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Restenosis after recanalization for Budd-Chiari syndrome: Management and long-term results of 60 patients

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World Journal of Clinical Cases 2020年第14期8卷 2930-2941页

作者： Wei Zhang Yu-Long Tian Qiao-Zheng Wang Xiao-Wei Chen Qi-Yang Li jin-hang han Xu-Dong Chen Ke Xu Department of Interventional Radiology Shenzhen People’s Hospitalthe Second Affiliated Hospital of Jinan UniversityShenzhen 518020Guangdong ProvinceChina Department of Interventional Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Budd-Chiari syndrome is defined as hepatic venous outflow tract *** Asian Budd-Chiari syndrome patients,the major treatment modality is recanalization(percutaneous transluminal angioplasty with or without stent implantation).The cumulative 1-,5-,and 10-year primary patency rates and survival rates are reported to be excellent or satisfactory,but the long-term outcome of patients with restenosis(the most common complication after recanalization)is *** To explore the treatment strategy for restenosis in patients with Budd-Chiari syndrome after interventional therapy and to evaluate the long-term follow-up *** The clinical data and follow-up results of 60 patients with restenosis after interventional therapy from November 1983 to December 2013 were retrospectively *** Sixty patients with restenosis were retrospectively divided into a percutaneous transluminal angioplasty(PTA)group(40 patients)and a PTA+stent group(20 patients)according to the primary recanalization *** the patients with restenosis in the PTA group,13 refused treatment,and 27 received further treatment;among these patients,five had a second restenosis,two had a third restenosis,and one had a fourth *** the patients with restenosis in the PTA+stent group,nine refused treatment,ten received PTA alone,and the other received PTA+stent *** the patients who received further treatment,five had a second restenosis,three had a third restenosis,and one had a fourth *** 1-,5-,10-,20-,and 25-year cumulative survival rates of the 38 patients who received further treatment after restenosis were 100%,78.3%,78.3%,70.5%,and 70.5%,respectively;however,for the 22 patients who refused treatment,the survival rates were 72.7%,45.9%,30.6%,10.2%,and unavailable,respectively(P<0.001).CONCLUSION Long-term follow-up after interventional therapy is very *** treatment for patients with restenosis can improve prognosis,an

关键词： Budd-Chiari syndrome Restenosis Long-term follow-up Treatment strategy

Theoretical and Experimental Study on the Performance of Hermetic Diaphragm Squeeze Film Dampers for Gas-Lubricated Bearings

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 151-169页

作者： Jianwei Wang Haoxi Zhang Shaocun han hang Li Peng Wang Kai Feng State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China

Low damping characteristics have always been a key sticking points in the development of gas *** application of squeeze film dampers can significantly improve the damping performance of gas lubricated *** paper proposed a novel hermetic diaphragm squeeze film damper(HDSFD)for oil-free turbomachinery supported by gas lubricated *** types of HDSFDs with symmetrical structure were proposed for good damping *** considering the compressibility of the damper fluid,based on hydraulic fluid mechanics theory,a dynamic model of HDSFDs under medium is proposed,which successfully reflects the frequency dependence of force *** on the dynamic model,the effects of damper fluid viscosity,bulk modulus of damper fluid,thickness of damper fluid film and plunger thickness on the dynamic stiffness and damping of HDSFDs were *** experimental test rig was assembled and series of experimental studies on HDSFDs were *** damper fluid transverse flow is added to the existing HDSFD concept,which aims to make the dynamic force coefficients independent of *** the force coefficient is still frequency dependent,the damping coefficient at high frequency excitation with damper fluid supply twice as that without damper fluid *** results serve as a benchmark for the calibration of analytical tools under development.

关键词： Hermetic diaphragm squeeze film damper Compressibility Dynamic model Experimental studies

Noteworthy phenomena in pediatric inherited cardiomyopathy

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World Journal of Pediatrics 2024年第6期20卷 635-637页

作者： jin-hang Jiang Jie Tian Bo Pan Department of Pediatric Cardiology National Clinical Key Cardiovascular SpecialtyNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren's Hospital of Chongqing Medical University136 Zhongshan Er RoadYuzhong DistirctChongqing 400014China Key Laboratory of Children's Important Organ Development and Diseases Chongqing Municipal Health CommissionChongqingChina

Pediatric cardiomyopathy has an early onset and poor ***,it was referred to as idiopathic cardiomyopathy due to unknown ***,recent advances in molecular genetics and molecular biology have demonstrated that most pediatric cardiomyopathy cases are related to genetic factors,mainly involving single gene and single nucleotide mutations[1,2].Although the pathogenicity of some gene mutations in patients has not been fully elucidated,genetic factors are still considered the main cause of pediatric cardiomyopathy.

关键词： cardiomyopathy pediatric etiology

Exploring precursor effect in in-situ reconstruction of Bi metal organic-frameworks during CO_(2)electroreduction reaction to tailor formate selectivity towards 100%

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Science China Chemistry 2024年第7期67卷 2190-2198页

作者： Zhida Liu Qikui Fan hang Huo Fanglei Yao Xiaoping Gao jin Wang College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Key Laboratory of Functional Molecular Solids Ministry of EducationCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Bi-based metal-organic frameworks(Bi-MOFs)as efficient catalysts for the CO_(2)electroreduction reaction(CRR)have been extensively *** has been established that Bi-MOFs usually undergo in-situ transformation during the CRR,ultimately converting into Bi ***,the effect of the MOF precursors on the structure of the derived Bi catalysts and consequently on their electrocatalytic properties has not been clearly *** this work,we prepared four variants of a novel Bi-MOF with different morphologies and dimensions,and explored the effects of the precursors on the resulting Bi catalysts and their CRR performance.A precursor-dependent in-situ transformation and its profound impact on tuning the CO_(2)-formate FE towards~100%have been *** the four examined variants,Bi-MOF with nanocube-like morphology(BiMOF-NC)is transformed into thin and flat Bi nanosheets capable of successfully enveloping the fibers of carbon paper(working electrode),while the other three variants with increased size and dodecahedral/octahedral geometry have been transformed into Bi nanoflowers,exposing a fair portion of the carbon fibers in the working ***,the transformation rate was found to be dependent on the precursors and BiMOF-NC exhibited the highest rate of reconstruction compared with other ***,the Bi catalyst derived from BiMOF-NC delivered a selectivity for the formate product of nearly 100%at-1.2 V(*** hydrogen electrode(RHE))and of over 95%in a wide potential range due to efficient suppression of the competing hydrogen evolution reaction(HER)over carbon *** in-situ transformed BiMOFNC also demonstrated equivalently high formate selectivity at large current densities(≥100 mA cm^(-2))in flow cell reactors as that in H-type reactors,underscoring its potential for industrial *** work highlights the necessity of finely tuning the structural features of MOF precursors to achieve optim

关键词： Bi-MOFs precursor effect in-situ transformation Bi nanosheets CO_(2)-to-formate

Investigation on the influence of vortex generator on particle resuspension

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Particuology 2024年第3期86卷 126-136页

作者： Dongchi Yu Jun-Li Lin jin-han Xie ASML 80W Tasman DrSan Jose95134CaliforniaUSA Department of Mechanics and Engineering Science at College of Engineering and State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing100081China

The vortex generator(VG)and its well-known effect in flow optimization are widely studied and employed across different engineering ***,while the same working principles of VG may be well suited for the applications on surface-cleaning technologies,such promising potential is hardly,if any,explored in the published ***,in the present study,the influence on flow-induced particle resuspension brought by a rectangular vG in a channel flow is investigated with the help of highfidelity computational fluid dynamics *** increases of particle removal forces and resuspension rates are discovered in long,strip-like regions with reduced boundary-layer thickness resulted from the vG-induced vortices,and the enhancement effect is especially significant for configurations with the VG installed at a greater angle of *** is also shown that while the resuspension enhancements on the lower and the upper surfaces of the channel exhibit distinct statistical characteristics,having a VG in the channel improves the overall particle-removing capability of the channel flow by introducing higher surface-averaged removal forces and particle resuspension *** but not least,the increase of resuspension rate is especially significant for the smaller,micron-scale particles which are otherwise hardly disturbed by a VG-less channel flow,and such resuspension-enhancement effectgenerally subsides with increasing particle size.

关键词： Particle resuspension Vortexgenerator CFD Surface cleaning

Improved nuclear mass formula with an additional term from the Fermi gas model

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Nuclear Science and Techniques 2024年第5期35卷 131-138页

作者： Xiao-Yu Xu Li Deng Ai-Xi Chen hang Yang Amir Jalili han-Kui Wang School of Science Zhejiang Sci-Tech UniversityHangzhou 310018China

Nuclear mass is a fundamental property of nuclear physics and a necessary input in nuclear *** to the complexity of atomic nuclei and nonperturbative strong interactions,conventional physical models cannot completely describe nuclear binding *** this study,the mass formula was improved by considering an additional term from the Fermi gas *** nuclear masses in the Atomic Mass Evaluation Database were reproduced with a root-mean-square deviation(RMSD)of -1.86 MeV(1.92 MeV).The new mass formula exhibits good performance in the neutron-rich nuclear *** RMSD decreases to 0.393 MeV when the ratio of the neutron number to the proton number is≥1.6.

关键词： Nuclear mass formula Neutron-rich nuclei Fermi-gas model

Tungsten chalcogenides as anodes for potassium-ion batteries

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Tungsten 2024年第2期6卷 278-292页

作者： Yu-han Wu Wei-Hao Xia Yun-Zhuo Liu Peng-Fei Wang Yu-hang Zhang jin-Ru Huang Yang Xu De-Ping Li Li-Jie Ci School of Environmental and Chemical Engineering Shenyang University of TechnologyShenyang 110870China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China State Key Laboratory of Advanced Welding and Joining School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Department of Chemistry University College LondonLondon WC1H 0AJUnited Kingdom

Potassium-ion batteries(PIBs)by virtue of their strong cost competitiveness and similar electrochemical properties to lithiumion batteries have been deemed to be a promising electrochemical energy storage *** promote the application in the commercial market,developing electrode materials with high specifi c capacities,superior cycling stability,and reliable safety is of great *** materials as an important component of PIBs play a decisive role,among which twodimensional transition metal chalcogenides(2D TMCs)have attracted wide attention owing to their unique material and electrochemical *** the 2D TMCs’family,molybdenum chalcogenides as fl agship are the most studied materials and demonstrated the potential as *** the deepening of research on 2D TMCs,another shining member that possesses similar properties to molybdenum chalcogenides,tungsten chalcogenides(WS_(2),WSe_(2),and WTe_(2)),has aroused tremendous *** many inspiring results,various challenges remain to be further addressed;meanwhile,some results are still unclear and ***,this review fi rst introduces their material properties and electrochemical storage ***,we systematically overview the research progress and put forward promoting improvement ***,challenges and opportunities that would be future research directions are discussed.

关键词： Electrochemical energy storage Potassium-ion batteries Anodes Tungsten chalcogenides

Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential

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World Journal of Stem Cells 2024年第5期16卷 512-524页

作者： hang Zhang Ling-Zi Wu Zhen-Yu Liu Zi-Bing jin Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

BACKGROUND Human induced pluripotent stem cell(hiPSC)technology is a valuable tool for generating patient-specific stem cells,facilitating disease modeling,and invest-igating disease ***,iPSCs carrying specific mutations may limit their clinical applications due to certain inherent *** To investigate the impact of MERTK mutations on hiPSCs and determine whether hiPSC-derived extracellular vesicles(EVs)influence anomalous cell junction and differentiation *** We employed a non-integrating reprogramming technique to generate peripheral blood-derived hiPSCs with and hiPSCs without a MERTK ***-somal karyotype analysis,flow cytometry,and immunofluorescent staining were utilized for hiPSC *** and proteomics were employed to elucidate the expression patterns associated with cell junction abnormalities and cellular differentiation ***,EVs were isolated from the supernatant,and their RNA and protein cargos were examined to investigate the involvement of hiPSC-derived EVs in stem cell junction and *** The generated hiPSCs,both with and without a MERTK mutation,exhibited normal karyotype and expressed pluripotency markers;however,hiPSCs with a MERTK mutation demonstrated anomalous adhesion capability and differentiation potential,as confirmed by transcriptomic and proteomic ***,hiPSC-derived EVs were involved in various biological processes,including cell junction and *** HiPSCs with a MERTK mutation displayed altered junction characteristics and aberrant differentiation ***,hiPSC-derived EVs played a regulatory role in various biological processes,including cell junction and differentiation.

关键词： Cell junction Cellular differentiation Extracellular vesicle Human induced pluripotent stem cells Transcriptomics Proteomics

METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs

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International Journal of Oral Science 2024年第3期16卷 528-538页

作者： Yizhou jin Xiao han Yuejun Wang Zhipeng Fan Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijingChina Beijing Laboratory of Oral Health Capital Medical UniversityBeijingChina Research Unit of Tooth Development and Regeneration Chinese Academy of Medical SciencesBeijingChina

Bisphosphonate-related osteonecrosis of jaw(BRONJ)is characterized by impaired osteogenic differentiation of orofacial bone marrow stromal cells(BMSCs).Corin has recently been demonstrated to act as a key regulator in bone development and orthopedic ***,the role of corin in BRONJ-related BMSCs dysfunction remains unclarified.A m6A epitranscriptomic microarray study from our group shows that the CORIN gene is significantly upregulated and m6A hypermethylated during orofacial BMSCs osteogenic *** knockdown inhibits BMSCs osteogenic differentiation,whereas corin overexpression or soluble corin(sCorin)exerts a promotion ***,corin expression is negatively regulated by bisphosphonates(BPs).Corin overexpression or sCorin reverses BPs-impaired BMSCs differentiation ***,we find altered expression of phos-ERK in corin knockdown/overexpression BMSCs and BMSCs under sCorin ***98059(a selective ERK inhibitor)blocks the corin-mediated promotion *** regard to the high methylation level of corin during osteogenic differentiation,we apply a non-selective m6A methylase inhibitor,Cycloleucine,which also blocks the corin-mediated promotion ***,we demonstrate that METTL7A modulates corin m6A modification and reverses BPs-impaired BMSCs function,indicating that METTL7A regulates corin expression and thus contributes to orofacial BMSCs differentiation *** conclude,our study reveals that corin reverses BPs-induced BMSCs dysfunction,and METTL7A-mediated corin m6A modification underlies corin promotion of osteogenic differentiation via the ERK *** hope this brings new insights into future clinical treatments for BRONJ.

关键词： impaired cor mediated