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Novel esophageal squamous cell carcinoma bone metastatic clone isolated by scintigraphy, X ray and micro PET/CT

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World Journal of Gastroenterology 2014年第4期20卷 1030-1037页

作者： Bi-Zeng Zhao Jie Cao jin-chen shao Yan-Bing Sun Li-Min Fan Chun-Yu Wu Sheng Liang Bao-Feng Guo Guang Yang Wen-Hui Xie Qing-cheng Yang Shun-Fang Yang Department of Orthopedics Shanghai Sixth Hospital of Shanghai Jiaotong University Department of Nuclear Medicine Shanghai Chest Hospital of Shanghai Jiaotong University Department of Pathology Shanghai Chest Hospital of Shanghai Jiaotong University Department of Radiology Shanghai Chest Hospital of Shanghai Jiaotong University Department of Thoracic Surgery Shanghai Chest Hospital of Shanghai Jiaotong University Department of Breast Surgery Shanghai Long Hua Hospital of Shanghai University of Traditional Chinese Medicine Micro PET/CT Center Department of Nuclear Medicine Shanghai RuiJin Hospital of Shanghai Jiaotong University Kyocera Communication Systems (Shanghai) Co. Ltd

AIM: To establish a Chinese esophageal squamous cell carcinoma (ESCC) cell line with high bone metastasis potency using 99mTc-methylene diphosphonate (99mTc-MDP) micro-pinhole scintigraphy, X ray and micro-positron emission tomography/computed tomography (PET/CT) for exploring the mechanism of occurrence and development in esophageal cancer.

关键词： Esophageal squamous cell carcinoma Cell line Bone metastasis Molecular imaging Real-time polymerase chain reaction

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基于DIAlux的隧道照明仿真设计

物联网技术 2013年第10期3卷 26-28页

作者：金绍晨长安大学电子与控制工程学院陕西西安710064

隧道的建立离不开支撑其正常运行的机电系统,其中隧道的照明系统就是隧道支撑系统中的重要部分。由于隧道照明中遇到情况的复杂性,需要在设计照明系统时进行隧道照明的仿真模拟。DIAlux软件是一款可以实现空间环境下的灯具选择、布设以... 详细信息

隧道的建立离不开支撑其正常运行的机电系统,其中隧道的照明系统就是隧道支撑系统中的重要部分。由于隧道照明中遇到情况的复杂性,需要在设计照明系统时进行隧道照明的仿真模拟。DIAlux软件是一款可以实现空间环境下的灯具选择、布设以及照明模拟的软件。文章介绍了隧道照明的视觉特点,阐述了隧道内的照明强度分配,并以DIAlux软件为基础,给出了实现隧道照明的仿真模拟方法。

关键词：隧道照明仿真模拟照度计算 DIAlux

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai Wang shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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基于视频数据分析的太阳影子定位法应用研究

西昌学院学报（自然科学版） 2017年第1期31卷 36-38,49页

作者：张进陈雨费绍金宿迁学院文理学院江苏宿迁223800

利用太阳高度角的正弦表达式,推导出物体影长与太阳高度角、当地经纬度和赤纬角的数学公式。据此,利用视频数据中物体影长变化规律,以及摄像机成像原理,建立最小二乘法约束规划数学模型,确定视频拍摄地点和日期。最后,讨论了此方法在现... 详细信息

利用太阳高度角的正弦表达式,推导出物体影长与太阳高度角、当地经纬度和赤纬角的数学公式。据此,利用视频数据中物体影长变化规律,以及摄像机成像原理,建立最小二乘法约束规划数学模型,确定视频拍摄地点和日期。最后,讨论了此方法在现实生活的一些应用。

关键词：最小二乘法摄像机成像原理太阳影子定位

The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis

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Neural Regeneration Research 2025年第5期20卷 1513-1520页

作者： Xueyun shao Longfei He Yangyang Liu Physical Education School Shenzhen UniversityShenzhenGuangdong ProvinceChina Shenzhen Institute of Neuroscience ShenzhenGuangdong ProvinceChina

Brain-derived neurotrophic factor is a crucial neurotrophic factor that plays a significant role in brain health. Although the vast majority of meta-analyses have confirmed that exercise interventions can increase brain-derived neurotrophic factor levels in children and adolescents, the effects of specific types of exercise on brain-derived neurotrophic factor levels are still controversial. To address this issue, we used meta-analytic methods to quantitatively evaluate, analyze, and integrate relevant studies. Our goals were to formulate general conclusions regarding the use of exercise interventions, explore the physiological mechanisms by which exercise improves brain health and cognitive ability in children and adolescents, and provide a reliable foundation for follow-up research. We used the Pub Med, Web of Science, Science Direct, Springer, Wiley Online Library, Weipu, Wanfang, and China National Knowledge Infrastructure databases to search for randomized controlled trials examining the influences of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents. The extracted data were analyzed using Review Manager 5.3. According to the inclusion criteria, we assessed randomized controlled trials in which the samples were mainly children and adolescents, and the outcome indicators were measured before and after the intervention. We excluded animal experiments, studies that lacked a control group, and those that did not report quantitative results. The mean difference(MD;before versus after intervention) was used to evaluate the effect of exercise on brain-derived neurotrophic factor levels in children and adolescents. Overall, 531 participants(60 children and 471 adolescents, 10.9–16.1 years) were included from 13 randomized controlled trials. Heterogeneity was evaluated using the Q statistic and I^(2) test provided by Review Manager software. The meta-analysis showed that there was no heterogeneity among the studies(P = 0.67,

关键词： adolescents brain-derived neurotrophic factor children exercise meta-analysis randomized controlled trials

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao jing-Dong J.Han Qi Liu Xiaohui Fan chen Li chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

曲安奈德在儿童眼内炎玻璃体切割手术中的应用

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眼科研究 2010年第5期28卷 458-461页

作者：谭叶辉蔡锦红陈燕邵毅吴东海肖启国厦门大学附属厦门眼科中心 361001 中山大学中山眼科中心广州510060 南华大学附二医院眼科衡阳421001

目的评价曲安奈德(TA)在儿童眼内炎玻璃体切割手术中的应用及疗效。方法回顾性分析2003年1月—2008年2月在厦门大学附属厦门眼科中心行巩膜外环扎术+玻璃体切割+TA注射联合硅油填充术的54例56眼儿童眼内炎患者的临床资料,并根据手术中... 详细信息

目的评价曲安奈德(TA)在儿童眼内炎玻璃体切割手术中的应用及疗效。方法回顾性分析2003年1月—2008年2月在厦门大学附属厦门眼科中心行巩膜外环扎术+玻璃体切割+TA注射联合硅油填充术的54例56眼儿童眼内炎患者的临床资料,并根据手术中是否玻璃体腔注射TA分为2组:A组29例29眼;B组25例27眼。术后随访(24.3±12.2)个月,按照患者视力改善情况和视网膜复位情况评估手术效果,并根据术后并发症的情况评价TA在玻璃体切割手术中应用的安全性。结果 54例56眼患者出院时眼内炎症均得到控制,脱离的视网膜均解剖复位。除3眼视力检查不合作外,术后视力提高42眼,其中A组26眼(26/29,占89.66%),B组16眼(16/27,占59.26%),2组比较差异有统计学意义(χ2=6.890,P=0.009)。37眼术后矫正视力>0.05,其中A组23眼(23/29,占79.31%);B组14眼(14/27,占51.85%),2组比较差异有统计学意义(χ2=4.703,P=0.030)。14眼患者玻璃体切割术后继发视网膜脱离,其中A组4例4眼,发生率为13.79%,B组9例10眼,发生率为37.04%,2组比较差异有统计学意义(χ2=4.029,P=0.045)。结论儿童眼内炎玻璃体切割手术过程中应用TA可明显改善患者的视力预后,有效预防玻璃体切割手术后视网膜脱离等并发症的发生,提高了手术的安全性和成功率。

关键词：曲安奈德儿童眼内炎玻璃体切割术

The Synthesis of 6-Alkyl-5-Fluorouracil Derivatives

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Chinese Chemical Letters 2000年第11期11卷 967-970页

作者： You, jin Zong chen, shao Yuan chen, Yao Zu Department of Chemistry Zhejiang University Hangzhou 310027 China Natl. Lab. of Appl. Organ. Chemistry Lanzhou University Lanzhou 730000 China

6-alkyl-5-fluorouracil derivatives (5a-5f) were synthesized by facile alkylation of lithiation of 5-fluorouracil derivatives with mthyl iodide (Mel) or alkyl trifluoromethanesulfonate (ROT1) in yield of 42-58%. We fou... 详细信息

关键词： FN MHz Cl The Synthesis of 6-Alkyl-5-Fluorouracil Derivatives

Research on the Limit Value of Shape Coefficient of Rural Residences in Severe Cold Regions

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Journal of Harbin Institute of Technology(New Series) 2014年第4期21卷 43-46页

作者： Hong jin Kai chen Teng shao School of Architecture Harbin Institute of Technology

Shape coefficient is a significant factor accounting for building energy consumption. In order to decrease the building energy consumption of rural residence in severe cold regions,this paper from the perspective of regulating the shape coefficient limit value,applies the field survey method to statistic and analyze the shape,width and depth of rural residence in severe cold regions and concludes the distribution characteristics and scope of building area. On this basis,though calculating and analyzing the relations between shape coefficient and length-width ratio under different building areas,meanwhile comprehensive considering the building function,farmers' living mode and requirements etc,it put forward that the shape coefficient of rural residence in severe cold regions should below 0. 8. It has important significance for guiding the rural energy-saving house design and construction of severe cold regions.

关键词： severe cold regions rural residences shape coefficient