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A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： qi Liu Jianye Xie Runxue Zhou jin Deng Weihong Nie Shuwei Sun Haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

人工流产术后即服用短效口服避孕药与单纯雌激素治疗对子宫内膜的影响

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中国妇幼保健 2018年第7期33卷 1583-1586页

作者：刘金铃马锦琪无锡市第八人民医院妇产科江苏无锡214000 南京医科大学附属无锡市人民医院妇产科江苏无锡214000

目的探讨人工流产术后即服用短效口服避孕药与单纯雌激素治疗对子宫内膜的影响,为临床治疗提供参考。方法选取2014年6月-2016年7月无锡市第八人民医院86例接受人工流产术女性为研究对象,随机数字表法分为对照组与观察组各43例。两组患... 详细信息

目的探讨人工流产术后即服用短效口服避孕药与单纯雌激素治疗对子宫内膜的影响,为临床治疗提供参考。方法选取2014年6月-2016年7月无锡市第八人民医院86例接受人工流产术女性为研究对象,随机数字表法分为对照组与观察组各43例。两组患者均接受无痛人工流产术,术后对照组采用补佳乐,观察组采用优思明,两组均持续治疗3个周期。治疗结束后1~3个月进行随访,统计对比两组术后恢复情况(术后出血量、月经复潮时间、阴道出血持续时间)、疗程结束后子宫内膜厚度和月经不适评分(MDQ)变化情况、并发症发生率及不良反应发生率。结果观察组术后出血量、月经复潮时间、阴道出血持续时间少于对照组,差异有统计学意义(均P0.05),治疗后两组MDQ评分较治疗前降低,且观察组低于对照组,差异有统计学意义(均P<0.05)。两组并发症发生率比较,观察组13.95%低于对照组34.88%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,观察组11.63%低于对照组37.21%,差异有统计学意义(P<0.05)。结论人工流产术后即服用短效口服避孕药效果优于单纯雌激素治疗,可减少术后出血量、阴道出血及月经恢复时间,增加子宫内膜厚度,减轻月经不适感,降低手术并发症发生率,安全性较高。

关键词：人工流产术短效口服避孕药单纯雌激素子宫内膜

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日本老年人介护模式及其理念的借鉴与思考

上海医药 2012年第2期33卷 23-24,36页

作者：金其林王颖丽上海市杨浦区卫生局上海200090

随着老龄化社会的加剧,机构提供老年医疗护理已无法满足需求。借鉴日本"介护"服务理念和模式,结合地区实际,发展"介护式"居家老年医疗护理服务是值得探索的方式。

关键词：老年人介护家庭病床

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-Lin Xiong Xiang-Yang Wen Xin-qiao Li Ce Cai Shuo Xiao qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong jin-Yuan Liao Yan-qiu Zhang Yue Huang Lu Li Xing Wen Fei Zhang jing Duan Chen-Wei Wang Dong-Li Shi Peng Zhang qi-Bin Yi Chao-Yang Li Yan-Bing Xu Xiao-Hua Liang Ya-qing Liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu Wang Sheng Yang Xiao-jing Liu Min Gao Mao-Shun Li jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen Xue Chao Zheng Jia-Cong Liu Xing-Bo Han jin-ling qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao Yang Dong-Jie Hou Yu-Sa Wang Rui qiao Xiang Ma Xiao-Bo Li Ping Wang Xin-Ying Song Li-Ming Song Shi-Jie Zheng Bing Li Hong-Mei Zhang Yue Zhu Wei Chen Jian-Jian He Zhen Zhang jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-Yu Wang Zong-Yuan Yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang Yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Gut microbiota shifts in hepatitis B-related portal hypertension after transjugular intrahepatic portosystemic shunt:Mechanistic and clinical implications

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World Journal of Gastroenterology 2025年第3期31卷 134-137页

作者： qi-Rong Jiang Da-Wu Zeng Department of Hepatology Hepatology Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina

In this article,we provide commentary on the recent article by Zhao et *** focus on the shifts in the gut microbiota of patients with hepatitis B virus(HBV)-associated cirrhosis/portal hypertension(PH)following transjugular intrahepatic portosystemic shunt(TIPS)and the implications for understanding the mechanisms,diagnosis,and *** comparing the gut microbiota composition and dynamic changes before and after TIPS in patients with and without hepatic encephalopathy,the authors found an increase in non-probiotic bacteria in those who developed hepatic encephalopathy post-TIPS,with Morganella species present only in the hepatic encephalopathy *** gut microbiota changes post-TIPS among patients without the occurrence of hepatic encephalopathy suggest potential therapeutic benefits through prophylactic microbiome ***,the specific gut microbiota alterations may hold promise to predict the risk of hepatic encephalopathy in individuals undergoing TIPS for HBVrelated *** these promising findings,future studies are needed to address limitations,including a small sample size,a relatively short evaluation period for gut microbiota alterations,the absence of data on dynamic alterations in gut microbiota post-TIPS and their correlation with blood ammonia levels,and the lack of validation in animal *** conclusion,Zhao et al's study has shed new light on the link of gut microbiota with post-TIPS hepatic encephalopathy,potentially through the intricate gut-liver axis,and has important clinical implications for improving the management of patients with HBV-related PH.

关键词： Hepatitis B virus Cirrhosis Portal hypertension Hepatic encephalopathy Transjugular intrahepatic portosystemic shunt Gut microbiota

Corrosion Behavior of Welded Joints for Cargo Oil Tanks of Crude Oil Carrier

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Journal of Iron and Steel Research International 2016年第9期23卷 955-962页

作者： jin-shan WEI Yan-chang qi Zhi-ling TIAN Yun PENG State Key Laboratory of Advanced Steel Processes and Products Central Iron & Steel Research Institute

E32 grade corrosion resistant steel was welded with welding wires with three different S contents. The mi crostructure, mechanical properties, inclusions, and corrosion behavior of welded joint were investigated. The joint coupon corrosion test and potentiodynamic polarization test were carried out under the simulated corrosion environ- ment of the inner bottom plates of cargo oil tanks. The pitting initiation and propagation mechanism of the weld metal were studied by scanning electron microscopy and infinite focus. The results indicated that the microstructures of three kinds of weld metals are all composed of acicular ferrite, ferrite side-plate and proeutectoid ferrite. The micro- structure of heat affected zone is composed predominantly of bainite. Joint welded with low S filler wire has good me- chanical properties. S can decrease free corrosion potential and increase the corrosion tendency. The pitting initiation is oxide inclusion or sulfide oxide inclusion complex. S can induce the formation of occluded area and promote the corrosion propagation. The chemical compositions of weld metal is similar to base metal, which can limit the galvanic corrosion between weld metal and base metal, and avoid formation of corrosion step.

关键词： cargo oil tank welded joint pit corrosion corrosion step

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo qi Han Tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-Wen Pan Jun-qing qi qiang Zhou Wei-Feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

THE DERIVATIVE ULTRACONVERGENCE FOR QUADRATIC TRIANGULAR FINITE ELEMENTS

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Journal of Computational Mathematics 2004年第6期22卷 857-864页

作者： qi-dingZhu ling-xiongMeng CollegeofMathematicsandComputerScience HunanNormalUniversityChangsha410081China

This work concerns the ultraconvergence of quadratic finite element approximations of elliptic boundary value problems. A new, discrete least-squares patch recovery technique is proposed to post-process the solution derivatives. Such recovered derivatives are shown to possess ultraconvergence. The keys in the proof are the asymptotic expansion of the bilinear form for the interpolation error and a “localized” symmetry argument. Numerical results are presented to confirm the analysis.

关键词： Superconvergence patch recovery (SPR) Ultra-closeness Ultraconvergence