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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2658-2670页

作者： Xiu-feng GONG jin YAO Bin YANG Wan-zhong YIN Yu-lian WANG Ya-feng fu School of Resources and Civil Engineering Northeastern UniversityShenyang 110819China School of Chemical Engineering China University of Mining and TechnologyXuzhou 221163China School of Materials Science and Engineering Shenyang Ligong UniversityShenyang 110159China Ansteel Beijing Research Institute Co. Ltd.Beijing 102200China

To achieve efficient flotation separation of brucite and calcite,flotation separation experiments were conducted on two minerals using dodecylamine(DDA)as the collector and potassium dihydrogen phosphate(PDP)as the *** action mechanism of DDA and PDP was explored through contact angle measurement,zeta potential detection,solution chemistry calculation,FTIR analysis,and XPS *** flotation results showed that when DDA dosage was 35 mg/L and PDP dosage was 40 mg/L,the maximum floating difference between brucite and calcite was 79.81%,and the selectivity separation index was *** detection analysis showed that the main dissolved component HPO_(4)^(2−)of PDP is selectively strongly adsorbed on the Ca site on the surface of calcite,promoting the adsorption of the main dissolved component RNH_(3)^(+)of DDA on calcite surface,while brucite is basically not affected by ***,PDP is an effective regulator for the reverse flotation separation of brucite and calcite in DDA system.

关键词： brucite calcite selective adsorption flotation separation

m^(6)A modification of lncRNA in middle ear cholesteatoma

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中南大学学报（医学版） 2024年第5期49卷 667-678页

作者： HE Jun XIE Shumin jin Li fu jinfeng YUAN Qiulin LIU Wei Department of Otolaryngology-Head and Neck Surgery Second Xiangya HospitalCentral South UniversityChangsha 410011 Clinical Medical Research Center for Otology in Hunan Province Changsha 410011 Department of Otolaryngology-Head and Neck Surgery Xiangya HospitalCentral South UniversityChangsha 410008 Otolaryngology Major Disease Research Key Laboratory of Hunan Province Changsha 410008 Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province Changsha 410008 National Clinical Research Center for Geriatric Disorders Xiangya HospitalChangsha 410008China

Objective:Middle ear cholesteatoma is a non-tumorous condition that typically leads to hearing loss,bone destruction,and other severe *** surgery being the primary treatment,the recurrence rate remains ***,exploring the molecular mechanisms underlying cholesteatoma is crucial for discovering new therapeutic *** study aims to explore the involvement of N6-methyladenosine(m^(6)A)methylation in long non-coding RNAs(lncRNAs)in the biological functions and related pathways of middle ear ***:The m^(6)A modification patterns of lncRNA in middle ear cholesteatoma tissues(n=5)and normal post-auricular skin tissues(n=5)were analyzed using an lncRNA m^(6)A transcriptome *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses were conducted to identify potential biological functions and signaling pathways involved in the pathogenesis of middle ear *** RNA immunoprecipitation(MeRIP)-PCR was used to validate the m^(6)A modifications in cholesteatoma and normal skin ***:Compared with normal skin tissues,1525 lncRNAs were differentially methylated in middle ear cholesteatoma tissues,with 1048 showing hypermethylation and 477 showing hypomethylation[fold change(FC)≥3 or<1/3,P<0.05].GO enrichment analysis indicated that hypermethylated lncRNAs were involved in protein phosphatase inhibitor activity,neuron-neuron synapse,and regulation ofα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid(AMPA)receptor *** lncRNAs were associated with mRNA methyltransferase activity,secretory granule membrane,and mRNA *** analysis revealed that hypermethylated lncRNAs were mainly associated with 5 pathways:the Hedgehog signaling pathway,viral protein interaction with cytokines and cytokine receptors,mitogen-activated protein kinase(MAPK)signaling pathway,cytokine-cytokine receptor interaction,and adrenergic signaling in ***

关键词： long non-coding RNA m6A modifications middle ear cholesteatoma

functional dissection of parabrachial substrates in processing nociceptive information

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Zoological Research 2024年第3期45卷 633-647页

作者： jin Ke Wei-Cheng Lu Hai-Yang jing Shen Qian Sun-Wook Moon Guang-fu Cui Wei-Xin Qian Xiao-jing Che Qian Zhang Shi-Shi Lai Ling Zhang Ying-Jie Zhu jing-Dun Xie Tian-Wen Huang Shenzhen Key Laboratory of Drug Addiction Shenzhen-Hong Kong Institute of Brain ScienceBrain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Anesthesiology State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China University of Science and Technology of China HefeiAnhui 230027China Department of Anesthesiology Shenzhen University General Hospital and Shenzhen University Academy of Clinical Medical SciencesShenzhen UniversityShenzhenGuangdong 518055China School of Medicine Yunnan UniversityKunmingYunnan 650091China

Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of *** lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity ***,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain *** this study,we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such ***,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external ***,both lPBNNK1R and elPBN neurons contribute to chemical irritant-induced nocifensive *** results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions.

关键词： Lateral parabrachial nucleus Substance P receptor Pain affect Defensive reaction Somatosensory

Folding encapsulation toward Lindqvist polyoxometalates within adaptive coordination cages for catalysis

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Science China Chemistry 2024年

作者： Ying-Mei Zhong jin-jin Xuan Xu-Jie Qin Han Xiao Zi-Jun Xia Li-Peng Zhou Xiao-Qing Guo Yu-Hang Hu Lu Zhang Chun-Sen Li Li-Xuan Cai Qing-fu Sun State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences College of Chemistry and Materials Science Fujian Normal University University of Chinese Academy of Sciences

In nature,enzymes at specific folded conformations exhibit high substrate complementarity,enabling them to efficiently and selectively catalyze biochemical *** by enzymes,coordination cages with conformational dynamics have been designed and are receiving increasing attention due to their versatile applications in allosteric guest binding and *** present here two enzyme-mimicking adaptive macrocycle-based coordination cages,Pd2L12and Pd2L22,from macrocycle-based ligands（L1and L2） and the encapsulation and stabilization of Lindqvist polyoxometalates anions M6O192-（M=W or Mo） in neutral aqueous solution.X-ray crystallographic studies have verified the formation of 1:1 host-guest complexes of two Pd2 L2 cages and the W6O192-anion,via an induced-fit folding *** with the free host,Pd2L12exhibited an induced-fit semi-folded conformation in the inclusion complex,while Pd2L22adopted an induced-fit fully-folded ***,the Mo6O19?Pd2L2host-guest complexes demonstrate high yield and selectivity in the oxidative decontamination reaction of the sulfur mustard simulant,2-chloroethyl ethyl *** work not only sheds light on the importance of conformational adaptability in enzyme-like systems but also paves the way for protecting labile POM clusters via host-guest encapsulation toward enhanced catalytic performance in aqueous solution.

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口服药物吸收分数的评价及影响因素综述

药学学报 2024年第1期59卷 84-93页

作者：张萍毕福林杨劲中国药科大学药学院药理系江苏南京210009

吸收分数(fraction absorbed,Fa)是一个描述口服药物吸收高低的重要参数,是制剂处方工艺开发和优化的重要依据,由于容易与绝对生物利用度概念混淆而未得到工业界的足够重视。影响Fa的因素非常多且复杂,直接影响Fa大小的是三个时间因素:... 详细信息

吸收分数(fraction absorbed,Fa)是一个描述口服药物吸收高低的重要参数,是制剂处方工艺开发和优化的重要依据,由于容易与绝对生物利用度概念混淆而未得到工业界的足够重视。影响Fa的因素非常多且复杂,直接影响Fa大小的是三个时间因素:制剂完全释放所需时间、药物完全吸收所需时间以及胃肠道停留时间,这三个时间因素的彼此关系决定了Fa的大小。通常大家更关心的是影响Fa大小的表观因素,包括自变量和协变量。自变量因素如给药剂量、途径、剂型等,协变量又分成内因和外因,外因包括食物因素、药物相互作用等;内因包括年龄、性别、疾病等。本文分析并系统梳理了自变量和协变量如何通过影响机体生理和内环境,直接或间接地影响三个时间因素,进而改变Fa这样一个复杂过程。了解该理论框架可以更好地优化自变量,以减少协变量对Fa的影响。另外本文还介绍了预测和评估Fa的最新进展,包括复杂溶出装置进展和软件预测的现状。

关键词：吸收分数时间因素表观因素

functional genomics of Brassica napus:Progresses,challenges,and perspectives

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Journal of Integrative Plant Biology 2024年第3期66卷 484-509页

作者： Zengdong Tan Xu Han Cheng Dai Shaoping Lu Hanzi He Xuan Yao Peng Chen Chao Yang Lun Zhao Qing-Yong Yang Jun Zou jing Wen Dengfeng Hong Chao Liu Xianhong Ge Chuchuan Fan Bing Yi Chunyu Zhang Chaozhi Ma Kede Liu jinxiong Shen jinxing tu Guangsheng Yang Tingdong fu Liang Guo Hu Zhao National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Yazhouwan National Laboratory Sanya 572025China

Brassica napus,commonly known as rapeseed or canola,is a major oil crop contributing over 13%to the stable supply of edible vegetable oil *** and understanding the gene functions in the *** genome is crucial for genomic breeding.A group of genes controlling agronomic traits have been successfully cloned through functional genomics studies in *** this review,we present an overview of the progress made in the functional genomics of ***,including the availability of germplasm resources,omics databases and cloned functional *** on the current progress,we also highlight the main challenges and perspectives in this *** advances in the functional genomics of *** contribute to a better understanding of the genetic basis underlying the complex agronomic traits in *** and will expedite the breeding of high quality,high resistance and high yield in *** varieties.

关键词： accelerate breeding Brassica napus functional genomics high resistance high yield

Epidemiological survey of cystic echinococcosis in southwest China:From the Qinghai-Tibet plateau to the area of Yunnan

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World Journal of Hepatology 2024年第2期16卷 229-240页

作者： jin-Rong Zi Dan Xiao Jia Peng Fang-Wei Wu Jian-Xiong Li Xin-Liu Yan Zheng-Qing Wang Xuan Cai Qian Xu Ben-fu Li Ya-Ming Yang Yunnan Provincial Center of Malaria Research Yunnan Institute of Parasitic DiseasesPuer 665000Yunnan ProvinceChina Yunnan Institute of Parasitic Diseases Yunnan Institute of Parasitic DiseasesPuer 665000Yunnan ProvinceChina Tibet Center for Disease Control and Prevention Tibet Center for Disease Control and PreventionLhasa 85000Tibet Autonomous RegionChina Yunnan Provincial Center of Malaria Research Yunnan Institute of Parasitic DiseasesPuer 655000Yunnan ProvinceChina

BACKGROUND Echinococcosis is prevalent in 9 provinces in Western and Northern *** epidemiological survey of echinococcosis in 2012 and 2016 showed cases of echinococcosis in Yunnan *** To understand the spatial distribution and epidemiological characteristics of echinococcosis in Yunnan for the prevention and control of echinococcosis and to reduce the risk of infection in Yunnan *** Based on the China Information System for Disease Control and Prevention(CISDCP),echinococcosis cases reported from 36 hospitals and 34 Centers for Disease Control were investigated and epidemiologically analyzed from 2021 to *** exclusion criteria included suspected cases,same case only counted once and cases not from Yunnan.A total of 705 cases were investigated,of which 397 cases were suitable for statistical *** these 397 cases,epidemiological investigation was tracked in 187 *** data were inputted using double entry in the Excel database,with error correction by double-entry *** data on echinococcosis cases in Yunnan Province were analyzed by ArcGIS 10.1 software to generate a density map of echinococcosis *** statistical analyses were conducted using SPSS 17.0,including the chi-square test,linear regression test and logistic univariate and multivariate regression *** A total of 397 cases were found in 89 counties in Yunnan *** number of cases in the top three prefectures were Dali(38.1%),Diqing(10.1%),and Kunming(8.3%),and the top five counties were Jianchuan(9.1%),Shangri La(8.3%),Eryuan(7.6%),Heqing(6.9%),and Dali Districts(5.0%).There were significant differences between the different *** case reporting rate by CISDCP(33.8%)was low;the first case was reported by CISDCP in 2002,and the highest number of cases was 50(2017).Confirmed and clinical cases accounted for 62.5%and 37.5%,***,90.9%of the cases of hydatid disease were reported by the hospital system,and only 9

关键词： Echinococcosis Cases Epidemiological analysis Yunnan province

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仿生凹坑型吸盘设计与试验

吉林大学学报（工学版） 2024年第4期54卷 1144-1152页

作者：丛茜徐金史孝杰金敬福陈廷坤吉林大学生物与农业工程学院长春130022 吉林大学汽车仿真与控制国家重点实验室长春130022 吉林大学工程仿生教育部重点实验室长春130022

为了提高吸盘的吸附性能,基于水蛭吸盘表面存在的凹坑形态,运用仿生学原理,在常规吸盘表面设计凹坑形态,使吸盘工作表面存在多个小型吸盘,提高吸盘的吸附性能。运用部分正交多项式回归分析,探究凹坑形态的直径、单排凹坑数量及排间距对... 详细信息

为了提高吸盘的吸附性能,基于水蛭吸盘表面存在的凹坑形态,运用仿生学原理,在常规吸盘表面设计凹坑形态,使吸盘工作表面存在多个小型吸盘,提高吸盘的吸附性能。运用部分正交多项式回归分析,探究凹坑形态的直径、单排凹坑数量及排间距对吸盘吸附力的影响。试验表明,不同凹坑的形态参数对吸盘吸附力具有不同的影响效果,当凹坑直径为1.5 mm、单排凹坑的数量为40个及排间距为4 mm时,仿生吸盘在基底表面的吸附力为49.54 N,相对于标准吸盘在基底表面的吸附力提高49.21%。建立设计因素与评价指标间的数学回归模型,确定对吸盘吸附力影响的显著性主次顺序为排间距、凹坑直径、单排凹坑数量。仿真分析表明,工作表面存在的凹坑形态改变了吸附时吸盘表面接触压力及摩擦应力的分布,并且仿生吸盘工作表面的摩擦应力和接触压力均大于标准吸盘,增大了仿生吸盘在基底表面的吸附力。

关键词：仿生凹坑吸盘吸附力吸附机理试验设计

Deep simulated annealing for the discovery of novel dental anesthetics with local anesthesia and anti-inflammatory properties

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3086-3109页

作者： Yihang Hao Haofan Wang Xianggen Liu Wenrui Gai Shilong Hu Wencheng Liu Zhuang Miao Yu Gan Xianghua Yu Rongjia Shi Yongzhen Tan Ting Kang Ao Hai Yi Zhao Yihang fu Yaling Tang Ling Ye jin Liu Xinhua Liang Bowen Ke State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China College of Computer Science Sichuan UniversityChengdu 610065China Department of Anesthesiology Laboratory of Anesthesia and Critical Care MedicineNational-Local Joint Engineering Research Centre of Translational Medicine of AnesthesiologyFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China

Multifunctional therapeutics have emerged as a solution to the constraints imposed by drugs with singular or insufficient therapeutic *** primary challenge is to integrate diverse pharmacophores within a single-molecule *** address this,we introduced DeepSA,a novel edit-based generative framework that utilizes deep simulated annealing for the modification of articaine,a wellknown local *** integrates deep neural networks into metaheuristics,effectively constraining molecular space during compound *** framework employs a sophisticated objective function that accounts for scaffold preservation,anti-inflammatory properties,and covalent *** a sequence of local editing to navigate the molecular space,DeepSA successfully identified AT-17,a derivative exhibiting potent analgesic properties and significant anti-inflammatory activity in various animal *** insights into AT-17 revealed its dual mode of action:selective inhibition of NaV1.7 and 1.8 channels,contributing to its prolonged local anesthetic effects,and suppression of inflammatory mediators via modulation of the NLRP3 inflammasome *** findings not only highlight the efficacy of AT-17 as a multifunctional drug candidate but also highlight the potential of DeepSA in facilitating AI-enhanced drug discovery,particularly within stringent chemical constraints.

关键词： Multifunctional drugs Deep simulated annealing Molecule generation Articaine derivatives AI-enhanced drug discovery

频域多方向C-UNet及动态损失的工业烟尘图像分割

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控制理论与应用 2024年第3期41卷 543-554页

作者：张大锦刘辉陈甫刚赵安昆明理工大学信息工程与自动化学院云南昆明650500 昆明理工大学云南省人工智能重点实验室云南昆明650500 云南昆钢电子信息科技有限公司云南昆明650302

工业烟尘污染等级监测中烟尘的准确分割是污染等级判定的重要前提.针对边缘模糊且方向多变烟尘在特征提取过程中边缘方向细节信息提取困难、分割不准确的问题,本文提出一种频域多方向C-UNet及动态损失的工业烟尘图像分割方法.首先,通过... 详细信息

工业烟尘污染等级监测中烟尘的准确分割是污染等级判定的重要前提.针对边缘模糊且方向多变烟尘在特征提取过程中边缘方向细节信息提取困难、分割不准确的问题,本文提出一种频域多方向C-UNet及动态损失的工业烟尘图像分割方法.首先,通过构建轮廓波多方向分解下采样结构增强编码阶段烟尘边缘方向信息的提取能力;其次,通过轮廓波变换提取烟尘8个边缘方向细节信息进行跳跃连接,提升持续采样过程中细节信息的表达准确度;然后,构建轮廓波细节重构上采样结构增强解码阶段烟尘边缘细节信息的恢复能力;最后,提出一种动态加权策略构建组合损失函数来优化训练网络,增强网络对烟尘边缘特征的提取能力.结果表明,本文方法与U-Net和其他同类方法相比在指标上有较好提升,改善了烟尘边缘分割不准确的问题,在不同烟尘场景上的分割效果也优于现有分割模型.

关键词：工业烟尘图像分割轮廓波变换特征提取动态损失函数