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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang chen Zhifeng chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin Xi Shi Wei chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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大学生蠕形螨感染情况调查

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咸宁学院学报（医学版） 2005年第4期19卷 290-291页

作者：覃金红陈喜珪罗金萍彭胜国咸宁学院医学院寄生虫学教研室湖北咸宁437100

目的了解本地大学生蠕形螨感染状况,为蠕形螨的防治提供理论依据。方法采用透明胶纸粘贴法对318名大学生进行蠕形螨感染调查。结果本地大学生蠕形螨感染率为26.10%,其中男性感染率为23.68%,女性感染率为29.69%。两者差异无显著性;高年... 详细信息

目的了解本地大学生蠕形螨感染状况,为蠕形螨的防治提供理论依据。方法采用透明胶纸粘贴法对318名大学生进行蠕形螨感染调查。结果本地大学生蠕形螨感染率为26.10%,其中男性感染率为23.68%,女性感染率为29.69%。两者差异无显著性;高年级学生的感染率高于一年级学生(P<0.01)。结论本地大学生蠕形螨感染较普遍。

关键词：大学生蠕形螨感染率

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Ileum perforation due to delayed operation in obturator hernia:A case report and review of literatures

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World Journal of Gastroenterology 2010年第1期16卷 126-130页

作者： Zhang, hong Cong, jin-Chun chen, Chun-Sheng China Med Univ Shengjing Hosp Dept Colorectal Tumor Surg Shenyang 110004 Liaoning Prov Peoples R China

A 83-year-old woman was admitted to our hospital because of intermittent abdominal colicky pain and vomiting for 26 *** pain localized over the periumbilical area with radiation along the medial side of the *** tomography scan with three-dimensional reconstruction revealed a loop of small bowel protruding into the left obturator canal. Incarcerated obturator hernia was diagnosed and emergency laparotomy was arranged immediately. Unfortunately,her family refused surgery because of her worsening *** the third evening after admission,the patient developed peritonitis and sepsis. Perforation of small bowel due to the incarceration was noted during *** resection and an endileostomy were *** recovered well despite of the complication of multiple organ dysfunction *** is reviewed,and the pathogenesis,clinical manifestation,imaging features and treatment are discussed.

关键词： Obturator hernia Intestinal obstruction Computed tomography

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Characterization and functional analysis of chitinase family genes involved in nymph-adult transition of Sogatella furcifera

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Insect Science 2021年第4期28卷 901-916页

作者： Xibin Yang Cao Zhou Guiyun Long hong Yang chen chen Daochao jin Provincial Key Laboratory for Agricultural Pest Management of Mountainous Regions Institute of EntomologyGuizhou UniversityGuiyangChina College of Tobacco Science of Guizhou University GuiyangChina Scientific Observing and Experimental Station of Crop Pest in Guiyang Ministry of AgricultureGuiyangChina

Chitinase degrades chitin in the old epidermis or peritrophic matrix of insects,which ensures normal development and *** our previous work,we comprehensively studied the function of SfCht7 in Sogatella ***,the number and function of chitinase genes in *** remain ***,we identified 12 full-length chitinase transcripts from ***,which included nine chitinase(Cht),two imaginal disc growth factor(IDGF),and one endo-β-N-acetylglucosaminidase(ENGase)*** analysis results revealed that the expression levels of eight genes(SfCht3,SfCht5,SfCht6-1,SfCht6-2,SfCht7,SfCht8,SfCht10,and SfIDGF2)with similar transcript levels peaked prior to molting of each nymph and were highly expressed in the *** on RNA interference(RNAi),description of the functions of each chitinase gene indicated that the silencing of SfCht5,SfCht10,and SfIDGF2 led to molting defects and *** inhibited the expressions of SfCht5,SfCht7,SfCht10,and SfIDGF2,which led to downregulated expressions of chitin synthase 1(SfCHS1,SfCHS1a,and SfCHS1b)and four chitin deacetylase genes(SfCDA1,SfCDA2,SfCDA3,and SfCDA4),and caused a change in the expression level of two trehalase genes(TRE1 and TRE2).Furthermore,silencing of SfCht7 induced a significant decrease in the expression levels of three wing development-related genes(SfWG,SfDpp,and SfHh).In conclusion,SfCht5,SfCht7,SfCht10,and SfIDGF2 play vital roles in nymph–adult transition and are involved in the regulation of chitin metabolism,and SfCht7 is also involved in wing development;therefore,these genes are potential targets for control of ***.

关键词： chitinase chitin deacetylase chitin synthesis RNA interference Sogatella furcifera wing development

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Gas Ionization During Carbothermal Reduction in Microwave Field and Its Effect

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Journal of Iron and Steel Research International 2009年第5期16卷 12-16,31页

作者： chen jin SHI Xue-hong ZHANG Meng ZHAO jing College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 Shanxi China

The reduction kinetic condition of the direct solid-phase reduction of metal oxide powder containing coal by microwave heating is better than that by the conventional heating process. The research shows that the gas ionization during carbothermal reduction accelerates the carbon gasification reaction and interface chemical reaction, and it also improves the kinetic conditions of carbothermal reduction. Thus, the formation mechanism and process of gas ionization as well as its effect during the carbotherrnal reduction of metal oxides containing coal by microwave heating are studied.

关键词： microwave heating carbothermal reduction gas ionization

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Interannual variability of boreal summer intraseasonal oscillation over the northwestern Pacific influenced by the Pacific Meridional Mode

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 6-11页

作者： Haoyu Zhou Pang-Chi Hsu Lin chen Yitian Qian Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjingChina

During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis *** elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget *** findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern *** increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective *** a process is pivotal in amplifying intraseasonal convection *** observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.

关键词： Boreal summer intraseasonal oscillation Interannual variability Pacific Meridional Mode Moisture budget analysis

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Au/Mg(OH)_2:Highly efficient for selective oxidation of 1,2-propanediol to lactic acid with molecular oxygen

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Science China Chemistry 2010年第7期53卷 1497-1501页

作者： MA hong NIE Xin CAI JiaYing chen chen GAO jin MIAO hong XU Jie State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Graduate University of Chinese Academy of Sciences Beijing 100049China

The catalytic oxidation of biomass-derived polyhydroxyl compounds provides an efficient and green route for biomass resource *** nanocrystals supported on Mg(OH)2 were synthesized by sol-immobilization method,characterized by XRD,TEM,UV-vis DRS,and tested in the selective oxidation of 1,2-propanediol to lactic *** gold particle size and the ratio of Au to 1,2-propanediol strongly influenced the catalytic *** Au/Mg(OH)2 with the majority of gold particles concentrated in 14-18 nm,excellent catalytic performance with 94.4% conversion and 89.3% selectivity to lactic acid has been achieved under 0.3 MPa O2 at 60°C for 6 h.

关键词： gold Mg(OH)2 catalysis oxidation 1,2-propanediol lactic acid

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老年高血压病患者颈动脉粥样硬化程度与血清尿酸和胆红素水平的关系

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现代医药卫生 2004年第14期20卷 1322-1323页

作者：费劲松季鸿陈范元上海市吴泾医院内科上海200241

目的 :观察血清尿酸和胆红素水平变化与颈动脉粥样硬化程度的关系。方法 :选择老年高血压病患者92例 ,按颈动脉超声检测结果分内膜增厚组、斑块形成组、管腔狭窄组 ,测定三组患者的血清尿酸和胆红素水平 ,并进行统计学分析。结果 :颈动... 详细信息

目的 :观察血清尿酸和胆红素水平变化与颈动脉粥样硬化程度的关系。方法 :选择老年高血压病患者92例 ,按颈动脉超声检测结果分内膜增厚组、斑块形成组、管腔狭窄组 ,测定三组患者的血清尿酸和胆红素水平 ,并进行统计学分析。结果 :颈动脉粥样硬化程度越严重 ,血清尿酸水平越高 ,三组间比较差异有显著性 (P0.05)。结论 :老年高血压病患者的血清尿酸和 (或 )胆红素水平变化与动脉粥样硬化关系密切。

关键词：高血压颈动脉粥样硬化血清尿酸胆红素老年人

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu chen Xue-Jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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微生物酸胁迫耐受性能强化的研究进展

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生物技术通报 2023年第11期39卷 137-149页

作者：胡锦超沈文琦徐超业樊雅祺卢浩宇蒋雯杰李世龙晋洪晨骆健美王敏工业发酵微生物教育部重点实验室(天津科技大学)天津市工业微生物重点实验室天津市微生物代谢与发酵过程控制技术工程中心天津科技大学生物工程学院天津300457

微生物在发酵生产中常面临各种酸性物质的累积,由此造成的酸胁迫严重抑制了菌株的发酵活力和生产性能。因此,微生物在长期进化过程中,通过协调胞内的多个生理系统、代谢途径和调控网络形成了复杂的响应机制以应对低pH胁迫。工业微生物... 详细信息

微生物在发酵生产中常面临各种酸性物质的累积,由此造成的酸胁迫严重抑制了菌株的发酵活力和生产性能。因此,微生物在长期进化过程中,通过协调胞内的多个生理系统、代谢途径和调控网络形成了复杂的响应机制以应对低pH胁迫。工业微生物酸胁迫耐受性能的强化是提高其生产效率的关键手段。本文概述了近年来利用适应性实验室进化、预适应、基因组重排、基因工程、全局转录机制工程、系统生物学和合成生物学等方法提高微生物耐酸性能的研究进展,并讨论了相关研究面临的挑战和未来的发展方向。

关键词：微生物酸胁迫耐受性强化菌株改造基因线路

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