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Comparative efficacy and safety of cognitive enhancers for treating vascular cognitive impairment: systematic review and Bayesian network meta-analysis

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Neural Regeneration Research 2019年第5期14卷 805-816页

作者： bo-Ru jin Hua-Yan Liu Department of Neurology First Affiliated Hospital China Medical University

Objective: To assess and compare the clinical efficacy and safety of cognitive enhancers(donepezil, galantamine, rivastigmine, and memantine) on cognition, behavior, function, and global status in patients with vascular cognitive *** sources: The initial literature search was performed with PubMed, EMBASE, the Cochrane Methodology Register, the Cochrane Central Register of Controlled Trials, and Cumulative Index to Nursing & Allied Health(CINAHL) from inception to January 2018 for studies regarding donepezil, galantamine, rivastigmine, and memantine for treatment of vascular cognitive *** selection: Randomized controlled trials on donepezil, galantamine, rivastigmine, and memantine as monotherapy in the treatment of vascular cognitive impairment were included. A Bayesian network meta-analysis was conducted. Outcome measures: Efficacy was assessed by changes in scores of the Alzheimer's Disease Assessment Scale, cognitive subscale, Mini-Mental State Examination, Neuropsychiatric Inventory scores and Clinician's Interview-Based Impression of Change Scale Plus Caregiver's Input, Activities of Daily Living, the Clinical Dementia Rating scale. Safety was evaluated by mortality, total adverse events(TAEs), serious adverse events(SAEs), nausea, vomiting. diarrhea, or cerebrovascular accidents(CVAs). Results: After screening 1717 citations, 12 randomized controlled trials were included. Donepezil and rivastigmine(mean difference(e) = –0.77, 95% confidence interval(CI): 0.25–1.32; MD = 1.05, 95% CI: 0.18–1.79) were significantly more effective than placebo in reducing Mini-Mental State Examination scores. Donepezil, galantamine, and memantine(MD = –1.30, 95% CI: –2.27 to –0.42; MD = –1.67, 95% CI: –3.36 to –0.06; MD = –2.27, 95% CI: –3.91 to –0.53) showed superior benefits on the Alzheimer's Disease Assessment Scale–cognitive scores compared with placebo. Memantine(MD = 2.71, 95% CI: 1.05–7.29) improved global status(Clinician's Interview-Based Impres

关键词： nerve regeneration vascular cognitive impairment vascular dementia pharmacotherapy cholinesterase inhibitors donepezil galantamine rivastigmine memantine systematic review Bayesian network meta-analysis neural regeneration

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A debris-flow impact pressure model combining material characteristics and flow dynamic parameters

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Journal of Mountain Science 2018年第12期15卷 2721-2729页

作者： TANG jin-bo HU Kai-heng Key Laboratory of Mountain Hazards and Surface Process Chinese Academy of SciencesChengdu 610041China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China

Impact force is a crucial factor to be considered in debris-resisting structure design. The impact of debris flow against a structural barrier depends not only on the flow dynamics but also on the barrier material. Based on the structural vibration equation and energy conservation law, a simple model for calculating debris-flow impact pressure is proposed, which includes the mechanical impedance of the material, debris-flow velocity and Froude number. Twenty-five impact tests have been conducted using different kinds of materials: steel, black granite, white granite, marble and polyvinyl chloride(PVC) board, and the ratio of the maximum impact time to the vibration period of the structure is determined for the model. It is found that the ratio's square root shows a linear relationship with the material solid Froude number. This indicates that the impedance of the structures plays an important role in the flow-barrier interaction. Moreover, the debrisflow impact force is found to decrease with the travel time of the elastic stress wave though the structures.

关键词： Debris flows Impact pressure Dynamical responses Mechanical impedance

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Improved quantum "Ping-pong" protocol based on GHZ state and classical XOR operation

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Science China(Physics,Mechanics & Astronomy) 2011年第9期54卷 1612-1618页

作者： LI Jian jin HaiFei jinG bo State Key Lab of Network and Switching Technology Beijing University of Posts and Telecommunications Beijing 100876 China Department of Computer Science Beijing Institute of Applied Meteorology Beijing 100029 China

In order to transmit the secure message, a deterministic secure quantum direct communication protocol which was called ＂Ping-pong＂ protocol was proposed by bostrrm and Felbinger [bostrom K, et al. Phys Rev Lett, 2002, 89： 187902]. But the protocol was proved very vulnerable, and can be attacked by an eavesdropper. An improved ＂Ping-pong＂ protocol is presented to overcome the problem. The GHZ state particles are used to detect eavesdroppers, and the classical XOR operation which serves as a one-time-pad is used to ensure the security of the protocol. During the security analysis, the method of the entropy theory is introduced, and three detection strategies are compared quantitatively by using the constraint between the information which an eavesdropper can obtain and the interference introduced. If the eavesdropper gets the full information, the detection rate of the original ＂Ping-pong＂ protocol is 50%; the detection rate of the second protocol which used two particles of EPR pair as detection particles is also 50%; and the detection rate of the presented protocol is 75%. In the end, the security of the pro-posed protocol is discussed. The analysis results show that the improved ＂Ping-pong＂ protocol in this paper is more secure than the other two.

关键词： "Ping-pong" protocol XOR operation GHZ state eavesdropping detection protocol security

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Diversity-oriented synthesis of marine sponge derived hyrtioreticulins and their anti-inflammatory activities

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Chinese Journal of Natural Medicines 2022年第1期20卷 74-80页

作者： CHEN bo-Ru gao Cheng-Long LIU jin GUO Yue-Wei JIANG Jian-Lan PANG Tao LI Xu-Wen School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China State Key Laboratory of Natural Medicines New Drug Screening CenterChina Pharmaceutical UniversityNanjing 210009China Open Studio for Druggability Research of Marine Natural Products Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Diversity-oriented synthesis is aimed to increase the chemical diversity of target natural products for extensive biological activity *** ring is an important functional group in a large number of drugs and other biologically active agents,and indole-containing natural products have been frequently isolated from marine sources in recent *** this paper,a series of indole-containing marine natural hyrtioreticulin derivatives,including 19 new ones,were designed,synthesized through a key Pictet-Spengler reaction,and evaluated for their inflammation related *** 13b displayed the most promising activity by inhibiting TNF-αcytokine release with an inhibitory rate of 92%at a concentration of 20μmol·L^(−1).A preliminary structure-activity relationship analysis was also *** research may throw light on the discovery of marine indole alkaloid derived anti-inflammatory drug leads.

关键词： Indole alkaloid Pictet-Spengler reaction Inflammation Hyrtioreticulin

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Synthesis and Structure of a La(Ⅲ) Complex of 1,10-Phenanthroline-2,9-dicarboxylate:a Three-dimensional Network via Hydrogen bonding Interactions

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Chinese Journal of Structural Chemistry 2008年第2期27卷 137-142页

作者： gao Qian XIE Ya-bo CHEN Yuan WANG Dao College of Environmental and Energy Engineering Beijing University of Technology Beijing 100022 China

A new La（Ⅲ） complex, {[La（L）（NO3）（H2O）3]·H2O}n （L = 1,10-phenanthroline- 2,9-dicarboxylate）, has been synthesized and structurally determined by X-ray diffraction analysis. The complex crystallizes in the monoclinic system, space group P21/c with a = 7.7358（17）, b = 8.1664（18）, c = 28.271（6） A, β= 95.184（4）°, V= 1778.6（7） A3, Z = 4, C14H14LaN3O11, Mr = 539.19, Dc = 2.014 g/cm^3, μ= 2.471 mm^-1, F（000） = 1056, the final R = 0.0350 and wR = 0.0659. In this complex, each metal center adopts a ten-coordination geometry formed by two N atoms from a ligand L and eight O atoms from three H2O molecules, a nitrate ion and carboxylates of two ligands. Each ligand adopts a N2,O3-pentdentate coordination mode using two N and two O atoms chelating a La（Ⅲ）, and using another O atom of carboxylate to bridge another La（Ⅲ） center resulting in a 1D helical chain molecule. Intermolecular strong O-H…O and weak C-H…O hydrogen bonds extend the 1D chain structure into a 3D supramolecular architecture.

关键词： hydrogen bonding 1,10-phenanthroline-2,9-dicarboxylate La(Ⅲ) complex,synthesis

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Paraffin wax as a diluent for extraction and separation of trivalent gallium, indium, and thallium with 2,6-bis-(l'-phenyl-3'-methyl-5'-oxopyrazole-4') pyridineacyl

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Rare Metals 2003年第2期22卷 86-90页

作者： gao jinzhang Deng Qiliang Peng bo Guo Xiaojun Chemistry & Chemical Engineering College Northwest Normal University Lanzhou 730070

A method is proposed for the extraction and separation of trivalent gallium,indium and thallium from their corresponding aqueous solutions at 65 deg C with 2,6-bis-(1'-phenyl-3'-methyl-5'-oxopyrazole-4') pyridineacyl (H_2PMBPP or H_2A) using molten paraffinwax as a diluent. The values of pH_(1/2) for extraction of gallium, indium and thallium are2.62,4.32 and 4.93, respectively. Gallium can he extracted by H_2PMBPP at a lower acid medium. Theeffect of solvent and the composition of the extracted species are reported. And the thermodynamicdata of the extraction are also obtained.

关键词： separation in inorganic chemistry solvent extraction gallium indium thallium H_2PMBPP

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On Enomoto's problems in a bipartite graph

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Science China Mathematics 2009年第9期52卷 1947-1954页

作者： YAN jin gao YunShu School of Mathematics Shandong UniversityJinan 250100China

In this paper, we obtain the following result: Let k, n 1 and n 2 be three positive integers, and let G = (V 1,V 2;E) be a bipartite graph with |V1| = n 1 and |V 2| = n 2 such that n 1 ? 2k + 1, n 2 ? 2k + 1 and |n 1 ? n 2| ? 1. If d(x) + d(y) ? 2k + 2 for every x ∈ V 1 and y ∈ V 2 with xy $ \notin $ E(G), then G contains k independent cycles. This result is a response to Enomoto’s problems on independent cycles in a bipartite graph.

关键词： bipartite graph balanced bipartite graph independent cycle 05C38 05C70

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Influencing Factors of Healthy Aging Risk Assessed Using Biomarkers:A Life Course Perspective

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China CDC weekly 2024年第11期6卷 219-224,I0014-I0017页

作者： Cedric Zhang bo Lua Yajie gao jinming Li Xingqi Cao Xinwei Lyu Yinuo Tu Shuyi jin Zuyun Liu Center for Clinical Big Data and Analytics of the Second Affiliated Hospital and Department of Big Data in Health Science School of Public Healththe Key Laboratory of Intelligent Preventive Medicine of Zhejiang ProvinceZhejiang University School of MedicineHangzhou CityZhejiang ProvinceChina Institute of Epidemiology and Health Care University College LondonLondonUK College of Chemical and Biological Engineering Zhejiang UniversityHangzhou CityZhejiang ProvinceChina

Assessing individual risks of healthy aging using biomarkers and identifying associated factors have become important areas of *** this study,we conducted a literature review of relevant publications between 2018 and 2023 in both Chinese and English *** studies have predominantly used single biomarkers,such as C-reactive protein,or focused on specific life course stages and factors such as socioeconomic status,mental health,educational levels,and unhealthy *** summarizing the progress in this field,our study provides valuable insights and future directions for promoting healthy aging from a life course perspective.

关键词： such insight directions

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Reduction potential of the energy penalty for CO_(2) capture in CCS

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Frontiers in Energy 2023年第3期17卷 390-399页

作者： Yawen ZHENG Lin gao Song HE Hongguang jin Laboratory of Integrated Energy System and Renewable Energy Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

CO_(2) capture and storage(CCS)has been acknowledged as an essential part of a portfolio of technologies that are required to achieve cost-effective long-term CO_(2) ***,the development progress of CCS technologies is far behind the targets set by roadmaps,and engineering practices do not lead to commercial *** of the crucial reasons for this delay lies in the unaffordable penalty caused by CO_(2) capture,even though the technology has been commonly recognized as *** the aspects of separation and capture technology innovation,the potential and promising direction for solving this problem were analyzed,and correspondingly,the possible path for deployment of CCS in China was *** the carbon neutral target recently proposed by the Chinese government,the role of CCS and the key milestones for deployment were indicated.

关键词： CO_(2)capture and storage(CCS) CO_(2)separation energy penalty

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Correlate phonon modes with ion transport via isotope substitution

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Science China Chemistry 2023年第3期66卷 768-777页

作者： Yirong gao Jianxing Huang Jun Cheng Shou-Hang bo University of Michigan–Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Physical Chemistry of Solid Surface iChEMCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Solid-State Battery Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Understanding the correlations between lattice dynamics(phonons) and ion transport is important for improving the ionic conductivity of solid-state electrolytes. This understanding largely hinges on selective tuning or excitation of specific phonon modes without changing the chemical environments of atoms, which is, however, challenging to be achieved. In this work, we used ~6Li isotope substitution to selectively change the phonon properties associated with lithium, without introducing additional defects or disorders which would affect the ion transport properties. The changes in the phonon modes were then related to ion transport properties through impedance measurements and deep potential molecular dynamics simulations. Our results demonstrated that lower lithium vibration frequency leads to higher ionic conductivity and lower activation energy in the garnet solid-state electrolyte of Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12). We furthermore quantified the effect of lithium-related phonons on the migration entropy and attempt frequency, which would be difficult to be achieved otherwise. Our work suggests an effective isotope substitution method to decouple the effect of phonon modes to ion transport from that of other complex structural factors. The obtained insights can contribute to innovative understanding of ion transport in solids and strategies to optimize the ionic conductivity of solid-state electrolytes.

关键词： solid-state electrolytes phonon modes ion transport isotope substitution lattice dynamics

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