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Building on the backbone of CD47-based therapy in cancer:Combination strategies,mechanisms,and future perspectives

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1467-1487页

作者： Zi-Han Ye Wei-Bang Yu Mu-Yang Huang Jun Chen Jin-Jian Lu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080China Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoMacao 999078China MoE Frontiers Science Center for Precision Oncology University of MacaoMacao 999078China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research University of MacaoMacao 999078China

Described as a“don't eat me”signal,CD47 becomes a vital immune checkpoint in cancer.Its interaction with signal regulatory protein alpha(SIRPa)prevents macrophage phagocytosis.In recent years,a growing body of evidences have unveiled that CD47-based combination therapy exhibits a superior anti-cancer effect.Latest clinical trials about CD47 have adopted the regimen of collaborating with other therapies or developing CD47-directed bispecific antibodies,indicating the combination strategy as a general trend of the future.In this review,clinical and preclinical cases about the current combination strategies targeting CD47 are collected,their underlying mechanisms of action are discussed,and ideas from future perspectives are shared.

关键词： CD47 Combination strategies Bispecific antibodies Clinical data Preclinical data Cancer Mechanisms Future perspectives

Identification of anti-cancer compounds from natural products

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Chinese Journal of Natural Medicines 2020年第7期18卷 481-482页

作者： lu jin-jian WANG Yi-Tao State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China

Natural products serve as abundant resources with diversity of chemical structures,which has been widely explored for the pharmacological researches and drug discovery[1,2].They are generally isolated from microorgani... 详细信息

关键词： cancer abundant compounds

Record Flood-Producing Rainstorms of July 2021 and August 1975 in Henan of China:Comparative Synoptic Analysis Using ERA5

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Journal of Meteorological Research 2022年第6期36卷 809-823页

作者： jian RAO jin XIE Yong CAO Suxing ZHU Qian lu Key Laboratory of Meteorological Disaster of Ministry of Education(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing210044China National Meteorological Centre China Meteorological AdministrationBeijing100081China School of Atmospheric Sciences Nanjing University of Information Science&TechnologyNanjing210044China

This study compares two rainstorms that swept through Henan Province of China in July 2021 and August 1975.The heavy rainfall and related synoptic systems and processes are diagnosed based on hourly ERA5 reanalysis data and precipitation observations from the China Meteorological Administration.It is estimated that most of the daily rainfall in Henan was caused by synoptic-scale precipitation,with the sub-synoptic convective rainfall intermittently dominating some of the hourly total rainfall.The rainband moved at about 2 m s^(-1) during the July 2021 rainstorm,whereas it was almost stationary during the August 1975 rainstorm when the heavy rainfall was concentrated in southern Henan.A double-typhoon circulation pattern with a subtropical high over the Bohai and Yellow Seas was observed during both rainstorms.The heavy rainfall during the July 2021 event was controlled remotely by Typhoons Cempaka and In-Fa,which provided a path for the transport of moisture via the southerly jet associated with Typhoon Cempaka and the easterly(or southeasterly)jet associated with Typhoon In-Fa.The rainstorm in August1975 was caused more directly by Typhoon Nina,which made landfall in Fujian Province and moved toward Henan Province.The rainfall around the inverted trough of the motionless Typhoon Nina produced a cumulative effect.The two rainstorms also differed in their circulation patterns in the upper troposphere.The intrusion of high potential vorticity air over Central China occurred in the July 2021 extreme rainstorm,whereas the South Asian high was enhanced and biased further north during the August 1975 rainstorm.Further analysis showed that the northward and westward transport of moisture took place during the July 2021 rainstorm,whereas the westward transport of moisture from the east of Henan dominated near the inverted trough of Typhoon Nina during the August 1975 rainstorm.

关键词： August 1975(“75.8”)rainstorm July 2021(“21.7”)rainstorm Henan rainstorms double-typhoon circulation patterns

Microstructure Evolution and Mechanical Properties of a SMATed Mg Alloy under In Situ SEM Tensile Testing

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Journal of Materials Science & Technology 2017年第3期33卷 224-230页

作者： Xiaowei Liu Yong Liu Bin jin Yang lu jian lu 1 CentreforAdvanced Structural Materials(CASM) Department of Mechanical and Biomedical EngineeringCity University ofHong KongKowloonHong KongChina Key Laboratory of Near Net Forming of jiangxi Province Nanchang UniversityNanchang 330031China Shenzhen Research Institute City University of HongKongShenzhen 518057China

Surface mechanical attrition treatment（SMAT） has been recently applied to bulk polycrystalline magnesium（Mg） alloys with gradient grain size distribution from the impact surface to inside matrix, hence effectively improving the alloys＇ mechanical performances. However, in-depth understanding of their mechanical property enhancement and grain size-dependent fracture mechanism remains unclear. Here,we demonstrated the use of in situ micro-tensile testing inside a high resolution scanning electron microscope（SEM） to characterize the microstructure evolution, in real time, of SMATed Mg alloy AZ31 samples with different grain sizes of ~10 μm（＇coarse-grain sample＇） and ~5 μm（＇fine-grain sample＇）, respectively, and compared the results with those of a raw Mg alloy AZ31. The quantitative tensile tests with in situ SEM imaging clearly showed that fracture of ‘fine-grain sample＇ was dominated by intergranular cracks,while both trans-granular and intergranular cracks led to the final failure of the ‘coarse-grain samples＇.It is expected that this in situ SEM characterization technique, coupled with quantitative tensile testing method, could be applicable for studying other grain-refined metals/alloys, allowing to optimize their mechanical performances by controlling the grain sizes and their gradient distribution.

关键词： Surface mechanical attrition treatment（SMAT） Mg alloy Mechanical property In situ SEM Microstructure characterization

Quantum-dot light-emitting diodes with Fermi-level pinning at the hole-injection/hole-transporting interfaces

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Nano Research 2022年第8期15卷 7453-7459页

作者： Maopeng Xu Desui Chen jian Lin Xiuyuan lu Yunzhou Deng Siyu He Xitong Zhu Wangxiao jin Yizheng jin Zhejiang Key Laboratory for Excited-State Materials State Key Laboratory of Silicon MaterialsDepartment of ChemistryZhejiang UniversityHangzhou 310027China School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China

Quantum-dot light-emitting diodes(QLEDs)are multilayer electroluminescent devices promising for next-generation display and solid-state-lighting technologies.In the state-of-the-art QLEDs,hole-injection layers(HILs)with high work functions are generally used to achieve efficient hole injection.In these devices,Fermi-level pinning,a phenomenon often observed in heterojunctions involving organic semiconductors,can take place in the hole-injection/hole-transporting interfaces.However,an in-depth understanding of the impacts of Fermi-level pinning at the hole-injection/hole-transporting interfaces on the operation and performance of QLEDs is still lacking.Here,we develop a set of NiOx HILs with controlled work functions of 5.2–5.9 eV to investigate QLEDs with Fermi-level pinning at the hole-injection/hole-transporting interfaces.The results show that despite that Fermi-level pinning induces identical apparent hole-injection barriers,the red QLEDs using HILs with higher work functions show improved efficiency roll-off and better operational stability.Remarkably,the devices using the NiOx HILs with a work function of 5.9 eV demonstrate a peak external quantum efficiency of~18.0%and a long T95 operational lifetime of 8,800 h at 1,000 cd·m^(−2),representing the best-performing QLEDs with inorganic HILs.Our work provides a key design principle for future developments of the hole-injection/hole-transporting interfaces of QLEDs.

关键词： quantum-dot light-emitting diodes Fermi-level pinning hole-injection/hole-transporting interfaces work function performance

The role of targeting protein for Xklp2 in tumorigenesis of hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 418-422页

作者： Ting Li lu-jian Zhu An-Min Huang Yi-Feng Wei Jun Xu Ye-jin Xu Department of Infectious Diseases Jinhua Municipal Central HospitalJinhua 321000China School of the First Clinical Medical Sciences(School of Information and Engineering) Wenzhou Medical UniversityWenzhou 325035China

To the Editor:Hepatocellular carcinoma(HCC)is a prevalent form of gastrointestinal malignancies.The current combination of immunotherapy and other treatments improves overall survival compared to conventional therapies,but the immunosuppressive microenvironment of HCC is a significant barrier to the efficacy of immunothera-peutic drugs[1].Tumor immune escape is promoted by interactions among immunosuppressive cells,including tumor-associated macrophages,marrow-derived suppressor cells,tumor-associated neutrophils,cancer-associated fibroblasts,and tumor-infiltrating Tregs[2].

关键词： drugs suppressor hepatocellular

A Feasible Point Method with Bundle Modification for Nonsmooth Convex Constrained Optimization

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Acta Mathematicae Applicatae Sinica 2018年第2期34卷 254-273页

作者： jin-bao jian Chun-ming TANG lu SHI College of Mathematics and Information Science Guangxi University Nanning 530004 China College of Science Guangxi University of Nationalities Nanning 530007 China Xingjian College of Science and Liberal Arts Guangxi University Nanning 530005 China

In this paper, a bundle modification strategy is proposed for nonsmooth convex constrained min- imization problems. As a result, a new feasible point bundle method is presented by applying this strategy. Whenever the stability center is updated, some points in the bundle will be substituted by new ones which have lower objective values and/or constraint values, aiming at getting a better bundle. The method generates feasible serious iterates on which the objective function is monotonically decreasing. Global convergence of the algorithm is established, and some preliminary numerical results show that our method performs better than the standard feasible point bundle method.

关键词： nonsmooth optimization feasible point method bundle modification global convergence

Acid-base alternation diagenesis and its influence on shale reservoirs in the Permian lucaogou Formation, Jimusar Sag, Junggar Basin, NW China

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Petroleum Exploration and Development 2020年第5期47卷 962-976页

作者： WANG jian ZHOU lu LIU jin ZHANG Xinji ZHANG Fan ZHANG Baozhen State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China Research Institute of Experiment and Detection PetroChina Xinjiang Oilfield CompanyKaramay 834000China School of Geosciences and Technology Southwest Petroleum UniversityChengdu 610500China Research Institute of Exploration and Development PetroChina Xinjiang Oilfield CompanyKaramay 834000China Fengcheng Oilfield Operation Area PetroChina Xinjiang Oilfield CompanyKaramay 834000China

The diagenesis and diagenetic facies of shale reservoirs in lucaogou Formation of Jimusar Sag were studied by means of microscopic observation and identification of ordinary thin sections and cast thin sections,X-ray diffraction,scanning electron microscope and electron probe tests.The results show that alkaline and acidic diagenetic processes occurred alternately during the deposition of Permian lucaogou Formation in Jimusar Sag.The evolution of porosity in the shale reservoirs was influenced by compaction and alternate alkaline and acidic diagenetic processes jointly,and has gone through three stages,namely,stage of porosity reduction and increase caused by alkaline compaction,stage of porosity increase caused by acid dissolution,and stage of porosity increase and reduction caused by alkaline dissolution.Correspondingly,three secondary pore zones developed in lucaogou Formation.The shale reservoirs are divided into three diagenetic facies:tuff residual intergranular pore-dissolution pore facies,tuff organic micrite dolomite mixed pore facies,and micrite alga-dolomite intercrystalline pore facies.With wide distribution,good pore structure and high oil content,the first two facies are diagenetic facies of favorable reservoirs in lucaogou Formation.The research results provide a basis for better understanding and exploration and development of the lucaogou Formation shale reservoirs.

关键词： acid-base alternation diagenesis porosity evolution shale oil shale reservoir Permian lucaogou Formation Jimusar Sag Junggar Basin

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Self-assembly of metalla[3]catenanes, Borromean rings and ring-in-ring complexes using a simple π-donor unit

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National Science Review 2020年第10期7卷 1548-1556页

作者： Ye lu Dong Liu Yue-jian Lin Zhen-Hua Li Guo-Xin jin State Key Laboratory of Molecular Engineering of Polymers Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsDepartment of Chemistry Fudan University

Despite extensive research and several stunning breakthroughs in the synthesis of interlocked molecular species, [3]catenanes, Borromean rings and ring-in-ring complexes are exceedingly rare and their targeted synthesis remains a formidable challenge. Herein, a series of Cp*Rh-based homogeneous and heterogeneous interlocked structures have been prepared by coordination-driven self-assembly, not only including metalla[2]catenanes and molecular Borromean rings, but also linear metalla[3]catenanes and ring-in-ring complexes. The interlocked structures are all based on bithiophenyl groups. The bithiophenyl groups effectively enhance the strength of the inter-ring interactions and play a crucial role in the formation of these interlocked structures. By taking advantage of the strong interaction between π-donor(D) andπ-acceptor(A) groups, the electron-deficient methylviologen cation was introduced into a cationic metallarectangle based on bithiophenyl groups. Taking inspiration from these results, a cationic metallarectangle based on A units was threaded into a metallarectangle based on D units, leading to a heterogeneous D–A ring-in-ring structure.

关键词： coordination-driven self-assembly supramolecular chemistry interlocked structure metallacatenanes molecular Borromean rings ring-in-ring complex