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Efficacy and Safety of Lenalidomide in the Treatment of Multiple Myeloma： A Systematic Review and Meta-analysis of Randomized Controlled Trials

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Chinese Medical Journal 2015年第9期128卷 1215-1222页

作者： Shu-Kai Qiao Xiao-Nan Guo jin-hai ren Han-Yun ren Department of Hematology The Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China Department of Hematology Peking University First Hospital Beijing 100034 China

Background：Lenalidomide has emerged as an important treatment for patients with multiple myeloma （MM）.However,its role in the management of MM is still controversial and requires further *** aim of this study was to evaluate efficacy and safety of lenalidomide for MM using a ***：We searched the electronic databases including：PubMed,EMBASE and the Cochrane Center Register of Controlled *** randomized clinical trials were identified,which included a total of 2357 patients with MM who received lenalidomide-containing,noncontaining lenalidomide regimens or placebo as induction therapy or maintenance *** outcomes included overall response （OR） rate,complete response （CR） rate,3-year progression-free survival （PFS） rate,3-year overall survival （OS） rate,and different types of treatment-related adverse *** calculated the risk ratios （RRs） as well as their 95％ confidence intervals of these outcomes and pooled the results using RevMan 5.2 ***：For patients with previously untreated MM,OR rate and CR rate was significantly higher in lenalidomide-containing group than the control *** relapsed or refractory MM patients,lenalidomide-containing regimens significantly improved the OR rate,CR rate,3-year PFS rate and 3-year OS *** regard to MM patients after autologous stem cell transplantation,lenalidomide maintenance therapy significantly improved 3-year PFS rate but did not result in improved 3-year OS *** terms oftoxicities,lenalidomide therapy has a higher rate of Grade 3-4 grade cytopenias,infection,deep-vein thrombosis,and ***,the incidence of second primary malignancies was significantly higher in the lenalidomide ***：The lenalidomide-containing regimens as induction therapy clearly increased response rates and improved intervals of survival with acceptable toxicity rates for patients with ***,when physicians choose to use the lenalidomide as maintenance

关键词： Lenalidomide Meta-analysis Multiple Myeloma

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RE-SEGNN:recurrent semantic evidence-aware graph neural network for temporal knowledge graph forecasting

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Science China(Information Sciences) 2025年

作者： Wenyu CAI Mengfan LI Xuanhua SHI Yuanxin FAN Quntao ZHU hai jin National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and TechnologyHuazhong University of Science and Technology

Temporal knowledge graph(TKG) reasoning, has seen widespread use for modeling real-world events, particularly in extrapolation settings. Nevertheless, most previous studies are embedded models, which require both entity and relation embedding to make predictions, ignoring the semantic correlations among different entities and relations within the same timestamp. This can lead to random and nonsensical predictions when unseen entities or relations occur. Furthermore, many existing models exhibit limitations in handling highly correlated historical facts with extensive temporal depth. They often either overlook such facts or overly accentuate the relationships between recurring past occurrences and their current counterparts. Due to the dynamic nature of TKG, effectively capturing the evolving semantics between different timestamps can be *** address these shortcomings, we propose the recurrent semantic evidenceaware graph neural network(RE-SEGNN), a novel graph neural network that can learn the semantics of entities and relations simultaneously. For the former challenge, our model can predict a possible answer to missing quadruples based on semantics when facing unseen entities or relations. For the latter problem, based on an obvious established force, both the recency and frequency of semantic history tend to confer a higher reference value for the current. We use the Hawkes process to compute the semantic trend, which allows the semantics of recent facts to gain more attention than those of distant facts. Experimental results show that RE-SEGNN outperforms all SOTA models in entity prediction on 6 widely used datasets, and 5 datasets in relation prediction. Furthermore, the case study shows how our model can deal with unseen entities and relations.

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Effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

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Tungsten 2025年第1期7卷 195-213页

作者： Zhi-Peng Zhu Dian Jia William Yi Wang Jun-Lei Yin Xing-Yu Gao Shu-Feng Yang hai-Feng Song jin-Shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

关键词： First-principles calculations Phase stability TCP phases Thermodynamic properties W–Re alloy

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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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Global Probabilistic Voltage Sensitivity Analysis of Active Distribution Networks Based on the Compound Gaussian Mixture Model

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Dianwang Jishu/Power System Technology 2025年第1期49卷 295-305页

作者： Zhang, ren Wang, Jian Shang, Jie hai, Chen Liu, Haoming School of Electrical and Power Engineering Hohai University Jiangsu Province Nanjing 211100 China College of Artificial Intelligence and Automation Hohai University Jiangsu Province Nanjing 211100 China

The stochasticity of the high penetration of distributed generations (DGs) exacerbates the voltage fluctuation of the active distribution networks (ADNs) and complicates its voltage safety analysis. Therefore, this paper proposes a global probability voltage sensitivity analysis method based on the compound Gaussian mixture model (GMM). Firstly, a shared node path impedance-based global voltage sensitivity analytical model of ADN is derived to quantify the impact of global power fluctuations on node voltage. Considering that the voltage fluctuation has the non-Gaussian characteristic under the superposition influence of power uncertainty injected by multiple nodes, the GMM is used to characterize the probability characteristics of DG and load forecasting errors. Then, based on the affine transformation of the global sensitivity matrix to the GMM of DG and load forecasting error, the probability analytic expression of the voltage fluctuation is constructed, which is caused by the uncertainty of DG and load. Finally, based on the GMM characteristic function, the compound GMM characteristic function of the combined influence of the uncertainty of DG and load on voltage fluctuation is derived, and the global probabilistic voltage sensitivity analysis model based on the compound GMM is established. The case study results show that the proposed method can reflect the probability characteristics of the impact of all node power fluctuations on node voltage, and can quickly and accurately calculate the probability of over-voltage in ADNs. © 2025 Power System Technology Press. All rights reserved.

关键词： Affine transforms

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Metastable seed-crystals: epitaxial growth of branched-array organic heterostructure nanowires

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Science China Chemistry 2025年

作者： jin Feng Zhen-Yu Geng Ting-Yao Song Ying-Xin Ma Chuan-Zeng Wang Wei Zhang Hong-Tao Lin jin Zhou Shu-Ping Zhuo Shu-hai Chen Xue-Dong Wang School of Chemistry and Chemical Engineering Shandong University of Technology Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow University College of Chemistry and Chemical Engineering Hunan Normal University

Tunable light–matter interactions are exhibited by organic low-dimensional crystals, making these crystals a promising platform for organic photonics. However, the precise synthesis of organic low-dimensional crystals remains challenging due to the stochastic nature of molecular nucleation processes. Herein, the directed nucleation process is driven by the introduction of metastable seed-crystals as the trunk, which ultimately leads to branched-array organic heterostructures. The successful formation of organic heterostructures with high-density branched arrays is attributed to the highest attachment energy (Eatt（023）=-104.25 kcal mol-1) of the exposed （023） crystal plane during the seed-crystal growth route. Significantly, these as-prepared heterostructures inherently have an ultralow lattice mismatch ratio η of 0.7%between trunk and branch, which contributes to the multi-channel photon transportation. Therefore, this work provides valuable insights into a versatile synthetic strategy for accessing low-dimensional heterostructures for integrated optoelectronics.

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乒乓球运动者正手弧圈球不同触地模式的下肢生物力学变化

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中国组织工程研究 2025年第14期29卷 2995-3001页

作者：晋鹏飞任杰上海体育大学中国乒乓球学院上海市200438

背景:探讨基于步法的足部触地模式对乒乓球运动中下肢关节运动特征的影响,可为指导下肢训练提供科学依据。目的:对比乒乓球运动中不同触地模式下的运动学和动力学差异。方法:使用动作捕捉和三维测力台同步采集17名专业乒乓球运动员在正... 详细信息

背景:探讨基于步法的足部触地模式对乒乓球运动中下肢关节运动特征的影响,可为指导下肢训练提供科学依据。目的:对比乒乓球运动中不同触地模式下的运动学和动力学差异。方法:使用动作捕捉和三维测力台同步采集17名专业乒乓球运动员在正常触地和全脚掌触地模式下优势侧下肢的运动学和动力学数据。配对样本t检验用于分析关节角度、地面反作用力、关节反作用力和关节力矩等离散指标的统计学差异;统计参数映射用于分析足底压力中心移动轨迹和膝关节力矩等时间序列数据的统计学差异。结果与结论:①正常触地模式下的膝关节内翻、侧向地面反作用力、膝关节垂直反作用力和伸膝力矩峰值显著高于全脚掌触地模式;②在足底压力中心移动距离中的89%-91%运动阶段,正常触地模式压力中心显著远于全脚掌触地模式;③在X轴力矩曲线中的23%-38%运动阶段,正常触地模式的伸膝力矩显著大于全脚掌触地模式;④在Y轴力矩曲线的8%-18%运动阶段,全脚掌触地模式显著大于正常触地模式。通过对比不同触地模式的下肢生物力学特征值和统计参数映射分析结果,认为全脚掌触地模式可能是影响乒乓球运动表现的重要因素。乒乓球运动中需要针对性地对触地模式进行调整和练习,避免使用全脚掌触地模式,提升乒乓球运动者下肢运动能力。

关键词：触地模式乒乓球运动学动力学运动表现

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TCP performance evaluation over AODV and DSDV in RW and SN mobility models

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第10期7卷 1683-1689页

作者： ren Wei YEUNG D.Y. jin hai School of Computer Sctence and Technology Huazhong University of Science and Technology Wuhan 430074 China Department of Computer Science Hong Kong University of Science and Technology Hong Kong China School of Information Zhongnan University of Economics and Law Wuhan 430074 China

This paper presents evaluation and comparison of the TCP performance in different mobile scenarios generated by Random Waypoint (RW) and Social Network (SN) mobility models. To our knowledge, TCP performance in SN mobility is discussed for the first time. The impact of AODV and DSDV routing protocols on the TCP goodput, delay and drop rate per- formance is also discussed. Extensive simulation results and analysis showed that TCP has better performance over AODV than over DSDV and has more stable performance in SN mobility than in RW mobility. We suggest using more mobility models, in particular, such as SN, in the evaluations of the transport layer or routing layer protocols because the mobility patterns have impacts on the protocol performance.

关键词： TCP Social Network (SN) Performance evaluation Mobility Mobile ad hoc networks

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On the consistency of two-phase local/nonlocal piezoelectric integral model

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Applied Mathematics and Mechanics(English Edition) 2021年第11期42卷 1581-1598页

作者： Yanming ren hai QING State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In this paper,we propose general strain-and stress-driven two-phase local/nonlocal piezoelectric integral models,which can distinguish the difference of nonlocal effects on the elastic and piezoelectric behaviors of *** nonlocal piezoelectric model is transformed from integral to an equivalent differential form with four constitutive boundary conditions due to the difficulty in solving intergro-differential equations *** nonlocal piezoelectric integral models are used to model the static bending of the Euler-Bernoulli piezoelectric beam on the assumption that the nonlocal elastic and piezoelectric parameters are coincident with each *** governing differential equations as well as constitutive and standard boundary conditions are *** is found that purely strain-and stress-driven nonlocal piezoelectric integral models are ill-posed,because the total number of differential orders for governing equations is less than that of boundary ***,the traditional nonlocal piezoelectric differential model would lead to inconsistent bending response for Euler-Bernoulli piezoelectric beam under different boundary and loading *** nominal variables are introduced to normalize the governing equations and boundary conditions,and the general differential quadrature method(GDQM)is used to obtain the numerical *** results from current models are validated against results in the *** is clearly established that a consistent softening and toughening effects can be obtained for static bending of the Euler-Bernoulli beam based on the general strain-and stress-driven local/nonlocal piezoelectric integral models,respectively.

关键词： nonlocal piezoelectric integral model softening effect toughening effect general differential quadrature method(GDQM)

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3D打印技术在食品中的研究进展

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南京农业大学学报 2025年第1期48卷 70-84页

作者：丁可盈金晶任玉金鹏郑永华吴正国南京农业大学食品科学技术学院江苏南京210095

3D打印技术是一种新兴的制造技术,其可以利用数字模型实现精准制造。近年来,3D打印技术已经被广泛应用于各个领域,包括食品、生物医药等。3D食品打印的优势在于能够制作复杂的食品模型、设计独特的图案以及精准定制。3D食品打印技术由... 详细信息

3D打印技术是一种新兴的制造技术,其可以利用数字模型实现精准制造。近年来,3D打印技术已经被广泛应用于各个领域,包括食品、生物医药等。3D食品打印的优势在于能够制作复杂的食品模型、设计独特的图案以及精准定制。3D食品打印技术由挤出式打印、黏结剂喷射和喷墨打印组成,其利用食品材料,基于逐层堆积的方式设计造型。本文重点介绍了3D打印技术在食品中的最新研究进展,深入总结了3D打印技术在不同类型食品应用中的特点和局限性。同时,通过介绍食品的精准营养递送、贮藏保鲜、食品加工、生物制造等方面,详细分析了3D打印在食品行业的应用现状。最后展望了未来食品3D打印技术的发展,以期为3D打印与食品产业的深度融合提供理论指导。

关键词： 3D打印食品加工精准营养食品包装

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