检索结果-南通市图书馆

Practical Paths towards Lowering Black Carbon Emissions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Climate Change Research 2011年第1期2卷 12-22页

作者： Guorui Zhi Xiaoye zhang Hongbing Cheng Junli jin fang zhang Tingting Wang Xiaochun zhang Chinese Academy of Meteorological Sciences ChiTta Meteorological Administration Bcijing 100081 China

Black carbon （BC） aerosol, accounting for a minor fraction of atmospheric aerosols, is attracting increased attentio1 due to its impact on air quality, human health, and climate change. Focusing on BC emission reduction, this paper give1 a brief introduction to the sources and global distribution of BC. Along with the decrease of BC emissions from sue1 actions as the reduction of global greenhouse gases （GHGs） and regulating local air quality, it also highlights othet BC reduction approaches such as control and improvement of combustion conditions, the elimination of open biomas burning, and the sequestration of BC by biomass pyrolysis. Finally, it is stressed that at this moment there is no enougt reason to push BC reduction into any climate change related negotiations, although BC has been included in some o so-called win-win reduction targets for the quick response to both climate and non-climate appeals.

关键词： black carbon reduction policy consideration

ZIF-8-functionalized polymer electrolyte with enhanced performance for high-temperature solid-state lithium metal batteries

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第3期43卷 984-994页

作者： jin-fang zhang Yuan-Yuan Wang Xiao-Feng Li Gen-Yan zhang Ying Li Rong Liu Sheng-Liang Hu Tuo-Ping Hu Ruth Knibbe Qing-Bing Xia School of Materials Science and Engineering North University of ChinaTaiyuan030051China School of Energy and Power Engineering North University of ChinaTaiyuan030051China School of Chemistry and Chemical Engineering North University of ChinaTaiyuan030051China School of Mechanical and Mining Engineering The University of QueenslandBrisbaneQLD4072Australia

Solid polymer electrolytes(SPEs)with high ionic conductivity are desirable for solid-state lithium metal batteries(SSLMBs)to achieve enhanced safety and energy *** nanofillers into a polymeric matrix to develop nanocomposite solid electrolytes(NCSEs)has become a promising method for improving the ionic conductivity of the ***,a novel ZIF-8-functionalized NCSE was prepared for high-temperature S SLMB s using an in situ radical polymerization *** is found that the ZIF-8 nanoparticles could reduce the crystallinity of polymer segments and offer a Lewis acid surface that promotes the dissociation of lithium bis(trifluoromethanesulfonyl)imide(LiTFSI)and stabilizes the TFSI^(-) anion ***,the as-prepared NCSE exhibits an outstanding ionic conductivity of 1.63×10^(-3)S·cm^(-1),an electrochem ical stability window of 5.0 V at 80℃,and excellent interface compatibility with lithium metal anode with a stable polarization over 2000 ***,the assembled SSLMBs with LiFePO_(4)cathode show dendrite-free Li-metal surface,good rate capability,and stable cycling stability with a capacity retention of 70%over 1000 cycles at a high temperature of 80℃.This work provides valuable insights into promoting the ionic conductivity of SPEs.

关键词： Lithium metal batteries Metal-organic frameworks Solid polymer electrolytes Lithium metal anode Interfacial compatibility

在线全文

学校读者我要写书评

暂无评论

间冷回热涡扇发动机热力学研究

推进技术 2017年第3期38卷 504-509页

作者：张琦刘程远滕金芳冯锦璋上海交通大学航空航天学院上海200240

利用MATLAB平台,参考欧盟和NASA近期发表的研究计划,建立双轴分排涡扇间冷回热发动机性能仿真模型,研究间冷技术和回热技术对涡扇发动机性能的影响,并将其与常规布局发动机进行对比分析。结果表明,间冷器的加入会使得单位燃油消耗率(SFC... 详细信息

利用MATLAB平台,参考欧盟和NASA近期发表的研究计划,建立双轴分排涡扇间冷回热发动机性能仿真模型,研究间冷技术和回热技术对涡扇发动机性能的影响,并将其与常规布局发动机进行对比分析。结果表明,间冷器的加入会使得单位燃油消耗率(SFC)上升但同时也会使得单位推力(Fs)增大;回热器的加入可以有效降低单位燃油消耗率,最大达28%,但同时使得单位推力下降;间冷回热的综合运用使得单位燃油消耗率进一步下降。对间冷回热发动机来说,总压比、涵道比以及回热器热效率是影响发动机SFC的主要因素,其中回热器热效率影响最大,最大可使得SFC下降32%。

关键词：间冷回热涡扇发动机热力学模拟仿真单位燃油消耗率

Autoantigen administration confers diabetes-preventive properties to NOD mice derived dendritic cells

在线全文

学校读者我要写书评

暂无评论

Journal of Microbiology and Immunology 2007年第1期5卷 69-77页

作者： MING XIANG XIAO LEI ZOU jinG XU YAO YAO jin fang zhang Department of Pharmacology School of Pharmacy Tongji Medical College Huazhong Science and Technology University Wuhan P. R. China

Administration of autoantigen can be of value for prevention of autoimmune diabetes and it has been speculated that the control point of dendritic cells(DC)for the induction of peripheral toler- ance may be highly *** examined the properties of DC associated with immune suppression in NOD mice by insulin injection subcutaneously and their ability to suppress diabetes transfer by diabeto- genic effector cells in secondary NOD-SCID *** data showed that the surface expressions of MHCⅡand CD86 on NOD-derived DC were increased after insulin treatment compared with those on PBS controlled *** dendritic cells with a mature phenotype and increased MLR stimulation adop- tively transferred immune tolerogenic effects on secondary NOD-SCID mice,which were associated with significantly greater IL-10,TGF-beta production and CD4^+ CD25^+ T differentiation from splenocytes compared with NOD-SCID control ***,treatment with DC remarkably decreased the incidence of diabetes in secondary *** results suggest that a subtype of DC generated by insulin subcutaneous treated NOD mice confers potential protection against diabetes through polarizing the immune response towards a Th2 regulatory pathway.

关键词： Diabetes Dendritic cells Immune tolerance NOD mice

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao fang Qiuxia Peng Wen Qin Xuebing Yan Kun zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Bending Stiffness of Concrete-Filled Steel Tube and Its Influence on Concrete Placement Timing of Composite Beam-String Structure

在线全文

学校读者我要写书评

暂无评论

Structural Durability & Health Monitoring 2025年第1期19卷 55-75页

作者： Zhenyu zhang Quan jin Haitao zhang Zhao Liu Yuyang Wu Longfei zhang Renzhang Yan CCCC Third Highway Engineering Co. Ltd.Beijing101300China School of Civil Engineering Chongqing Jiaotong UniversityChongqing400074China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-filled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during construction,the influence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefficient on the bending stiffness are analyzed parametrically by the numerical simulation technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placement first and then prestress-tensioning is proposed.

关键词： Concrete panels freeze-thaw damage compression-shear crack tension-shear crack

Exploration of Gas‑Dependent Self‑Adaptive Reconstruction Behavior of Cu_(2)O for Electrochemical CO_(2)Conversion to Multi‑Carbon Products

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第3期17卷 280-296页

作者： Chaoran zhang Yichuan Gu Qu Jiang Ziyang Sheng Ruohan Feng Sihong Wang Haoyue zhang Qianqing Xu Zijian Yuan fang Song State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Structural reconstruction of electrocatalysts plays a pivotal role in catalytic performances for CO_(2)reduction reaction(CO_(2)RR),whereas the behavior is by far superficially ***,we report that CO_(2)accessibility results in a universal self-adaptive structural reconstruction from Cu_(2)O to Cu@CuxO composites,ending with feeding gas-dependent microstructures and catalytic *** CO_(2)-rich atmosphere favors reconstruction for CO_(2)RR,whereas the CO_(2)-deficient one prefers that for hydrogen evolution *** the assistance of spectroscopic analysis and theoretical calculations,we uncover a CO_(2)-induced passivation behavior by identifying a reductionresistant but catalytic active Cu(I)-rich amorphous layer stabilized by*CO ***,we find extra CO production is indispensable for the robust production of *** inverse correlation between durability and FECO/FEC2H4 is disclosed,suggesting that the selfstabilization process involving the absorption of*CO intermediates on Cu(I)sites is essential for durable *** by this insight,we design hollow Cu_(2)O nanospheres for durable and selective CO_(2)RR electrolysis in producing *** work recognizes the previously overlooked passivation reconstruction and self-stabilizing behavior and highlights the critical role of the local atmosphere in modulating reconstruction and catalytic processes.

关键词： CO_(2)reduction reaction Electrocatalysts Cu_(2)O Reconstruction Self-adaptive electrocatalysis

Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-β-susceptible hepatocellular carcinoma cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第17期18卷 2035-2042页

作者： Lei Jiang Yiu-Kay Lai jin-fang zhang Chu-Yan Chan Gang Lu Marie CM Lin Ming-Liang He Ji-Cheng Li Hsiang-Fu Kung Laboratory of Internal Medicine The First AffiliatedHospital of Wenzhou Medical College Wenzhou 325000 Zhejiang Province China Department of Life Science National Tsing HuaUniversity Hsinchu 30013 Taiwan Stanley Ho Centre for Emerging Infectious Diseases The Chinese University of Hong Kong Shatin 999077 HongKong China Brain Tumor Centre and Division ofNeurosurgery Department of Surgery The Chinese University ofHong Kong Shatin 999077 Hong Kong China Institute of Cell Biology Zhejiang UniversityHangzhou 310058 Zhejiang Province China

AIM:To investigate the role of transforming growth factor(TGF)-β-inducible early gene 1(TIEG1) in TGF-β-induced growth inhibition in hepatocellular carcinoma(HCC) ***:Human hepatocyte and HCC cell lines with varied susceptibilities to TGF-β1 were tested by methylthiazoletetrazolium(MTT) *** expression changes of Smad2,Smad3,Smad4,Smad7,TIEG1 and TIEG2 gene following treatment with TGF-β1 in a TGF-β-sensitive hepatocyte cell line(MIHA),a TGF-β-sensitive hepatoma cell line(Hep3B) and two TGF-β-insensitive hepatoma cell lines(HepG2 and Bel7404) were *** targeting TIEG1 was transfected into Hep3B cells and the sensitivity of cells to TGF-β1 was *** of TIEG1 was induced by lentiviral-mediated transduction in TGF-β1-resistant hepatoma cell lines(Bel7404 and HepG2).MTT assay and 4',6-Diamidino-2-phenylindole staining were used to identify cell viability and apoptosis,*** expression level of stathmin was measured by reverse transcriptase polymerase chain reaction and Western-blotting analysis,and stathmin promoter activity by TIEG1 was monitored by a luciferase reporter gene ***:TIEG1 was significantly upregulated by TGF-β1 in the TGF-β1-sensitive HCC cell line,Hep3B,but not in the resistant cell *** suppression of TIEG1 by siRNAs decreased the sensitivity of Hep3B cells to TGF-β1,whereas the overexpression of TIEG1 mediated growth inhibition and apoptosis in TGF-β1-resistant HCC cell lines,which resembled those of TGF-β1-sensitive HCC cells treated with TGF-β*** data further suggested that stathmin was a direct target of TIEG1,as stathmin was signif icantly downregulated by TIEG1 overexpression,and stathmin promoter activity was inhibited by TIEG1 in a dose-dependent ***:Our data suggest that transactivation of TIEG1 conferred growth inhibition of TGF-β-susceptible human HCC cells.

关键词： Growth inhibition Hepatocellular carcinoma Stathmin Transforming growth factor-β Transforming growth factor-β-inducible early gene 1

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing fang Liangming zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury