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Endoscopic full-thickness resection for treating small tumors originating from the muscularis propria in the gastric fundus: An improvement in technique over 15 years

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 1054-1064页

作者： Nan ge jin-Long Hu Fei Yang Fan Yang si-Yu Sun Endoscopy Center Shengjing Hospital of China Medical University

BACKGROUND The fundus of the stomach is regarded as a difficult area for endoscopic resection of small tumors originating from the muscularis propria(MP tumors).Three endoscopic resection techniques have been developed to treat these tumors,including ligation-assisted endoscopic full-thickness resection(L-EFTR),snareassisted EFTR(S-EFTR),and endoscopic submucosal dissection-assisted EFTR(EEFTR).To date,no studies have compared these *** We aimed to evaluate and compare S-EFTR with L-EFTR and E-EFTR for treating small MP tumors in the gastric *** We retrospectively reviewed patients with primary small MP tumors in the gastric fundus and treated by these three techniques between January 2016 and December 2018 at Shengjing Hospital,*** demographic and clinicopathologic data,including sex,age,tumor size,surgeon details,and pathological results,were *** regarding operation duration,cost,enbloc resection,and severe complications were also extracted and *** A total of 36 patients(27 women)with a mean age of 55.8±10.20 years were included in this *** mean tumor size was 9.0±3.98 *** the methods showed a 100%en-bloc resection rate and 0%severe complication *** was no statistically significant difference among the three groups in the operation duration(P=0.148).The cost comparison for the whole procedure was as follows:E-EFTR>L-EFTR>S-EFTR(5837.5±7212.96 CNY,5970.7±3465.27 CNY,5852.0±6438.25 CNY,respectively,PsiON S-EFTR,L-EFT,and E-EFTR are all effective for resection of small MP tumors in the gastric fundus.S-EFTR is superior in terms of cost-effectiveness.

关键词： Endoscopic full-thickness resection Ligation Muscularis propria Snare Endoscopic submucosal dissection Cost

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli si Naijia Xue Yi Liu Ran Zheng Ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

B位掺杂提升CsSnI_(3)钙钛矿结构和电荷稳定性的第一性原理研究

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原子与分子物理学报 2025年第6期42卷 144-152页

作者：赵思健葛治中杨旭东上海交通大学材料科学与工程学院上海200240

全无机CsSnI_(3)钙钛矿拥有理想的带隙宽度(1.3 eV),光电转化效率理论峰值达到33%.目前CsSnI_(3)太阳能电池的发展受制于的CsSnI_(3)的结构不稳定性和Sn^(2+)易被氧化为Sn^(4+)的问题.研究基于第一性原理,详细探讨了一系列金属元素对CsS... 详细信息

全无机CsSnI_(3)钙钛矿拥有理想的带隙宽度(1.3 eV),光电转化效率理论峰值达到33%.目前CsSnI_(3)太阳能电池的发展受制于的CsSnI_(3)的结构不稳定性和Sn^(2+)易被氧化为Sn^(4+)的问题.研究基于第一性原理,详细探讨了一系列金属元素对CsSnI_(3)进行B位掺杂改性的方案,旨在提升CsSnI_(3)结构稳定性,并抑制CsSnI_(3)中Sn^(2+)被氧化为Sn^(4+)的问题.计算结果表明,在CsSnI_(3)钙钛矿B位掺杂三价金属Sb、Bi能够阻碍CsSnI_(3)相变生成Cs_(2)SnI_6,并且抑制Sn^(2+)的氧化;尤其在晶格中存在锡空位缺陷时,Sb、Bi掺杂对于Sn^(4+)形成的抑制效果更为显著.同时,低浓度的Sb、Bi掺杂不会改变CsSnI_(3)的直接带隙特性,且带隙宽度变化较小,因此能够在维持CsSnI_(3)优良光电活性的基础上进一步提高结构和电荷的稳定性.研究结果为实现高效且稳定的CsSnI_(3)钙钛矿太阳能电池提供了重要的理论指导.

关键词：全无机锡基钙钛矿第一性原理 B位掺杂相稳定性电子结构

Management of massive fistula bleeding after endoscopic ultrasound-guided pancreatic pseudocyst drainage using hemostatic forceps: A case report

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World Journal of Clinical Cases 2019年第23期7卷 4157-4162页

作者： Nan ge si-Yu Sun Endoscopy Center Shengjing Hospital of China Medical University

BACKGROUND Endoscopic ultrasound(EUS)-guided drainage is the optimal method for treatment of pancreatic fluid collections(PFCs),and is associated with ease,safety,and *** is one of the main procedure-related complications,and often requires surgery or radiologic ***,endoscopic management of this complication is *** SUMMARY A 42-year-old man presented for evaluation of abdominal pain and distention for approximately 2 *** computed tomography revealed a pancreatic pseudocyst located in the tail of the ***-guided pancreatic pseudocyst was *** stent placement,massive bleeding was noted from the ***,hemostasis was successfully achieved using hemostatic forceps within the *** Bleeding vessel grasp and coagulation may represent a successful treatment for a fistula hemorrhage during EUS-guided drainage for a PFC,which may be tried before application of balloon or stent compression.

关键词： Pancreatic fluid collections Endoscopic ultrasound Drainage Hemorrhage Case report

Role of albumin-bilirubin score in non-malignant liver disease

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World Journal of Gastroenterology 2024年第9期30卷 999-1004页

作者： Shi-Xue Xu Fan Yang Nan ge jin-Tao Guo si-Yu Sun Department of Gastroenterology Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic TechniquesShengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

The albumin-bilirubin(ALBI)score,which was proposed to assess the prognosis of patients with hepatocellular carcinoma,has gradually been extended to other liver diseases in recent years,including primary biliary cholangitis,liver cirrhosis,hepatitis,liver transplantation,and liver *** ALBI score is often compared with classical scores such as the Child-Pugh and model for end-stage liver disease scores or other noninvasive prediction *** is widely employed because of its immunity to subjective evaluation indicators and ease of obtaining detection *** increasing number of studies have confirmed that it is highly accurate for assessing the prognosis of patients with chronic liver disease;additionally,it has demonstrated good predictive performance for outcomes beyond survival in patients with liver diseases,such as decompensation *** article presents a review of the application of ALBI scores in various non-malignant liver diseases.

关键词： Albumin-bilirubin score Liver cirrhosis Primary biliary cholangitis Hepatitis Liver transplantation Liver injury

Endoscopic ultrasonography elastography in the diagnosis of intrapancreatic ectopic spleen: A case report

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World Journal of Clinical Cases 2020年第9期8卷 1729-1734页

作者： Nan ge si-Yu Sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Intrapancreatic accessory spleen(IPAS)mimics a pancreatic neoplasm on imaging studies,and due to the lack of radiological diagnostic criteria,patients undergo unnecessary distal *** ultrasonography(EUS)is a reliable and efficient diagnostic modality for pancreatic ***,no EUS criteria have been established for *** present the EUSelastography image of IPAS,which may minimize the chance of misdiagnosis in the *** SUMMARY A 50-year-old man was referred for an EUS evaluation after computed tomography showed a hypervascular enhanced mass in the tail of the pancreas,which indicated a neuroendocrine *** elastography demonstrated that the lesion of interest covered no more than 25%of the region of *** patient underwent distal ***,the resected tissue was evaluated,and the patient was finally diagnosed with *** IPAS should be considered in patients with suspected pancreatic neuroendocrine tumors of the pancreatic tail before surgery is *** differentiation between IPAS and pancreatic neuroendocrine tumors can be demonstrated using EUS-elastography.

关键词： Intrapancreatic accessory spleen Endoscopic ultrasonography Elastography Case report

Delayed perforation after endoscopic resection of a colonic laterally spreading tumor:A case report and literature review

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World Journal of Clinical Cases 2020年第16期8卷 3608-3615页

作者： ge-Yu-Jia Zhou jin-Long Hu Sheng Wang Nan ge Xiang Liu Guo-Xin Wang si-Yu Sun jin-Tao Guo Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)have been widely used for the treatment of early gastrointestinal *** piecemeal mucosal resection(EPMR)is derived from the combination of EMR and *** perforation with peritonitis after colonic EPMR is a rare but severe complication,sometimes requiring *** are some associated risk factors,including patient-(location,diameter,and presence of fibrosis)and procedure-related *** recognition and timely treatment are crucial for its *** SUMMARY We report a case in which delayed perforation with peritonitis was treated using endoscopic closure.A 54-year-old man was diagnosed with a 30-mm-diameter laterally spreading tumor in the colonic hepatic *** hours after endoscopic resection,peritonitis caused by delayed perforation occurred and gradually *** treatment was ineffective and no obvious perforation was *** timely endoscopic closure,the patient was discharged on postoperative day *** In occasion of localized peritonitis aggravating without macroscopic perforation,endoscopic closure is an effective treatment for delayed perforation with stable vital signs in the early stage.

关键词： Endoscopic mucosal resection Endoscopic submucosal dissection Endoscopic piecemeal mucosal resection Delayed perforation Endoscopic closure Case report

先天性心脏病儿童156例营养不良发生现状及影响因素分析

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安徽医药 2025年第1期29卷 83-86页

作者：肖瑾朱琳陈思陕西省森林工业职工医院儿童保健科陕西西安710300

目的探讨先天性心脏病儿童营养不良发生现状及影响因素。方法选取陕西省森林工业职工医院2019年6月至2022年7月收治的156例先天性心脏病病人,采用Z评分法评估病人的营养状况。根据病人营养状况将其分为营养不良组和正常组,比较两组病人... 详细信息

目的探讨先天性心脏病儿童营养不良发生现状及影响因素。方法选取陕西省森林工业职工医院2019年6月至2022年7月收治的156例先天性心脏病病人,采用Z评分法评估病人的营养状况。根据病人营养状况将其分为营养不良组和正常组,比较两组病人一般资料,采用多因素回归分析先天性心脏病病人营养不良的影响因素。结果156例先天性心脏病病人中营养不良发生率为58.97%,其中急性营养不良发生率为26.92%,慢性营养不良发生率为32.05%;营养不良组病情复杂占比(57.61%比34.37%)、家庭经济收入低占比(45.65%比21.88%)、母亲对疾病感知度不准确占比(57.61%比35.94%)、低出生体质量儿占比(38.04%比23.44%)、心脏增大占比(21.74%比9.37%)、治疗前有症状占比(73.91%比34.38%)、确诊时间≥1年占比(68.48%比29.69%)、住院次数>4次占比(33.70%比12.50%)、感染占比(70.65%比29.69%)及来自农村占比(63.04%比40.62%)均高于营养正常组(均P<0.05);logistic回归分析发现,病情复杂程度、家庭经济收入、出生体质量、确诊时间、住院次数及感染均是先天性心脏病病人发生营养不良的独立危险因素(P<0.05)。结论病情复杂程度、出生体质量、住院次数以及家庭来源均是先天性心脏病病人营养不良的独立危险因素。

关键词：先天性心脏病儿童营养不良营养状况影响因素

Vibrotactile Sensation:A Systematic Review of the Artificial Pacinian Corpuscle

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Journal of Bionic Engineering 2023年第4期20卷 1401-1416页

作者： si Chen Zhiheng Yang Qin Huang Kuo Li Shirong ge Fluid Machinery Center Jiangsu UniversityZhenjiang221116China School of Mechanical&Information Engineering China University of Mining and TechnologyBeijing100083China

Pacinian corpuscle is a tactile receptor that responds to high-frequency(20-1000 Hz)vibration and has high-pass filtering and mechanical signal amplification *** is the main receptor of vibration tactility closely related to fine touch sensation,which is the ability to perceive and localize objects’shape,texture,and ***,it is still difficult to measure and calculate the friction generated by robots grasping *** resolution of touch and vibration sensors cannot satisfy the demand for understanding tribological *** simulation of Pacinian corpuscles’structure and replication of its key functions will bring richer touch information to *** this review article,the structure and functions of Pacinian corpuscles are summarized from the internal structure of a single Pacinian corpuscle and the spatial distribution of multiple Pacinian ***,theoretical models and research on the bionics design of Pacinian corpuscles are introduced based on the three reception processes of Pacinian corpuscles:mechanical transmission,electromechanical transduction,and neural ***,the bottlenecks of current research on the simulation of Pacinian corpuscles are summarized,followed by the proposal of research ideas on the simulation of Pacinian corpuscles.

关键词： Pacinian corpuscle Vibrotactile Bionic sensor