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IMP & HIRFL Annual Report 2010年第1期 151-151页

作者： jin xiaodong li qiang dai zhongying

Progress in heavy ion cancer therapy at IMP and future development

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Malignancy Spectrum 2024年第2期1卷 91-98页

作者： qiang li Xinguo liu zhongying dai Pengbo He Yuanyuan Ma Guosheng Shen xiaodong jin Fei Ye Xiaogang Zheng Ting Zhao Hui Zhang Zheng li Bingwen Zou Yuehu Pu Weiqiang Chen Institute of Modern Physics Chinese Academy of SciencesLanzhouGansuChina Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences LanzhouGansuChina Gansu Provincial Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine LanzhouGansuChina University of Chinese Academy of Sciences BeijingChina Division of Thoracic Tumor Multimodality Treatment and Department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuanChina Medical Equipment Innovation Research Center West China HospitalSichuan UniversityChengduSichuanChina

Basic research on heavy ion cancer therapy such as radiobiology, medicalphysics, and therapeutic technique has been conducted at the Institute ofModern Physics (IMP), Chinese Academy of Sciences since 1995. Based on theachievements acquired in the basic research and the requirements for a heavyion accelerator for radiotherapy purposes, a dedicated heavy ion therapy facilitynamed Heavy Ion Medical Machine (HIMM) was designed at IMP andconstructed in Wuwei, China. The HIMM facility consists of two electroncyclotron resonance ion sources, one cyclotron as the injector and onesynchrotron as the main accelerator, and four different treatment roomsequipped with passive or active beam delivery systems, and accelerates carbonions up to 400 MeV/u. After the performance inspection of HIMM organized bythe National Medical Device Inspection Center, preclinical tests like cell andanimal radiobiological experiments and dosimetric verification using anthropomorphicphantoms for elucidating the biophysical properties of the carbon ionbeams provided by HIMM were carried out. According to the Chinese medicaldevice regulations, a clinical trial in which 46 tumor patients were recruited andtwo hospitals participated was conducted in the HIMM facility, aiming atevaluating the treatment safety and short-term efficacy of the medical *** success of the clinical trial helped the HIMM facility be authorized by theChinese government as a class III medical device. In this paper, all the aspectsmentioned above are introduced and discussed, and implications for futureimprovements are also given.

关键词： heavy ion cancer therapy clinical trial performance inspection dosimetric verification medical device

3 - 61 Test of a Ridge Filter with 4 cm SOBP in Heavy Ion Therapy Terminal at HIRFL-CSR

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IMP & HIRFL Annual Report 2010年第1期 159-160页

作者： liu Xinguo li qiang jin xiaodong Wu Qingfeng dai zhongying

Bystander Effect in HepG2 Cells Caused by Medium Transfers at Different Times afer High-LET Carbon Ion Irradiation

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 148-149页

作者： Wu Qingfeng li qiang jin xiaodong liu Xinguo dai zhongying

3 - 56 Proteomic Analysis of Heavy Ion Induced Bystander Effect in HepG2 Cells

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IMP & HIRFL Annual Report 2010年第1期 153-154页

作者： Wu Qingfeng li qiang li Ping jin xiaodong liu Xinguo dai zhongying

A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by High-LET Radiation

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 149-150页

作者： jin xiaodong li qiang li Ping Wu Qingfeng liu Xinguo dai zhongying

Therapeutic Beam Tests and Pre-clinical Experiments in Deep-seated Tumor Heavy-ion Therapy Terminal at HIRFL-CSR

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2008年第1期 88-89页

作者： li qiang dai zhongying liu Xinguo Wu Qingfeng jin xiaodong li Ping Tao Jiajun

Reducing Distal Dose Fall-off by Combination of Two Different Mini Ridge Filters in Ion Beam Therapy

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 143-144页

作者： liu Xinguo li qiang dai zhongying Ye Fei jin xiaodong Wu Qingfeng li Ping

Guidelines of Physical and Technological Quality Assurance for Carbon Ion Therapy

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IMP & HIRFL Annual Report 2019年第1期 147-148页

作者： dai zhongying li qiang 不详

Institute's medical physics researchers have developed a guideline for quality assurance procedure for carbon ion therapy based on the protocols used in the current carbon ion therapy system(or rather,a combination of... 详细信息

关键词： Quality assurance Carbon

3 - 70 Correction of Calibration Factors for Online Beam Monitor in Heavy Ion Spot Scanning at IMP

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IMP & HIRFL Annual Report 2012年第1期 165-166页

作者： dai zhongying li qiang