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Risk factors for fatal recurrence of hepatocellular carcinoma and their role in selecting candidates for liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2008年第2期7卷 145-151页

作者： Zou, Wei-Long Zang, yun-jin Chen, Xin-Guo Shen, Zhong-Yang Gen Hosp Chinese Peoples Armed Police Forces Inst Organ Transplantat Beijing 100039 Peoples R China

BACKGROUND: With the maturation and popularization of skills in liver transplantation (LT), patients with hepatocellular carcinoma (HCC) have an alternative choice. LT as a curative treatment for HCC provides good liver function and systemic condition to recipients. Preoperative tumor characteristics are critical in selecting optimal candidates for LT to optimize the use of donor livers and to achieve a long-term survival. The present study aimed to elucidate the risk factors of HCC involved in fatal recurrence in the first year after LT and to investigate their utility in selecting suitable candidates for LT. METHODS: From April 2002 to October 2005, 303 patients who had received orthotopic LT for HCC were reviewed. Of these patients, those with diffuse intrahepatic or multiple systemic recurrent lesions who died within I year after surgery were investigated as fatal recurrence group (48 patients) and the remaining patients including those who were disease-free without recurrence, those who were alive with recurrence in the first year, or those who died in the first year of other causes, served as control group (255). The two groups were compared by demographics, tumor, and histopathological characteristics for their prognostic significance by logistic regression analysis. RESULTS: Multivariate analysis between the fatal recurrence group and the control group showed that the presence of vascular invasion, a tumor size greater than 6.5 cm, and a preoperative serum alpha-fetoprotein (AFP) level greater than 1000 mu g/L were risk factors for fatal recurrence. Increased risk factors reduced the suitability of candidates for LT and diminished survival in the first year. 85.71% of the patients with all three risk factors, 37.84% of those with two factors, 13.64% of those with one factor, and 6.71% of those without risk factors died from tumor recurrence within I year after transplantation. CONCLUSIONS: Vascular invasion, tumor size >= 16.5 cm, and preoperative serum AFP

关键词： hepatocellular carcinoma liver transplantation recurrence mortality

Recent Advances on the Technologies to Increase Fertilizer Use Efficiency

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Agricultural Sciences in China 2008年第4期7卷 469-479页

作者： YAN Xiang jin Ji-yun HE Ping LIANG Ming-zao Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China Key Laboratory of Plant Nutrition and Nutrient Cycling Ministry of Agriculture Beijing 100081 P.R.China International Plant Nutrition institute （IPNI） China Program Beijing 100081 P.R.China

To increase fertilizer use efficiency （FUE） and to minimize its negative impact on environment have been the focal points in the world for a long time. It is very important to increase FUE in China for its relatively low FUE and serious losses of nutrients. Recent advances of the technologies to increase FUE are reviewed in this article. These include site-specific and real-time nitrogen management, non-destructive quick test of the nitrogen status of plants, new types of slow release and controlled release fertilizers, site-specific nutrient management, and use of urease inhibitor and nitrification inhibitor to decrease nitrogen losses. Future outlook in technologies related to FUE improvement is also discussed.

关键词： fertilizer use efficiency site-specific/real-time nitrogen management slowly release/controlled release fertilizer site specific nutrient management urease/nitrification inhibitor

Inhibition of Ubiquitin-specific Protease 4 Attenuates Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via Transforming Growth Factor Beta Receptor Type Ⅰ

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Current Medical Science 2022年第5期42卷 1000-1006页

作者： jin-yun PU Yu ZHANG Li-xia WANG Jie WANG Jian-hua ZHOU Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Ubiquitin-specific protease 4(USP4)facilitates the development of transforming growth factor-beta 1(TGF-β1)-induced epithelial-mesenchymal transition(EMT)in various cancer ***,EMT of renal tubular epithelial cells(RTECs)is required for the progression of renal interstitial ***,the role of USP4 in EMT of RTECs remains *** present study aimed to explore the effect of USP4 on the EMT of RTECs as well as the involved *** In established unilateral ureteral obstruction(UUO)rats and NRK-52E cells,immunohistochemistry and Western blot assays were *** USP4 expression was increased significantly with obstruction *** NRK-52E cells stimulated by TGF-β1,USP4 expression was increased in a time-dependent *** addition,USP4 silencing with specific siRNA indicated that USP4 protein was suppressed ***,USP4 siRNA treatment restored E-cadherin and weakened alpha smooth muscle actin(α-SMA)expression,indicating that USP4 may promote *** treatment with USP4 siRNA and TGF-β1 for 24 h,the expression of TGF-β1 receptor type I(TβRI)was *** USP4 promotes the EMT of RTECs through upregulating TβRI,thereby facilitating renal interstitial *** findings may provide a potential target of USP4 in the treatment of renal fibrosis.

关键词： ubiquitin-specific protease 4 renal tubular epithelial cells epithelial-mesenchymal transition transforming growth factor-beta 1 receptor type I renal interstitial fibrosis

基于CFX的豆粕组合三螺杆流道混合机理分析

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山东工业技术 2024年第1期 17-22页

作者：刘祺王丽艳金子云王梦杰沈阳化工大学机械与动力工程学院辽宁沈阳110142

针对目前传统三螺杆膨化机挤压性能和混合效率所存在的缺陷,为了提高挤出产品质量,这里设计了一种新型的组合式三螺杆膨化机。以豆粕为原料,利用CFX有限元仿真模块来对反向螺纹的组合三螺杆流道进行数值模拟,通过分析在宏观压力、速度... 详细信息

针对目前传统三螺杆膨化机挤压性能和混合效率所存在的缺陷,为了提高挤出产品质量,这里设计了一种新型的组合式三螺杆膨化机。以豆粕为原料,利用CFX有限元仿真模块来对反向螺纹的组合三螺杆流道进行数值模拟,通过分析在宏观压力、速度矢量、速度迹线上的特性来与传统三螺杆进行比较,总结豆粕在流道内的运动规律。分析结果显示,流道内-0.24 m,-0.22 m,-0.18 m处涡流区的出现改变了物料的运动模式,延长了物料的挤出时间,提高了物料的分散混合。研究结果表明,反螺纹三角排列给物料带来反复的周期性剪切与挤压能有效改善物料的挤出质量,其研究结果为优化三螺杆膨化机的加工提供了一定的理论依据。

关键词：三螺杆膨化机组合螺纹豆粕 CFX 涡流区

超声E成像无创定量评价慢性肝病肝纤维化临床研究

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生物医学工程与临床 2024年第4期28卷 540-545页

作者：汪向前马云飞吴意赟邓正明乔飞傅吉强夏云锦周希乔南京中医药大学第一临床学院江苏南京210023 南京中医药大学附属医院超声医学科江苏南京210029 南京中医药大学附属医院普外科江苏南京210029 南京中医药大学附属医院感染科江苏南京210029 南京中医药大学附属医院内分泌科江苏南京210029

目的应用超声E成像(即剪切波弹性成像,SWE)技术对慢性肝病患者进行检测和分析,探讨该技术在无创定量评价慢性肝病肝纤维化程度中临床应用价值。方法选择2019年8月至2021年7月在南京中医药大学附属医院就诊的慢性肝病患者148例,其中男性5... 详细信息

目的应用超声E成像(即剪切波弹性成像,SWE)技术对慢性肝病患者进行检测和分析,探讨该技术在无创定量评价慢性肝病肝纤维化程度中临床应用价值。方法选择2019年8月至2021年7月在南京中医药大学附属医院就诊的慢性肝病患者148例,其中男性56例,女性92例;年龄17~75岁,平均年龄48.9岁;身高1.47~1.87 m,平均身高1.65 m;体质量44~106 kg,平均体质量65.50 kg;身体质量指数(BMI)17.51~35.85 kg/m^(2),平均BMI 24.00 kg/m^(2);疾病类型,病毒性肝炎44例,代谢相关脂肪性肝病36例,自身免疫性肝炎22例,药物性肝炎20例,原发性胆汁性胆管炎26例。对所有患者肝脏均应用SWE技术进行检测并行超声引导下肝脏组织穿刺活检,以病理诊断为金标准,对肝脏SWE弹性测值与肝脏纤维化分期关系进行统计学分析。结果经病理诊断,慢性肝病有肝纤维化患者130例,无纤维化患者18例。两者SWE弹性测值、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBiL)、直接胆红素(DBiL)及高密度脂蛋白胆固醇(HDL-C)比较,差异均有统计学意义[(9.34±4.73)kPa vs(6.24±1.46)kPa,(147.89±62.79)U/L vs(73.32±34.78)U/L,(270.56±60.95)U/L vs(105.94±52.97)U/L,(57.12±10.82)μmol/L vs(20.57±5.01)μmol/L,(38.41±7.95)μmol/L vs(9.35±4.88)μmol/L,(1.35±0.36)mmol/L vs(1.39±0.84)mmol/L。t=2.755、1.972、2.615、3.898、3.957、0.359,P<0.05]。对慢性肝病肝纤维化组患者SWE弹性测值与各项指标间进行相关分析显示,SWE弹性测值与年龄(r=0.338)、纤维化分期(r=0.736)、血糖(GLU)(r=0.174)及凝血酶原时间(PT)(r=0.424)呈正相关(P<0.05)。SWE技术对慢性肝病肝纤维化诊断效能分析,受试者工作特性(ROC)曲线分析结果显示,应用SWE技术诊断慢性肝病肝纤维化S0/S1期、S1/S2期、S2/S3期及S3/S4期SWE弹性测值截断值分别为6.35 kPa、7.65 kPa、8.35 kPa、17.30 kPa,其曲线下面积(AUC)分别为0.736[95%可信区间(CI)0.628~0.844]、0.751(95%CI 0.657~0.845)、0.803(95%CI 0.680~0.927)及0.752(95%CI 0.566~0.939)。结论SWE技术作为一种实时超声弹性成像技术,操作简便、无创,患者接受度高,其弹性测值可用来无创定量评价慢性肝病肝纤维化及其分期,具有良好的临床应用前景。

关键词：实时剪切波弹性成像慢性肝病肝纤维化病理学

NICKEL(Ⅱ)ion-intercalated MXene membranes for enhanced H_(2)/CO_(2) separation

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Frontiers of Chemical Science and Engineering 2021年第4期15卷 882-891页

作者： Yiyi Fan jinyong Li Saidi Wang Xiuxia Meng yun jin Naitao Yang Bo Meng Jiaquan Li Shaomin Liu School of Chemical Engineering Shandong University of TechnologyZibo 255049China Department of Chemical Engineering Curtin UniversityPerthWA 6845Australia College of Chemical Engineering Beijing University of Chemical TechnologyBeijing 100029China

Hydrogen fuel has been embraced as a potential long-term solution to the growing demand for clean energy.A membrane-assisted separation is promising in producing high-purity H_(2).Molecular sieving membranes(MSMs)are endowed with high gas selectivity and permeability because their well-defined micropores can facilitate molecular exclusion,diffusion,and *** this work,MXene nanosheets intercalated with Ni^(2+) were assembled to form an MSM supported on Al_(2)O_(3) hollow fiber via a vacuum-assisted filtration and drying *** prepared membranes showed excellent H_(2)/CO_(2) mixture separation performance at room *** factor reached 615 with a hydrogen permeance of 8.35×10^(-8) mol·m^(-2)·s^(-1) ·Pa^(-1).Compared with the original Ti_(3)C_(2)T_(x)/Al_(2)O_(3) hollow fiber membranes,the permeation of hydrogen through the Ni^(2+)-Ti_(3)C_(2)T_(x)/Al_(2)O_(3) membrane was considerably increased,stemming from the strong interaction between the negatively charged MXene nanosheets and Ni^(2+).The interlayer spacing of MSMs was tuned by Ni^(2+).During 200-hour testing,the resultant membrane maintained an excellent gas separation without any substantial performance *** results indicate that the Ni2+tailored Ti_(3)C_(2)T_(x)/Al_(2)O_(3) hollow fiber membranes can inspire promising industrial applications.

关键词： MXene H_(2)/CO_(2)separation nickel ions hollow fiber

Design of wideband graded-index antireflection coatings at oblique light incidence

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Chinese Physics B 2012年第1期21卷 199-203页

作者： Zhang Jun-Chao Fang Ming jin yun-Xia He Hong-Bo Key Laboratory of Material Science and Technology for High Power Lasers Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Graduate University of Chinese Academy of Sciences Beijing 100049China

We suggest a design method of graded-refractive-index （GRIN） antireflection （AR） coating for s-polarized or p- polarized light at off-normal incidence. The spectrum characteristic of the designed antireflection coating with a quintic effective refractive-index profile for a given state of polarization has been discussed. In addition, the genetic algorithm was used to optimize the refractive index profile of the GRIN antireflection for reducing the mean reflectance of s- and p-polarizations. The average reflectance loss was reduced to only 0.04% by applying optimized GRIN AR coatings onto BK7 glass over the wavelength range from 400 to 800 nm at the incident angle of θo = 70°.

关键词： antireflection coatings oblique incidence graded-refractive-index profile genetic algo-rithm

Function projective synchronization between two different complex networks with correlated random disturbances

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Chinese Physics B 2015年第4期24卷 555-562页

作者：金运国钟守铭安娜 School of Mathematical Sciences University of Electronic Science and Technology of China Key Laboratory for Neuroinformation of Ministry of Education University of Electronic Science and Technology of China School of Mathematics and Systems Science Beihang University

Although function projective synchronization in complex dynamical networks has been extensively studied in the literature, few papers deal with the problem between two different complex networks with correlated random disturbances. In this paper, we present some novel techniques to analyze the problem of synchronization. A probability approach is introduced to obtain an almost sure synchronization criterion. We also present some efficient approaches to analyze the problem of exponential synchronization. For the problem of synchronization in some complex networks, our approaches not only can replace the LaSalle-type theorem but also allow improvements of existing results in the literature. Finally, some numerical examples are provided to demonstrate the effectiveness of the proposed approaches.

关键词： complex networks random disturbances synchronization martingale Ito integral

Type-B response regulator OsRR22 forms a transcriptional activation complex with OsSLR1 to modulate OsHKT2;1 expression in rice

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Science China(Life Sciences) 2023年第12期66卷 2922-2934页

作者： Yutong Liu Xiaoyuan Peng Ao Ma Wenxin Liu Bao Liu Dae-jin yun Zheng-Yi Xu Key Laboratory of Molecular Epigenetics of the Ministry of Education(MOE) Northeast Normal UniversityChangchun 130024China Department of Biomedical Science and Engineering Konkuk UniversitySeoul 05029Republic of Korea

Soil salinity severely limits crop yields and *** have evolved several strategies to mitigate the adverse effects of salinity,including redistribution and compartmentalization of toxic ions using ion-specific ***,the mechanisms underlying the regulation of these ion transporters have not been fully ***-of-function mutants of OsHKT2;1,which is involved in sodium uptake,exhibit strong salt stress-resistant *** this study,OsHKT2;1 was identified as a transcriptional target of the type-B response regulator ***-of-function osrr22 mutants showed resilience to salt stress,and OsRR22-overexpression plants were sensitive to salt ***22 was found to activate the expression of OsHKT2;1 by directly binding to the promoter region of OsHKT2;1 via a consensus cis-element of type-B response ***,rice DELLA protein OsSLR1 directly interacted with OsRR22 and functioned as a transcriptional *** study has uncovered a novel transcriptional regulatory mechanism by which a type-B response regulator controls sodium transport under salinity stress.

关键词： Oryza sativa type-B response regulator transcriptional regulation sodium transport