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The safety of radium-223 combined with new-generation hormonal agents in bone metastatic castration-resistant prostate cancer: a systematic review and network meta-analysis

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Asian Journal of Andrology 2023年第4期25卷 441-447页

作者： Ming-Hao Wang jin-Dong Dai Xing-Ming Zhang Jin-Ge Zhao Guang-Xi Sun Yu-Hao Zeng Hong Zeng Nan-Wei Xu Hao Zeng Peng-Fei Shen Department of Urology West China Hospital of Sichuan UniversityChengdu 610041China

Patients with bone metastatic castration-resistant prostate cancer (mCRPC) might benefit from radium-223 (^(223)Ra) combined withnew-generation hormonal agents (NHAs) in terms of survival and quality of life (QoL). However, the safety of combination therapiesremains unclear. Therefore, we aimed to perform a network meta-analysis by reviewing the literature about the combination of^(223)Ra with abiraterone acetate plus prednisone (AAP) or enzalutamide and to evaluate the safety of combination therapy in bonemCRPC patients. Ultimately, ten studies (2835 patients) were selected, including four randomized controlled trials (RCTs), fiveretrospective cohort studies, and one single-arm study. Overall, there was no difference in the incidence of fracture between the^(223)Ra+NHA combination group and the ^(223)Ra monotherapy group (odds ratio [OR]: 1.46, 95% confidence interval [CI]: 0.91–2.34,P = 0.66), but the incidences in both the ^(223)Ra+NHA combination group (OR: 3.22, 95% CI: 2.24–4.63, P < 0.01) and the ^(223)Ramonotherapy group (OR: 2.24, 95% CI: 1.23–4.08, P < 0.01) were higher than that in the NHA monotherapy group. However, inthe meta-analysis involving only RCTs, there was no difference between the ^(223)Ra monotherapy group and the NHA monotherapygroup (OR: 1.14, 95% CI: 0.22–5.95, P = 0.88), while the difference between the ^(223)Ra+NHA combination group and the NHAmonotherapy group remained significant (OR: 3.22, 95% CI: 2.24–4.63, P < 0.01). Symptomatic skeletal events (SSEs), SSE-freesurvival (SSE-FS), all grades of common adverse events (AEs), and ≥grade 3 AEs among all groups did not show any significantdifference. Our results indicate that the combination of ^(223)Ra with NHAs was well tolerated in bone mCRPC patients compared to ^(223)Ra monotherapy, even though the incidence of fracture was higher in patients who received ^(223)Ra than that among those whoreceived NHA monotherapy. More evidence is needed to explore the safety and efficiency of ^(223)Ra combination therapies.

关键词： meta-analysis metastatic castration-resistant prostate cancer new-generation hormonal agents radium-223 safety

Design and experiment of concentrated flexibility-based variable camber morphing wing

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Chinese Journal of Aeronautics 2022年第5期35卷 455-469页

作者： Yuzhu LI Wenjie ge jin ZHOU Yonghong ZHANG Donglai zhao Zhuo WANG Dianbiao DONG School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China School of Aeronautic Science and Engineering Beihang UniversityBeijing 100083China

The morphing wing has a significant positive effect on the aerodynamic performance of the aircraft.This paper describes a leading-edge of variable camber wing with concentrated flexibility based on the geared five-bar mechanism.The driving points of morphing skin formed by the glass fibre composite sheet were optimized to make the skin deformation smooth.A geared fivebar kinematic mechanism rigidly connected to the skin was proposed to drive the leading-edge deformation.Besides,a new kind of concentrated flexure hinge was designed using the pseudorigid-body method and applied to the joint between the rigid mechanism and the skin.Finally,the leading-edge prototypes with traditional hinges and flexure hinges were produced,respectively.The feasibility of the concentrated flexibility leading-edge was verified through the comparative experiments of ground deformation.Simultaneously,aerodynamic analysis was carried out to compare the concentrated flexure leading-edge wing with the original airfoil.

关键词： Aircraft Concentrated flexure hinge Leading-edge Morphing wing Pseudo-rigid-body model

A new pathway for formic acid electro-oxidation:The electro-chemically decomposed hydrogen as a reaction intermediate

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Journal of Energy Chemistry 2022年第8期31卷 188-191,I0006页

作者： Xiaolong Yang Qinglei Meng Xian Wang zhao jin Changpeng Liu Junjie ge Wei Xing State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 Jilin China School of Applied Chemistry and Engineering University of Science and Technology of China

Formic acid electro-oxidation reaction(FAOR)is generally believed that follows a two-pathway mechanism.Herein,we resorted to in situ electrochemical mass spectrometry and successfully captured the trace of H_(2),as the new intermediate species,during the process of FAOR on both Pt based catalyst and two single atom catalysts(Rh-N-C and Ir-N-C).Inspired by this,we proposed a new reaction path named hydrogen oxidation pathway:at the oxidation potential,formic acid will break the C–H bond and combine with the protons in the solution to form H_(2) species,then hydrogen oxidation reaction(HOR)will occur to generate two protons.This process is accompanied by electron transfer and contributes currently to the whole reaction.

关键词： Formic acid electro-oxidation reaction Hydrogen Pt Single atom catalysts Reaction pathway

Revealing the true origin of size-dependent Pd/C catalytic behavior towards formic acid decomposition

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Chinese Chemical Letters 2023年第1期34卷 457-460页

作者： Qinglei Meng Xian Wang Meiling Xiao zhao jin Junjie ge Changpeng Liu Wei Xing Laboratory of Advanced Power Sources Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China Jilin Province Key Laboratory of Low Carbon Chemical Power Sources Changchun 130022China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Formic acid decomposition(FAD)is considered a promising hydrogen production route to facilitate the ambient storage and on demand release of hydrogen energy.To optimize the catalysts for FAD,efforts have been paid to explore the underlying reason for the varied catalytic activity among catalysts with similar composition but differed structure.However,such endeavors are highly challenging due to the deeply intermingled effects of electronic structure,particle size,and facets,etc.Herein,to separately evaluate the respective effects of these factors,a series of catalysts with the same surface electronic structure and different particle size was prepared by cation dipole adjustment method.The performance and characterization results showed that the catalysts with different sizes and facets exhibited similar intrinsic activity with deviation of less than 5%.However,they showed 252%deviation of site stability,indicating that only the optimized electronic structure could enhance the intrinsic activity and a smaller particle size could extend the catalyst’s life.

关键词： Hydrogen production Formic acid Catalyst deactivation Size effect Facets effect

Detecting Anomalous Bus-Driving Behaviors from Trajectories

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Journal of Computer Science & Technology 2020年第5期35卷 1047-1063页

作者： zhao-Yang Wang Bei-Hong jin Tingjian ge Tao-Feng Xue State Key Laboratory of Computer Science Institute of SoftwareChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Computer Science University of Massachusetts LowellLowellMA 01854U.S.A.

In urban transit systems,discovering anomalous bus-driving behaviors in time is an important technique for monitoring the safety risk of public transportation and improving the satisfaction of passengers.This paper proposes a two-phase approach named Cygnus to detect anomalous driving behaviors from bus trajectories,which utilizes collected sensor data of smart phones as well as subjective assessments from bus passengers by crowd sensing.By optimizing support vector machines,Cygnus discovers the anomalous bus trajectory candidates in the first phase,and distinguishes real anomalies from the candidates,as well as identifies the types of driving anomalies in the second phase.To improve the anomaly detection performance and robustness,Cygnus introduces virtual labels of trajectories and proposes a correntropy-based policy to improve the robustness to noise,combines the unsupervised anomaly detection and supervised classification,and further refines the classification procedure,thus forming an integrated and practical solution.Extensive experiments are conducted on real-world bus trajectories.The experimental results demonstrate that Cygnus detects anomalous bus-driving behaviors in an effective,robust,and timely manner.

关键词： anomaly detection bus trajectory crowd sensing bus-driving safety

Role of Smad4 from ocular surface ectoderm in retinal vasculature development

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International Journal of Ophthalmology(English edition) 2020年第2期13卷 231-238页

作者： jing Li jin-Song Zhang Jiang-Yue zhao Guo-ge Han Tianjin Eye Hospital Tianjin Eye InstituteTianjin Key Lab of Ophthalmology and Visual ScienceNankai UniversityTianjin 300000China Shenyang Aier Excellence Eye Hospital Shenyang 110000Liaoning ProvinceChina Department of Ophthalmology the Fourth Affiliated Hospital of China Medical UniversityEye Hospital of China Medical UniversityKey Lens Research LaboratoryShenyang 110000Liaoning ProvinceChina

●AIM:To investigate how signals from lens regulate retinal vascular development and neovascularization.●METHODS:Le-Cre transgenic mouse line was employed to inactivate Smad4 in the surface ectoderm selectively.Standard histological and whole-mount retina staining were employed to reveal morphological changes of retinal vasculature in Smad4 defective eye.cDNA microarray and subsequent analyses were conducted to investigate the molecular mechanism underlying the vascular phenotype.Quantitative polymerase chain reaction(qPCR)was carried out to verify the microarrays results.●RESULTS:We found that inactivation of Smad4 specifically on surface ectoderm leads to a variety of retinal vasculature anomalies.Microarray analyses and qPCR revealed that Sema3 c,Sema3 e,Nrp1,Tie1,Sox7,Sox17,and Sox18 are significantly affected in the knockout retinas at different developmental stages,suggesting that ocular surface ectoderm-derived Smad4 can signal to the retina and regulates various angiogenic signaling in the retina.●CONCLUSION:Our data suggest that the cross-talk between ocular surface ectoderm and retina is important for retinal vasculature development,and Smad4 regulates various signaling associated with sprouting angiogenesis,vascular remodeling and maturation in the retina of mice.

关键词： Smad4 retinal vasculature surface ectoderm

Anode Catalytic Dependency Behavior on Ionomer Content in Direct CO Polymer Electrolyte Membrane Fuel Cell

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Chemical Research in Chinese Universities 2022年第5期38卷 1251-1257页

作者： LI Yang WANG Xian LIU Jie jin zhao LIU Changpeng ge Junjie XING Wei State Key Laboratory of Electroanalytic Chemistry Jilin Province Key Laboratory of Low Carbon Chemistry PowerChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022P.R.China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026P.R.China

In this work,the effect of Nafion ionomer content on the structure and catalytic performance of direct CO polymer electrolyte membrane fuel cell(CO-PEMFC)by using Rh-N-C single-atom catalyst as the anode catalyst layers was studied.The ionic plaque and roughness of the anode catalyst layers increase with the increase of Nafion ionomer content.Furthermore,the contact angle measurement results show that the hydrophilicity of the anode catalyst layers also increases with the increase of Nafion ionomer content.However,when the Nafion ionomer content is too low,the binding between microporous layers,catalyst layers and membrane cannot meet the requirement for either electric conductivity or mass transfer.While Nafion ionomer content increased above 30%,the content of water in anode is difficult to control.Therefore,it was found that AN 30(30%Nafion ionomer content of anode)is the best level to effectively extend the three-phase boundary and improve CO-PEMFCs performance.

关键词： Anode catalyst Carbon monoxide Polymer electrolyte membrane fuel cell(PEMFC) Nafion ionomer content

Hydrogen etching induced hierarchical meso/micro-pore structure with increased active density to boost ORR performance of Fe-N-C catalyst

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Journal of Energy Chemistry 2019年第8期28卷 17-23,I0002页

作者： Liqin Gao Meiling Xiao zhao jin Changpeng Liu Junjie ge Wei Xing State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of ScienceChangchun 130022 Jilin China University of Chinese Academy of Sciences Beijing 100039 China Laboratory of Advanced Power Sources Changchun Institute of Applied ChemistryChangchun 130022 Jilin China

Rational regulation on pore structure and active site density plays critical roles in enhancing the performance of Fe-N-C catalysts. As the microporous structure of the carbon substrate is generally regarded as the active site hosts, its hostility to electron/mass transfer could lead to the incomplete fulfillment of the catalytic activity. Besides, the formation of inactive metallic Fe particles during the conventional catalyst synthesis could also decrease the active site density and complicate the identification of real active site. Herein, we developed a facial hydrogen etching methodology to yield single site Fe-N-C catalysts featured with micro/mesoporous hierarchical structure. The hydrogen concentration in pyrolysis process was designated to effectively regulate the pore structure and active site density of the resulted catalysts.The optimized sample achieves excellent ORR catalytic performance with an ultralow H2O2 yield(1%)and superb stability over 10,000 cycles. Our finding provides new thoughts for the rational design of hierarchically porous carbon-based materials and highly promising non-precious metal ORR catalysts.

关键词： Hierarchical meso/micro-pore structure Hydrogen etching Single site Fe-N-C catalysts Carbon-nitrogen-coordinated iron(FeN4) Oxygen reduction reaction

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本雅明《讲故事的人》之口头诗学发微

海南大学学报（人文社会科学版） 2023年第6期41卷 1-8页

作者：朝戈金中国社会科学院民族文学研究所北京100732 内蒙古师范大学非物质文化遗产研究院内蒙古呼和浩特010022

瓦尔特·本雅明的《讲故事的人——尼古拉·列斯科夫作品考察》(1936)生动描摹人类社会讲故事的古老传统濒临消亡的症状,进而揭櫫其缘由。本雅明是在两个维度上同时开展讨论的,一个是古老的民众故事讲述传统是如何生成和运作的,再一个... 详细信息

瓦尔特·本雅明的《讲故事的人——尼古拉·列斯科夫作品考察》(1936)生动描摹人类社会讲故事的古老传统濒临消亡的症状,进而揭櫫其缘由。本雅明是在两个维度上同时开展讨论的,一个是古老的民众故事讲述传统是如何生成和运作的,再一个是当代的代表性作家列斯科夫是如何继承传统诗性智慧从而形成其叙事艺术的风格的。本雅明以其一贯的知微见著的风格,交错讨论了传统叙事智慧的本体论问题和对传统叙事智慧列斯科夫式利用的工具论问题,从而使其《讲故事的人》具有宽广的论域和巨大的张力——小说艺术、故事美学和口头诗学等领域,皆可从中获得深刻启迪。

关键词：本雅明故事讲述人口头诗学