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Inter-chromosomal insertions into wild-type chromosomes induced by SCRaMbLE

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 125-135页

作者： Sijie Zhou Junyanrui Li Xichen Cui Ying Wang Ying-jin yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Frontiers Research Institute for Synthetic Biology Tianjin UniversityTianjin 300072China

Genomic rearrangements play a crucial role in shaping biological phenotypic diversity and driving species *** chromosome rearrangement and modification by LoxP-mediated evolution(SCRaMbLE)has been applied to explore large-scale genomic rearrangements,yet it has been observed that these rearrangements occur exclusively in genomic regions containing loxPsym ***,we found that SCRaMbLE of synthetic yeast harboring synthetic chromosome V and X can generate a variety of synthetic segment insertions into wild-type chromosomes,ranging from 1 to 300 ***,it was revealed that the novel insertions impacted the transcriptional level of neighboring regions and affected the production of exemplar pathway of ***,our results improve the understanding of the ability of SCRaMbLE to generate complex structural variations in nonsynthetic regions and provide a potential model to explore genomic transposable events.

关键词： genomic rearrangements synthetic yeast genome SCRaMbLE inter-chromosomal insertions synthetic biology

Transient self-assembly driven by chemical fuels

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ChemPhysMater 2024年第1期3卷 1-23页

作者： Ling Wang jin yuan jingcheng Hao Key Laboratory of Colloid and Interface Chemistry Shandong UniversityMinistry of EducationJinan 250100China School of Chemistry and Chemical Engineering Qilu Normal UniversityJinan 250200China

Self-assembly has been extensively studied in chemistry,physics,biology,and materials engineering and has become an important“bottom-up”approach in creating intriguing structures for different *** dissipative self-assembly to construct fuel-dependent,energy-consuming,and dynamic nonequilibrium systems is important for developing intelligent life-like ***,dissipative self-assembly has become a research hotspot in materials chemistry,biomedical science,environmental chemistry,and physical *** in-depth understanding of the process and mechanism provides useful insights to the researchers for devel-oping materials using dissipative self-assembly and also helps guide future innovation in material *** critical review comprehensively analyzes various chemical fuel input and energy consumption mechanisms,supported by numerous illustrative *** transient assemblies,including gels,vesicles,micelles,and nanoparticle aggregates,have been systematically studied in our and other *** relationship between the molecular structure of precursors and temporal assemblies in dissipative self-assemblies is discussed from the perspective of physical *** dissipative self-assembly methods to construct functional assemblies provides important implications for constructing high-energy,nonequilibrium,and intelligent functional materials.

关键词： Self-Assembly Chemical Fuel Consumption mechanisms Functional assemblies

Research Progress in the Fabrication of Covalent Organic Framework Membranes for Chemical Separations

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Chinese Journal of Polymer Science 2024年第2期42卷 141-158,I0005页

作者： Cui-Ting Ding jin-Qiu yuan Meng-Ying Xie Qing-yuan Liu Zeng-Guang Yao Shi-Yu Zhang Run-Nan Zhang Hong Wu Zhong-Yi Jiang Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China Zhejiang Institute of Tianjin University NingboZhejiang315201China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China Tianjin Key Laboratory of Membrane Science and Desalination Technology Tianjin UniversityTianjin300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou350207China

Membrane technology has become one of the most promising separation technologies for its energy saving, high separation efficiency, environmental friendliness, and economic feasibility. Covalent organic frameworks(COFs) with intrinsically high porosity, controllable pore size, uniform pore size distribution and long-range ordered channel structure, have emerged as next-generation materials to fabricate advanced separation membranes. This feature article summarizes some latest studies in the development of pure COF membranes in our lab, including their fabrication and applications in chemical separations. Finally, current challenges facing high-performance COF separation membranes are discussed.

关键词： Covalent organic frameworks Covalent organic framework membranes Water treatment Organic solvent nanofiltration Gas separation

Insight into vertical piezoelectric characteristics regulated thermal transport in van der Waals two-dimensional materials

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Rare Metals 2024年第2期43卷 770-779页

作者： Dong-Hai Wei E Zhou jin-yuan Xu Hui-Min Wang Chen Shen Hong-Bin Zhang Zhen-Zhen Qin Guang-Zhao Qin State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha410082China Hunan Key Laboratory for Micro-Nano Energy Materials and Device and School of Physics and Optoelectronics Xiangtan UniversityXiangtan411105China Institute of Materials Science Technical University of DarmstadtAlarich-Weiss-Str.264287DarmstadtGermany School of Physics and Microelectronics Zhengzhou UniversityZhengzhou450001China

The urgent demand of extreme(ultra-high/low)thermal conductivity materials is triggered by the high-power device,where exploring the theories and mechanisms of regulating thermal transport properties plays a key ***,we elaborately investigate the effect of vertical(out-of-plane)piezoelectric characteristics on thermal transport,which is historically *** different stacking-order(AA and AB)bilayer boron nitride(Bi-BN)in two-dimensional(2D)materials are selected as study *** performing state-of-the-art first-principles calculations,it is found that the polarization charge along the out-of-plane orientation ascends significantly with the increasing piezoelectric response in AB stacked Bi-BN(Bi-BN-AB)followed by the enhanced interlayer B–N atomic ***,the amplitude of phonon anharmonicity in Bi-BN-AB increases larger than that in the AA stacked Bi-BN(Bi-BN-AA),resulting in the dramatic weakening of the thermal conductivity by 20.34%under 18%*** research reveals the significant role of the vertical(out-of-plane)piezoelectric characteristic in regulating thermal transport and provides new insight into accurately exploring the thermal transport performance of 2D van der Waals materials.

关键词： Thermal conductivity Piezoelectric effect 2D materials Bilayer BN Strain engineering

Salidroside Ameliorates Lung Injury Induced by PM_(2.5) by Regulating SIRT1-PGC-1αin Mice

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Biomedical and Environmental Sciences 2024年第4期37卷 367-376页

作者： LI Xiao Hong LIU Yu Mei SHAN Hui TAN jin Feng ZHOU Jian SONG yuan jin LI Si Qi LIU Chen XU Dong Qun YU Li LI Wan Wei School of Public Health Shandong Second Medical UniversityWeifang 261053ShandongChina Key Laboratory of Health Inspection and Quarantine Weifang 261053ShandongChina Weifang Environmental Monitoring Station Weifang 261042ShandongChina Department of Orthopedics The 80th Army Hospital of PLAWeifang 261000ShandongChina Environment and Health Related Product Safety Institute of Chinese Center for Disease Control and Prevention Beijing 100021China School of Basic Medicine Shandong Second Medical UniversityWeifang 261053ShandongChina

Objective This study aimed to clarify the intervention effect of salidroside(SAL)on lung injury caused by PM_(2.5) in mice and illuminate the function of SIRT1-PGC-1ɑ*** Specific pathogen-free(SPF)grade male C57BL/6 mice were randomly assigned to the following groups:control group,SAL group,PM_(2.5) group,SAL+PM_(2.5) *** the first day,SAL was given by gavage,and on the second day,PM_(2.5) suspension was given by intratracheal *** whole experiment consist of a total of 10 cycles,lasting 20 *** the end of treatment,blood samples and lung tissues were collected and *** of pathological changes in lung tissue using inverted microscopy and transmission electron *** expression of inflammatory,antioxidants,apoptosis,and SIRT1-PGC-1ɑproteins were detected by Western *** Exposure to PM_(2.5) leads to obvious morphological and pathologica changes in the lung of ***_(2.5) caused a decline in levels of antioxidant-related enzymes and protein expressions of HO-1,Nrf2,SOD2,SIRT1 and PGC-1ɑ,and an increase in the protein expressions of IL-6,IL-1β,Bax,caspase-9 and cleaved ***,SAL reversed the aforementioned changes caused by PM_(2.5) by activating the SIRT1-PGC-1α *** SAL can activate SIRT1-PGC-1ɑ to ameliorate PM2.5-induced lung injury.

关键词： PM_(2.5) Salidroside Oxidative stress Inflammation Apoptosis SIRT1-PGC-1α

The prognostic value of collateral circulation in coronary chronic total occlusion underwent percutaneous coronary intervention

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Journal of Geriatric Cardiology 2024年第2期21卷 232-241页

作者： Xiao-Ying HU Wei-Xian YANG Chang-Dong GUAN Li-Hua XIE Ke-Fei DOU Yong-Jian WU jin-Qing yuan Jie QIAN Yue-jin YANG Shu-Bin QIAO Lei SONG Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina National Clinical Research Center for Cardiovascular Diseases BeijingChina Catheterization Laboratories Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

BACKGROUND The prognostic value of coronary collateral circulation(CC)in patients undergoing chronic total occlusion(CTO)percutaneous coronary intervention(PCI)is *** purpose of the study was to assess the prognostic value of current two CC grading systems and their association with long-term outcomes in patients with CTO underwent *** We consecutively enrolled patients with single-vessel CTO underwent PCI between January 2010 and *** patients were categorized into well-developed or poor-developed collaterals group according to angiographic Werner's CC(grade 2 *** 0–1)or Rentrop(grade 3 *** 0–2)grading *** primary endpoint was 5-year cardiac *** Of 2452 enrolled patients,the overall technical success rate was 74.1%.Well-developed collaterals were present in686 patients(28.0%)defined by Werner's CC grade 2,and in 1145 patients(46.7%)by Rentrop grade *** to Werner's CC grading system,patients with well-developed collaterals had a lower rate of 5-year cardiac death compared with those with poordeveloped collaterals(1.6%vs.3.3%,P=0.02),those with suboptimal recanalization was associated with higher rate of 5-year cardiac death compared with optimal recanalization(4.7%vs.0.8%,P=0.01)and failure patients(4.7%vs.1.6%,P=0.12).However,the similar effect was not shown in Rentrop grading *** In patients with the single-vessel CTO underwent PCI,well-developed collaterals by Werner's CC definition were associated with lower rate of 5-year cardiac ***'s CC grading system had a greater prognostic value than Rentrop grading system in patients with CTO underwent PCI.

关键词： coronary collateral occlusion

Efficient spectral single-pixel imaging via Morton frequency-domain scanning [Invited]

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Chinese Optics Letters 2024年第6期22卷 8-14页

作者： Zi-Dong Zhao Zhao-Hua Yang Zhi-Hao Zhao Ling-An Wu yuan-jin Yu School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Automation MIIT Key Laboratory of Complex-field Intelligent SensingBeijing Institute of TechnologyBeijing 100081China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314019China

Single-pixel imaging (SPI) captures two-dimensional images utilizing a sequence of modulation patterns and measurements recorded by a single-pixel detector. However, the sequential measurement of a scene is time-consuming, especially for high-spatial-resolution imaging. Furthermore, for spectral SPI, the enormous data storage and processing time requirements substantially diminish imaging efficiency. To reduce the required number of patterns, we propose a strategy by optimizing a Hadamard pattern sequence via Morton frequency domain scanning to enhance the quality of a reconstructed spectral cube at low sampling rates. Additionally, we expedite spectral cube reconstruction, eliminating the necessity for a large Hadamard matrix. We demonstrate the effectiveness of our approach through both simulation and experiment,achieving sub-Nyquist sampling of a three-dimensional spectral cube with a spatial resolution of 256×256 pixels and181 spectral bands and a reduction in reconstruction time by four orders of magnitude. Consequently, our method offers an efficient solution for compressed spectral imaging.

关键词： single-pixel imaging spectral imaging optimized Hadamard basis

Botulinum toxin type A in treating early-stage patients with small-angle acute acquired comitant esotropia

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1094-1101页

作者： Run-Ting Ma Die-Wen-Jie Hu Lian-Hong Zhou Wen-Ping Li yuan-jin Li Bei-Xi Yi Department of Ophthalmology Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

AIM:To investigate botulinum toxin A(BTXA)efficacy on small-angle(≤25Δ)acute acquired concomitant esotropia(AACE)in early-stage ***:The electronic medical record data of AACE patients during March 2019 and June 2023 were collected in this retrospective and hospital-based cohort study.A total of 72 small-angle AACE patients received BTXA extraocular muscle *** were grouped by onset-to-treatment time(Group A:≤6mo,Group B:>6mo).Deviation of esotropia,eye alignment and stereopsis were analyzed at the period of pre/post-injection(1wk,1,3,and 6mo).Orthophoria rate at 6mo(horizontal deviation0.05)between two groups except onset-to-treatment time(2mo vs 11mo,P0.05);while in 3 and 6mo Group A was significantly smaller than group B(all P6mo)may reduce BTXA *** BTXA intervention benefits long-term eye alignment and stereopsis recovery.

关键词： acute acquired comitant esotropia botulinum toxin type A stereopsis

Robust,self-adhesive,and low-contact impedance polyvinyl alcohol/polyacrylamide dual-network hydrogel semidry electrode for biopotential signal acquisition

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SmartMat 2024年第2期5卷 67-82页

作者： Guangli Li Ying Liu Yuwei Chen Yonghui Xia Xiaoman Qi Xuan Wan yuan jin Jun Liu Quanguo He Kanghua Li Jianxin Tang Hunan Key Laboratory of Biomedical Nanomaterials and Devices College of Life Sciences and ChemistryHunan University of TechnologyZhuzhouChina Department of Neurology Zhuzhou People's HospitalZhuzhouChina Zhuzhou Institute for Food and Drug Control ZhuzhouChina

Herein,we fabricated a flexible semidry electrode with excellent mechanical performance,satisfactory self-adhesiveness,and low-contact impedance using physical/chemical crosslinked polyvinyl alcohol/polyacrylamide dual-network hydrogels(PVA/PAM DNHs)as an efficient saline *** resultant PVA/PAM DNHs showed admirable adhesive and compliance to the hairy scalp,facilitating the establishment of a robust electrode/skin interface for biopotential signal ***,the PVA/PAM DNHs steadily released trace saline onto the scalp to achieve the minimized potential drift(1.47±0.39 mV/min)and low electrode–scalp impedance(18.2±8.9 kΩ@10 Hz).More importantly,the application feasibility of real-world brain−computer interfaces(BCIs)was preliminarily validated by 10 participants using two classic BCI *** mean temporal cross-correlation coefficients between the semidry and wet electrodes in the eyes open/closed and the N200 speller paradigms are 0.919±0.054 and 0.912±0.050,*** electrodes demonstrate anticipated neuroelectrophysiological responses with similar *** semidry electrode could also effectively capture robust P-QRS-T peaks during electrocardiogram *** their outstanding advantages of fast setup,user-friendliness,and robust signals,the proposed PVA/PAM DNH-based electrode is a promising alternative to wet electrodes in biopotential signal acquisition.

关键词： brain-computer interface dual-network hydrogel electrocardiogram signals electroencephalography signals semidry electrode