检索结果-南通市图书馆

Phosphorylation of KAT-2B by WKS1/Yr36 redirects the lipid flux to jasmonates to enhance resistance against wheat stripe rust

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2023年第11期50卷 872-882页

作者： yan yan xiao-Ming Li Yun Chen Tian-Tian Wu Ci-Hang ding Mei-Qi Zhang Yue-Ting Guo Chu-yang wang Junli Zhang Xuebin Zhang Awais Rasheed Shengchun Xu Meng-Lu wang Zhongfu Ni Qixin Sun 缑金营 Frontiers Science Center for Molecular Design Breeding(MOE) China Agricultural UniversityBeijing 100193China Xianghu Laboratory HangzhouZhejiang 311231China school of Life sciences Fudan UniversityShanghai 200438China institute of Metabolism and Integrative biology Fudan UniversityShanghai 200438China State Key Laboratory of Crop Stress Adaptation and Improvement Henan Joint International Laboratory for Crop Multi-Omics ResearchSchool of Life SciencesHenan UniversityKaifengHenan 475004China International Maize and Wheat Improvement Center(CIMMYT) Chinese Academy of Agricultural SciencesBeijing 100081China

Wheat(Triticum aestivum)is one of the most essential human energy and protein ***,wheat production is threatened by devastating fungal diseases such as stripe rust,caused by Puccinia striiformis ***(Pst).Here,we reveal that the alternations in chloroplast lipid profiles and the accumulation of jasmonate(JA)in the necrosis region activate JA signaling and trigger the host *** collapse of chloroplasts in the necrosis region results in accumulations of polyunsaturated membrane lipids and the lipid-derived phytohormone JA in transgenic lines of Yr36 that encodes Wheat Kinase START 1(WKS1),a high-temperature-dependent adult plant resistance ***1.1,a protein encoded by a full-length splicing variant of WKS1,phosphorylates and enhances the activity of keto-acyl thiolase(KAT-2B),a critical enzyme catalyzing theβ-oxidation reaction in JA *** premature stop mutant,kat-2b,accumulates less JA and shows defects in the host defense against ***,overexpression of KAT-2B results in a higher level of JA and limits the growth of ***,JA inhibits the growth and reduces pustule densities of *** study illustrates the WKS1.1-KAT-2B-JA pathway for enhancing wheat defense against fungal pathogens to attenuate yield loss.

关键词： Wheat Stripe rust cell death Jasmonate Hostdefense

Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2022年第7期9卷 17-31页

作者： Yujuan jin Qiqi Zhao Weikang Zhu yan Feng Tian xiao Peng Zhang Liyan Jiang Yingyong Hou Chenchen Guo Hsinyi huang Yabin Chen Xinyuan Tong Jiayu Cao Fei Li Xueliang Zhu Jun Qin Dong Gao Xin-Yuan Liu hua Zhang Luonan Chen Roman K.Thomas Kwok-Kin Wong Lei Zhang Yong wang Liang hu Hongbin Ji State Key Laboratory of cell biology Chinese Academy of Sciences shanghai institute of biochemistry and cell biology Chinese Academy of Sciences Center for Excellence in Molecular cell Science Chinese Academy of Sciences Center for Excellence in Mathematical sciences National Center for Mathematics and Interdisciplinary Sciences Key Laboratory of ManagementDecision and Information SystemHua Loo-Keng Center for Mathematical Sciences Academy of Mathematics and Systems ScienceChinese Academy of Sciences Shenzhen Key Laboratory of Translational Medicine of Tumor Department of Cell Biology and Genetics Shenzhen University Health Sciences Center shanghai Pulmonary Hospital Tongji University shanghai Chest Hospital Shanghai Jiaotong University Zhongshan Hospital Fudan University Department of Pathology School of Basic Medical Sciences Fudan University school of Life Science and Technology Shanghai Tech University CAS Key Laboratory of Tissue Microenvironment and Tumor CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Nutrition and Health SciencesChinese Academy of Sciences Laura and Isaac Perlmutter Cancer Center New York University Langone Medical Center school of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Department of Translational Genomics Center of Integrated Oncology Cologne-BonnMedical FacultyUniversity of Cologne Department of Pathology University Hospital Cologne

Small-cell lung cancer(SCLC) is a recalcitrant cancer characterized by high ***,the exact cell type contributing to metastasis remains *** a Rb1L/L/Trp53L/Lmouse model,we identify the NCAMhiCD44lo/-subpopulation as the SCLC metastasizing cell(SMC),which is progressively transitioned from the non-metastasizing NCAMloCD44hicell(non-SMC).Integrative chromatin accessibility and gene expression profiling studies reveal the important role of the SWI/SNF complex,and knockout of its central component,Brgl,significantly inhibits such phenotypic transition and ***,TAZ is silenced by the SWI/SNF complex during SCLC malignant progression,and its knockdown promotes SMC transition and ***,ectopic TAZ expression reversely drives SMC-to-non-SMC transition and alleviates ***-cell RNA-se quencing analyses identify SMC as the dominant subpopulation in human SCLC metastasis,and immunostaining data show a positive correlation between TAZ and patient *** data uncover high SCLC plasticity and identify TAZ as the key mole cular switch in orchestrating SCLC phenotypic transition and metastasis.

关键词： small cell lung cancer SWI/SNF complex TAZ phenotypic transition metastasis

BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Molecular cell biology 2023年第5期15卷 21-37页

作者： Rufeng Xu Kaiyuan wang Zhengjian Yao yan Zhang Li jin jing Pang Yuncai Zhou Kai wang Dechen Liu Yaqin Zhang Peng Sun Fuqiang wang xiaoai Chang Tengli Liu Shusen wang Yalin Zhang Shuyong Lin Cheng hu Yunxia Zhu xiao Han Key Laboratory of human Functional Genomics of Jiangsu Province Nanjing Medical UniversityNanjing 211166China institute for Metabolic Disease Fengxian Central Hospital Affiliated to Southern Medical UniversityShanghai 201499China shanghai Diabetes institute Shanghai Key Laboratory of Diabetes MellitusShanghai Clinical Center for DiabetesShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China Analysis Center Nanjing Medical UniversityNanjing 210029China Organ Transplant Center Tianjin First Central HospitalNankai UniversityTianjin 300192China State Key Laboratory for cellular Stress biology School of Life SciencesXiamen UniversityXiamen 361102China

Brain-specific serine/threonine-protein kinase 2(BRSK2)plays critical roles in insulin secretion andβ-cell ***,whether BRSK2 is associated with human type 2 diabetes mellitus(T2DM)has not been ***,we report that BRSK2 genetic variants are closely related to worsening glucose metabolism due to hyperinsulinemia and insulin resistance in the chinese ***2 protein levels are significantly elevated inβcells from T2DM patients and high-fat diet(HFD)-fed mice due to enhanced protein *** with inducibleβ-cell-specific Brsk2 knockout(βKO)exhibit normal metabolism with a high potential for insulin secretion under chow-diet ***,βKO mice are protected from HFD-induced hyperinsulinemia,obesity,insulin resistance,and glucose ***,gain-of-function BRSK2 in matureβcells reversibly triggers hyperglycemia due toβ-cell hypersecretion-coupled insulin ***,BRSK2 senses lipid signals and induces basal insulin secretion in a kinase-dependent *** enhanced basal insulin secretion drives insulin resistance andβ-cell exhaustion and thus the onset of T2DM in mice fed an HFD or with gain-of-function BRSK2 inβ*** findings reveal that BRSK2 links hyperinsulinemia to systematic insulin resistance via interplay betweenβcells and insulin-sensitive tissues in the populations carrying human genetic variants or under nutrient-overload conditions.

关键词： type 2 diabetes mellitus genetic variant BRSK2 β-cell hypersecretion hyperinsulinemia insulin resistance

A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第6期8卷 3070-3086页

作者： Chao Zhang Qiang Guo Lifeng Chen Zheming Wu xiao-Jian yan Chengyang Zou Qiuxue Zhang Jiahong Tan Tian Fang Qunxian Rao yang Li Shizhen Shen Min Deng Liewei wang huanyao Gao Jia Yu hu Li Cheng Zhang Somaira Nowsheen Jake Kloeber Fei Zhao Ping Yin Chunbo Teng Zhongqiu Lin Kun Song Shuzhong Yao Liangqing Yao Lingying Wu Yong Zhang xiaodong Cheng Qinglei Gao Jian Yuan Zhenkun Lou jin-San Zhang Beijing institute of Basic Medical sciences 100850BeijingChina Department of Oncology Mayo ClinicRochesterMN55905USA school of Pharmaceutical sciences Wenzhou Medical University325035WenzhouZhejiangChina Key Laboratory of Endocrine Gland Diseases of Zhejiang Province Zhejiang Provincial People’s Hospital310014HangzhouZhejiangChina Department of Gynecology Zhejiang Provincial People’s Hospital310014HangzhouZhejiangChina Department of Gynecology the First Affiliated Hospital of Wenzhou Medical University325000WenzhouZhejiangChina Wuhan Kingwise Biotechnology Co. Ltd.430206WuhanHubeiChina Cancer biology Research Center(Key Laboratory of the Ministry of Education) Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430030WuhanHubeiChina Department of Gynecological Oncology Sun Yat-sen Memorial HospitalSun Yat-sen University510120GuangzhouGuangdongChina Zhejiang Provincial Key Laboratory of Traditional chinese Medicine for Reproductive Health Research 310006HangzhouZhejiangChina Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases 310006HangzhouZhejiangChina Department of Molecular Pharmacology and Experimental Therapeutics Mayo ClinicRochesterMN55905USA Department of Dermatology University of California San DiegoSan DiegoCA92122USA Key Laboratory of Saline-alkali Vegetation Ecology Restoration Ministry of EducationCollege of Life ScienceNortheast Forestry University150040HarbinChina Division of Gynecology Oncology Department of Obstetrics and GynecologyQilu HospitalShandong University250012JinanShandongChina Department of Obstetrics and Gynecology the First Affiliated HospitalSun Yat-Sen University510080GuangzhouGuangdongChina Department of Gynecologic Oncology Obstetrics and Gynecology Hospital of Fudan University200090ShanghaiChina Department of Gynecologic Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of

Poly(ADP-ribose)polymerase(PARP)inhibitors are one of the most exciting classes of targeted therapy agents for cancers with homologous recombination(HR)***,many patients without apparent HR defects also respond well to PARP inhibitors/*** biomarker responsible for this mechanism remains ***,we identified a set of ribosomal genes that predict response to PARP inhibitors/cisplatin in HR-proficient *** inhibitor/cisplatin selectively eliminates cells with high expression of the eight genes in the identified panel via DNA damage(ATM)signaling-induced pro-apoptotic ribosomal stress,which along with ATM signaling-induced pro-survival HR repair constitutes a new model to balance the cell fate in response to DNA ***,the combined examination of the gene panel along with HR status would allow for more precise predictions of clinical response to PARP inhibitor/*** gene panel as an independent biomarker was validated by multiple published clinical datasets,as well as by an ovarian cancer organoids library we *** importantly,its predictive value was further verified in a cohort of PARP inhibitor-treated ovarian cancer patients with both RNA-seq and WGS ***,we identified several marketed drugs capable of upregulating the expression of the genes in the panel without causing HR deficiency in PARP inhibitor/cisplatin-resistant cell *** drugs enhance PARP inhibitor/cisplatin sensitivity in both intrinsically resistant organoids and cell lines with acquired ***,our study identifies a marker gene panel for HR-proficient patients and reveals a broader application of PARP inhibitor/cisplatin in cancer therapy.

关键词： drugs BRCA panel

Profiling B and T cell immune responses to co-infection of Mycobacterium tuberculosis and hookworm in humans

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2015年第1期4卷 133-142页

作者： Xin-Xu Li Jia-Xu Chen Li-Xia wang Jun Sun Shao-Hong Chen Jun-hu Chen xiao-yan Zhang xiao-Nong Zhou National institute of Parasitic Diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector BiologyMinistry of HealthWHO Collaborating Centre for MalariaSchistosomiasis and Filariasis207 Rui Jin Er RoadHuangpu DistrictShanghai 200025PR China(PRC) National Center for Tuberculosis Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206PR China shanghai Public Health Clinical Center Key Laboratory of Medical Molecular Virology of Ministry of EducationInstitutes of Biomedical SciencesFudan UniversityShanghai 201508PR China

Background:humoral and cellular immune responses play protective roles against Mycobacterium tuberculosis(MTB)***,hookworm infection decreases the immune response to hookworm and bystander ***,immune responses to co-infection of MTB and hookworm are still unknown,although co-infection has been one of the public health problems in co-endemic areas of pulmonary tuberculosis(PTB)and hookworm ***,it is essential to evaluate B and T cell immune responses to the ***:Seventeen PTB cases co-infected with hookworm,26 PTB cases,15 patients with hookworm infection,and 24 healthy controls without PTB or hookworm infection were enrolled in the *** of CD3,CD4,CD8,CD10,CD19,CD20,CD21,CD25,CD27,CD38,FoxP3,and PD-1 were assessed on B and T cell subsets using multicolor flow ***:For the B cell(CD19+)subsets,naïve B cells(CD10−CD27−CD21+CD20+),plasma cells(CD10−CD27+CD21−CD20−),and tissue-like memory B cells(CD10−CD27−CD21−CD20+)had higher proportions,whilst resting memory B cells(CD10−CD27+CD21+CD20+)had lower proportions in the group co-infected with MTB and hookworm as compared to other *** of activated memory B cells(CD10−CD27+CD21−CD20+)did not differ among the four *** the T cell(CD3+)subsets,frequencies of regulatory T cells(CD4+CD25+Foxp3+)and exhausted CD4+and CD8+T cells(CD4+PD-1+and CD8+PD-1+)were higher,and frequencies of activated CD4+and CD8+T cells(CD4+CD38+and CD8+CD38+)were lower in the co-infected group as compared to the other ***:The change patterns of the cell profile of circulating lymphocytes were indentified in human co-infection of MTB and hookworm,which might indicate that the humoral and cellular immune responses are more suppressed.

关键词： Co-infection Mycobacterium tuberculosis Hookworm Immune response

Analysis of risk factors for early stent thrombosis in the chinese population:A multicenter restrospective study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2021年第3期12卷 192-197页

作者： Yu-peng wang Lei ding Rui-tao Zhang xiao-zeng wang Dan-qing Yu Shou-yan Hao jin-wei Tian Zhen-yu Liu Xiang-qian Qi hu Tan Hong-yi Wu Feng-hua ding Li-jun Guo Ya-ling Han Department of Cardiology and institute of Vascular Medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptor ResearchBeijing 100191China Department of Cardiology General Hospital of Northern Theatre CommandShenyang 110016China Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Cardiology the First Hospital of Jilin UniversityChangchun 130021China Department of Cardiology the Second Affi liated Hospital of Harbin Medical UniversityKey Laboratory of Myocardial IschemiaMinistry of EducationHarbin 150001China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China TEDA International Cardiovascular Hospital Tianjin 300457China institute of Cardiovascular Diseases of PLA the Second Affi liated HospitalArmy Medical UniversityChongqing 400037China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Cardiology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China

BACKGROUND:The predictive scoring systems for early stent thrombosis(EST)remains blank in *** study aims to evaluate the risk factors and conduct a prediction model of EST in the chinese ***:EST was defined as thrombosis that occurs within the first 30 days after primary percutaneous coronary intervention(PCI).Patients from ten chinese hospitals diagnosed as stent thrombosis(ST)from January 2010 to December 2016 were retrospectively included as the study group.A control group(1 case:2 controls)was created by including patients without ST,major adverse cardiovascular events,or cerebrovascular events during *** present study evaluated 426 patients with single-vessel lesions and ultimately included 40 patients with EST and 80 control patients,who were included to identify factors that predicted EST and to develop a prediction scoring *** other 171 patients without integrated 1:2 pair were used for external ***:EST was independently associated with a low hemoglobin concentration(adjusted odds ratio[OR]0.946,95%confi dence interval[95%CI]0.901-0.993,P=0.026),a high pre-PCI Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery(SYNTAX)score(OR 1.166,95%CI 1.049-1.297,P=0.004),and a DAPT(DAPT)duration of<30 days(OR 28.033,95%CI 5.302-272.834,P<0.001).The simple EST prediction score provided an area under the curve(AUC)of 0.854(95%CI 0.777-0.932,P<0.001)with 70.0%sensitivity and 90.0%specifi city,and 0.742(95%CI 0.649-0.835,P<0.001)with 54.5%sensitivity and 81.0%specifi city for external validation ***:EST may be independently associated with DAPT discontinuation within 30 days,a low hemoglobin concentration,and a high SYNTAX *** scoring system also has a good ability to predict the risk of EST and may be useful in the clinical setting.

关键词： Coronary heart disease Stent thrombosis Risk stratifi cation Predictive scoring system

维普期刊数据库

Safety and efficacy of thalidomide in patients with transfusiondependentβ-thalassemia:a randomized clinical trial

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第12期6卷 3723-3729页

作者： Jiang-Ming Chen Wei-Jian Zhu Jie Liu Gui-Zhen wang xiao-Qin Chen Yun Tan Wei-Wei Xu Li-Wei Qu jin-yan Li huan-Ju yang Lan huang Ning Cai Wei-Da wang Ken huang Jian-Quan Xu Guo-hui Li Sheng He Tian-Ying Luo Yi huang Song-hua Liu Wen-Qiang Wu Qi-yang Lu Mei-Guang Zhou Shu-Ying Chen Rong-Lan Li Mei-Ling hu Ying huang jin-hua Wei Jun-Min Li Sai-Juan Chen Guang-Biao Zhou Department of Hematology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina Department of Hematology Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 541000 GuangdongChina State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Reproductive Medicine The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000 HebeiChina State Key Laboratory of Oncology in South china Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhou 510060 GuangdongChina State Key Laboratory of Medical Genomics Shanghai Institute of HematologyNational Research Center for Translational MedicineRuijin Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200025China State Key Laboratory of Membrane biology Institute of ZoologyChinese Academy of Sciences&University of Chinese Academy of SciencesBeijing 100101China Department of Pediatrics Affiliated Hospital of Youjiang Medical University for NationalitiesBaise City 533000 GuangxiChina Department of Hematology Yulin Guinan HospitalYulin 537005 GuangxiChina Department of neurology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina Guangxi Key Laboratory of Basic Research on Birth Defects Prevention and Treatment Guangxi Zhuang Autonomous Region Women and Children Health Care HospitalNanning 530000 GuangxiChina Department of Hematology Guigang People’s HospitalGuigang 537100 GuangxiChina Department of Hematology Hospital of Traditional Chinese Medicine of Wuzhou CityWuzhou 543002 GuangxiChina Department of Hematology Wuzhou Red Cross HospitalWuzhou 543002 GuangxiChina Department of Hematology Hechi People’s HospitalHechi City 547000 GuangxiChina

Thalidomide inducesγ-globin expression in erythroid progenitor cells,but its efficacy on patients with transfusion-dependentβ-thalassemia(TDT)remains *** this phase 2,multi-center,randomized,double-blind clinical trial,we aimed to determine the safety and efficacy of thalidomide in TDT patients.A hundred patients of 14 years or older were randomly assigned to receive placebo or thalidomide for 12 weeks,followed by an extension phase of at least 36 *** primary endpoint was the change of hemoglobin(Hb)level in the *** secondary endpoints included the red blood cell(RBC)units transfused and adverse *** the placebo-controlled period,Hb concentrations in patients treated with thalidomide achieved a median elevation of 14.0(range,2.5 to 37.5)g/L,whereas Hb in patients treated with placebo did not significantly *** the 12 weeks,the mean RBC transfusion volume for patients treated with thalidomide and placebo was 5.4±5.0 U and 10.3±6.4 U,respectively(P<0.001).Adverse events of drowsiness,dizziness,fatigue,pyrexia,sore throat,and rash were more common with thalidomide than *** the extension phase,treatment with thalidomide for 24 weeks resulted in a sustainable increase in Hb concentrations which reached 104.9±19.0 g/L,without blood *** increase in Hb concentration and reduction in RBC transfusions were associated with nonβ0/β0 and HBS1L-MYB(rs9399137 C/T,C/C;rs4895441 A/G,G/G)*** results demonstrated that thalidomide is effective in patients with TDT.

关键词： transfusion patients thalidomide

利用原子力显微镜峰值力定量测量模式分析人间充质干细胞早期分化的力学表型

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

第二军医大学学报 2017年第10期38卷 1261-1266页

作者：刘知晓张金金王鑫艳陈峰胡钧吕军鸿中国科学院上海应用物理研究所物理生物学实验室上海201800 中国科学院大学化学与化工学院无机化学教研室北京100049 国家蛋白质科学中心(上海) 上海200031 首都医科大学附属北京世纪坛医院北京100038

目的建立通过力学表型来灵敏反映人间充质干细胞分化早期微小力学性质变化的技术。方法使用基于原子力显微镜峰值力定量纳米力学作图(peak force quantitative nanomechanical mapping,PF-QNM)技术,测量在不同浓度氯化锂诱导下人间充质... 详细信息

目的建立通过力学表型来灵敏反映人间充质干细胞分化早期微小力学性质变化的技术。方法使用基于原子力显微镜峰值力定量纳米力学作图(peak force quantitative nanomechanical mapping,PF-QNM)技术,测量在不同浓度氯化锂诱导下人间充质干细胞的力学变化过程。结果 4mmol/L和30mmol/L氯化锂处理干细胞48h后其纳米力谱就有显著的差异;但要到72h之后,平均杨氏模量才能区分不同浓度氯化锂处理所导致的差别。结论纳米力谱比平均杨氏模量更能反映干细胞分化早期的力学性质变化。基于纳米力谱的力学表型可以作为物理生物学标记来鉴定干细胞的早期分化。

关键词：间质干细胞力学表型纳米力谱细胞分化

维普期刊数据库

Somatosensory Neuron Types Identified by High-Coverage Single-cell RNA-Sequencing and Functional Heterogeneity

在线全文

学校读者我要写书评

暂无评论

Somatosensory Neuron Types Identified by High-Coverage Singl...