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人脐带间充质干细胞在膝骨关节炎治疗中的研究进展

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协和医学杂志 2025年第1期16卷 75-82页

作者：龚瑾张进进陈立力王辉邢颜超新疆医科大学研究生院乌鲁木齐830054 新疆军区总医院输血科乌鲁木齐830099

膝骨关节炎(knee osteoarthritis,KOA)是一种常见的膝关节退行性疾病,病理特征为滑膜炎症、软骨丢失等,常表现为关节疼痛和活动功能受限,严重影响患者的生活质量。传统治疗手段,如药物注射和手术干预,主要致力于缓解症状,对于软骨的修... 详细信息

膝骨关节炎(knee osteoarthritis,KOA)是一种常见的膝关节退行性疾病,病理特征为滑膜炎症、软骨丢失等,常表现为关节疼痛和活动功能受限,严重影响患者的生活质量。传统治疗手段,如药物注射和手术干预,主要致力于缓解症状,对于软骨的修复效果有限。人脐带间充质干细胞(human umbilical cord mesenchymal stem cells,hUC-MSCs)因具有抗炎和软骨再生能力,成为治疗KOA的新希望。本文结合国内外最新研究成果,对临床中应用hUC-MSCs治疗KOA的理论依据、研究设计及疗效评价进行论述,同时围绕hUC-MSCs临床应用中面临的问题,以及未来需攻克的方向展开探讨,以期为临床应用hUC-MSCs治疗KOA提供理论支持。

关键词：人脐带间充质干细胞膝骨关节炎软骨再生

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Complex Wave Solutions for (2+1)-Dimensional Modified Dispersive Water Wave System

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Communications in Theoretical Physics 2009年第7期52卷 17-22页

作者： LIANG jin-Fu gong Lun-Xun School of Physics and Electronic Science Guizhou Normal University Guiyang 550001 China

The extended Riccati mapping approach^[1] is further improved by generalized Riccati equation, and combine it with variable separation method, abundant new exact complex solutions for the （2＋1）-dimensional modified dispersive water-wave （MDWW） system are obtained. Based on a derived periodic solitary wave solution and a rational solution, we study a type of phenomenon of complex wave.

关键词： MDWW system generalized Riccati equation variable separation method complex wave

The Production of Pseudo Goldstone Boson in Top Quark Rare Decay

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Communications in Theoretical Physics 2002年第5期38卷 566-570页

作者： HUANG jin-Shu LU gong-Ru Department of Physics Henan Nanyang Normal College Nanyang 473061 China Department of Physics Henan Normal University Xinxiang 453002 China

We calculate the flavor changing t → cπ0 decay in the framework of the topcolor assisted multiscaletechnicolor model. We find that (a) the branching ratio of t → cπ0 is insensitive to mπ, mπs and mπt, while it increasesquickly as ε increases; (b) for reasonable ranges of the parameters, the maximum of the branching ratio in this modelmay reach 7 × 10-6, seven orders larger compared to the one t → cH0 calculated in the standard model. This mightprovide an opportunity to detect the rare decay of the top quark in experiments.

关键词： branching ratio, rare decay of the top quark, pseudo Goldstone boson, technicolor

Parametric formulae for axial stiffness of CHS X-joints subjected to brace axial tension

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第2期12卷 121-130页

作者： Guo-zhi QIU jing-hai gong jin-cheng ZHAO Department of Civil Engineering Shanghai Jiao Tong University Shanghai 200240 China

Recent research has shown that circular hollow section(CHS) joints may exhibit non-rigid behavior under axial load or bending. The non-rigid behavior significantly affects the mechanical performance of structures. This paper is concerned with the parametric formulae for predicting axial stiffness of CHS X-joints while braces are in tension. The factors influencing the axial stiffness of CHS X-joints under brace axial tension are investigated,including the joint geometric parameters,the axial force of the chord,and bending moments of braces in two directions,etc. Effects of various parameters on axial stiffness of CHS X-joints are examined by systematic single-parameter nonlinear analysis using shell finite element methods. The analysis is implemented in a finite element code,ANSYS. The observed trends form the basis of the formulae for calculating the joint axial stiffness under brace axial tension by multivariate regression technique. In order to simplify the formulae,two non-dimensional variables are introduced. The proposed formulae can be used to calculate the joint axial stiffness in the design of single-layer steel tubular structures.

关键词： Joint stiffness Brace tension Parametric analysis Stiffness formula

FLUORINATED PHTHALAZINONE-CONTAINING COPOLYIMIDES FOR PASSIVE OPTICAL WAVEGUIDES

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Chinese Journal of Polymer Science 2005年第1期23卷 71-74页

作者： jin-yanWang gong-xiongLiao YuanSong Shu-deXiao Xi-gaoJian DepartmentofPolymerMaterialsandScience DalianUniversityofTechnologyDalian116012China

A series of fluorinated copolyimides containing phthalazinone moieties were prepared from 2,2-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride(6FDA),3,3'4,4'-benzophenone-tetracarboxylic dianhydride(BPDA)and2-(4-aminophenyl)-4-[4-(4-aminophenoxyl)phenyl]-2,3-phthalazin-1-one(DHPZ-2NH_2)for making polymeric *** resulting copolymers containing 0-50 mo1% BPDA/DHPZ-2NH_2 show good solubility and are soluble insome organic polar aprotic *** copolyimides also present excellent thermal *** polymers possess highglass transition temperature higher than 603 K and high decomposition temperature above 742 K determined by differentialscanning calorimetry and thennogravimetric analysis,respectively,under a nitrogen *** refractive indicescould be controlled by varying the ratio of 6FDA and BPDA in the copolymer from 0.5 to 1.0,and the in-plane refractiveindices(n_(TE))range from 1.6366 to 1.6668 and the out-of-plane refractive indices(n_(TM))from 1.6024 to 1.6280 at 632.8 *** polymers birefringence(0.0342-0.0388)is almost independent of the 6FDA content of copolymer,which indicated thatthe phthalazinone-containing copolyimides could be suitable to fabricate optical waveguides possessing a low polarizationdependent loss(PDL).

关键词： Polymeric optical waveguides Fluorinated polyimides Phthalazinone.

Oxidation behavior of low-grade vanadiferous titanomagnetite concentrate with high titanium

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Journal of Iron and Steel Research International 2024年第2期31卷 329-341页

作者： jin-sheng Liu Zhen-xing Xing gong-jin Cheng Xue-yong Ding Xiang-xin Xue School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina Liaoning Key Laboratory of Recycling Science for Metallurgical Resources Shenyang110819LiaoningChina Innovation Research Institute of Vanadium and Titanium Resource Industry Technology Northeastern UniversityShenyang110819LiaoningChina

In order to clarify the oxidation mechanisms and make better use of the low-grade vanadiferous titanomagnetite concentrate with high titanium(LVTC),the oxidation behavior of LVTC was *** results showed that oxidation degree was achieved within 90 min when temperature was not lower than 700°C,and the main phases of the oxidized LVTC consisted of Fe9TiO15,Fe2O3,CaSiTiO5 and a small amount of *** temperature is favorable to the formation of *** surface of LVTC gradually becomes rough,with fine particles of needle-like and granular shape appearing on the surface,which finally turn from laminar to creamy,spread out,and are interspersed with many tiny *** phase oxidation paths in LVTC were as follows:(1)Fe2.75Ti0.25O4→Fe9TiO15+Fe2O3;(2)Fe2.75Ti0.25O4→Fe2O3+FeTiO3→Fe2TiO5;(3)FeTiO3→Fe2O3+Fe2Ti3O9→*** is predominantly mesoporous whether oxidized or not,with the pores mainly distributed in the range of 2–40 nm,and the specific surface area of LVTC decreases significantly with increasing temperature.

关键词： Low-grade vanadiferous titanomagnetite concentrate Oxidation degree Phase transformation Micromorphology Oxidation path Pore structure

Effect of diboron trioxide on the crushing strength and smelting mechanism of high-chromium vanadium–titanium magnetite pellets

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International Journal of Minerals,Metallurgy and Materials 2017年第11期24卷 1228-1240页

作者： gong-jin Cheng Zi-xian Gao He Yang Xiang-xin Xue School of Metallurgy Northeastern University Shenyang 110819 China Liaoning Key Laboratory of Recycling Science for Metallurgical Resources Shenyang 110819 China

The effect of diboron trioxide(B_2O_3) on the crushing strength and smelting mechanism of high-chromium vanadium–titanium magnetite pellets was investigated in this work. The main characterization methods were X-ray fluorescence, inductively coupled plasma–atomic emission spectroscopy, mercury injection porosimetry, X-ray diffraction, metallographic microscopy, and scanning electron microscopy–energy-dispersive X-ray spectroscopy. The results showed that the crushing strength increased greatly with increasing B_2O_3 content and that the increase in crushing strength was strongly correlated with a decrease in porosity, the formation of liquid phases, and the growth and recrystallization consolidation of hematite crystalline grains. The smelting properties were measured under simulated blast furnace conditions; the results showed that the smelting properties within a certain B_2O_3 content range were improved and optimized except in the softening stage. The valuable element B was easily transformed to the slag, and this phenomenon became increasingly evident with increasing B_2O_3 content. The formation of Ti(C,N) was mostly avoided, and the slag and melted iron were separated well during smelting with the addition of B_2O_3. The size increase of the melted iron was consistent with the gradual optimization of the dripping characteristics with increasing B_2O_3 content.

关键词： high-chromium vanadium–titanium magnetite pellets diboron trioxide crushing strength smelting mechanism

Regulation of surface carbides on palladium nanocubes with zeolitic imidazolate frameworks for propyne selective hydrogenation

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Nano Research 2021年第5期14卷 1559-1564页

作者： Linzhong Wu Mingyu Chu jin gong Muhan Cao Yu Liu Yong Xu Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversityNo.199 Ren’ai RoadSuzhou215123China Guangzhou Key Laboratory of Low-Dimensional Materials and Energy Storage Devices Collaborative Innovation Center of Advanced Energy MaterialsSchool of Materials and EnergyGuangdong University of TechnologyGuangzhou510006China

The selective hydrogenation of propyne to propylene has attracted great attention in chemical industry for removing trace amount of propyne for producing polymer-grade propylene. As the state-of-the-art catalyst, Pd suffers from the disadvantage of poor propylene selectivity due to the over-hydrogenation of propylene to propane. We here demonstrate that Pd nanocubes (NCs) coated by zeolitic imidazolate frameworks (i.e., Pd NCs@ZIF-8) can serve as highly active and selective catalysts for propyne selective hydrogenation (PSH). Benefitting from the unique properties and abundant groups of ZIF-8, Pd carbide (Pd-C) is formed on the surface of Pd NCs after thermal treatment, which acts the active sites for PSH to propylene. More importantly, the content of Pd-C can be precisely controlled by altering the calcination temperature without aggregation of Pd NCs and obvious changes in the framework of ZIF-8. The formation of Pd-C on Pd NCs@ZIF-8 can strongly suppress the H2 adsorption, and thus selectively catalyze propyne to propylene. Consequently, the optimized catalyst (i.e., Pd NCs@ZIF-8-100) exhibits a propylene selectivity of 96.4% at a propyne conversion of 93.3% at 35 °C and atmospheric pressure. This work may not only provide an efficient catalyst for PSH, but also shed a new light on the catalytic application of ZIFs.

关键词： propyne selective hydrogenation Pd nanocubes zeolitic imidazolate frameworks core-shell nanostructures Pd carbide

A geochemical investigation of the free and carbonate-bound organic matter in the clay-sized fraction of argillaceous source rocks and its significance for biogenic interpretation

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Petroleum Science 2018年第4期15卷 681-694页

作者： Yue Zhao jin-gong Cai Tian-Zhu Lei Yan Yang Research Institute of Petroleum Exploration and Development Beijing 100083China State Key Laboratory of Marine Geology Tongji University Shanghai 200092China Key Laboratory of Petroleum Resources Research Institute of Geology and GeophysicsChinese Academy of SciencesLanzhou 730000GansuChina Jidong Oil Company PetroChinaTangshan 063004HebeiChina

The molecular composition and biomarker distribution of various occurrences of organic matter in argillaceous source rocks developed in fresh and saline lacustrine environments were revealed by successive treatments of solvent extraction followed by acid hydrolysis using gas chromatography–mass spectrometry. The free fraction obtained by solvent extraction provided abundant geochemical information concerning the sedimentary environment, thermal maturity and biogenic origin, and obvious differences existed between fresh and saline lacustrine source rock samples. Our research results indicate that the carbonate-mineral-bound(CM-bound) fraction released by successive acid hydrolysis could also serve as a significant biogenic indicator, as the bicyclic sesquiterpenoids, indicative of Botryococcus braunii origin, were specifically detected in quite high abundance in the acid-soluble fraction. In addition, the light end hydrocarbons were much better preserved in the acid-soluble fraction, and elemental sulfur was only detected in the CM-bound fraction, suggesting a relatively confined environment for the CM-bound fraction, which thus could preserve additional geochemical information compared to that of the free fraction. The CM-bound fraction also exhibited discernable differences between fresh and saline lacustrine samples. Therefore, it can be concluded that comprehensive analysis of free and CM-bound fractions in the argillaceous source rocks can provide a more authentic and objective interpretation of geologic conditions.

关键词： Argillaceous source rock Occurrence Free fraction CM-bound fraction Bicyclic sesquiterpenoids Botryococcus braunii Biogenic significance