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Rapid and sensitive detection of pesticides by surface-enhanced Raman spectroscopy technique based on glycidyl methacrylate-ethylene dimethacrylate(GMA-EDMA) porous material

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Chinese Chemical Letters 2013年第4期24卷 332-334页

作者： Qing-Qing Li Yi-Ping Du Ying Xu Xuan Wang Shi-Qian Ma jin-pei geng Peng Cao Tao Sui Shanghai Key Laboratory of Functional Materials Chemistry & Research Centre of Analysis and Test East China University of Science and Technology Yantai Entry-Exit Inspection and Quarantine Bureau

A novel method of fast and sensitive SERS detection using GMA-EDMA porous material combined with a miniature device was reported in this study. A 100 μL solution containing sample, silver colloid and NaC1 was evenly mixed to ensure the sample molecules would adsorb onto silver nanoparticles. Then the mixture was added onto the porous material surface slowly, so that the aggregation of silver colloid would stay on the surface while the liquid components would flow away. This technology can improve the sensitivity of SERS detection. By this method, two pesticides tricyclazole and paraquat were successfully detected at concentrations of 5 × 10 3 mg/L and I × 10-3 mg/L, respectively.

关键词： rSurface-enhanced Raman spectroscopyGMA-EDMA porous materialTricyclazoleParaquat

Regulating interfacial chemistry and kinetic behaviors of F/Mo co-doping Ni-rich layered oxide cathode for long-cycling lithium-ion batteries over-20°C-60°C

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Journal of Energy Chemistry 2024年第7期94卷 449-457页

作者： Siqi Guan Lin Tao pei Tang Ruopian Fang Huize Wu Nan Piao Huicong Yang Guangjian Hu Xin geng Lixiang Li Baigang An Feng Li Institute of Energy Materials and Electrochemistry Research University of Science and Technology LiaoningAnshan 114051LiaoningChina Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016LiaoningChina Shenyang King Power Tech.Co. Ltd.Shenyang 110016LiaoningChina School of Chemical Engineering The University of New South WalesSydney 2052NSWAustralia

Ni-rich layered oxide cathodes have shown promise for high-energy lithium-ion batteries(LIBs)but are usually limited to mild environments because of their rapid performance degradation under extreme temperature conditions(below0°C and above 50 °C).Here,we report the design of F/Mo co-doped LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(FMNCM)cathode for high-performance LIBs from-20 to 60°C.F^(-) doping with high electronegativity into the cathode surface is found to enhance the stability of surface lattice structure and protect the interface from side reactions with the electrolyte by generating a LiF-rich surface ***,the Mo^(6+) doping suppresses phase transition,which blocks Li^(+)/Ni^(2+) mixing,and stabilizes lithium-ion diffusion ***,the FMNCM cathode demonstrates excellent cycling stability at a high cutoff voltage of 4.4 V,even at 60°C,maintaining 90.6%capacity retention at 3 C after 150 ***,at temperatures as low as-20°C,it retains 77.1%of its room temperature capacity,achieving an impressive 97.5%capacity retention after 500 *** stable operation under wide temperatures has been further validated in practical Ah-level *** study sheds light on both fundamental mechanisms and practical implications for the design of advanced cathode materials for wide-temperature LIBs,presenting a promising path towards high-energy and long-cycling LIBs with temperatureadaptability.

关键词： Anion-cation co-doping Wide temperature operation Ni-richlayered cathode Phase transition Surface/interface

Endoscopic features and treatments of gastric cystica profunda

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World Journal of Gastroenterology 2024年第7期30卷 673-684页

作者： Zi-Han geng Yan Zhu pei-Yao Fu Yi-Fan Qu Wei-Feng Chen Xia Yang Ping-Hong Zhou Quan-Lin Li Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Gastric cystica profunda(GCP)represents a rare condition characterized by cystic dilation of gastric glands within the mucosal and/or submucosal *** is often linked to,or may progress into,early gastric cancer(EGC).AIM To provide a comprehensive evaluation of the endoscopic features of GCP while assessing the efficacy of endoscopic treatment,thereby offering guidance for diagnosis and *** This retrospective study involved 104 patients with GCP who underwent endoscopic *** demographic and clinical data,regular patient followups were conducted to assess local *** Among the 104 patients diagnosed with GCP who underwent endoscopic resection,12.5%had a history of previous gastric *** primary site predominantly affected was the cardia(38.5%,n=40).GCP commonly exhibited intraluminal growth(99%),regular presentation(74.0%),and ulcerative mucosa(61.5%).The leading endoscopic feature was the mucosal lesion type(59.6%,n=62).The average maximum diameter was 20.9±15.3 mm,with mucosal involvement in 60.6%(n=63).Procedures lasted 73.9±57.5 min,achieving complete resection in 91.3%(n=95).Recurrence(4.8%)was managed via either surgical intervention(n=1)or through endoscopic resection(n=4).Final pathology confirmed that 59.6%of GCP cases were associated with *** analysis indicated that elderly males were more susceptible to GCP associated with ***,multivariate analysis identified lesion morphology and endoscopic features as significant risk *** analysis demonstrated no statistically significant difference in recurrence between GCP with and without EGC(P=0.72).CONCLUSION The findings suggested that endoscopic resection might serve as an effective and minimally invasive treatment for GCP with or without EGC.

关键词： Gastric cystica profunda Early gastric cancer Endoscopic features Endoscopic resection Endoscopy

Phonon transport properties of Janus Pb_(2)XAs(X=P,Sb,and Bi)monolayers:A DFT study

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Chinese Physics B 2024年第4期33卷 71-76页

作者：耿嘉鑫张培汤准韵欧阳滔 School of Physics and Optoelectronics and Hunan Key Laboratory for Micro-Nano Energy Materials and Device Xiangtan UniversityXiangtan 411105China Hunan Provincial Key Laboratory of Intelligent Sensors and Advanced Sensor Materials School of Physics and ElectronicsHunan University of Science and TechnologyXiangtan 411201China

Grasping the underlying mechanisms behind the low lattice thermal conductivity of materials is essential for the efficient design and development of high-performance thermoelectric materials and thermal barrier coating *** this paper,we present a first-principles calculations of the phonon transport properties of Janus Pb_(2)PAs and Pb_(2)SbAs *** materials possess low lattice thermal conductivity,at least two orders of magnitude lower than graphene and *** room temperature thermal conductivity of Pb_(2)SbAs(0.91 W/m K)is only a quarter of that of Pb_(2)PAs(3.88 W/m K).We analyze in depth the bonding,lattice dynamics,and phonon mode level information of these ***,it is determined that the synergistic effect of low group velocity due to weak bonding and strong phonon anharmonicity is the fundamental cause of the intrinsic low thermal conductivity in these Janus *** regular residual analysis further indicates that the four-phonon processes are limited in Pb_(2)PAs and Pb_(2)SbAs,and the three-phonon scattering is sufficient to describe their *** this study,the thermal transport properties of Janus Pb_(2)PAs and Pb_(2)SbAs monolayers are illuminated based on fundamental physical mechanisms,and the low lattice thermal conductivity endows them with the potential applications in the field of thermal barriers and thermoelectrics.

关键词： lattice thermal conductivity weak bonding phonon anharmonicity first principles calculations

PIM1-HDAC2 axis modulates intestinal homeostasis through epigenetic modification

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3049-3067页

作者： Jianming Yang Yawen Xiao Ningning Zhao geng pei Yan Sun Xinyu Sun Kaiyuan Yu Chunhui Miao Ran Liu Junqiang Lv Hongyu Chu Lu Zhou Bangmao Wang Zhi Yao Quan Wang Key Laboratory of Immune Microenvironment and Disease(Ministry of Education) Tianjin Institute of ImmunologyState Key Laboratory of Experimental Hematologythe Province and Ministry Co-sponsored Collaborative Innovation Center for Medical EpigeneticsDepartment of ImmunologySchool of Basic Medical SciencesTianjin Institute of Urologythe Second Hospital of Tianjin Medical UniversityTianjin Key Laboratory of Cellular and Molecular ImmunologyTianjin Medical UniversityTianjin 300070China Department of Pathology Tianjin Medical University Cancer Institute and Hospital/National Clinical Research Center of Cancer/Key Laboratory of Cancer Prevention and TherapyTianjin/Tianjin’s Clinical Research Center of CancerTianjin 30060China Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300070China

The mucosal barrier is crucial for intestinal homeostasis,and goblet cells are essential for maintaining the mucosal barrier *** proviral integration site for Moloney murine leukemia virus-1(PIM1)kinase regulates multiple cellular functions,but its role in intestinal homeostasis during colitis is ***,we demonstrate that PIM1 is prominently elevated in the colonic epithelia of both ulcerative colitis patients and murine models,in the presence of intestinal *** PIM1 leads to decreased goblet cells,thus impairing resistance to colitis and colitis-associated colorectal cancer(CAC)in ***,PIM1 modulates goblet cell differentiation through the Wnt and Notch signaling ***,PIM1 interacts with histone deacetylase 2(HDAC2)and downregulates its level via phosphorylation,thereby altering the epigenetic profiles of Wnt signaling pathway ***,these findings investigate the unknown function of the PIM1-HDAC2 axis in goblet cell differentiation and ulcerative colitis/CAC pathogenesis,which points to the potential for PIM1-targeted therapies of ulcerative colitis and CAC.

关键词： PIM1 HDAC2 Goblet cell Gut microbiota Intestinal homeostasis Epigenetic modification Ulcerative colitis CAC

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中药配方颗粒趋势分析与监管策略的思考

中国中药杂志 2024年第15期49卷 4249-4260页

作者：朱佩佩李耿杨洪军江西中医药大学院士工作站江西南昌330000 中国中医科学院北京100700 中国中医科学院中药研究所北京100700

随着中药配方颗粒“后试点时代”的到来,当前在其生产、监管、应用实践中,仍面临着一系列的政策、技术、产业问题。该文通过系统梳理中药配方颗粒的发展历程和相关政策沿革;并从质量标准、医保支付、市场格局等方面归纳了其产业现状;基... 详细信息

随着中药配方颗粒“后试点时代”的到来,当前在其生产、监管、应用实践中,仍面临着一系列的政策、技术、产业问题。该文通过系统梳理中药配方颗粒的发展历程和相关政策沿革;并从质量标准、医保支付、市场格局等方面归纳了其产业现状;基于中药配方颗粒与传统饮片对比分析与定位探讨。认为当前该领域还存在以下现实问题:(1)尚未形成合理的竞争演化机制,产品“提质增效”困难;(2)国家标准数量有限,地方标准各自为战;(3)生产工艺相对受限;(4)固定当量与原料波动的矛盾;(5)市场定位待明确,用药场景局限。进而,基于塑造良性中药产业生态和促进中医临床合理用药视角,提出了相关建议:(1)引导中药配方颗粒形成按产品竞争格局;(2)推动建立中药配方颗粒全过程监管体系;(3)系统研究配方颗粒当量与摄入量关系;(4)突破应用场景,合理拓展配方颗粒应用形式。

关键词：中药配方颗粒产业现状市场定位科学监管

FRP-混凝土组合式护栏防护重型车辆撞击的能力

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重庆大学学报 2024年第4期47卷 51-63页

作者：郑植杨波袁佩耿波重庆大学土木工程学院重庆400045 招商局重庆交通科研设计院有限公司桥梁工程结构动力学国家重点实验室重庆400067

为提高低等级混凝土护栏防护重型车辆的能力,设计了3种不同构造形式的复合材料护板,分别设置在混凝土护栏表面形成组合式护栏。建立车-护栏精细化有限元模型,通过与实车碰撞试验结果对比,验证了有限元模型的可靠性。考虑撞击力、碰撞角... 详细信息

为提高低等级混凝土护栏防护重型车辆的能力,设计了3种不同构造形式的复合材料护板,分别设置在混凝土护栏表面形成组合式护栏。建立车-护栏精细化有限元模型,通过与实车碰撞试验结果对比,验证了有限元模型的可靠性。考虑撞击力、碰撞角度、车辆轨迹、货厢尾部抬高、车辆动态外倾值、车辆外倾角6个评价指标,对比分析了3种方案护栏的防车撞性能。结果表明,在整体式货车撞击下,3种方案护栏均能顺利引导车辆转向,不带阻坎的方案一的各主要指标均优于其他方案,防护能力最优;在拖挂式货车撞击下,方案一的护栏导向与阻挡性能依然良好,驶出角仅为0.75°;改造后的组合式护栏防护能量达到650 kJ,防护能力是改造前的4倍。

关键词：组合式护栏碰撞仿真防车撞能力复合材料

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一种基于突变流量的在野黑产应用采集方法

软件学报 2024年第8期35卷 3684-3697页

作者：陈沛洪赓邬梦莹陈晋松段海新杨珉复旦大学计算机科学技术学院上海201203 清华大学网络科学与网络空间研究院北京100084 中关村实验室北京100081

近年来,移动互联网的兴起使以诈骗、博彩和色情为主的网络黑产移动应用(APP)变得更加猖獗,亟待采取有效措施进行管控.目前,研究人员针对黑产应用的研究较少,其原因是由于执法部门持续对黑产应用的传统分发渠道进行打击,已有的通过基于... 详细信息

近年来,移动互联网的兴起使以诈骗、博彩和色情为主的网络黑产移动应用(APP)变得更加猖獗,亟待采取有效措施进行管控.目前,研究人员针对黑产应用的研究较少,其原因是由于执法部门持续对黑产应用的传统分发渠道进行打击,已有的通过基于搜索引擎和应用商店的采集方法效果不佳,缺乏大规模具有代表性的在野黑产应用数据集,已经成为开展深入研究的一大掣肘.为此,尝试解决在野黑产应用大规模采集的难题,为后续深入全面分析黑产应用及其生态提供数据支撑.提出了一种基于突变流量分析的黑产应用批量捕获方法,以黑产应用分发的关键途径为抓手,利用其具有的突变和伴随流量特点,批量快速发现正处于传播阶段的新兴在野黑产应用,为后续实时分析和追踪提供数据基础.在测试中,该方法成功获取了3439条应用下载链接和3303个不同的应用.捕获的移动应用中,不但有91.61%的样本被标记为恶意软件,更有98.14%的样本为首次采集发现的零天应用.上述结果证明了所提出的方法在黑产应用采集方面的有效性.

关键词：网络黑产网络犯罪移动应用流量分析

基于界面本构模型的砂土中单桩荷载−沉降响应预测方法

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岩土力学 2024年第6期45卷 1686-1698页

作者：周攀李镜培李盼盼刘耕云张超哲同济大学岩土及地下工程教育部重点实验室上海200092 同济大学地下建筑与工程系上海200092 东南大学岩土工程研究所江苏南京211189

基于界面本构模型提出了一种新的砂土中单桩荷载沉降响应的预测方法。首先,从土−结构界面本构模型出发推导了严格的桩−土界面非线性荷载传递模型,该模型承继了界面本构模型特征,能够模拟桩−土界面上发生的应变硬化/软化、剪胀与应力路... 详细信息

基于界面本构模型提出了一种新的砂土中单桩荷载沉降响应的预测方法。首先,从土−结构界面本构模型出发推导了严格的桩−土界面非线性荷载传递模型,该模型承继了界面本构模型特征,能够模拟桩−土界面上发生的应变硬化/软化、剪胀与应力路径依赖性等行为。此外,采用双曲线荷载传递模型模拟桩端−土相互作用的非线性应力−位移关系。上述荷载传递模型所需参数可以通过室内界面剪切试验和土工试验进行校准。继而,基于荷载传递法,提出了单桩荷载沉降响应分析的一维计算模型,并采用迭代算法进行数值求解。最后,将理论解答与已报道的模型试验、自主开展的模型桩试验以及数值模拟结果进行比较,以验证所提出的理论方法的正确性。试验结果表明,预测值与实测值吻合较好,且该方法能够很好地预测非位移桩与位移桩的荷载沉降响应。提出了一个基于界面本构模型的单桩荷载沉降响应分析框架,为竖向荷载下砂土中单桩优化设计提供了理论参考。

关键词：单桩砂土荷载-沉降响应桩-土相互作用界面本构模型模型试验