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Influence of granulocyte-macrophage colonystimulating factor and tumor necrosis factor on anti-hepatoma activities of human dendritic cells

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World Journal of Gastroenterology 2000年第5期6卷 718-720页

作者： jin kun zhang jin Lun Sun Hai Bin Chen Yang Zeng Yao Jun Qu Cencer Pathology Laboratory Shantou University Medical CollegeShantou 515031Guangdong ProvinceChina Department of Allergy Peking Union Medical College HospitalBeijing 100730China

INTRODUCTIONDendritic cells (DCs) play a key regulatory role inantitumor immunity,especially in its immuneaccessory role via MHC-Ⅰ *** haverecently reported that DCs were able to enhance thekilling activity of Lymphokine and PHA activatedkiller (LPAK) cells in *** the presentstudy,we evaluated the effects of GM-CSF andTNF upon antitumor activities of freshly

关键词： dendritic cells granulocytemacrophage colony-stimulating factor tumor necrosis factor anti-hepatoma cell activities in vitro peripheral blood

Effect of Ti_(p) Content on the Work Hardening and Softening Behavior of Mg-Zn-Ca Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 551-560页

作者： jin-Kai zhang Cui-Ju Wang Yi-Dan Fan Chao Xu Kai-Bo Nie kun-kun Deng Shanxi Key Laboratory of Advanced Magnesium-Based Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China

The Ti_(p)/ZX60 composites with different Ti_(p) contents were prepared by semi-solid stirring *** extrusion,the microstructure,work hardening and softening behavior of the Ti_(p)/ZX60 composites were analyzed compared with the ZX60(Mg-6Zn-0.2Ca)*** results showed that the addition of Ti_(p) could not only promote the nucleation of dynamic recrystallized(DRXed)grains,but also be propitious to the refinement of DRXed *** increasing Ti_(p) content,the size of DRXed grains decreased accompanied with increasing volume fraction of DRXed *** the Ti_(p) content increased to 15 vol.%,the average size and volume fraction of DRXed grains reached to~0.32μm and 93.2%,***,both the strength and elongation were improved by the addition of Ti_(p).With increasing content of Ti_(p),a substantial increase in the strength was achieved with little change in the ***,the elongation decreased sharply when the Ti_(p) content further increased to 15 vol.%.The addition of Ti_(p) led to an increase in the work hardening rate,which gradually increased with increasing Ti_(p) ***,the softening rate did not demonstrate the same tendency with increasing Ti_(p) *** the conventional ceramic particles,the Ti_(p) can be deformed in coordination with the matrix alloy,which imparted a higher softening rate to the matrix *** though the softening rate improved as the Ti_(p) content increased from 5 to 10 vol.%,it dropped deeply as the Ti_(p) content increased to 15 vol.%owing to the fracture of Ti_(p) during extrusion.

关键词： Titanium particle content Particle reinforced magnesium matrix composites Work hardening Softening behavior Mechanical properties

Programmable repulsive potential for tight-binding from Chen-Möbius inversion theorem

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 71-83页

作者： Jian-Gao Li jin-kun Tang Hong-Quan Song Gotthard Seifert Dong-Bo zhang College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China Department of Physics Beijing Normal UniversityBeijing 100875China College of Physics and Telecommunication Engineering Zhoukou Normal UniversityZhoukou 466001China Theoretische Chemie Technische Universität DresdenDresden D-01062Germany

An accurate total energy calculation is essential in materials *** date,many tight-binding(TB)approaches based on parameterized hopping can produce electronic structures comparable to those obtained using first-principles ***,TB approaches still have limited applicability for determining material properties derived from the total *** is,the predictive power of the TB total energy is impaired by an inaccurate evaluation of the repulsive *** complexity associated with the parametrization of TB repulsive potentials is the weak link in this *** this study,we propose a new method for obtaining the pairwise TB repulsive potential for crystalline materials by employing the Chen-Möbius inversion *** show that the TB-based phonon dispersions,calculated using the resulting repulsive potential,compare well with those obtained by first-principles calculations for various systems,including covalent and ionic bulk materials and twodimensional *** present approach only requires the first-principles total energy and TB electronic band energy as input and does not involve any *** striking feature enables us to generate repulsive potentials programmatically.

关键词： tight binding first-principles calculation total energy repulsive potential phonon dispersion

Recent progress of Pt-based oxygen reduction reaction catalysts for proton exchange membrane fuel cells

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Rare Metals 2024年第6期43卷 2444-2468页

作者： Feng Zhan kun-Song Hu jin-Hua Mai Li-Sheng zhang Zhen-Guo zhang Huan He Xin-Hua Liu School of Resources Environment and MaterialsGuangxi UniversityNanning530004China School of Transportation Science and Engineering Beihang UniversityBeijing 102206China IDTECH(Suzhou)Co.Ltd Suzhou 215217China Dyson School of Design Engineering Imperial College LondonLondon SW72AZUK

With the increasing consumption of fossil fuels,proton exchange membrane fuel cells(PEMFCs)have attracted considerable attention as green and sustainable energy conversion *** slow kinetics of the cathodic oxygen reduction reaction(ORR)has a major impact on the performance of PEMFCs,and although platinum(Pt)can accelerate the reaction rate of the ORR,the scarcity and high cost of Pt resources still limit the development of ***,the development of low-cost high-performance ORR catalysts is essential for the commercial application and development of *** paper reviews the research progress of researchers on Pt-based ORR catalysts in recent years,including Pt/C catalysts,Pt-based alloy catalysts,Pt-based intermetallic compounds,and Pt-based single-atom catalysts(SACs),with a focus on Pt-based alloy catalysts with different *** described in detail the difficulties and solutions in the research process of various ORR catalysts and explained the principle of their activity enhancement with density functional theory(DFT).In addition,an outlook on the development of Pt-based catalysts is given,and reducing the amount of Pt used and improving the performance of catalysts are the directions to work on in the coming period.

关键词： Pt-based catalysts PEMFCs Pt-based intermetallic compounds Single-atom catalysts

Multidimensional hollow SiO_(2)/C nanofibers modified by magnetic nanocrystals for electromagnetic energy conversion and lithium battery storage

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Nano Research 2024年第8期17卷 7301-7314页

作者： Chen Han Qi Zheng Juncheng jin Jiajia zhang Wen-Qiang Cao kun Xiang Min zhang Mao-Sheng Cao Anhui Provincial Laboratory of Biomimetic Sensor and Detecting Technology College of Materials and Chemical EngineeringWest Anhui UniversityLu’an 237012China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Department of Physics Beijing Technology and Business UniversityBeijing 100048China

Multifunctional materials are powerful tools to support the advancement of energy conversion *** with prominent electromagnetic and electrochemical properties can realize the conversion of electromagnetic energy and solve the subsequent storage ***,an electrospinning-thermal reduction method is employed to construct ultrafine nickel nanoparticle modified porous SiO_(2)/C(Ni-SiO_(2)/C)hollow nanofibers as promising materials for applications in both electromagnetic wave absorption(EMA)and lithium-ion ***,when used as an EMA material,the reflection loss(RL)of Ni-SiO_(2)/C can reach−47.8 dB at 15.8 GHz with a matching thickness of 2.2 *** excellent microwave absorption performance can be attributed to the enhanced conduction loss,polarization relaxation,synergistic magnetic loss,and preferred impedance matching,which result from multi-component magnetic/dielectric synergy and the unique interconnected multidimensional hollow ***,the electronic conductivity and electrochemical activity of the samples are significantly enhanced due to the uniform distribution of ultrafine Ni nanoparticles in the amorphous SiO_(2)/C ***,the hierarchical hollow porous structure provides sufficient free space for volume change during lithiation/delithiation ***,the Ni-SiO_(2)/C nanocomposite exhibits a high reversible capacity of 917.6 mAh·g^(−1)at 0.1 A·g^(−1).At a high current density of 2 A·g^(−1),a capacity of 563.9 mAh·g^(−1)can be maintained after 300 *** energy conversion-storage device is designed to store waste electromagnetic energy in the form of useful electrical *** work inspires the development of high-performance bifunctional materials.

关键词： Ni-SiO_(2)/C nanofiber electromagnetic absorption lithium-ion storage electrospinning multidimensional structure

Ultra-broadband microwave absorber and high-performance pressure sensor based on aramid nanofiber,polypyrrole and nickel porous aerogel

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1912-1921页

作者： Leyi zhang Hongyu jin Hanxin Liao Rao zhang Bochong Wang Jianyong Xiang Congpu Mu kun Zhai Tianyu Xue Fusheng Wen State Key Laboratory of Metastable Materials Science&Technology Yanshan UniversityQinhuangdao 066004China Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan UniversityQinhuangdao 066004China

Electronic devices have become ubiquitous in our daily lives,leading to a surge in the use of microwave absorbers and wearable sensor devices across various sectors.A prime example of this trend is the aramid nanofibers/polypyrrole/nickel(APN)aerogels,which serve dual roles as both microwave absorbers and pressure *** this work,we focused on the preparation of aramid nanofibers/polypyrrole(AP15)aerogels,where the mass ratio of aramid nanofibers to pyrrole was 1:*** employed the oxidative polymerization method for the preparation *** this,nickel was thermally evaporated onto the surface of the AP15 aerogels,resulting in the creation of an ultralight(9.35 mg·cm^(-3)).This aerogel exhibited a porous *** introduction of nickel into the aerogel aimed to enhance magnetic loss and adjust impedance matching,thereby improving electromagnetic wave absorption *** minimum reflection loss value achieved was-48.7 dB,and the maximum effective absorption bandwidth spanned 8.42 GHz with a thickness of 2.9 *** impressive metrics can be attributed to the three-dimensional network porous structure of the aerogel and perfect impedance ***,the use of aramid nanofibers and a three-dimensional hole structure endowed the APN aerogels with good insulation,flame-retardant properties,and compression *** under a compression strain of 50%,the aerogel maintained its resilience over 500 *** incorporation of polypyrrole and nickel particles further enhanced the conductivity of the ***,the final APN aerogel sensor demonstrated high sensitivity(10.78 kPa-1)and thermal *** conclusion,the APN aerogels hold significant promise as ultra-broadband microwave absorbers and pressure sensors.

关键词： porous aerogel aramid nanofibers microwave absorbers pressure sensor porous structure

Effect of bilateral testicular resection on thymocyte and its microenvironment in aged mice

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Asian Journal of Andrology 2001年第4期3卷 271-275页

作者： Xi-Yun WEI jin-kun zhang Jun LI Su-Biao CHEN Department of Anatomy,Histology and Embryology,Shantou University Medical College,Shantou 515031,China Department of Anatomy Histology and Embryology Shantou University Medical College China. junkunzh@***

Aim: To observe the changes in thymocyte and its microenvironment in aged mice after bilateral testicular ***: In male old mice, at the 25th day after testicular resection, the peripheral blood and thymus were collect-ed . Blood and thymus suspension smears were prepared for quantitative histochemistry and immunohistochemistry studyunder light and electron microscopes. Results; In testes resected mice the size and the weight of thymus weremarkedly increased. The demarcation between cortex and medulla was clear. The cortex was thickened and the celldensity was increased. The ratio of cortex/medulla stereometry was increased. The total cell count, thymocyte count,the percentage of acid a-naphthyl acetate esterase (ANAE) positive thymocytes, nonlymphocytes and the rosette forma-tion of macrophages and thymocytes were all increased. The thymocytes surrounded closely to the light thymic epithelialcells, dendritic cells or macrophages. The lymphocytes, particularly the ANAE positive lymphocytes of peripheralblood were increased. Conclusion; After bilateral testicular resection, the thymus of aged male mice showed mor-phological regeneration and the thymocytes and its microenvironment appeared to be definitely improved. It is suggestedthat testicular resection may improve immune function. (Asian J Androl 2001 Dec; 3; 271 — 275)

关键词： testis orchiectomy thymocyte microenvironment mice

A Fair and Trusted Trading Scheme for Medical Data Based on Smart Contracts

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Computers, Materials & Continua 2024年第2期78卷 1843-1859页

作者： Xiaohui Yang kun zhang School of Cyber Security and Computer Hebei UniversityBaoding071000China

Data is regarded as a valuable asset,and sharing data is a prerequisite for fully exploiting the value of ***,the current medical data sharing scheme lacks a fair incentive mechanism,and the authenticity of data cannot be guaranteed,resulting in low enthusiasm of participants.A fair and trusted medical data trading scheme based on smart contracts is proposed,which aims to encourage participants to be honest and improve their enthusiasm for *** scheme uses zero-knowledge range proof for trusted verification,verifies the authenticity of the patient’s data and the specific attributes of the data before the transaction,and realizes privacy *** the same time,the game pricing strategy selects the best revenue strategy for all parties involved and realizes the fairness and incentive of the transaction *** smart contract is used to complete the verification and game bargaining process,and the blockchain is used as a distributed ledger to record the medical data transaction process to prevent data tampering and transaction ***,by deploying smart contracts on the Ethereum test network and conducting experiments and theoretical calculations,it is proved that the transaction scheme achieves trusted verification and fair bargaining while ensuring privacy protection in a decentralized *** experimental results show that the model improves the credibility and fairness of medical data transactions,maximizes social benefits,encourages more patients and medical institutions to participate in the circulation of medical data,and more fully taps the potential value of medical data.

关键词： Blockchain data transactions zero-knowledge proof game pricing

Effect of microalloying on wettability and interface characteristics of Zr-based bulk metallic glasses with W substrate

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China Foundry 2024年第4期21卷 352-359页

作者： Zhen zhang Lin-na Feng jin-he Wang Zheng-kun Li Hua-meng Fu Hong Li Zheng-wang Zhu Hai-feng zhang School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Metallurgy Northeastern UniversityShenyang 110004China

The infiltration casting method is widely employed for the preparation of ex-situ composite ***,the production of composite materials using this method must necessitates a comprehensive understanding of the wettability and interface characteristics between the reinforcing phase and the bulk metallic glasses(BMGs).This work optimized the composition of Zr-based BMGs through microalloying methods,resulting in a new set of Zr-based BMGs with excellent glass-forming *** experiments between the Zr-based BMGs melts and W substrates were conducted using the traditional sessile drop method,and the interfaces were characterized utilizing a scanning electron microscope(SEM)equipped with energy dispersive X-ray spectroscopy(EDS).The work demonstrates that the microalloying method substantially enhances the wettability of the Zr-based BMGs ***,the incorporation of Nb element impedes the formation of W-Zr phases,but the introduction of Nb element does not alter the extent of interdiffusion between the constituent elements of the amorphous matrix and W element,indicating that the influence of Nb element on the diffusion of individual elements is minute.

关键词： Zr-based BMGs infiltration casting method wettability interface characteristics W-Zr phases