance and thermal effect are also analyzed.The dynamic resistance under different operation modes is demonstrated to have different generation mechanisms.Finally,the device characteristics with system operating conditions are combined,and the effects of temperature and dynamic resistance under different operating conditions are evaluated.

关键词： GaN wireless power transfer dynamic resistance thermal effect

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Clinical significance of nuchal translucency measurement in routine prenatal examination

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Chinese Medical Journal 2021年第8期134卷 991-992页

作者： Xin-Rong Zhao Li Gao Jin-Ling Sun Ren-Yi Hua Yi Wu Yan-Lin Wang Departm ent of Prenatal Diagnostic Center The International Peace Maternity&Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200030China

To the Editor:Measurement of nuchal translucency(NT)is a validated marker for aneuploidy,fetal abnormalities,and other pathologic conditions,[1] which makes it crucial to ensure the accuracy of NT measurement in clinical treatment.Ever since 2012,all the pregnant women visiting our hospital(The International Peace Maternity&Child Health Hospital Affliated to Shanghai Jiao Tong University School of Medicine,China)need to receive a routine first-trimester sonographic marker assessment.

关键词： routine fetal clinical

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Mitochondrial fusion protein 2 regulates endoplasmic reticulum stress in preeclampsia

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第2期22卷 165-170页

作者： Dandan sun Hui ZHU ling AI Hanbing WU Yanting WU Jihua jin Department of Obstetrics Jiaxing Municipal Maternal and Child Health Care HospitalJiaxing 314051China Department of Obstetrics Women and Children Hospital Affiliated to Jiaxing UniversityJiaxing 314051China Department of Obstetrics Jiaxing Women and Children Hospital Affiliated to Wenzhou Medical UniversityJiaxing 314051China

Preeclampsia(PE)refers to a group of dysfunction syndromes associated with elevated blood pressure and proteinuria in women with previously normal blood pressure after 20 weeks of pregnancy,and it may be accompanied b... 详细信息

关键词： elevated headache reticulum

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