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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Inhibitory effects of polysaccharides isolated from Phellinus gilvus on benzo(a)pyrene-induced forestomach carcinogenesis in mice

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World Journal of Gastroenterology 2005年第4期11卷 577-579页

作者： Jae-Sung Bae Kwang-ho Jang Hyunee yim Seung-Chun Park Hee-Kyung jin College of Veterinary Medicine Kyungpook National University Daegu 702-701 Republic of Korea Department of Pathology Ajou University School of Medicine Suwon Republic of Korea

AIM: Although polysaccharides from Phellinus mushrooms are a well-known material with anti-tumor properties, there is no information about the effect of polysaccharides from Phellinus gilvus (PG) on tumor. The modulating effect of polysaccharides isolated from PG on the benzo(a)pyrene (BaP)-induced forestomach carcinogenesis in ICR female mice was investigated in this ***: A forestomach carcinogenesis model was established in 40 ICR female mice receiving oral administration of BaP for 4 wk. The mice were randomly assigned to 4 groups (10 each). The mice in each group were treated with sterile water or PG for 4 and 8 wk (SW4,PGW4, SW8, and PGW8 groups). Eight or 12 wk after the first dose of BaP, forestomachs were removed for histopathological and RT-PCR ***: In histopathological changes and RT-PCR analysis, sterile water-treated mice showed significant hyperplasia of the gastric mucosa with a significantly increased expression of mutant p53 mRNA compared to mice treated with PG for 8 ***: Polysaccharides isolated from PG may inhibit BaP-induced forestomach carcinogenesis in mice bydown-regulating mutant p53 expression.

关键词： Forestomach carcinogenesis Phellinus gilvus Polysaccharides p53 Gene

Overlooked impact of precursor mixing:Implications in the electrochemical performance of battery electrode materials

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Journal of Energy Chemistry 2023年第7期82卷 56-65,I0003页

作者： jinHa Shim jin ho Bang Department of Applied Chemistry Center for Bionano Intelligence Education and ResearchHanyang University55 Hanyangdaehak-roSangnok-guAnsanGyeonggi-do 15588Republic of Korea Department of Chemical and Molecular Engineering Hanyang University55 Hanyangdaehak-roSangnok-guAnsanGyeonggi-do 15588Republic of Korea

Solid-state reactions are an essential part of the synthesis of various cathode materials for lithium-ion batteries(LIBs).Despite the simplicity and effectiveness for mass production,a subtle variation in synthesis conditions can often give rise to unexpectedly different physical properties,significantly affecting the electrochemical performance of electrode ***,this aspect has long been overlooked in the LIB community,which should focus on advancement in understanding the influence of synthesis *** solid-state reactions occur only at the interface of precursor materials,maximizing the interfacial contact area between mixed precursor powders is *** milling and/or mixing are common practices that have been performed in both academia and industry for this *** the common belief that this pre-treatment before calcination would be of great benefit for the preparation of high-performance LIB materials,we revealed in this work that this practice is not always successful for this *** our case study of the preparation of LiCoO_(2),we demonstrated that mechanical mixing-a routinely implemented process for homogeneous mixing of precursors-can be harmful if it is performed without assuring optimal working conditions for *** underlying reasons for this surprising result are elucidated in this work,and we hope that this new insight can help avoid the potential pitfall of routine implementations performed for LIB materials.

关键词： LiCoO_(2) Solid-state reaction Mechanical mixing Cathode material Lithium-ion battery

Effects of dispersoid preforming via multistep sintering of oxide dispersion-strengthened CoCrFeMnNi high-entropy alloy

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Journal of Materials Science & Technology 2023年第9期140卷 187-200页

作者： SeungHyeok Chung Ji ho Shin ho jin Ryu Department of Nuclear and Quantum Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Central Research Institute Korea Hydro and Nuclear Power Co.Ltd.(KHNP)Daejeon 34101Republic of Korea

Dispersoid formation and microstructural evolution in an oxide dispersion-strengthened CoCrFeMnNi high-entropy alloy(HEA)using a newly designed multistep sintering process are *** proposed multistep sintering consists of a dispersoid preforming heat treatment of as-milled 0.1 wt%Y_(2)O_(3)-CoCrFeMnNi high-entropy alloy powders at 800℃,followed by sintering at 800–1000℃ under uniaxial *** the conventional single-step sintered bulk,the coarsened BCC Y_(2)O_(3)dispersoids mainly form with an incoherent interface with the HEA *** contrast,finer FCC Y_(2)O_(3)dispersoids,an atypical form of Y_(2)O_(3),are formed in the matrix region after multistep *** of FCC Y_(2)O_(3)disper-soids is initiated on the favorable facet,the{111}plane of the austenitic matrix,with the formation of a semi-coherent interface with the matrix during the dispersoid preforming heat treatment and it maintains its refined size even after *** is found that dispersoid preforming prior to sintering appears promising to control the finer dispersoid formation and refined grain structure.

关键词： Oxide dispersion strengthening High-Entropy alloy Multistep sintering Dispersoid preforming Microstructure evolution Interfacial structure

Classifying cubic symmetric graphs of order 10p or 10p^(2)

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Science China Mathematics 2006年第3期49卷 300-319页

作者： KWAK jin ho Department of Mathematics

A graph is called s-regular if its automorphism group acts regularly on the set of its s-arcs. In this paper, the s-regular cyclic or elementary abelian coverings of the Petersen graph for each s ≥ 1 are classified when the fibre-preserving automorphism groups act *** an application of these results, all s-regular cubic graphs of order 10p or 10p2 are also classified for each s ≥ 1 and each prime p, of which the proof depends on the classification of finite simple groups.

关键词： s-regular graph, regular covering, Petersen graph.

A study on the interference effects for tidal current power rotors

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Science China(Technological Sciences) 2010年第11期53卷 3094-3101页

作者： Chul-Hee JO Kang-Hee LEE jin-Young yim Department of Naval Architecture & Ocean Engineering Inha University

Due to global warming, the need to secure an alternative resource has become more important nationally. With the high tidal range of up to 9.7 m on the west coast of Korea, numerous tidal current projects are being planned and constructed. To extract a significant quantity of power, a tidal current farm with a multi-arrangement is necessary in the ocean. The rotor, which initially converts the energy, is a very important component because it affects the efficiency of the entire system, and its performance is determined by various design variables. The power generation is strongly dependent on the size of the rotor and the incoming flow velocity. however, the interactions between devices also contribute significantly to the total power capacity. Therefore, rotor performance considering the interaction problems needs to be investigated for generating maximum power in a specific field. This paper documents a performance study of devices considering the interference between rotating rotors with axial, transverse and diagonal arrangements.

关键词： TCP (tidal current power) renewable energy interference effect rotor CWC (circulation water channel) CFD (computational fluid dynamics)

Current management of hepatocellular carcinoma:An Eastern perspective

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World Journal of Gastroenterology 2015年第13期21卷 3826-3842页

作者： Hyung Joon yim Sang Jun Suh Soon ho Um Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Ansan HospitalAnsan-si 425-707Gyeonggi-doSouth Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Anam HospitalKorea University College of MedicineSeoul 136-705South Korea

Hepatocellular carcinoma(HCC) is one of the leading causes of cancer death, especially in Eastern areas. With advancements in diagnosis and treatment modalities for HCC, the survival and prognosis of HCC patients are improving. however, treatment patterns are not uniform between areas despite efforts to promote a common protocol. Although many hepatologists in Asian countries may adopt the principles of the Barcelona Clinic Liver Cancer staging system, they are also independently making an effort to expand the indications of each treatment and to combine therapies for better outcomes. Several expanded criteria for liver transplantation in HCC have been developed in Asian countries. Living donor liver transplantation is much more commonly performed in these countries than deceased donor liver transplantation, and it may be preceded by other treatments such as the down-staging of tumors. Local ablation therapies are often combined with transarterial chemoembolization( TACE) and the outcome is comparable to that of surgical resection. The indications of TACE are expanding, and there are new types of transarterial therapies. Although data on drug-eluting beads, TACE, and radioembolization in Asian countries are still relatively sparse compared with Western countries, these methods are gradually gaining popularity because of better tolerability and the possibility of improved response rates. Hepatic arterial infusion chemotherapy and radiotherapy are not included in Western guidelines, but are currently being used actively in several Asian countries. For more advanced HCCs, appropriate combinations of TACE, radiotherapy, and sorafenib can be considered, and emerging data indicate improved outcomes of combination therapies compared with single therapies. To include these paradigm shifts into newer treatment guidelines, more studies may be needed, but they are certainly in progress.

关键词： Hepatocellular carcinoma Eastern Treatment Guideli

Robust digital receiver for EPC sensor network

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Journal of Systems Engineering and Electronics 2013年第1期24卷 44-51页

作者： Cheng jin Sung ho Cho Department of Electronics and Computer Engineering Hanyang University

A robust digital receiver based on a matched filter （MF） is proposed for the radio frequency identification （RFID） reader system to enhance the reliability of signal processing in the electronic product code （EPC） sensor network （ESN）. The performance of the proposed receiver is investigated by examining the anti-collision algorithm in the EPC global Class1 Generation2 protocol. The validity and usefulness are demonstrated by both computer simulations and experiments. Based on the verification results, comparing with the conventional zero crossing detector （ZCD） based receiver, the proposed receiver is very robust against strong amplitude distortions and considerable frequency deviations happening on the backscattered signal from a passive tag.

关键词： electronic product code (EPC) sensor network (ESN) signal distortion matched filter radio frequency identification (RFID) receiver.

Flow Visualization and Performance Measurements of a Flagellar Propeller

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Journal of Bionic Engineering 2012年第3期9卷 322-329页

作者： Hyejin Jeon Yoon-Cheol Kim Dongwook yim Jung Yui Yoo Songwan jin School of Mechanical and Aerospace Engineering Seoul National University Seoul 151-744 Korea Department of Mechanical Engineering Korea Polytechnic University Siheung-si Gyeonggi-do 429-793 Korea

A new type of propeller that is optimized for low Reynolds numbers is required to propel a small object in a medium where the flow is dominated by viscous rather than inertial forces. A propeller in the shape of a bacterial flagellum seems an appro- priate choice for driving a small object. Accordingly, in this study, we visualized the velocity field induced by a spring-like propeller inspired by the Escherichia coli flagellum, using a macroscopic model and applying stereoscopic particle image velocimetry. We also experimentally evaluated the effect of pitch and rotational speed on the performance of this flagellar propeller. Silicone oil, which has a kinematic viscosity 100,000 times that of water, was used as the working fluid to generate a low Reynolds number for the macroscopic model. Thrust, torque, and velocity were measured as functions of pitch and rota- tional speed, and the efficiency of the propeller was calculated from the measured results. We found that the flagellar propeller reached a max!mum efficiency when the pitch angle was approximately 53°. Compared to pitch, rotational speed had a relatively small effect on the efficiency, and the pitch altered the flow pattern behind the rotating propeller.

关键词： flagellar propeller stereoscopic PIV bacterial flagellum small swimming object