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Comparison of Ex‑PRESS implantation versus trabeculectomy combined with phacoemulsification in primary open‑angle glaucoma:a retrospective in vivo confocal microscopy study

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Eye and Vision 2024年第2期10卷 1-11页

作者： Yuqiao Zhang Beiting He Yulin Zhang jin zeng Yanlei Chen Yongyi Niu Honghua Yu Yongjie Qin Hongyang Zhang Department of Ophthalmology Guangdong Eye InstituteGuangdong Academy of Medical SciencesGuangdong Provincial People’s HospitalNo.106 Zhongshan Er RoadGuangzhou 510080China Shantou University Medical College ShantouChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhouChina Department of Ophthalmology School of MedicineSouth China University of TechnologyGuangzhouChina

Background:To compare the efficacy of Ex-PRESS implantation versus trabeculectomy combined with ***:A retrospective 12-month study on patients with coincident primary open-angle glaucoma(POAG)and *** patients underwent combined phacoemulsification and Ex-PRESS implant(Phaco-ExPRESS,n=35)or phacotrabeculectomy(Phaco-Trab,n=35).The morphological structures of the filtering bleb were examined by slitlamp,anterior segment optical coherence tomography(AS-OCT)and in vivo confocal microscopy(IVCM).Complete success was defined as postoperative intraocular pressure(IOP)<18 mmHg without the use of anti-glaucoma *** success was defined as postoperative IOP<18 mmHg with or without anti-glaucoma *** data were collected preoperatively and postoperatively at 2 weeks,1 month,3 months,6 months,and 12 ***:No significant difference in the variables such as age,IOP and perimetry was found between the groups of Phaco-ExPRESS and *** the one-year postoperative visit for filtering blebs,Phaco-ExPRESS increased the mean area of epithelial microcysts significantly from 0.10±0.05 to 0.20±0.09μm^(2)perμm^(2),while Phaco-Trab decreased the mean area significantly from 0.08±0.04 to 0.04±0.06μm^(2)perμm^(2).Notably,the hyperreflective dots detected by IVCM decreased by 84.9%in Phaco-ExPRESS but increased by 36.3%in *** hyperreflective dots were further identified as neutrophil-and monocyte-like *** number of these cells were negatively correlated with the microcysts area(r=−0.7,P<0.01)but positively associated with the grade of connective tissue(r=0.5,P<0.01).By creating different microstructural changes in the filtering blebs,Phaco-ExPRESS produced a higher complete success rate(84.9%vs.41.2%,P<0.01)and significant decrease in the number of anti-glaucoma medications(P<0.01)when compared with those in ***,the qualified success showed no significant difference between the two groups(

关键词： POAG Ex-PRESS Phacoemulsification Confocal microscopy

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MOF and its derivative materials modified lithium-sulfur battery separator:a new means to improve performance

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Rare Metals 2024年第6期43卷 2418-2443页

作者： Rong-Wei Huang Yong-Qi Wang Dan You Wen-Hao Yang Bin-Nan Deng Fei Wang Yue-jin zeng Yi-Yong Zhang Xue Li National Local Joint Engineering Research Center for Lithium-Ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Batteries Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093China State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Centre of Chemistry for Energy MaterialsState-Province Joint Engineering Laboratory of Power Source Technology for New Energy VehicleEngineering Research Center of Electrochemical TechnologyMinistry of EducationCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

In recent years,lithium-sulfur batteries(LSBs)are considered as one of the most promising new generation energies with the advantages of high theoretical speeific capacity of sulfur(1675 mAh·g^(-1)),abundant sulfur resources,and environmental friendliness storage technologies,and they are receiving wide attention from the ***,the problems of the shuttle effect and lithium dendrite growth in LSBs have limited their practical application,so there is a need to find ways to solve these *** is an excellent choice to use novel materials to modify battery *** those novel materials,the metal-organic framework(MOF)has the properties of regular pores and controllable *** applied as a positive electrode and diaphragm,it can restrain the shuttle effect and lithium dendrite growth,especially since it shows excellent performance in diaphragm ***,various design strategies and synthesis methods of MOF-modified separators are reviewed in this paper,and the applications of MOF in LSBs separators in different forms are introduced,including the composite of MOF and carbon-based materials,the compounding of MOF and polymer,self-carbonization to form MOF-derived *** the same time,different characterization techniques are systematically reviewed to obtain the physical and chemical properties of MOF particles and the working mechanism of MOF-modified diaphragm,which provides a basis for further research in this ***,some future research trends and directions are put forward to fully tap the future commercial potential of MOF-modified diaphragm in LSBs.

关键词： MOF Lithium-sulfur battery Modified diaphragms Design strategies Prospect Characterization

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Comparative study of anti-inflammatory effects of different processed products through the COX-2/PGE2 signaling pathway: based on network pharmacology and molecular docking

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Pharmacology Discovery 2024年第2期4卷 32-45页

作者： Ping Chen Yun-Yun Quan An-Qi zeng Ying Dai jin zeng Translational Chinese Medicine Key Laboratory of Sichuan Province Sichuan Academy of Chinese Medicine SciencesChengdu 610041China Translational Chinese Medicine Key Laboratory of Sichuan Province Sichuan Institute for Translational Chinese MedicineChengdu 610041China

Background:Radix Aconiti Lateralis Preparata(Fu-zi)is a traditional Chinese medicinal herb,which has been widely used in the clinic and has potent anti-inflammatory *** aimed to explore the mechanisms of extract containing alkaloids from different Fu-zi Processed Products(FPP)in treating inflammation,especially rheumatoid arthritis(RA).Methods:Firstly,using network pharmacology technology,the ingredients,and targets of Fu-zi were obtained by searching and screening,the targets involving RA were acquired,the intersection targets were constructed a"component-target-pathway"network.A comprehensive investigation was conducted on the anti-rheumatoid arthritis mechanisms of 5 FPPs in lipopolysaccharide(LPS)induced RAW264.7 cells,which serve as a model for *** production of NO and inflammatory cytokines were measured by ELISA *** Real-time PCR(qRT-PCR)was utilized to measure the mRNA ***-2/PGE2 signaling pathway-associated proteins were determined by western ***:According to a network pharmacological study,16 chemical components and 43 common targets were found in Fu-zi and 6 key targets including PTGS2 were closely related to the mechanism of Fu-zi in treating *** in vitro study revealed that the levels of NO,TNF-α,and IL-1βwere substantially decreased by the 5 *** 5 FPPs significantly suppressed the expression of proteins COX-2,iNOS,and NF-κB,with particularly notable effects observed for PFZ and ***:Altogether,these results demonstrated that the 5 PPS containing alkaloids have a good anti-RA-related inflammatory effect,and the mechanism may be related to COX-2/PGE2 signaling pathway,particularly,Fu-zi prepared utilizing a traditional Chinese technique.

关键词： Radix Aconiti Lateralis Preparata(Fu-zi) rheumatoid arthritis anti-inflammatory network pharmacology COX-2/PGE2 signaling pathway

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Accurate prediction of myopic progression and high myopia by machine learning

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Precision Clinical Medicine 2024年第1期7卷 14-20页

作者： Jiahui Li Simiao zeng Zhihuan Li Jie Xu Zhuo Sun jing Zhao Meiyan Li Zixing Zou Taihua Guan jin zeng Zhuang Liu Wenchao Xiao Ran Wei Hanpei Miao Ian Ziyar Junxiong Huang Yuanxu Gao Yangfa zeng Xing-Tao Zhou Kang Zhang Guangzhou Women and Children's Medical Center Guangzhou Medical UniversityGuangzhou 510120China Guangzhou National Laboratory Guangzhou 510o0oChina Zhuhai International Eye Center of the First Affiliated Hospital of Faculty of Medicine Macao University of Science and TechnologyZhuhai 519000China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100069China Key Laboratory of Myopia Ministry of HealthShanghai Key Laboratory of Visual Impairment and RestorationDepartment of OphthalmologyEye InstituteEye and EarNoseand Throat HospitalFudan UniversityShanghai 200031China DongguanPeople's Hospital The First School of Clinical MedicinelSouthern Medical UniversityDongguan 523059China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Wenzhou Eye Hospital and Institute for Advanced Study on Eye Health and Diseases Wenzhou Medical UniversityWenzhou 32500oChina

Background Myopia is a leading cause of visual impairment in Asia and ***,accurately predicting the progression of myopia and the high risk of myopia remains a *** study aims to develop a predictive model for the development of *** We first retrospectively gathered 612530 medical records from five independent cohorts,encompassing 227543 patients ranging from infants to young ***,we developed a multivariate linear regression algorithm model to predict the progression of myopia and the risk of high *** The model to predict the progression of myopia achieved an R^(2) value of 0.964 vs a mean absolute error(MAE)of 0.119D[95%confidence interval(CI):0.119,1.146]in the internal validation *** demonstrated strong generalizability,maintaining consistent performance across external validation sets:R^(2)=0.950 vs MAE=0.119D(95%CI:0.119,1.136)in validation study 1,R^(2)=0.950 vs MAE=0.121D(95%CI:0.121,1.144)in validation study 2,and R^(2)=0.806 vs MAE=−0.066D(95%CI:−0.066,0.569)in the Shanghai Children Myopia *** the Beijing Children Eye Study,the model achieved an R^(2) of 0.749 vs a MAE of 0.178D(95%CI:0.178,1.557).The model to predict the risk of high myopia achieved an area under the curve(AUC)of 0.99 in the internal validation set and consistently high area under the curve values of 0.99,0.99,0.96 and 0.99 in the respective external validation *** Our study demonstrates accurate prediction of myopia progression and risk of high myopia providing valuable insights for tailoring strategies to personalize and optimize the clinical management of myopia in children.

关键词： myopia progression machine learning prevention precision medicine

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Prognositic value of anoikis and tumor immune microenvironment-related gene in the treatment of osteosarcoma

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中南大学学报（医学版） 2024年第5期49卷 758-774页

作者： WANG Dong DENG Qing PENG Yi TONG Zhaochen LI Zixin HUANG Liping zeng jin LI jinsong MIAO jinglei CHEN Shijie Department of Spine Surgery Third Xiangya HospitalCentral South UniversityChangsha 410013 Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China

Objective:Osteosarcoma is a highly aggressive primary malignant bone tumor commonly seen in children and adolescents,with a poor ***-dependent cell death(anoikis)has been proven to be indispensable in tumor metastasis,regulating the migration and adhesion of tumor cells at the primary ***,as a type of programmed cell death,anoikis is rarely studied in osteosarcoma,especially in the tumor immune *** study aims to clarify prognostic value of anoikis and tumor immune microenvironment-related gene in the treatment of ***:Anoikis-related genes(ANRGs)were obtained from *** information and ANRGs expression profiles of osteosarcoma patients were sourced from the therapeutically applicable research to generate effective therapies and Gene Expression Omnibus(GEO)*** highly associated with tumor immune microenvironment were identified by the estimate package and the weighted gene coexpression network analysis(WGCNA)*** learning algorithms were performed to construct long-term survival predictive strategy,each sample was divided into high-risk and low-risk subgroups,which was further verified in the GEO ***,based on single-cell RNA-seq from the GEO database,analysis was done on the function of signature genes in the osteosarcoma tumor ***:A total of 51 hub ANRGs closely associated with the tumor microenvironment were identified,from which 3 genes(MERTK,BNIP3,S100A8)were selected to construct the prognostic *** differences in immune cell activation and immune-related signaling pathways were observed between the high-risk and low-risk groups based on tumor microenvironment analysis(all P<0.05).Additionally,characteristic genes within the osteosarcoma microenvironment were identified in regulation of intercellular crosstalk through the GAS6-MERTK signaling ***:The prognostic model based on ANRGs and tumor microenvironment

关键词： anoikis tumor immune microenvironment bioinformatics prognosis osteosarcoma

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Deep learning-based multi-modal data integration enhancing breast cancer disease-free survival prediction

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Precision Clinical Medicine 2024年第2期7卷 132-145页

作者： Zehua Wang Ruichong Lin Yanchun Li jin zeng Yongjian Chen Wenhao Ouyang Han Li Xueyan Jia Zijia Lai Yunfang Yu Herui Yao Weifeng Su Guangdong Key Laboratory of Cross-Application of Data Science and Technology Beijing Normal University-Hong Kong Baptist University United International CollegeZhuhai 519087China Faculty of Innovation Engineering Macao University of Science and TechnologyTaipaMacao 999078China Department of Computer and Information Engineering Guangzhou Huali CollegeGuangzhou 511325China Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Guangzhou National Laboratory Guangzhou 510005China Dermatology and Venereology Division Department of Medicine SolnaCenter for Molecular MedicineKarolinska InstitutetStockholm 17177Sweden Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Medical OncologyBreast Tumor CentrePhase I Clinical Trial CentreSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China The Second Clinical Medical College Southern Medical UniversityGuangzhou 510515China Faculty of Medicine Macao University of Science and TechnologyTaipaMacao 999078China

Background:The prognosis of breast cancer is often unfavorable,emphasizing the need for early metastasis risk detection and accurate treatment *** study aimed to develop a novel multi-modal deep learning model using preoperative data to predict disease-free survival(DFS).Methods:We retrospectively collected pathology imaging,molecular and clinical data from The Cancer Genome Atlas and one independent institution in *** developed a novel Deep Learning Clinical Medicine Based Pathological Gene Multi-modal(DeepClinMed-PGM)model for DFS prediction,integrating clinicopathological data with molecular *** patients included the training cohort(n=741),internal validation cohort(n=184),and external testing cohort(n=95).Result:Integrating multi-modal data into the DeepClinMed-PGM model significantly improved area under the receiver operating characteristic curve(AUC)*** the training cohort,AUC values for 1-,3-,and 5-year DFS predictions increased to 0.979,0.957,and 0.871,while in the external testing cohort,the values reached 0.851,0.878,and 0.938 for 1-,2-,and 3-year DFS predictions,*** DeepClinMed-PGM's robust discriminative capabilities were consistently evident across various cohorts,including the training cohort[hazard ratio(HR)0.027,95%confidence interval(CI)0.0016-0.046,P<0.0001],the internal validation cohort(HR 0.117,95%CI 0.041-0.334,P<0.0001),and the external cohort(HR 0.061,95%CI 0.017-0.218,P<0.0001).Additionally,the DeepClinMed-PGM model demonstrated C-index values of 0.925,0.823,and 0.864 within the three cohorts,***:This study introduces an approach to breast cancer prognosis,integrating imaging and molecular and clinical data for enhanced predictive accuracy,offering promise for personalized treatment strategies.

关键词： breast cancer multi-modality deep learning pathological disease-free survival

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基于复杂环境的城市5G移动网络优化设计

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移动信息 2024年第2期46卷 1-3,15页

作者：曾进中国电子科技集团公司第二十八研究所南京210007

随着科学技术的快速发展,信息化技术被全面普及到日常生活中,人们对移动通信提出了更高的要求,这促使了移动通信由传统网络向5G网络发展,以全面增强移动网络的通信能力,给人们带来便捷的上网体验。但在应用无线网络的过程中,其存在各种... 详细信息

随着科学技术的快速发展,信息化技术被全面普及到日常生活中,人们对移动通信提出了更高的要求,这促使了移动通信由传统网络向5G网络发展,以全面增强移动网络的通信能力,给人们带来便捷的上网体验。但在应用无线网络的过程中,其存在各种问题,如受到5G超高频段组网限制,降低了其穿透能力和绕射能力,加上小基站大规模布局难度较高,楼宇建筑结构过于复杂,导致室内常出现深度覆盖不足甚至无覆盖的问题。基于此,文中以复杂城市环境为主要研究对象,概述了5G移动网络技术,分析了5G移动网络的应用现状,规范了城市复杂环境下5G移动网络的优化设计思路,并提出了合理的优化措施,构建了健全的网络评估模型,以充分发挥5G移动网络的作用。

关键词： 5G 网络优化覆盖增强上行载波聚合干扰控制

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现代金融倾斜服务业发展的研究方向与实践探析

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市场周刊 2024年第17期37卷 56-59页

作者：曾进南京浦口康和物业管理有限公司江苏南京210000

文章深入分析了现代金融在推动服务业发展中的关键作用及其实施政策。通过对比国内外金融支持服务业的成功案例,揭示了金融创新与服务业融合的最佳实践。研究指出,金融政策的优化调整、金融产品与服务的创新是服务业增长的重要驱动力。... 详细信息

文章深入分析了现代金融在推动服务业发展中的关键作用及其实施政策。通过对比国内外金融支持服务业的成功案例,揭示了金融创新与服务业融合的最佳实践。研究指出,金融政策的优化调整、金融产品与服务的创新是服务业增长的重要驱动力。文章还讨论了面对全球化挑战时,如何通过金融工具和机制促进服务业的可持续发展。最后,提出了加强金融基础设施建设、提高金融服务效率与质量、促进金融与服务业深度融合的策略建议。

关键词：金融创新服务业发展政策优化可持续增长

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市场经济视角下物业管理模式创新研究

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市场周刊 2024年第14期37卷 21-24页

作者：曾进南京浦口康和物业管理有限公司江苏南京210000

文章从市场经济的视角出发,对物业管理模式进行深入研究,旨在揭示物业管理行业在市场经济条件下的发展现状,并探索物业管理模式创新的有效途径。首先,利用“互联网+”的策略,可以有效丰富物业管理服务的内容,适应现代社会对物业服务多... 详细信息

文章从市场经济的视角出发,对物业管理模式进行深入研究,旨在揭示物业管理行业在市场经济条件下的发展现状,并探索物业管理模式创新的有效途径。首先,利用“互联网+”的策略,可以有效丰富物业管理服务的内容,适应现代社会对物业服务多样化和高效化的需求;其次,全面而切实地提升物业服务人员的专业能力和服务素质,是确保高质量物业服务的关键;再次,积极推动物业服务向更专业化方向发展,以提升行业竞争力;最后,根据市场的供需关系合理设定物业管理的收费标准,寻找优化物业管理模式的经济杠杆。这些措施的实施,在推动物业管理行业市场化水平提升的同时,也能够实现物业服务供需双方的共赢,为物业管理行业的健康发展提供坚实的基础。

关键词：市场经济物业管理服务

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Molecular Oxygen Abundance in Galactic Massive Star Formation Regions Based on SWAS Observations

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Research in Astronomy and Astrophysics 2024年第9期24卷 85-100页

作者： Bing-Ru Wang Di Li Paul F.Goldsmith jingwen Wu Chao-Wei Tsai Donghui Quan Xia Zhang Junzhi Wang Gary J.Melnick jin-zeng Li Gary A.Fuller jinjin Xie National Astronomical Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Tsinghua University Research Center for Astronomical Computing Zhejiang Laboratory Jet Propulsion Laboratory California Institute of Technology Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Xinjiang Astronomical Observatory Chinese Academy of Sciences Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi University Center for Astrophysics Harvard&Smithsonian60 Garden Street Jodrell Bank Center for Astrophysics Department of Physics&AstronomyUniversity of Manchester I.Physikalisches Institut University of Cologne

Molecular oxygen abundance is a key parameter in understanding the chemical network of the interstellar *** estimate the molecular oxygen column density and abundance for a sample of Galactic massive star formation regions based on observations from the Submillimiter Wave Astronomy Satellite （SWAS） *** obtained an averaged O2spectrum based on this sample using the （SWAS） survey data （O2,487.249 GHz,N=3–1,J=3–2）.No emission or absorption feature is seen around the supposed central velocity with a total integration time of ttotal=8.67×10～3hr and an rms noise per channel of 1.45 m *** a kinetic temperature Tkin=30 K,we derive the 3σupper limit of the O2column density to be 3.3×1015cm-2,close to the lowest values reported in Galactic massive star formation regions in previous *** corresponding O2abundance upper limit is6.7×10-8,lower than all previous results based on SWAS observations and is close to the lowest reported value in massive star formation *** a galactic scale,our statistical results confirm a generally low O2abundance for Galactic massive star formation *** abundance is also lower than results reported in extragalactic sources.

关键词： ISM: molecules galaxies: abundances ISM: lines and bands Galaxy: abundances HERSCHEL HIFI OBSERVATIONS CARBON-MONOXIDE ABUNDANCE WAVE-ASTRONOMY-SATELLITE ODIN OBSERVATIONS THERMAL BALANCE UPPER LIMITS CLOUD CORES INTERSTELLAR O-2 SEARCH

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