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Neutrophil-to-lymphocyte ratio associated with renal function in type 2 diabetic patients

World Journal of Clinical Cases 2024年第14期12卷 2308-2315页

作者： jin-li gao Jue Shen li-Ping Yang li liu Kai Zhao Xiao-Rong Pan Lei li Ji-Ji Xu Department of Prevention and Health Care Community Health Service Center of Miaohang TownShanghai 200443China Department of Prevention and Health Care Community Health Service Center of Songnan TownShanghai 200434China Department of General Practice Community Health Service Center of Songnan TownShanghai 200434China Department of Administrative Community Health Service Center of Songnan TownShanghai 200434China

BACKGROUND Type 2 diabetes mellitus(T2DM)is a leading risk factor for the development and progression of chronic kidney disease(CKD).However,an accurate and con-venient marker for early detection and appropriate management of CKD in in-dividuals with T2DM is *** studies have demonstrated a strong correlation between the neutrophil-to-lymphocyte ratio(NLR)and ***-theless,the predictive value of NLR for renal damage in type 2 diabetic patients remains *** study included 1040 adults aged 65 or older with T2DM from Shanghai's Community Health Service *** total number of neutrophils and lym-phocytes was detected,and NLR levels were *** was defined as an estimated glomerular filtration rate≤60 mL/min/1.73 m².Participants were di-vided into four groups based on NLR *** clinical data and biochemical characteristics were compared among groups.A multivariate logistic regression model was used to analyze the association between NLR levels and *** Significant differences were found in terms of sex,serum creatinine,blood urea nitrogen,total cholesterol,and low-density lipoprotein cholesterol among patients with T2DM in different NLR groups(Plinical and pathological parameters(P=0.0001,odds ratio=1.41,95%confidence intervals:1.18-1.68).CONCLUSION An elevated NLR in patients with T2DM is associated with higher prevalence of CKD,suggesting that it could be a marker for the detection and evaluation of diabetic kidney disease.

关键词： Type 2 diabetes mellitus Neutrophil-to-lymphocyte ratio Chronic kidney disease Logistic regression Diabetes mellitus

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Unveiling the size effect of nitrogen-doped carbon-supported copper-based catalysts on nitrate-to-ammonia electroreduction

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Nano Research 2024年第4期17卷 2438-2443页

作者： Ran li Taotao gao Wenxi Qiu Minghao Xie Zhaoyu jin Panpan li College of Materials Science and Engineering Sichuan UniversityChengdu 610065China Institute for Advanced Study Chengdu UniversityChengdu 610106China Materials Science and Engineering Program and Walker Department of Mechanical Engineering The University of Texas at AustinAustinTexas 78712USA Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China

The electrocatalytic nitrate reduction reaction(NitRR)represents a promising approach toward achieving economically and environmentally sustainable ***,it remains a challenge to regulate the size effect of electrocatalysts to optimize the catalytic activity and ammonia ***,the Cu-based catalysts were tailored at the atomic level to exhibit a size gradient ranging from single-atom catalysts(SACs,0.15–0.35 nm)to single-cluster catalysts(SCCs,1.0–2.8 nm)and nanoparticles(NPs,20–30 nm),with the aim of studying the size effect for the NO_(3)^(-)-to-NH_(3) reduction ***,the Cu SCCs exhibit enhanced metal–substrate and metal–metal interactions by taking advantageous features of Cu SACs and Cu ***,Cu SCCs achieve exceptional electrocatalytic performance for the NitRR with a maximum Faradaic efficiency of ca.96%NH_(3)and the largest yield rate of ca.1.99 mg·h^(-1)·cm^(-2) at-0.5 V *** hydrogen electrode(RHE).The theoretical calculation further reveals the size effect and coordination environment on the high catalytic activity and selectivity for the *** work provides a promising various size-controlled design strategy for aerogel-based catalysts effectively applied in various electrocatalytic reactions.

关键词： nitrate electroreduction ammonia electrosynthesis size effect single-cluster catalyst

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Numerical study on the wave pattern characteristic of air layer in cavity and the effects of multiple influence factors

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Journal of Hydrodynamics 2023年第5期35卷 923-941页

作者： Xiao-song Zhang Xue-qin Ji Lei-qiang Chen li-jin gao Hong-bo Huang Fang-wen Hong CSSC Shanghai Marine Energy Saving Technology Co.Ltd. Shanghai200011China China Ship Scientific Research Center Shanghai Branch Shanghai200011China China Ship Scientific Research Center Wuxi214082China School of Naval Architecture Ocean and Civil EngineeringState Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai200240China

Air-layer drag reduction (ALDR) technology for ship energy saving is getting more and more attention in recent years because of the outstanding drag reduction effect. In order to promote practical application, it is necessary to fully understand the two phase flow characteristics of the air layer. Recent experimental studies have shown that the surface of the air layer presents wave pattern, which has an important influence on its damage risk. However, it is difficult to measure the wave pattern quantificationally due to the interference of equipment. The main goal of the present paper is to investigate the wave pattern characteristic of air layer in cavity using numerical simulation method. On this basis, the effect of flow and geometric influence factors are discussed to understand the key control conditions. A computational fluid dynamics (CFD) numerical method based on Reynolds averaged Navier-Stokes (RANS) equations and volume of fluid (VOF) interface capturing method is established, and has been successfully applied in the simulation of air layer wave pattern. Both 2-D and 3-D simulations are carried out, aiming at analyzing air-water interface flow and vortex flow directly. Based on the simulation results, several important conclusions about the mechanism of air layer wave pattern can be obtained. Firstly, it is found to be an inherent characteristic that the wave height of the upstream air layer is higher than that of the downstream. The extremely high wave peak is easy to contact with the flat plate, leading to the breakup of air layer and a “central blank area” phenomenon. With the help of flow analysis, it is found that this characteristic is mainly caused by the strong counterclockwise vortex behind the bow wedge block. Secondly, the air layer stability is reduced with the increase of water flow velocity by affecting the wave height. There is a saturation point of air flow rate to reach maximum thickness of air layer. Thirdly, cavity configuration has ob

关键词： Air layer drag reduction wave pattern of air-water interface numerical simulation multiple influence factors vortex flow fields

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The Role of Calcium in Mediating SliAAs Expression in Tomato Pedicel Explants

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Agricultural Sciences in China 2010年第7期9卷 980-984页

作者： ZUO Xian-hong XU Tao QI Ming-fang LU Shuang-shuang li jin-hong li Hong gao Song li Tian-lai Key Laboratory of Protected Horticulture of liaoning Province/College of Horticulture Shenyang Agricultural University Shenyang 110161 P.R. China

In order to illuminate the effect of calcium on the IAA signal transduction,we studied the expression of eight SliAA genes which were up-regulated by calcium during the abscission after short-term（1 h） and long-term（16 h） treatments with calcium,IAA and calcium *** results indicated that calcium induced SliAAs expression in 1 h at low concentration,EGTA affected little SliAAs expression;it also increased IAA-induced transcript level of SliAAs,TFP（named trifluoperazine） decreased most SliAAs expression below the level of calcium combined with IAA-induced expression,except for ***-term treatment of calcium or calcium inhibitors suppressed some SliAAs expression,whereas TFP enhanced all SliAAs ***,SliAA29 was induced by most treatments excluding 16 h EGTA.

关键词： tomato calcium IAA calcium inhibitors SIlAA gene

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Effect of Photoperiod Treatments on Dormancy Induction and Changes in Correlated Respiratory Rate of Nectarine Peach Bud

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Agricultural Sciences in China 2008年第12期7卷 1445-1450页

作者： li jin gao Dong-sheng ZHAO Kai YU Qin XU Chen-shan State Key Laboratory of Crop Biology College of Horticulture Science and Engineering Shandong Agricultural University Tai＇an271018 P.R.China

The responses of dormancy induction to illumination and the characteristics of respiratory rate were studied with the nectarine peach bud in this article. The trial was conducted with nectarine （Prunus persica var. nectariana cv. Shuguang） and involved three treatments： a short day treatment （8 h）, a long day treatment （16 h）, and the normal condition as the control. The dormancy status was determined with the growth of shoot and the sprouting ability, and the respiratory rate was mensurated with oxygen electrode. Short day treatment could induce the growth stopping of peach shoots ahead, promote the development of dormancy, and induce buds into dormancy with 21 d previous to control. Long day treatment postponed the growth stopping and the induction and development of dormancy. The respiratory rate decreased according to the development of dormancy induction. The minimum respiratory rate appeared about 7 days after the start of dormancy induction. Bud respiratory rate increased during this period and then declined and remained at low level during dormancy period. Long day reduced buds respiratory rate slightly. Short day could induce dormancy obviously, and long day postponed dormancy induction. The changes of respiratory rate were correlated with the development of dormancy induction, and the bud respiratory rate was also affected by photoperiod.

关键词： peach dormancy induction photoperiod respiratory rate

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Enhanced photocatalytic hydrogen production from Co-MOF/CN by nitrogen and sulfur co-doped coal-based carbon quantum dots

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Journal of Rare Earths 2024年第5期42卷 838-850,I0002页

作者： Shiyong Xu Mei li Yijun Wang Caiyun gao Rongsheng Xu Zhiliang jin School of Chemistry and Chemical Engineering North Minzu UniversityYinchuan750021China Ningxia Key Laboratory of Solar Chemical Conversion Technology.North Minzu University.Yinchuan 750021China State Key Laboratory of National Ethnic Affairs Commission Chemical Technology.North Minzu University Yinchuan750021China

A novel composite photocatalyst for photocatalytic decomposition of water for hydrogen evolution was successfully synthesized by in-situ growth of nitrogen and sulfur co-doped coal-based carbon quantum dots(NSCQDs)nanoparticles on the surface of sheet cobalt-based metal-organic framework(Co-MOF)and graphitic carbon nitride(g-C_(3)N_(4),CN).The structure and properties of the obtained catalysts were systematically *** effectively broaden the absorption of Co-MOF and CN in the visible *** new composite photocatalyst has high hydrogen production activity and the hydrogen production rate reaches 6254μmol/(g·h)at pH=*** the same time,NSCQDs synergy Co-MOF/CN composites have good *** four cycles of hydrogen production,the performance remains relatively *** tran sient photocurrent response and Nyquist plot experimental results further demonstrate the improvement of carrier separation efficiency in composite *** semiconductor type(n-type semico nductor)of the single-phase catalyst was determined by the Mott-Schottky test,and the band structure was *** conductive and valence bands of CN are-0.99 and 1.72 eV,respectively,and the conduction and valence bands of Co-MOF are-1.85 and 1.33 eV,*** e mechanism of the photocatalytic reaction can be inferred,that is,Z-type heterojunction is formed between CN an d Co-MOF,and NSCQDs was used as cocatalyst.

关键词： Nitrogen and sulfur co-doped Coal-based carbon quantum dots Co-MOF CN Photocatalytic hydrogen evolution Rare earths

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Car-following strategy of intelligent connected vehicle using extended disturbance observer adjusted by reinforcement learning

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 365-373页

作者： Ruidong Yan Penghui li Hongbo gao jin Huang Chengbo Wang School of Traffic and Transportation The Beijing Jiaotong UniversityBeijingChina Department of Automation School of Information Science and TechnologyUniversity of Science and Technology of ChinaHefeiChina School of Vehicle and Mobility The Tsinghua UniversityBeijingChina liverpool Logistics Offshore and Marine Research Institute(LOOM)Liverpool John Moores UniversityLiverpoolUK

Disturbance observer-based control method has achieved good results in the carfollowing scenario of intelligent and connected vehicle(ICV).However,the gain of conventional extended disturbance observer(EDO)-based control method is usually set manually rather than adjusted adaptively according to real time traffic conditions,thus declining the car-following *** solve this problem,a car-following strategy of ICV using EDO adjusted by reinforcement learning is *** from the conventional method,the gain of proposed strategy can be adjusted by reinforcement learning to improve its estimation *** the“equivalent disturbance”can be compensated by EDO to a great extent,the disturbance rejection ability of the carfollowing method will be improved *** Lyapunov approach and numerical simulations are carried out to verify the effectiveness of the proposed method.

关键词： adaptive system autonomous vehicle intelligent control

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Formation mechanism of fault accommodation zones under combined stress in graben basin:Implications from geomechanical modeling

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Petroleum Science 2024年第1期21卷 54-76页

作者： Qi-Qiang Ren jin-liang gao Rong-Tao Jiang jin Wang Meng-Ping li Jian-Wei Feng Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China Jianghan Oilfield Oil and Gas Production Capacity Construction Management Center Chongqing408000China Sinopec Chongqing Fuling Shale Gas Exploration and Development Company Chongqing408000China College of Energy Chengdu University of TechnologyChengdu 610059SichuanChina School of Geoscience China University of Petroleum(East China)Qingdao 266580ShandongChina

A fault accommodation zone is a type of structure that is defined as regulating displacement and strain between faults *** numbers of fault accommodation zones are being identified in graben basins,indicating the potential exploration target and petroleum accumulation *** study aims to analyze the formation mechanism and development of fault accommodation zones under combined stress by a numerical simulation method considering geomechanical *** three-dimensional(3-D)seismic interpretation and fractal dimension method,exampled with the Dongxin fault zone,the fault activity and fault combination pattern were conducted to quantitatively characterize the activity difference in fault accommodation *** with mechanical experiment test,a geomehcanical model was established for fault accommodation zones in a graben *** the paleostress numerical simulations and structural physical simulation experiment,the developmental characteristics and genetic mechanism of fault accommodation zones were *** by multi movements and combined stresses,three significant tectonic evolution stages of the Dongxing Fault Zone(DXFZ)were distinguished:During the E_(s)^(3)sedimentary period,the large difference in the stress,strain,and rupture distribution in various faults were significant,and this stage was the key generation period for the prototype of the DXFZ,including the FAZ between large-scale *** the E_(s)^(2)sedimentary period,the EW-trending symmetric with opposite dipping normal faults and the NE-SW trending faults with large scale were furtherly *** junction area of two secondary normal faults were prone to be ruptured,performing significant period for inheriting and developing characteristics of fault accommodation *** the Es1 sedimentary period,the high-order faults in the DXFZ exhibited the obvious fault depressions and strike-slip activity,and the fault accommodation zones were

关键词： Fault accommodation zone Graben basin Fault activity Tectonic physical simulation experiment Finite element numerical simulation Dongxin fault zone

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A survey on dynamic graph processing on GPUs: concepts, terminologies and systems

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Frontiers of Computer Science 2024年第4期18卷 1-23页

作者： Hongru gao Xiaofei liAO Zhiyuan SHAO Kexin li Jiajie CHEN Hai jin National Engineering Research Center for Big Data Technology and System/Services Computing Technology and System Lab/Cluster and Grid Computing Lab School of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Zhejiang Lab Hangzhou 311121China

Graphs that are used to model real-world entities with vertices and relationships among entities with edges,have proven to be a powerful tool for describing real-world problems in *** most real-world scenarios,entities and their relationships are subject to constant *** that record such changes are called dynamic *** recent years,the widespread application scenarios of dynamic graphs have stimulated extensive research on dynamic graph processing systems that continuously ingest graph updates and produce up-to-date graph analytics *** the scale of dynamic graphs becomes larger,higher performance requirements are demanded to dynamic graph processing *** the massive parallel processing power and high memory bandwidth,GPUs become mainstream vehicles to accelerate dynamic graph processing ***-based dynamic graph processing systems mainly address two challenges:maintaining the graph data when updates occur(i.e.,graph updating)and producing analytics results in time(i.e.,graph computing).In this paper,we survey GPU-based dynamic graph processing systems and review their methods on addressing both graph updating and graph *** comprehensively discuss existing dynamic graph processing systems on GPUs,we first introduce the terminologies of dynamic graph processing and then develop a taxonomy to describe the methods employed for graph updating and graph *** addition,we discuss the challenges and future research directions of dynamic graph processing on GPUs.

关键词： dynamic graphs graph processing graph algorithms GPUs

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A non-peptide-based chymotrypsin-targeted long-wavelength emission fluorescent probe with large Stokes shift and its application in bioimaging

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Chinese Chemical Letters 2024年第10期35卷 456-462页

作者： Chuanfeng Fan Jian gao Yingkai gao Xintong Yang gaoning li Xiaochun Wang Fei li jin Zhou Haifeng Yu Yi Huang jin Chen Yingying Shan li Chen Key Laboratory of Optic-electric Sensing and Analytical Chemistry for life Science MOE Shandong Provincial Key Laboratory of Biochemical EngineeringQingdao Nucleic Acid Rapid Detection Engineering Research Center College of Marine Science and Biological Engineering Qingdao University of Science and Technology School of Chemistry and life Science Anshan Normal University Liaoning Key Laboratory of Development and Utilization for Natural Products Active Molecules Biomedical Analysis Center Army Medical University School of Pharmacy Weifang Medical University College of Chemistry Baicheng Normal University

As a hydrolase, chymotrypsin(CHT) is involved in many physiological activities, and its abnormal activity is closely related to diabetes, pancreatic fibrosis, chronic pancreatitis and pancreatic cancer. In this work,an innovative long-wavelength emission fluorescent probe TCF-CHT was designed and synthesized for the high specificity detection of CHT, which utilized TCF-OH and a mimetic peptide substrate 4-bromobutyryl as chromogenic group and recognition group, respectively. TCF-CHT exhibited excellent selectivity and eye-catching sensitivity(8.91 ng/m L) towards CHT, “off-on” long-wavelength emission at 670 nm and large Stokes shift(140 nm). Furthermore, the successful fulfillment and perfect performance in imaging endogenous CHT in complex organisms(P815 cells, HepG2 cells, zebrafish and tumor-bearing mice) verified its potential as a powerful tool for the recognition of CHT in complicated biological environments.

关键词： Bioimaging Chymotrypsin Fluorescent probe Large Stokes shift Long-wavelength emission

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