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UCat: heterogeneous memory management for unikernels

Frontiers of Computer Science 2023年第1期17卷 51-61页

作者： Chong tian Haikun LIU Xiaofei LIAO Hai jin National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab/Cluster and Grid Computing LabSchool of Computing Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

Unikernels provide an efficient and lightweight way to deploy cloud computing services in application-specialized and single-address-space virtual machines (VMs). They can efficiently deploy hundreds of unikernel-based VMs in a single physical server. In such a cloud computing platform, main memory is the primary bottleneck resource for high-density application deployment. Recently, non-volatile memory (NVM) technologies has become increasingly popular in cloud data centers because they can offer extremely large memory capacity at a low expense. However, there still remain many challenges to utilize NVMs for unikernel-based VMs, such as the difficulty of heterogeneous memory allocation and high performance overhead of address *** this paper, we present UCat, a heterogeneous memory management mechanism that support multi-grained memory allocation for unikernels. We propose front-end/back-end cooperative address space mapping to expose the host memory heterogeneity to unikernels. UCat exploits large pages to reduce the cost of two-layer address translation in virtualization environments, and leverages slab allocation to reduce memory waste due to internal memory fragmentation. We implement UCat based on a popular unikernel--OSv and conduct extensive experiments to evaluate its efficiency. Experimental results show that UCat can reduce the memory consumption of unikernels by 50% and TLB miss rate by 41%, and improve the throughput of real-world benchmarks such as memslap and YCSB by up to 18.5% and 14.8%, respectively.

关键词： unikernel virtualization non-volatile memory heterogeneous memory large page slab allocation

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Inhibition of Ciliogenesis Enhances the Cellular Sensitivity to Temozolomide and Ionizing Radiation in Human Glioblastoma Cells

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Biomedical and Environmental Sciences 2022年第5期35卷 419-436页

作者： WEI Li MA Wei CAI Hui PENG Shao Peng tian Huan Bing WANG Ju Fang GAO lan HE jin Peng School of Life Sciences Lanzhou UniversityLanzhou 730000GansuChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000GansuChina Key Laboratory of Space Radiobiology of Gansu Province&CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000GansuChina University of Chinese Academy of Sciences Beijing 100049China

Objective To investigate the function of primary cilia in regulating the cellular response to temozolomide(TMZ)and ionizing radiation(IR)in glioblastoma(GBM).Methods GBM cells were treated with TMZ or X-ray/carbon *** primary cilia were examined by immunostaining with Arl13 b andγ-tubulin,and the cellular resistance ability was measured by cell viability assay or survival fraction *** with cilia ablation by IFT88 depletion or chloral hydrate and induction by lithium chloride,the autophagy was measured by acridine orange staining *** DNA damage repair ability was estimated by the kinetic curve ofγH2 AX foci,and the DNAdependent protein kinase(DNA-PK)activation was detected by immunostaining *** Primary cilia were frequently preserved in GBM,and the induction of ciliogenesis decreased cell *** and IR promoted ciliogenesis in dose-and time-dependent manners,and the suppression of ciliogenesis significantly enhanced the cellular sensitivity to TMZ and *** inhibition of ciliogenesis elevated the lethal effects of TMZ and IR via the impairment of autophagy and DNA damage *** interference of ciliogenesis reduced DNA-PK activation,and the knockdown of DNA-PK led to cilium formation and *** Primary cilia play a vital role in regulating the cellular sensitivity to TMZ and IR in GBM cells through mediating autophagy and DNA damage repair.

关键词： Primary cilia Glioblastoma Cellular sensitivity Temozolomide Ionizing radiation Autophagy DNA damage response DNA-PK

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Review of precipitation strengthening in ultrahigh-strength martensitic steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 256-269页

作者： Zhihao tian Chunlei Shang Chaolei Zhang Xiaoye Zhou Honghui Wu Shuize Wang Guilin Wu Junheng Gao Jiaming Zhu Xinping Mao Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute of Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110004China Department of Materials Science and Engineering Shenzhen MSU-BIT UniversityShenzhen 518172China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China School of Civil Engineering Shandong UniversityJinan 250061China

Martensite is an important microstructure in ultrahigh-strength steels,and enhancing the strength of martensitic steels often involves the introduction of precipitated phases within the martensitic *** considerable research efforts devoted to this area,a systematic summary of these advancements is *** review focuses on the precipitates prevalent in ultrahigh-strength martensitic steel,primarily carbides(e.g.,MC,M_(2)C,and M_(3)C)and intermetallic compounds(e.g.,Ni Al,Ni_(3)X,and Fe_(2)Mo).The precipitation-strengthening effect of these precipitates on ultrahigh-strength martensitic steel is discussed from the aspects of heat treatment processes,microstructure of precipitate-strengthened martensite matrix,and mechanical ***,a perspective on the development of precipitation-strengthened martensitic steel is presented to contribute to the advancement of ultrahigh-strength martensitic *** review highlights significant findings,ongoing challenges,and opportunities in the development of ultrahigh-strength martensitic steel.

关键词： ultrahigh-strength martensitic steel precipitation strengthening mechanical property carbide intermetallic compound

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Development and validation of a model to determine risk of refractory benign esophageal strictures

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World Journal of Clinical Cases 2019年第13期7卷 1623-1633页

作者： Qing Lu tian-tian Lei Yi-lan Wang Hai-Lin Yan Bo Lin Lin-Lin Zhu Hong-Sheng Ma jin-Lin Yang Department of Gastroenterology West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China Department of Day Surgery West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China

BACKGROUND Current research has identified several risk factors for refractory benign esophageal strictures (RBES), but research is scarce on the prediction of RBES in benign esophageal strictures patients. Meanwhile, the long-term outcomes of RBES remain unclear. The aim of this study was to develop and validate a model to determine the progression of RBES in patients with benign esophageal strictures. And we also explored the long-term outcomes and safety in patients with RBES. AIM To develop and validate a model to determine the progression of RBES in patients with benign esophageal strictures, based on the demographic data and endoscopic findings. METHODS A total of 507 benign esophageal stricture patients treated by dilation alone or in combination with stenting were retrospectively enrolled between January 2009 and February 2018. The primary outcome was to establish a risk-scoring model predicting RBES in benign esophageal strictures. The secondary outcome was to explore the clinical effectiveness and adverse events in patients with RBES. RESULTS In the study, age, etiology, and number and length of strictures were the independent risk factors for the refractory performance of benign esophageal strictures. According to risk factors of benign esophageal strictures, a risk-scoring model for predicting RBES in benign esophageal strictures was established: The risk score ranged from 0 to 8 points, and the risk scores were divided into low risk (0-2 points), intermediate risk (3-5 points), and high risk (6-8 points). The proportions of RBES in the corresponding risk categories were 1.0%, 12.2%, and 76.0%, respectively. Among 507 patients, 57 had RBES (39 males;median age, 60 years). The success rate of dilation treatment (51.2%, 21/41) was higher than that of stent placement (37.5%, 6/16). CONCLUSION In this study, 11.3%(57/507) patients had RBES at our hospital. The risk-scoring model predicting RBES in benign esophageal strictures could predict the longterm outco

关键词： Refractory benign esophageal strictures Esophageal dilation Esophageal stents Long-term outcomes Retrospective analysis

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A 3D-printed Robot Hand with Three Linkage-driven Underactuated Fingers

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International Journal of Automation and computing 2018年第5期15卷 593-602页

作者： Xia-Li Li Li-Cheng Wu tian-Yi lan School of Information Engineering Minzu University of China

In this study, we improved an underactuated finger mechanism by using Solidworks to simulate the grasp operation of a finger in some different situations. In addition, a robot palm is designed for the three-finger robot hand with the designed underactuated fingers. A Solidworks simulation was used to verify the rationality of the design. Some parts of the hand were modified to fit for 3D printing, and a prototype of the hand was produced by 3D printing, which could reduce the cost of the production process, as well as provide design flexibility and other advantages. Finally, some grasping experiments were made with the prototype. The results showed that the robot could grasp objects with different sizes, and further verified the rationality of the design and feasibility of fabricating the robot hand using 3D printing.

关键词： Mechanical finger three-finger robotic hand underactuation grasping simulation Solidworks.

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Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer

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World Journal of Gastroenterology 2016年第8期22卷 2524-2532页

作者： He-jin Jia Peng-Jun Zhang Yu-lan Liu Chao-Guang Jiang Xu Zhu Ya-Ping tian Core Laboratory of Translational Medicine State Key Laboratory of Kidney Disease Chinese PLA General Hospital Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Interventional Therapy Department Peking University Cancer Hospital & Institute The Medical Department of Educational Administration Chinese PLA General Hospital

AIM: To investigate the relationship of serum levels of polyunsaturated fatty acid(PUFA) with kinds of cytokines in colorectal cancer(CRC).METHODS: Serum samples of 100 CRC patients were collected. The concentration of total n-3 PUFA which included C18:3 n-3, C20:5 n-3, C22:5 n-3, C22:6 n-3 and the total n-6 PUFA included C18:2 n-6, C18:3 n-6, C20:3 n-6, C20:4 n-6, and C22:5 n-6 were detected onGC-2010 Plus Gas Chromatograph with a Omegawax TM 250 column. Cytokines were detected by Mag Plex TM-C microspheres. P values for the trend were estimated by creating a continuous variable using the median value within ***: Interleukin-6(IL-6) showed significantly positive association with the C20:4 n-6(P for trend = 0.004). Interferon gamma(IFN-γ) showed significant positive association with the C22:5 n-3(P for trend = 0.035). IL-8 and matrix metalloproteinase-9(MMP-9) showed significant inverse association with the C22:6 n-3(P for trend = 0.049, and 0.021). MMP-2 showed significant inverse association with the C20:5 n-3(P for trend = 0.008). MMP-7 showed significantly positive association with the ratio of n-6 PUFA and n-3 PUFA(P for trend = 0.008). MMP-7 also showed significantly inverse association with the ratio of C20:4 n-6 and(n-6 PUFA + n-3 PUFA)(P for trend = 0.024). IL-10(P for trend = 0.023) and IL-6(P for trend = 0.036) showed significantly positive association with the ratio of C20:4 n-6 and C20:5 ***: Our data suggested that serum levels of PUFA is related to the inflammation of CRC, and also play different role in regulation of immune response.

关键词： Polyunsaturated fatty acids Cytokine Colorectal cancer Odds ratio Nutrition

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Antifouling Technology Trends in Marine Environmental Protection

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Journal of Bionic Engineering 2021年第2期18卷 239-263页

作者： Limei tian Yue Yin Wei Bing E jin Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun 130022China Weihai Institute for Bionics-Jilin University Weihai 264207China School of Chemistry and Life Science Changchun University of TechnologyChangchun 130012China

Marine fouling is a worldwide problem,which is harmful to the global marine ecological environment and economic *** traditional antifouling strategy usually uses toxic antifouling agents,which gradually exposes a serious environmental ***,green,long-term,broad-spectrum and eco-friendly antifouling technologies have been the main target of engineers and *** recent years,many eco-friendly antifouling technologies with broad application prospects have been developed based on the low toxicity and non-toxicity antifouling agents and *** this review,contemporary eco-friendly antifouling technologies and materials are summarized into bionic antifouling and non-bionic antifouling strategies(2000-2020).Non-bionic antifouling technologies mainly include protein resistant polymers,antifoulant releasing coatings,foul release coatings,conductive antifouling coatings and photodynamic antifouling *** antifouling technologies mainly include the simulated shark skin,whale skin,dolphin skin,coral tentacles,lotus leaves and other biology *** future research directions and challenges are also discussed in the end,and we expect that this review would boost the development of marine antifouling technologies.

关键词： biofouling antifouling technologies bionic non-bionic biofilm

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A local pseudo arc-length method for hyperbolic conservation laws

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Acta Mechanica Sinica 2014年第6期30卷 956-965页

作者： Xing Wang tian-Bao Ma Hui-lan Ren Jian-Guo Ning State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology

A local pseudo arc-length method（LPALM）for solving hyperbolic conservation laws is presented in this *** key idea of this method comes from the original arc-length method,through which the critical points are bypassed by transforming the computational *** method is based on local changes of physical variables to choose the discontinuous stencil and introduce the pseudo arc-length parameter,and then transform the governing equations from physical space to arc-length *** order to solve these equations in arc-length coordinate,it is necessary to combine the velocity of mesh points in the moving mesh method,and then convert the physical variable in arclength space back to physical *** examples have proved the effectiveness and generality of the new approach for linear equation,nonlinear equation and system of equations with discontinuous initial ***-oscillation solution can be obtained by adjusting the parameter and the mesh refinement number for problems containing both shock and rarefaction waves.

关键词： Numerical method Local pseudo arc-length method Hyperbolic conservation laws Mesh adaptation

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Effects of nano-Al_2O_3 and nano-ZrO_2 on the microstructure, behavior and abrasive wear resistance of WC-8Co cemented carbide

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Rare Metals 2011年第5期30卷 533-538页

作者： YANG tian＇en XIONG Ji SUN lan GUO Zhixing QIN Kangcai School of Manufacturing Science and Engineering Sichuan University Chengdu 610065 China

WC-8wt.% Co cemented carbides with varied nano-Al 2 O 3 and nano-ZrO 2 contents were prepared respectively following conventional powder metallurgical procedures. Effects of nano-Al 2 O 3 and nano-ZrO 2 on the microstructure, behavior, and abrasive wear resistance were investigated. The result shows that a finer and more homogenous microstructure can be achieved by increasing nano-Al 2 O 3 , and increasing nano-ZrO 2 makes the microstructure more refined. Nano-Al 2 O 3 and nano-ZrO 2 could both help to give increased hardness. Transverse rupture strength is higher if the above nano-oxides are doped appropriately, whereas excess addition is deleterious. Abrasive wear resistance presents different variations with respect to increasing nano-Al 2 O 3 and nano-ZrO 2 . By contrast, increasing nano-ZrO 2 enhances the abrasive wear resistance more effectively than increasing nano-Al 2 O 3 . The influence of the two nano-oxides contents on the abrasive wear resistance does not almost vary with wear time, and the optimum addition level of nano-Al 2 O 3 in WC-8% Co cemented carbide is 0.3 wt.% from the stand of abrasive wear resistance. In addition, both of the nano-oxides can retard the increase of wear rate in long-term abrasive wear.

关键词： cemented carbides microstructure abrasion wear resistance oxides mechanical properties

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The paleoclimatic environment reconstruction of Lop Nur in NW China in UAV spectroscopy

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Journal of Oceanology and Limnology 2023年第4期41卷 1425-1443页

作者： lan YANG Tingting ZHANG Huaze GONG Yuyang GENG Guangjin tian Laboratory of Target Microwave Properties Deqing Academy of Satellite ApplicationsHuzhou 313200China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100049China School of Government Beijing Normal UniversityBeijing 100875China

The change in the ecological environment in the arid core area is a critical issue in the context of global *** study the paleoclimate evolution,precise identification of minerals deposited in Asia’s arid hinterland,Lop Nur Salt Lake,NW China was *** hyperspectral data of the salt crust was sampled to identify the species and content of sedimentary minerals,and the multispectral photos were used to reconstruct the salt crust morphology using the unmanned aerial vehicles *** SUnSAL(sparse unmixing by variable splitting and augmented Lagrangian)method was employed to inverse the sedimentary mineral components along the *** heterogeneity of salt and clay minerals in bright and dark ear-shaped strips was *** paleoclimatic environment associated with salt lake extinction was reconstructed by analyzing paleoclimate records of sediments,spectral reflectance and morphology of the salt *** show that:(1)the variations in the micro-geomorphology of the salt crust are obviously the reason for the formation of bright and dark ear-shaped strips and the differences in the species and relative content of the sedimentary minerals are the microscopic *** high ratio of sedimentary salt minerals to clay minerals(RS/C)contributes to the high reflectivity,and the salt crust presents a bright *** low RS/C results in the low reflectivity,salt crust presents a dark texture;(2)the bright and dark ear-shaped strips represent warm-arid and cold-humid *** shape of the Lop Nur Lake shoreline evolved due to alternating warm-dry and cold-humid paleoclimate changes.

关键词： UAV remote sensing Lop Nur sparse spectral unmixing salt lake paleoclimate change

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