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Achievements and challenges of primate conservation in China

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Zoological Research(Diversity and Conservation) 2024年第1期1卷 66-74页

作者： bao-Guo Li He Zhang Ming Li xue-Long Jiang Peng-Fei fan Jiang Zhou Song-Tao Guo Xiao-Guang Qi jin-Hua Li Ji-Qi Lu Dong-Po Xia liang-Wei Cui Zuo-Fu xiang Qi-Hai Zhou Zhi-Pang Huang cheng-Ming Huang Wen Xiao Hui-Jian Hu Zhi-Xin Zhou Ming-Yong chen Da-Yong Li Peng-Lai fan yin Yang Ru-liang Pan Shaanxi Key Laboratory for Animal Conservation College of Life SciencesNorthwest UniversityXi’anShaanxi 710069China Jiangxi Provincial Key Laboratory of Conservation Biology College of ForestryJiangxi Agricultural UniversityNanchangJiangxi 330045China Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China School of Life Sciences Sun Yat-sen UniversityGuangzhouGuangdong 510275China School of Karst Science Guizhou Normal UniversityGuiyangGuizhou 550025China International Collaborative Research Center for Huangshan Biodiversity and Tibetan Macaque Behavioral Ecology Anhui UniversityHefeiAnhui 230601China Institute of Biodiversity and Ecology Zhengzhou UniversityZhengzhouHenan 450001China Key Laboratory for Conserving Wildlife with Small Populations in Yunnan Southwest Forestry UniversityKunmingYunnan 650224China College of Life Sciences and Technology Central South University of Forestry and TechnologyChangshaHunan 410004China Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Ministry of Education) Guangxi Normal UniversityGuilinGuangxi 541004China International Centre of Biodiversity and Primate Conservation Centre Dali UniversityDaliYunnan 671003China Guangdong Key Laboratory of Animal Conservation and Resource Utilization Institute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510663China School of Life Sciences Yunnan UniversityKunmingYunnan 650500China Key Laboratory of Southwest China Wildlife Resources Conservation(Ministry of Education) China West Normal UniversityNanchongSichuan 637001China Institute of International Rivers and Eco-security Yunnan UniversityKunmingYunnan 650500China School of Human Sciences The University of Western AustraliaPerthWA 6009Australia

The dual impact of climate change and human activities has precipitated a sharp decline in primate biodiversity *** is home to the most diverse primate species in the Northern hemisphere,which face severe ecological threats due to the expansion of modern agriculture,extensive exploitation and consumption of natural resources,and excessive land development during its transition from an agricultural to a modern *** response,China has implemented various ecological conservation measures,including habitat restoration and *** efforts have made substantial strides in biodiversity conservation,with certain regions witnessing an increase in primate *** the current study,we conducted a systematic review of historical documents and field research data related to Chinese primates,evaluating the endangered status of primate species in *** improvements in the habitats of most primate species and some population growth,many species still face severe threats,including declining and small *** such as the Myanmar snub-nosed monkey(Rhinopithecus strykeri),eastern black crested gibbon(Nomascus nasutus),and Hainan gibbon(***)remain particularly vulnerable due to their limited distribution ranges and extremely small *** scientific data,fragmented information,and not enough studies in conservation biology further compound the ***,there is a notable lack of detailed population monitoring data for species such as the Bengal slow loris(Nycticebus bengalensis),pygmy slow loris(***),Indochinese gray langur(Trachypithecus crepusculus),Shortridge’s langur(***),and capped langur(***),which hinders the development of practical and targeted conservation management ***,for national biodiversity conservation,there is an urgent need for specialized primate surveys,enhancing habitat protection and restoration,and increasing focus on cross-border conse

关键词： Primates Biodiversity Habitat fragmentation Habitat restoration Conservation strategies

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浮泥-流泥路基中防淤堵排水板排水行为

中国公路学报 2024年第6期37卷 228-239页

作者：鲍树峰董志良莫海鸿张劲文江学良刘攀罗晓晓广州交通大学(筹)土木与工程管理学院广东广州510725 广东省近海基础设施绿色建造与智能运维重点实验室广东广州510725 中交四航工程研究院有限公司广东广州510230 中交集团交通基础工程环保与安全重点实验室广东广州510230 华南理工大学土木与交通学院广东广州510641

浮泥-流泥路基真空预压期间塑料排水板易出现严重淤堵,为避免出现该现象,有必要针对浮泥-流泥的物理特性对防淤堵排水板的排水行为进行专项研究。首先基于典型工程的浮泥-流泥试样和典型的防淤堵土工滤膜构成“土-滤膜”过滤排水结构,... 详细信息

浮泥-流泥路基真空预压期间塑料排水板易出现严重淤堵,为避免出现该现象,有必要针对浮泥-流泥的物理特性对防淤堵排水板的排水行为进行专项研究。首先基于典型工程的浮泥-流泥试样和典型的防淤堵土工滤膜构成“土-滤膜”过滤排水结构,并综合采用改进的梯度比试验方法、压汞试验方法以及电子显微镜扫描测试方法,分析了分级真空预压下过滤排水结构的过滤排水行为;然后,基于典型的防淤堵土工滤膜和原生料芯板构成典型弯折形态的排水板复合体,采用改进的纵向通水量仪进行了纵向通水能力对比试验,分析了排水板复合体的排水行为,并综合讨论了淤堵评价标准;最后,基于具体工程实例进行了验证。研究结果表明:该类路基分级真空预压设计时,应重点基于等效孔径、渗透系数和孔洞结构特征3项关键技术指标对防淤堵土工滤膜进行选型研究;芯板板槽的压屈强度和排水板复合体的过水断面面积是排水板通水量折减率的关键影响因素,芯板的弯折角和弯折率可作为评价其排水能力的具体控制指标,而排水板的通水量折减率和井阻增幅可作为理论评价指标;该类路基中塑料排水板淤堵评价标准建议定为土工滤膜的梯度比大于4.0,芯板的弯折率大于60%且弯折角小于45°,其理论评价指标可定为弯折状态下排水板的通水量折减率大于90%或井阻增幅大于9。所提出的关于典型弯折形态下排水板复合体室内纵向通水量的试验方法及其数据分析方法,可纳入到《土工合成材料测试规程》(SL-235—2012)以及规范ASTM D6917-16中。

关键词：路基工程浮泥-流泥宏微观试验塑料排水板排水行为淤堵评价标准

Infection with SARS-CoV-2 can cause pancreatic impairment

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2143-2160页

作者： Wei Deng Linlin bao Zhiqi Song Ling Zhang Pin Yu Yanfeng xu Jue Wang Wenjie Zhao Xiuqin Zhang Yunlin Han Yanhong Li Jiangning Liu Qi Lv xujian liang Fengdi Li Feifei Qi Ran Deng Siyuan Wang yibai Xiong Ruiping Xiao hongyang Wang Chuan Qin NHC Key Laboratory of Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China Institute of Molecular Medicine College of Future TechnologyPeking UniversityBeijing 100871China Beijing Key Laboratory of Cardiometabolic Molecular Medicine Peking UniversityBeijing 100871China State Key Laboratory of Biomembrane and Membrane Biotechnology Peking-Tsinghua Center for Life SciencesBeijing 100871China Chinese Academy of Engineering Eastern Hepatobiliary Surgery Hospital225 Changhai RoadYangpu DistrictShanghai 200438China International Co-operation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteSecond Military Medical UniversityShanghai 200438PR China National Laboratory for Oncogenes and Related Genes Cancer Institute of Shanghai Jiao Tong UniversityShanghai 200441PR China Changping National laboratory(CPNL) Beijing 102206China State Key Laboratory of Respiratory Health and Multimorbidity National Health Commission of the People’s Republic of ChinaBeijingPR China

Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction and an even higher risk of the occurrence of ***,we retrospectively analyzed pancreatic lesions in autopsy tissues from 67 SARS-CoV-2 infected non-human primates(NHPs)models and 121 vaccinated and infected NHPs from 2020 to 2023 and COVID-19 ***-label immunofluorescence revealed direct infection of both exocrine and endocrine pancreatic cells by the virus in NHPs and *** and limited phenotypic and histopathological changes were observed in adult *** proteomics and metabolomics results indicated metabolic disorders,mainly enriched in insulin resistance pathways,in infected adult NHPs,along with elevated fasting C-peptide and C-peptide/glucose ratio ***,in elder COVID-19 NHPs,SARS-CoV-2 infection causes loss of beta(β)cells and lower expressed-insulin in situ characterized by islet amyloidosis and necrosis,activation ofα-SMA and aggravated fibrosis consisting of lower collagen in serum,an increase of pancreatic inflammation and stress markers,ICAM-1 and G3BP1,along with more severe glycometabolic *** contrast,vaccination maintained glucose homeostasis by activating insulin receptorαand insulin receptorβ.Overall,the cumulative risk of diabetes post-COVID-19 is closely tied to age,suggesting more attention should be paid to blood sugar management in elderly COVID-19 patients.

关键词： infected elevated homeostasis

Security analysis of satellite-to-ground reference-frame-independent quantum key distribution with beam wandering

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Chinese Physics B 2024年第8期33卷 192-201页

作者：周淳赵燕美杨晓亮陆宜飞周雨姜晓磊汪海涛汪洋李家骥江木生汪翔张海龙李宏伟鲍皖苏 Henan Key Laboratory of Quantum Information and Cryptography SSF IEUZhengzhou 450001China Synergetic Innovation Centre of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

The reference-frame-independent(RFI)quantum key distribution(QKD)is suitable for satellite-based links by removing the active alignment on the reference ***,how the beam wandering influences the performance of RFI-QKD remains a pending issue in satellite-to-ground *** this paper,based on the mathematical model for characterizing beam wandering,we present the security analysis for satellite-to-ground RFI-QKD and analytically derive formulas for calculating the secret key rate with beam *** simulation results show that the performance of RFI-QKD is better than the Bennett–Brassard 1984(BB84)QKD with beam wandering in asymptotic ***,the degree of influences of beam wandering is specifically presented for satellite-to-ground RFI-QKD when statistical fluctuations are taken into *** work can provide theoretical support for the realization of RFI-QKD using satellite-to-ground links and have implications for the construction of large-scale satellite-based quantum networks.

关键词： quantum key distribution satellite-to-ground beam wandering

鼠妇内生真菌Talaromyces malicola的次生代谢产物研究

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中国中药杂志 2024年第16期49卷 4470-4476页

作者：杨晨宇陈科良刘洋易诚贾兴宝刘云宝中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室北京100050

对节肢动物鼠妇内生真菌Talaromyces malicola的次生代谢产物进行研究,采用硅胶柱色谱、凝胶柱色谱、半制备液相色谱等进行分离纯化,共从鼠妇内生真菌***发酵物的乙酸乙酯部位中分离鉴定出11个化合物。结合核磁共振波谱、高分辨质谱、... 详细信息

对节肢动物鼠妇内生真菌Talaromyces malicola的次生代谢产物进行研究,采用硅胶柱色谱、凝胶柱色谱、半制备液相色谱等进行分离纯化,共从鼠妇内生真菌***发酵物的乙酸乙酯部位中分离鉴定出11个化合物。结合核磁共振波谱、高分辨质谱、紫外、红外以及圆二色谱等分析方法确定了化合物的结构,分别为talarosesquiterpene A(1)、(3β,5α,6α,15α,22E)-5,6-epoxyergosta-8(14),22-diene-3,7,15-triol(2)、vermistatin(3)、hydroxyvermistatin(4)、bercheminol A(5)、penicillide(6)、lunatinin(7)、penipurdin A(8)、emodin(9)、BE-25327(10)、(-)-regiolone(11)。化合物1为新的diaporol型倍半萜类化合物,化合物2、4~5、7~11为首次从篮状菌属真菌中分离得到。

关键词：鼠妇内生真菌 Talaromyces malicola 次生代谢产物

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基于检索增强的噪声标签细粒度图像分类方法

北京航空航天大学学报 2024年第7期50卷 2284-2292页

作者：暴恒邓理睿张良陈训逊中国科学院大学网络空间安全学院北京100049 清华大学计算机科学与技术系北京100084 国家计算机网络应急技术处理协调中心北京100029

在互联网音视频内容分析的应用中,快速建立低标注代价的图像细粒度分类方法具有重要意义。由于类别间具有相似的外观特征,并且存在光照、视角、背景遮挡等干扰因素,细粒度图像分类面临类别数量多、类间差异性小,以及标注代价高、标签信... 详细信息

在互联网音视频内容分析的应用中,快速建立低标注代价的图像细粒度分类方法具有重要意义。由于类别间具有相似的外观特征,并且存在光照、视角、背景遮挡等干扰因素,细粒度图像分类面临类别数量多、类间差异性小,以及标注代价高、标签信噪比低等挑战。为改善在带有噪声标签的数据环境下海量图像细粒度分类的效果,提出一种基于检索增强的图像细粒度分类方法,在迭代清洗噪声标签的基础上,利用检索范式通过简单类别标注获取更具表达性的特征,提升分类器的识别能力,并在包含1 500个细粒度的食物类别和超过50万张图像的数据集上取得良好的效果。

关键词：细粒度图像分类网络安全图像检索数据清洗噪声标签

Role of gut microbiota in Crohn’s disease pathogenesis:Insights from fecal microbiota transplantation in mouse model

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World Journal of Gastroenterology 2024年第31期30卷 3689-3704页

作者： Qiang Wu Lian-Wen Yuan Li-Chao Yang Ya-Wei Zhang Heng-Chang Yao liang-Xin Peng bao-Jia Yao Zhi-Xian Jiang Geriatric Surgery of Department of General Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Inflammatory bowel disease,particularly Crohn’s disease(CD),has been associated with alterations in mesenteric adipose tissue(MAT)and the phenomenon termed“creeping fat”.Histopathological evaluations showed that MAT and intestinal tissues were significantly altered in patients with CD,with these tissues characterized by inflammation and *** To evaluate the complex interplay among MAT,creeping fat,inflammation,and gut microbiota in *** Intestinal tissue and MAT were collected from 12 patients with *** manifestations and protein expression levels were analyzed to determine lesion *** samples were collected from five recently treated CD patients and five control subjects and transplanted into *** intestinal and mesenteric lesions in these mice,as well as their systemic inflammatory status,were assessed and compared in mice transplanted with fecal samples from CD patients and control *** Pathological examination of MAT showed significant differences between CDaffected and unaffected colons,including significant differences in gut microbiota *** microbiota transplantation(FMT)from clinically healthy donors into mice with 2,4,6-trinitrobenzene sulfonic acid(TNBS)-induced CD ameliorated CD symptoms,whereas FMT from CD patients into these mice exacerbated CD ***,FMT influenced intestinal permeability,barrier function,and levels of proinflammatory factors and ***,FMT from CD patients intensified fibrotic changes in the colon tissues of mice with TNBS-induced *** Gut microbiota play a critical role in the histopathology of *** MAT and creeping fat may therefore have potential in the treatment of patients with CD.

关键词： Mesenteric adipose tissue Crohn’s disease Fecal microbiota transplantation Intestinal fibrosis Intestinal barrier

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惰性气体在LIBS中的辅助测量研究

光谱学与光谱分析 2024年第3期44卷 601-609页

作者：许杰谷懿宋宝林葛良全张庆贤杨文佳成都理工大学核技术与自动化工程学院四川成都610059 成都理工大学地学核技术重点实验室四川成都610059 中广核工程有限公司广东深圳518124 四川省安全科学技术研究院综合所四川成都610041

激光诱导击穿光谱(LIBS)是一种发射光谱分析技术,因其实时、多元素、无损、远程等优势,在分析高危环境和重要文物等方面具有极大潜力。目前,LIBS测量技术仍受实验设备,测量环境等因素影响,其中,气氛环境对LIBS测量的影响尤为显著。惰性... 详细信息

激光诱导击穿光谱(LIBS)是一种发射光谱分析技术,因其实时、多元素、无损、远程等优势,在分析高危环境和重要文物等方面具有极大潜力。目前,LIBS测量技术仍受实验设备,测量环境等因素影响,其中,气氛环境对LIBS测量的影响尤为显著。惰性气体因其优秀的物理性质(比热容,导电率,稳定的化学性质,较大的相对分子质量等)有利于辅助LIBS测量,增强光谱信号,提高检测下限,在激光诱导击穿光谱测量中的应用愈发频繁。因此,在详细调研了惰性气体于LIBS测量过程中的应用基础上,解析了其对光谱信号的影响因素,如很低的化学活性有效降低了空气中其他气体(氧气,氮气等)对光谱信号的吸收湮灭、较大的原子体积限制了等离子体向外扩张,使得单位体积内的温度大幅度上升、丰富的核外电子使产生的等离子体中自由电子大幅度上升,提高了电子密度、亚稳态的存在促使惰性气体对待测样品的延迟激发,辅助激发某些较轻元素并大幅度增加等离子体寿命、能量传递更能特定增强某些特殊能级的发射谱线,获得更高的增强因子、还分析了氡气通过衰变对发射谱线的影响,惰性气体的发射谱线也可用于计算样品的等离子体温度和电子密度等,对LIBS的辅助测量有重要影响。列举了亚稳态在LIBS测量中的应用和惰性气体在不同测量对象中对谱线信号的增强因子。分析比较了不同惰性气体在信号增强,烧蚀质量,时间演化方面的差异,结果表明,氦气相比其他惰性气体较为特殊,归结于其特殊的物理性质和核外结构,而其他气体随着周期数的增加,信号增强因子逐渐增加而烧蚀质量却逐渐减小,等离子的时间演化也逐渐变长,为LIBS测量中选择合适的惰性气体提供理论支持和参考。

关键词：光谱测量原子发射光谱分析法惰性气体综述

Parkinson disease drug screening based on the interaction between D2 dopamine receptor and beta-arrestin 2 detected by capillary zone electrophoresis

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Protein & Cell 2011年第11期2卷 899-905页

作者： Zheng Zhou jun-Ming Liao Peng Zhang jun-bao fan Jie chen yi liang State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430072China

Parkinson’s disease is the second most common neurodegenerative disease in the ***-arrestin-2 has been reported to be an important protein involved in D2 dopamine receptor desensitization,which is essential to Parkinson’s ***,the potential value of pharmacological inactivation of G protein-coupled receptor kinase or arrestin in the treatment of patients with Parkinson’s disease has recently been *** studied the interaction between D2 dopamine receptor and beta-arrestin-2 and the pharmacological regulation of chemical compounds on such interaction using capillary zone *** results from screening more than 40 compounds revealed three compounds that remarkably inhibit the beta-arrestin-2/D2 dopamine receptor interaction among *** compounds are promising therapies for Parkinson’s disease,and the method used in this study has great potential for application in large-scale drug screening and evaluation.

关键词： drug screening D2 dopamine receptor beta-arrestin-2 capillary zone electrophoresis proteinprotein interaction Parkinson’s disease