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Safety,immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly:a prospective longitudinal study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2738-2747页

作者： Hong-Hong Liu Yunbo Xie Bao-Peng Yang Huan-Yue Wen Peng-Hui Yang jin-e lu Yan Liu Xi Chen Meng-Meng Qu Yang Zhang Wei-Guo Hong Yong-Gang Li Junliang Fu Fu-Sheng Wang Out-patient Department of Day Diagnosis and Treatment The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Chinese PLA Medical School Chinese PLA General HospitalBeijing 100039China Hunyuan County People’s Hospital Datong 037499 Shanxi ProvinceChina Faculty of Hepato-Pancreato-Biliary Surgery Institute of Hepatobiliary SurgeryThe First Medical CenterChinese PLA General HospitalBeijing 100853China

The safety and efficacy of COVID-19 vaccines in the elderly,a high-risk group for severe COVID-19 infection,have not been fully *** clarify these issues,this prospective study followed up 157 elderly and 73 young participants for 16 months and compared the safety,immunogenicity,and efficacy of two doses of the inactivated vaccine BBIBP-CorV followed by a booster dose of the recombinant protein vaccine *** results showed that this vaccination protocol was safe and tolerable in the *** administering two doses of the BBIBP-CorV,the positivity rates and titers of neutralizing and anti-RBD antibodies in the elderly were significantly lower than those in the young *** the ZF2001 booster dose,the antibody-positive rates in the elderly were comparable to those in the young;however,the antibody titers remained ***,age,and underlying diseases were independently associated with vaccine immunogenicity in elderly *** pseudovirus neutralization assay showed that,compared with those after receiving two doses of BBIBP-CorV priming,some participants obtained immunological protection against BA.5 and BF.7 after receiving the ZF2001 *** infection symptoms last longer in the infected elderly and pre-infection antibody titers were negatively associated with the severity of post-infection *** antibody levels in the elderly increased significantly after breakthrough infection but were still lower than those in the *** data suggest that multiple booster vaccinations at short intervals to maintain high antibody levels may be an effective strategy for protecting the elderly against COVID-19.

关键词： vaccination vaccine doses

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Active flutter suppression of nonlinear fin-actuator system via inverse system and immersion and invariance method

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Chinese Journal of Aeronautics 2024年第4期37卷 343-362页

作者： jin lu Zhigang WU Chao YANG Chinese Aeronautical establishment Beijing 100029China School of Aeronautic Science and engineering Beihang UniversityBeijing 100191China

Structural nonlinearities such as freeplay will affect the stability and even flight safety of the fin-actuator *** is a lack of a practical method for designing Active Flutter Suppression (AFS) control laws for nonlinear fin-actuator systems.A design method for the AFS controller of the nonlinear all-movable fin-electromechanical actuator system is established by combining the inverse system and the Immersion and Invariance (I&I) ***,the composite control law combining the inverse system principle and internal model control is used to offset the nonlinearity and dynamics of the actuator,so that its driving torque can follow the ideal ***,the ideal torque of the actuator is designed employing the I&I *** unfavorable oscillation of the fin is suppressed by making the output torque of the actuator track the ideal *** simulation results reveal that the proposed AFS method can increase the flutter speed of the nonlinear finactuator system with freeplay,and a set of controller parameters is also applicable for wider freeplay within a certain *** power required for the actuator does not exceed the power that can be provided by the commonly used aviation *** method can also resist a certain level of noise and external disturbance.

关键词： Aeroelasticity Active flutter suppression Fin-actuator system Freeplay Inverse system Immersion and invariance

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Optimal synthesis of heat-integrated distillation configurations using the two-column superstructure

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Chinese Journal of Chemical engineering 2024年第2期66卷 238-249页

作者： Xiaodong Zhang lu jin jinsheng Sun School of Chemical engineering and Technology Tianjin UniversityTianjin 300072China

In the realm of the synthesis of heat-integrated distillation configurations,the conventional approach for exploring more heat integration possibilities typically entails the splitting of a single column into a twocolumn ***,this approach frequently necessitates tedious enumeration procedures,resulting in a considerable computational *** surmount this formidable challenge,the present study introduces an innovative remedy:The proposition of a superstructure that encompasses both single-column and multiple two-column ***,a simultaneous optimization algorithm is applied to optimize both the process parameters and heat integration structures of the twocolumn *** effectiveness of this approach is demonstrated through a case study focusing on industrial organosilicon *** results underscore that the superstructure methodology not only substantially mitigates computational time compared to exhaustive enumeration but also furnishes solutions that exhibit comparable performance.

关键词： Superstructure Process synthesis Heat integration Simulation-based optimization Industrial organosilicon separation

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Configuration Synthesis and Grasping Performance Analysis of Multi-Loop Coupling Capture Mechanism for Launch and Recovery of Torpedo-Shaped Autonomous Underwater Vehicle

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China Ocean engineering 2024年第3期38卷 453-466页

作者： ZHANG Guo-xing XIA Xin-lu GUO jin-wei School of Mechanical engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Research of capture mechanisms with strong capture adaptability and stable grasp is important to solve the problem of launch and recovery of torpedo-shaped autonomous underwater vehicles(AUVs).A multi-loop coupling capture mechanism with strong adaptability and high retraction rate has been proposed for the launch and recovery of torpedo-shaped AUVs with different morphological ***,the principle of capturing motion retraction is described based on the appearance characteristics of torpedo-shaped AUVs,and the configuration synthesis of the capture mechanism is carried out using the method of constrained chain ***,the screw theory is employed to analyze the degree of freedom(DoF)of the capture ***,the 3D model of the capture mechanism is established,and the kinematics and dynamics simulations are carried *** with the capture orientation requirements of the capture mechanism,the statics and vibration characteristics analyses are carried ***,considering the capture process and the underwater working environment,the motion characteristics and hydraulics characteristics of the capture mechanism are ***,a principle prototype is developed and the torpedo-shaped AUVs capture experiment is *** work provides technical reserves for the research and development of AUV capture special equipment.

关键词： capture mechanism torpedo-shaped AUVs configuration synthesis launch and recovery grasping performance analysis

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experimental realization of deterministic joint remote preparation of an arbitrary two-qubit pure state via GHZ states

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Science China(Information Sciences) 2024年第3期67卷 317-318页

作者： Nachuan LI lu XU jin-Ming LIU State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal University Hefei Origin Quantum Computing Technology Co. Ltd.

Quantum teleportation(QT) [1] enables secure transfer of an unknown quantum state between remote locations without physically transmitting the initial state. Unlike QT,with the sender possessing complete knowledge of the initial state, remote state preparation(RSP) [2] exhibits a tradeoff between the amount of the entanglement resource used and the classical communication cost.

关键词： Quantum communication

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Analytic Formulae for estimating Motor Proportion of Load Model Under Small Disturbance

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CSee Journal of Power and energy Systems 2024年第4期10卷 1599-1607页

作者： Ping Ju Shiqiu Xia Yuqing jin lu Cao School of electrical and Power engineering Hohai UniversityNanjing 211100China the east China Branch of the State Grid Corporation of China Shanghai 200120China

In the composite load model(CLM),which is commonly used in China,an equivalent motor and equivalent static load are used to represent all electrical equipment and networks connected to a load *** research has determined typical values of electrical and mechanical parameters for load models of different load types,which improves the basis for load ***,the motor proportion parameter is not the same for different load buses or at different times;therefore,obtaining the actual motor proportion is key to establishing an accurate load *** the existing load modeling method,motor proportion is commonly identified along with other parameters under rare large disturbances;therefore,the value of the motor proportion is fixed by the time when a large disturbance *** this paper,formulae are derived to estimate motor proportion under small disturbances,and these formulae allow direct calculation of motor proportion without using any optimization *** proposed estimation formulae do not rely on any parameters of load model or power system but instead rely only on measurement of the voltage and active power at steady-state points before and after a small *** of universality of small disturbances in power systems,estimating time-varying motor proportion under small disturbances will be helpful for solving the time-varying problem of load ***,the proposed motor proportion estimation formulae are validated by simulations,physical experiments,and field experiments.

关键词： Composite load model load modeling motor proportion parameter estimation

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An adaptive physics-informed deep learning method for pore pressure prediction using seismic data

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Petroleum Science 2024年第2期21卷 885-902页

作者： Xin Zhang Yun-Hu lu Yan jin Mian Chen Bo Zhou State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Petroleum engineering China University of Petroleum(Beijing)Beijing102249China College of Artificial Intelligence China University of Petroleum(Beijing)Beijing102249China PetroChina Tarim Oilfield Company KorlaXinjiang841000China

Accurate prediction of formation pore pressure is essential to predict fluid flow and manage hydrocarbon production in petroleum *** deep learning technique has been receiving more interest due to the great potential to deal with pore pressure ***,most of the traditional deep learning models are less efficient to address generalization *** fill this technical gap,in this work,we developed a new adaptive physics-informed deep learning model with high generalization capability to predict pore pressure values directly from seismic ***,the new model,named CGP-NN,consists of a novel parametric features extraction approach(1DCPP),a stacked multilayer gated recurrent model(multilayer GRU),and an adaptive physics-informed loss *** machine training,the developed model can automatically select the optimal physical model to constrain the results for each pore pressure *** CGP-NN model has the best generalization when the physicsrelated metricλ=0.5.A hybrid approach combining eaton and Bowers methods is also proposed to build machine-learnable labels for solving the problem of few *** validate the developed model and methodology,a case study on a complex reservoir in Tarim Basin was further performed to demonstrate the high accuracy on the pore pressure prediction of new wells along with the strong generalization *** adaptive physics-informed deep learning approach presented here has potential application in the prediction of pore pressures coupled with multiple genesis mechanisms using seismic data.

关键词： Pore pressure prediction Seismic data 1D convolution pyramid pooling Adaptive physics-informed loss function High generalization capability

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Chemico-biological conversion of carbon dioxide

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Journal of energy Chemistry 2024年第2期89卷 371-387,I0009页

作者： Liangwei Hu Junzhu Yang Qi Xia jin Zhang Hongxin Zhao Yuan lu Zhejiang Province Key Laboratory of Plant Secondary Metabolism and Regulation College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou 310018ZhejiangChina Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084China Department of Chemical engineering Tsinghua UniversityBeijing 100084China College of Biological and Chemical engineering Jiaxing UniversityJiaxing 314000ZhejiangChina

The unabated carbon dioxide(CO_(2))emission into the atmosphere has exacerbated global climate change,resulting in extreme weather events,biodiversity loss,and an intensified greenhouse *** address these challenges and work toward carbon(C)neutrality and reduced CO_(2)emissions,the capture and utilization of CO_(2)have become imperative in both scientific research and *** cutting-edge approach to achieving efficient catalytic performance involves integrating green bioconversion and chemical *** innovative strategy offers several advantages,including environmental friendliness,high efficiency,and *** study provides a comprehensive review of existing technical routes for carbon sequestration(CS)and introduces two novel CS pathways:the electrochemicalbiological hybrid and artificial photosynthesis *** also thoroughly examines the synthesis of valuable Cnproducts from the two CS systems employing different catalysts and *** both systems heavily rely on electron transfer,direct and mediated electron transfer has been discussed and summarized in ***,this study explores the conditions suitable for different catalysts and assesses the strengths and weaknesses of *** also explored the biocompatibility of the electrode materials and developed novel *** materials were specifically engineered to combine with enzymes or microbial cells to solve the biocompatibility problem,while improving the electron transfer efficiency of ***,this review summarizes the relevant systems developed in recent years for manufacturing different products,along with their respective production efficiencies,providing a solid database for development in this *** novel chemical-biological combination proposed herein holds great promise for the future conversion of CO_(2)into advanced organic ***,it offers exciting prospects for utilizing CO_(2)in synthesizing

关键词： Carbon dioxide Bioelectric synthesis Artificial photosynthesis Synthetic product

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experimental study of the damage characteristics of rocks containing non-penetrating cracks under cyclic loading

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International Journal of Mining Science and Technology 2024年第2期34卷 197-210页

作者： Jun Xu Xiaochun Xiao lu Ma Sen luo Jiaxu jin Baijian Wu School of Mechanics and engineering Liaoning Technical UniversityFuxin 123000China School of Civil engineering Liaoning Technical UniversityFuxin 123000China Department of engineering Mechanics Southeast UniversityNanjing 211189China

The damage evolution process of non-penetrating cracks often causes some unexpected engineering *** specimens containing non-penetrating crack(s)are used to study the damage evolution and characteristics under cyclic *** results show that under cyclic loading,the relationship between the number of non-penetrating crack(s)and the characteristic parameters(cyclic number,peak stress,peak strain,failure stress,and failure strain)of the pre-cracked specimens can be represented by a decreasing linear *** damage evolution equation is fitted by calibrating the accumulative plastic strain for each cycle,and the damage constitutive equation is proposed by the concept of effective ***,non-penetrating cracks are more likely to cause uneven stress distribution,damage accumulation,and local failure of *** local failure can change the stress distribution and relieve the inhibition of non-penetrating crack extension and eventually cause a dramatic destruction of the ***,the evolution process caused by non-penetrating cracks can be regarded as one of the important reasons for inducing *** results are expected to improve the understanding of the process of spalling formation and rockburst and can be used to analyze the stability of rocks or rock structures.

关键词： Damage characteristics Constitutive model Fissured rocks Non-penetrating crack Cyclic loading

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Current optimization-based control of dual three-phase PMSM for low-frequency temperature swing reduction

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Defence Technology（防务技术） 2024年第4期34卷 238-246页

作者： Linlin lu Xueqing Wang luhan jin Qiong Liu Yun Zhang Yao Mao Key Laboratory of Optical engineering Chinese Academy of SciencesChengdu 610209China Institute of Optics and electronics Chinese Academy of SciencesChengdu 610209China University of Chinese Academy of Sciences Beijing 100049China College of electrical engineering Sichuan UniversityChengdu 610065China

In this paper,a control scheme based on current optimization is proposed for dual three-phase permanent-magnet synchronous motor(DTP-PMSM)drive to reduce the low-frequency temperature *** reduction of temperature swing can be equivalent to reducing maximum instantaneous phase copper loss in this ***,a two-level optimization aiming at minimizing maximum instantaneous phase copper loss at each electrical angle is ***,the optimization is transformed to a singlelevel optimization by introducing the auxiliary variable for easy *** that singleobjective optimization trades a great total copper loss for a small reduction of maximum phase copper loss,the optimization considering both instantaneous total copper loss and maximum phase copper loss is proposed,which has the same performance of temperature swing reduction but with lower total *** this way,the proposed control scheme can reduce maximum junction temperature by 11%.Both simulation and experimental results are presented to prove the effectiveness and superiority of the proposed control scheme for low-frequency temperature swing reduction.

关键词： Dual three-phase PMSM Low-frequency temperature swing Copper loss Current optimization Connected neutral points

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