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Is combined lipid-regulating therapy safe and feasible for the very old patients with mixed dyslipidemia?

Journal of geriatric Cardiology 2013年第4期10卷 349-354页

作者： Xiao Zou Quan-jin si The First Department of the geriatric Cardiology Chinese PLA General Hospital NO.28 Fuxing Road Beijing 100853 China

OBJECTIVES: To detect the efficacy and safety of combined lipid-regulating therapies in the very old patients with mixed dyslipidemia and determine an appropriate therapy for them。 METHODS: Four hundred and fifty patients aged over 75 with mixed dyslipidemia were divided into five groups according to different combination therapies。 Lipid levels and drug related adverse events were tested during the study。 RESULTS: Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were reduced in every group compared to baseline: statin + ezetimibe: -30.0% and -55.5%; statin + policosanol: -31.1% and -51.2%; statin + fibrates: -23.7% and -44.6%; statin + niacin: -25.2% and -43.0%; and niacin + fibrates: -11。3% and -23.5%。 The target achievement rates of LDL-C all exceeded 50%, except in niacin + fibrates (42.0%); statin + ezetimibe: 57.0%; statin + policosanol: 56.0%; statin + niacin: 52.0%; and statin + fibrates: 50.0%。 However, overall, the niacin + fibrates group was the most effective in decreasing triglyceride (TG) and increasing high-density lipoprotein cholesterol (HDL-C) as follows: niacin + fibrates: -39.3% and 28.6%; statin + fibrates: -29.3% and 18.4%; statin + niacin: -18.5% and 16.7%; statin + ezetimibe: -17.1% and 7.1%; and statin + policosanol: -15.6% and 9.5%。 The achievement rates of TG and HDL-C levels in niacin + fibrates (58.0% and 39.0%) were better than the other four groups: statin + niacin (34.0% and 34.0%), statin + fibrates (43.0% and 28.0%), statin + policosanol (30.0% and 24.0%) and statin + ezetimibe (28.0% and 25.0%)。 Patients in all five groups experiencing drug adverse events were only 2% and no severe adverse events occurred。 CONCLUsiONS: Statin + ezetimibe was the most effective group in lowering TC and LDL-C levels, while niacin + fibrates was the most effective in decreasing TG and increasing HDL-C levels。 The commonly used combined lipid-regulating therapies with common dosages in this study were all quite safe and fea

关键词： Combination therapies Elderly patients Mixed dyslipidemia Safety

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Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 1164-1183页

作者： Na Li Fan Yang Dong-Yan Liu jin-Tao Guo Nan ge si-Yu Sun Department of Hospice Care Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Medical Research Center Shengjing Hospital of China Medical UniversityBenxi 111700Liaoning ProvinceChina

BACKGROUND Pancreatic cancer is a highly malignant tumor of the gastrointestinal system whose emerging resistance to chemotherapy has necessitated the development of novel antitumor ***,a traditional Chinese medicine monomer with a wide range of pharmacological properties,has attracted considerable attention for its antitumor *** To explore the potential antitumor effect of scoparone on pancreatic cancer and the possible molecular mechanism of *** The target genes of scoparone were determined using both the bioinformatics and multiplatform *** effect of scoparone on pancreatic cancer cell proliferation,migration,invasion,cell cycle,and apoptosis was detected in *** expression of hub genes was tested using quantitative reverse transcription polymerase chain reaction(qRT-PCR),and the molecular mechanism was analyzed using Western *** in vivo effect of scoparone on pancreatic cancer cell proliferation was detected using a xenograft tumor model in nude mice as well as *** The hub genes involved in the suppression of pancreatic cancer by scoparone were obtained by network bioinformatics analyses using publicly available databases and platforms,including SwissTargetPrediction,STITCH,geneCards,CTD,STRING,Webgestalt,Cytoscape,and gepia;AKT1 was confirmed using qRT-PCR to be the hub *** Counting Kit-8 assay revealed that the viability of Capan-2 and SW1990 cells was significantly reduced by scoparone treatment exhibiting IC50 values of 225.2μmol/L and 209.1μmol/L,*** healing and transwell assays showed that scoparone inhibited the migration and invasion of pancreatic cancer ***,flow cytometry confirmed that scoparone caused cell cycle arrest and induced *** also increased the expression levels of Bax and cleaved caspase-3,decreased the levels of MMP9 and Bcl-2,and suppressed the phosphorylation of Akt without affecting total PI3K and ***

关键词： Pancreatic cancer Scoparone Akt1 PI3K/Akt signaling pathway Bioinformatics analysis Xenograft tumor

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Effects of premedication with Pronase for endoscopic ultrasound of the stomach: A randomized controlled trial

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World Journal of Gastroenterology 2016年第48期22卷 10673-10679页

作者： Guo-Xin Wang Xiang Liu Sheng Wang Nan ge jin-Tao Guo si-Yu Sun Endoscopy Center Shengjing Hospital of China Medical University

AIM To analyze the effects of premedication with Pronase for endoscopic ultrasound(EUS) examination of the *** This was a prospective, randomized and controlled clinical study. All patients were randomly assigned to either the Pronase group or placebo group. The pretreatment solution was a mixed solution of 20000 U of Pronase and 60 m L sodium bicarbonate solution in the Pronase group, while an equal amount of sodium bicarbonate solution was administered to the placebo group. All operators, image evaluators and experimental recorders in EUS did not participate in the preparation and allocation of pretreatment solution. Two blinded investigators assessed the obscurity scores for the EUS images according to the size of artifacts(including ultrasound images of the gastric cavity and the gastric wall). Differences in imaging quality, the duration of examination and the usage of physiological saline during the examination process between the Pronase group and the control group were *** No differences existed in patient demographics between the two groups. For the gastric cavity, the Pronase group had significantly lower mean obscurity scores than the placebo group(1.0476 ± 0.77 vs 1.6129 ± 0.96, respectively, P = 0.000). The mean obscurity scores for the gastric mucosal surface were significantly lower in the Pronase group than the placebo group(1.2063 ± 0.90 vs 1.7581 ± 0.84, respectively, P = 0.001). The average EUS procedure duration for the Pronase group was 11.60 ± 3.32 min, which was significantly shorter than that of the placebo group(13.13 ± 3.81 min, P = 0.007). Less saline was used in the Pronase group than the placebo group, and the difference was significant(417.94 ± 121.38 m L vs 467.42 ± 104.52 mL, respectively, P = 0.016).CONCLUsiON The group that had Pronase premedication prior to the EUS examination had clearer images than the placebo group. With Pronase premedication, the examination time was shorter, and the amount of saline us

关键词： Artifacts Randomized controlled trial Endosonography Pronase Stomach

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Multiarm Star Poly(ε-caprolactone) with Hyperbranched Polyamidoamine as Core Capable of Selective Accommodating Cationic or Anionic Guests

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Chinese Journal of Polymer Science 2015年第6期33卷 920-930页

作者： Chen Zhan si Li jin Cui 陈宇 Department of Chemistry School of SciencesTianjin Universityand Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) National Foodstuff Inspection Center Tianjin Product Quality Inspection Technology Research Institute

Hyperbranched polyamidoamines （HPAs） were directly employed as macroinitiators to initiate the Sn（Oct）2 catalyzed ring-opening polymerization of ε-caprolactone （CL）, resulting in multiarm star copolymers with poly（6- caprolactone）（PCL） as shells and HPA as core （HPA-b-PCL）. From 1H-NMR characterization it was deduced that both the primary amines and the secondary amide groups of HPAs could initiate the CL polymerization, and the initiation efficiency increased when more CL monomers were fed. The average arm-numbers of the obtained stars were in the range of 115-353. Differential scanning calorimetry measurements demonstrated that the melting and crystallization temperatures, fusion and crystallization enthalpy and the degree of crystallinity of the star polymers increased as the PCL arm length increased. HPA- b-PCL stars could be used as nanocarriers to efficiently accommodate anionic dyes at acidic condition, while load cationic dyes at basic condition. Compared with the dye-loading behavior of multiarrn star PCL with the neutral hyperbranched polyglycerol as core, it was deduced that HPA-b-PCL nanocarriers accommodated anionic dyes using the HPA core, while loaded cationic dyes using both the HPA core and the PCL shell. Dynamic light scattering analyses also supported such deduction. Furthermore, HPA-b-PCL nanocarriers could selectively load the anionic Eosin Y or the cationic methylene blue from their mixture at pH = 6 or 9, respectively, realizing their separation.

关键词： Nanocarrier Hyperbranched Polyamidoamine Poly(ε-caprolactone) Star polymers.

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科学数据伦理治理:政策框架与路径——以英国为例

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现代情报 2025年第1期45卷 112-123,134页

作者：刘先瑞司莉武汉大学信息管理学院湖北武汉430072

[目的/意义]完善科学数据伦理治理有助于规范科学数据收集、共享和使用,发挥数据作为科研的关键资源与要素的功能,优化科学数据管理服务。[方法/过程]本研究基于扎根理论分析英国科学数据伦理政策,总结其政策框架与内容,并通过矩阵编码... 详细信息

[目的/意义]完善科学数据伦理治理有助于规范科学数据收集、共享和使用,发挥数据作为科研的关键资源与要素的功能,优化科学数据管理服务。[方法/过程]本研究基于扎根理论分析英国科学数据伦理政策,总结其政策框架与内容,并通过矩阵编码与社会网络分析方法揭示治理特征,提出我国优化科学数据伦理治理的建议。[结果/结论]研究发现,伦理政策框架包括治理环境、主体与策略3层面。伦理治理环境内容分为适用领域、适用主体、概念定义、问题分析与现有政策;伦理治理主体内容涉及治理主体界定与促进主体协作;伦理治理策略内容涵盖治理指导与各阶段治理措施。其治理特征有3维度:注重定义概念,明确分配主体权责与促进协作,全面厘定治理策略与加强伦理风险防控。据此提出4条治理路径:形成治理体系,规范治理理论,明确各方权责与协作方式,细化各阶段治理措施。

关键词：科学数据数据伦理数据治理政策分析英国

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From macroautophagy to mitophagy:Unveiling the hidden role of mitophagy in gastrointestinal disorders

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World Journal of Gastroenterology 2024年第23期30卷 2934-2946页

作者： Duo-Lun Gao Meng-Ran Lin Nan ge jin-Tao Guo Fan Yang si-Yu Sun Department of Gastroenterology Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

In this editorial,we comment on an article titled“Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases”,which was published in a recent issue of the World Journal of *** focused on the statement that“autophagy is closely related to the digestion,secretion,and regeneration of gastrointestinal cells”.With advancing research,autophagy,and particularly the pivotal role of the macroautophagy in maintaining cellular equilibrium and stress response in the gastrointestinal system,has garnered extensive ***,the significance of mitophagy,a unique selective autophagy pathway with ubiquitin-dependent and independent variants,should not be *** recent decades,mitophagy has been shown to be closely related to the occurrence and development of gastrointestinal diseases,especially inflammatory bowel disease,gastric cancer,and colorectal *** interplay between mitophagy and mitochondrial quality control is crucial for elucidating disease mechanisms,as well as for the development of novel treatment *** the pathogenesis behind gastrointestinal diseases and providing individualized and efficient treatment for patients are subjects we have been *** article reviews the potential mechanism of mitophagy in gastrointestinal diseases with the hope of providing new ideas for diagnosis and treatment.

关键词： Mitophagy Gastrointestinal diseases Parkin Autophagic receptor Colorectal cancer Gastric cancer Inflammatory bowel disease

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Optimal energy-efficient power control for cognitive radio based on static and dynamic features of primary users

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High Technology Letters 2011年第4期17卷 350-353页

作者： ge Wendong Ji Hong si Pengbo School of Information and Communication Engineering Beijing University of Posts and Telecommunications Beijing 100876 P.R. China School of Electronics Information and Control Engineering Beijing University of Teclmology Beijing 100022 P.R.China

In this paper, the energy-efficient power control problem in cognitive radio （CR） networks is studied not only to provide energy-efficient transmission, but also to guarantee the normal operation of primary users （PUs）. Moreover, the static energy-efficient power control （SEPC） algorithm is proposed in static scenario to maximize the capacity of secondary users （SUs） and to reduce the power consumption according to the interference from PU to SU. Furthermore, based on the analysis of PU＇s dynamic feature with Markov chain and SEPC algorithm,the dynamic energy-efficient power control （DEPC） algorithm is proposed taking into account the probability of detection and false alarm caused by sensing errors. Extensive simulation results show that the performance of the proposed algorithms is significantly improved compared with the existing algorithm.

关键词： cognitive radio(CR) power control energy-efficient Markov false alarm

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Dynamics of low-speed streak evolution and interaction in laminar boundary layer

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Acta Mechanica sinica 2014年第5期30卷 636-645页

作者： si-Chao Deng Chong Pan jin-Jun Wang Fluid Mechanics Key Laboratory of Ministry of Education Beihang University

The present paper presents an experimental effort on the regeneration process of two low-speed laminar streaks in a zero-pressure-gradient laminar boundary layer. Two vertical thin wires separated by a spanwise distance of 30 mm are used to introduce disturbances of two rolls of transitional Karmain vortex street to the downstream boundary layer. Both hydrogen bubble visualization and particle image velocimetry （PIV） measurement show that two lowspeed streaks are induced through leading-edge receptivity process. As these streaks develop in the downstream, two additional low-speed streaks begin to appear outboard of the flank of the original two, together with complex dynamics of streak splitting and merging. A flow pattern of four streaks aligned along the spanwise direction occurs finally in the far downstream. It is found that besides the mechanisms of streak breakdown, the streak interaction is also an important factor characterizing the instability of low speed streaks and their regeneration process.

关键词： Low-speed streak - Boundary layer transition Streak reproduction

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The development,performances and applications of the monochromatic X-rays facilities in(0.218–301)keV at NIM,China

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Nuclear Science and Techniques 2021年第6期32卷 108-121页

作者： si-Ming Guo jin-Jie Wu Dong-Jie Hou National Institute of Metrology BeijingChina

Space scientific exploration is rapidly becoming the primary battlefield for humankind to explore the *** worldwide have launched numerous space exploration *** calibration of the detectors on the ground is a crucial element for space science satellites to obtain observational *** the purpose of providing calibration for various satellite-borne detectors,multiple monochromatic X-rays facilities have been built at the National Institute of Metrology,***(NIM).These facilities mainly pertain to grating diffraction and Bragg diffraction,and the energy range of the produced monochromatic X-rays is 0.218–301 ke *** facilities have a high performance in terms of energy stability,monochromaticity,and flux *** monochromaticity was greater than 3.0%.The energy stability of the facility is 0.02%at 25 ke V over 8 h,and the flux stability was within 1.0%at 25 ke V over 8 *** experiments on the properties of satellite-borne detectors,such as energy linearity,energy resolution,detection efficiency,and temperature response,can be conducted at the *** far,the calibration of two satellites has been completed by the authors,and the work on three other satellites is in *** study will contribute to the advancement of X-ray astronomy the development of Chinese space science.

关键词： Monochromatic X-rays Monochromator Bragg diffraction Energy spectra Calibration

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Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology:Progress and updates

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 1-18页

作者： Fan Yang si-Yu Sun Sheng Wang jin-Tao Guo Xiang Liu Nan ge Guo-Xin Wang Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

Gastrointestinal(GI)tumors,including liver,pancreatic,gastric,and colorectal cancers,have a high incidence rate and low survival rate due to the lack of effective therapeutic methods and frequent *** and postoperative chemoradiotherapy have largely reduced the fatality rates for most GI tumors,but these therapeutic approaches result in poor prognoses due to severe adverse reactions and the development of drug *** studies have shown that ferroptosis plays an important role in the onset and progression of GI *** is a new non-apoptotic form of cell death,which is iron-dependent,non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species(ROS).The activation of ferroptosis can lead to tumor cell ***,regulating ferroptosis in tumor cells may become a new therapeutic approach for tumors,making it become a research *** studies suggest that ferroptosis is mainly triggered by the accumulation of lipid ***,several studies have indicated that ferroptosis may be a new approach for the treatment of GI ***,we review current research progress on the mechanism of ferroptosis,current inducers and inhibitors of ferroptosis,and the role of ferroptosis in GI tumors to propose new methods for the treatment of such tumors.

关键词： Ferroptosis Gastrointestinal oncology Hepatocellular carcinoma Pancreatic cancer Gastric cancer Colorectal cancer

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