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Biomarkers for response to immunotherapy in hepatobiliary malignancies

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 413-419页

作者： Zhi-Fei Lin Lun-Xiu Qin jin-hong chen Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China

Background:The advent of immune checkpoint inhibitors(ICIs)has revolutionized the therapeutic options of hepatobiliary ***,the clinical benefit provided by immunotherapy seems limited to a small subgroup of patients with hepatobiliary *** identification of reliable predictors of the response to immunotherapy is urgently *** sources:Literature search was conducted in Pub Med for relevant articles published up to May *** of clinical trials was obtained from https://***/.Results:Biomarkers for ICI response of hepatobiliary malignancies remain in the exploration stage and lack compelling *** programmed death-ligand 1(PD-L1)expression is the most widely studied biomarker in hepatocellular carcinoma(HCC)and biliary tract cancers(BTCs),but there are conflicting results on its predictive *** mutational burden(TMB)is generally low both in HCC and BTCs,and the clinical trials of TMB are rare in hepatobiliary ***,mismatch repair deficiency(dMMR)/high microsatellite instability(MSI-H)may be a predictive biomarker of response to antiPD-1 therapy in ***,some emerging biomarkers,such as gut microbiota,show predictive potential in the preliminary *** and liquid-biopsy biomarkers,including circulating tumor cells,circulating tumor DNA(ct DNA)and exosomal PD-L1 provide a quick and non-invasive approach for monitoring the ICI response,showing a new promising ***:Multiple potential biomarkers for predicting ICI response of hepatobiliary malignancies have been explored and tried to apply in *** there is no robust evidence to prove their clinical value in predicting immunotherapeutic response for patients with hepatobiliary *** identification of predictors for response to ICIs is an urgent need and major *** studies are warranted to validate the role of emerging biomarkers in predicting immunotherapeut

关键词： Biomarker Immunotherapy Hepatocellular carcinoma Biliary tract cancers

Expert consensus-promoting clinical excellence and ultimately benefitting patients

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 743-745页

作者： jin-hong chen Lun-Xiu Qin Hepatobiliary Surgery Department of General SurgeryHuashan HospitalFudan UniversityShanghaiChina

Evidence-based medicine serves as the cornerstone of modern *** on current evidence in the field of evidence-based medicine,a team of authoritative experts in the industry engages in comprehensive discussions to develop expert consensus,following standardized *** consensus serves as a foundation for clinical ***,the abundance of expert consensus varies in quality,and some viewpoints even contradict each other,leading to confusion in clinical decision-making.

关键词： Consensus guideline evidence-based medicine

Acute or chronic inflammation role in gastrointestinal oncology

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1600-1603页

作者： hong-jin chen Gui-You Liang Xiong chen Zhou Du Translational Medicine Research Center Guizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Guizhou Institute of Precision Medicine Affiliated Hospital of Guizhou Medical UniversityGuiyang 550009Guizhou ProvinceChina Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Hernia and Abdominal Wall Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

The following letter to the editor highlights the review titled“Inflammatory bowel disease-related colorectal cancer:Past,present and future perspectives”in World J Gastrointest Oncol 2022 March 15;14(3):*** is nece... 详细信息

关键词： Inflammatory Gastrointestinal cancers Development Letter to the Editor Colorectal cancer

Interaction of CdTe/CdS quantum dots with antibodies

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Chinese Chemical Letters 2009年第9期20卷 1119-1122页

作者： chen Shi Xiang Yi Huang Chao Qing Dong hong jin chen Ji Cun Ren College of Chemistry & Chemical Engineering Shanghai Jiaotong University Shanghai 200240 China

In the study, we observed the strong adsorption of CdTe/CdS QDs to antibodies and the formation of QDs-antibodies conjugates. Capillary electrophoresis with laser-induced fluorescence detection （CE-LIF）, fluorescence spectrometry and fluorescence correlation spectroscopy （FCS） were used to characterize the QDs conjugates with antibody. We found that the QDs-antibody conjugates possessed high fluorescence, small hydrodynamic radii and good stability in aqueous solution. 2009 Ji Cun Ren. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： CdTe/CdS quantum dots Antibodies Capillary electrophoresis Fluorescence correlation spectroscopy Interaction

Magnetization of a Gapped Spin 1/2 Antiferromagnetic Ising Chain near the Critical External Field

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Communications in Theoretical Physics 2001年第12期36卷 733-736页

作者： LIU Yi-Chang chen Yu-Guan LOU Ji-Zhong QIN Shao-jin chen hong Institute of Theoretical Physics P.O. Box 2735 Beijing 100080 China Department of Physics Tongji University Shanghai 200092 China Department of Physics University of Nevada Las Vegas NV 89154 USA Institute of Theoretical Physics P.O. Box 2735 Beijing 100080 China Department of Physics Kyushu University Hakozaki Higashi-ku Fukuoka 812-8581 Japan Department of Physics Tongji University Shanghai 200092 China

We study the magnetization of gapped spin 1/2 XXZ Heisenberg Ising chains and calculate the scattering length among massive spinons. We obtain the magnetization close to the critical external magnetic field. The leading correction term determined by the scattering length among massive spinons is given. Our results are in agreement with exact results and with experimental results. We show that the deviation from the massive free hard core boson picture can be accounted very well by the leading correction term due to the spinon-spinon interaction. We show that the deviation increases along with the increasing of the Ising term.

关键词： magnetization, XXZ spin 1/2 chain, spinon-spinon scattering length

Local events-based fast RTM surface-offset gathers via dip-guided interpolation

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Petroleum Science 2021年第3期18卷 773-782页

作者： Yang Zhao Feng-Lin Niu Lei Fu cheng cheng jin-hong chen Shou-Dong Huo State Key Laboratory of Petroleum Resources and Prospecting Unconventional Petroleum Research InstituteChina University of PetroleumBeijing 100083China Department of Earth Environmental and Planetary SciencesRice UniversityHoustonTXUSA Department of Earth and Planetary Science University of CaliforniaBerkeleyCAUSA Aramco Research Center Aramco Services CompanyHoustonTXUSA Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China

Reverse Time Migration(RTM)Surface Ofset Gathers(SOGs)are demonstrated to deliver more superior residual dip information than ray-based *** appears more powerful in complex geological settings,such as salt ***,the computational cost of constructing RTM SOGs is a big challenge in applying it to 3D feld *** tackle this challenge,we propose a novel method using dips of local events as a guide for RTM gather *** residual-dip information of the SOGs is created by connecting local events from depth-domain to time-domain via ray *** proposed method is validated by a synthetic experiment and a feld *** mitigates the computational cost by an order of magnitude while producing comparable results as fully computed RTM SOGs.

关键词： Surface-ofset gathers Reverse-time migration Dip-guided interpolation Reduced costs Local-event raytracing

Long-term outcome of infliximab combined with surgery for perianal fistulizing Crohn's disease

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World Journal of Gastroenterology 2015年第8期21卷 2475-2482页

作者： Bo-Lin Yang Yu-Gen chen Yun-Fei Gu hong-jin chen Gui-Dong Sun Ping Zhu Wan-jin Shao Department of Colorectal Surgery the Affiliated Hospital of Nanjing University of Chinese Medicine

AIM:To evaluate the efficacy and long-term outcome of infliximab combined with surgery to treat perianal fistulizing Crohn’s disease(CD).METHODS:The work was performed as a prospective *** patients received infliximab combined withsurgery to treat perianal fistulizing CD,which was followed by an immunosuppressive agent as maintenance ***:A total of 28 patients with perianal fistulizing CD were *** week 30,89.3%(25/28)of the patients were clinically cured with an average healing time of 31.4 *** CD activity index decreased to70.07±77.54 from 205.47±111.13(P<0.01)after infliximab *** perianal CD activity index was decreased to 0.93±2.08 from 8.54±4.89(P<0.01).C-reactive protein,erythrocyte sedimentation rate,platelets,and neutrophils all decreased significantly compared with the pretreatment levels(P<0.01).Magnetic resonance imaging results for 16 patients after therapy showed that one patient had a persistent presacral-rectal fistula and another still had a cavity without clinical symptoms at *** a median follow-up of 26.4 mo(range:14-41 mo),96.4%(27/28)of the patients had a clinical ***:Infliximab combined with surgery is effective and safe in the treatment of perianal fistulizing CD,and this treatment was associated with better longterm outcomes.

关键词： Infliximab Surgery Crohn’s disease Anal fistula

Association of hidradenitis suppurativa with Crohn’s disease

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World Journal of Clinical Cases 2021年第15期9卷 3506-3516页

作者： Meng Zhang Qun-De chen Hai-Xia Xu Yu-Meng Xu hong-jin chen Bo-Lin Yang Department of Colorectal Surgery TheAffiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjing 210029Jiangsu ProvinceChina First Clinical Medical College The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

Hidradenitis suppurativa(HS)is a chronic inflammatory skin disorder characterized by recurrent nodules,abscesses,and sinus ***’s disease(CD)is characterized by inflammation of the entire digestive tract and belongs to the group of inflammatory bowel diseases,and there are many extraintestinal manifestations,among which hidradenitis suppurativa is one of the rare extraintestinal *** appears to be a strong association between CD and HS based on clinical and histological similarities(sinus tract development,granulomatous inflammation,and scarring),intersections in pathogenesis(genetic loci,immune dysregulation mechanisms,and microbiome changes),and commonality in *** this review,we summarize recent studies on the association between HS and CD.

关键词： Hidradenitis suppurativa Crohn's disease Epidemiology Clinical features Pathogenesis Treatment

Optimized timing of using infliximab in perianal fistulizing Crohn's disease

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World Journal of Gastroenterology 2020年第14期26卷 1554-1563页

作者： Xue-Liang Sun Shi-Yi chen Shan-Shan Tao Li-Chao Qiao hong-jin chen Bo-Lin Yang First Clinical Medical College the Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Colorectal Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou 215000Jiangsu ProvinceChina Department of Colorectal Surgery The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

Infliximab(IFX),as a drug of first-line therapy,can alter the natural progression of Crohn’s disease(CD),promote mucosal healing and reduce complications,hospitalizations,and the incidence of *** fistulas are responsible for the refractoriness of CD and represent a more aggressive *** has been demonstrated as the most effective drug for the treatment of perianal fistulizing ***,a significant proportion of patients only partially respond to IFX,and optimization of the therapeutic strategy may increase clinical *** is a significant association between serum drug concentrations and the rates of fistula *** IFX levels during induction are associated with a complete fistula response in these *** the apparent relapse of perianal fistulizing CD,maintenance therapy with IFX over a longer period seems to be more *** appears that patients without deep remission are at an increased risk of relapse after stopping anti-tumor necrosis factor ***,only patients in prolonged clinical remission should be considered for withdrawal of IFX treatment when biomarker and endoscopic remission is demonstrated,especially when the hyperintense signals of fistulas on T2-weighed images have disappeared on magnetic resonance ***,the optimal timing of IFX use is highly individualized and should be determined by a multidisciplinary team.

关键词： Infliximab Crohn’s disease Perianal fistula Optimization Trough level Deep remission