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Journal of Materials Science & Technology 2019年第5期35卷 891-901页

作者： woo jin lee Jisoo Kim Hyung wook Park Department of Mechanical Aerospace and Nuclear Engineering Ulsan National Institute of Science and Technology

Large pulsed electron beam(LPEB) irradiation was employed as a surface treatment of magnesium(Mg)alloy AZ31B to enhance its corrosion and wear resistance. Selective evaporation of Mg induced by LPEB irradiation at an energy density of 5J/cm^2 for 40 cycles has led to the formation of an Al-enriched resolidified layer with nano-grained structure consisting of Mg3.1 Al0.9 metastable phase. The formation of such a re-solidified layer after LPEB irradiation has enabled a decrease in corrosion rate of Mg alloy AZ31B in 3.5% NaCl solution. Different equivalent electrical circuit models were proposed to account for the corrosion behavior of untreated Mg alloy AZ31B and those subjected to LPEB irradiation. A decrease in wear depth when compared to that of the untreated alloy suggests an increase in wear resistance of LPEB-irradiated Mg alloy AZ31B. Adhesive wear is the predominant mechanism of untreated Mg alloy AZ31B while abrasive wear mechanism dominates for LPEB-irradiated Mg alloy AZ31B.

关键词： Magnesium alloys Electron beam treatment Corrosion resistance Microstructure Rapid re-solidification Wear resistance

Development of EMC-based empirical model for estimating spatial distribution of pollutant loads and its application in rural areas of Korea

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Journal of Environmental Sciences 2015年第9期27卷 1-11页

作者： Qitao Yi Hui Li jin-woo lee Youngchul Kim School of Earth and Environment Anhui University of Science and Technology Dowha Engineering Consulting Co.Ltd. Department of Environmental Engineering Hanseo University

An integrated approach to easily calculate pollutant loads from agricultural watersheds is suggested and verified in this research. The basic concepts of this empirical tool were based on the assumption that variations in event mean concentrations（EMCs） of pollutants from a given agricultural watershed during rainstorms were only attributable to the rainfall *** one sets of EMC values were obtained from nine different watersheds located in the rural areas of Korea, and these data were used to develop predictive tools for the EMCs in rainfall runoff. The results of statistical tests of these formulas show that they are fairly good in predicting actual EMC values of some parameters, and useful in terms of calculating pollutant loads for any rainfall event time span such as daily, weekly, monthly, and yearly. This model was further checked in for its field applicability in a reservoir receiving stormwater after a cleanup of the sediments, covering 17 consecutive rainfall events from 1 July to 15 August in2007. Overall the predicted values matched the observed values, indicating the feasibility of this empirical tool as a simple and useful solution in evaluating timely distribution of nonpoint source pollution loads from small rural watersheds of Korea.

关键词： EMC Empirical model Nonpoint source pollution Spatial distribution

Endoscopic management of occluded metal biliary stents:Metal versus 10F plastic stents

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World Journal of Gastroenterology 2010年第42期16卷 5347-5352页

作者： Won Jae Yoon Ji Kon Ryu Jung Won lee Dong-Won Ahn Yong-Tae Kim Yong Bum Yoon Sang Myung woo woo jin lee Division of Gastroenterology Department of Internal MedicineSeoul National University College of Medicine101 Daehang-roJongno-guSeoul110-744South Korea Center for Liver Cancer National Cancer Center323 Ilsan-roIlsandong-guGoyang-siGyeonggi-do410-769South Korea

AIM:To compare the efficacy of self-expandable metal stents(SEMSs) with 10F plastic stents(PSs) in the endoscopic management of occluded ***:We retrospectively reviewed the medical records of 56 patients who underwent SEMS insertion for palliation of unresectable malignant biliary obstruction between 2000 and 2007 and subsequent endoscopic retrograde biliary drainage(ERBD) with SEMS or PS for initial SEMS occlusion between 2000 and ***:Subsequent ERBD with SEMS was performed in 29 patients and with PS in *** median time to stent occlusion after subsequent ERBD was 186 d in the SEMS group and 101 d in the PS group(P= 0.118).Overall median stent patency was 79 d for the SEMS group and 66 d for the PS group(P = 0.379).The mean number of additional biliary drainage procedures after subsequent ERBD in patients that died(n = 50) during the study period was 2.54 ± 4.12 for the SEMS group and 1.85 ± 1.95 for the PS group(P = 0.457).The mean total cost of additional biliary drainage procedures after the occlusion of subsequent SEMS or PS was $410.04 ± 692.60 for the SEMS group and $630.16 ± 671.63 for the PS group(P = 0.260).Tumor ingrowth as the cause of initial SEMS occlusion was the only factor associated with a shorter time to subsequent stent occlusion(101 d for patients with tumor ingrowth vs 268 d for patients without tumor ingrowth,P = 0.008).CONCLUSION:Subsequent ERBD with PSs offered similar patency and number of additional biliary drainage procedures compared to SEMSs in the management of occluded SEMS.

关键词： Stents Biliary tract neoplasms Obstructive jaundice Endoscopy Endoscopic retrograde cholangiopancreatography

Aqueous-processable,naphthalene diimide-based polymers for eco-friendly fabrication of high-performance,n-type organic electrolyte-gated transistors

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Science China Chemistry 2022年第5期65卷 973-978页

作者： Dahyun Jeong Min Je Kim Seungjin lee jin-woo lee Youngwoong Kim Hyeong Jun Kim Jeong Ho Cho Bumjoon J.Kim Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Chemical and Biomolecular Engineering Sogang UniversitySeoul 04107Republic of Korea

Organic electrolyte-gated transistors(OEGTs) have the benefits of low power consumption and large current ***,the electrical performance of n-type OEGTs lags far behind that of p-type *** this study,we design a series of polymers,P(NDITEG-T) and P(NDIMTEG-T),comprising a naphthalene diimide backbone for n-type charge transport and oligo(ethylene glycol)(OEG) side chains for high ionic conductivity and eco-friendly solution *** incorporation of the OEG chain facilitates the electrochemical doping of the semiconductor by ions to realize high-performance,n-type ***,in OEGTs,P(NDITEG-T) achieves a high electron mobility of 1.0 × 10^(-1) cm^(2) V^(-1) s^(-1),which represents the highest value reported for solution-processed,n-type *** is noted that the fabrication of the OEGTs is achieved by solution processing with eco-friendly ethanol/water mixtures in virtue of the hydrophilic OEG *** work demonstrates the molecular design of the P(NDITEG-T) polymer and its significant ability to produce aqueous-processable,high-performance,and n-type OEGTs.

关键词： organic electrolyte-gated transistors n-type transistors oligo(ethylene glycol)polymers eco-friendly solution process high electron mobility

Prognosis of hepatocellular carcinoma expressing cytokeratin 19:Comparison with other liver cancers

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World Journal of Gastroenterology 2012年第34期18卷 4751-4757页

作者： Jung Il lee jin-woo lee Joon Mee Kim Ja Kyung Kim Hyun Jung Chung Young Soo Kim Department of Internal Medicine School of MedicineInha UniversityIncheon 400-711South Korea Department of Pathology School of MedicineInha UniversityIncheon 400-711South Korea Department of Internal Medicine Yonsei University College of MedicineGangnam Severance HospitalSeoul 135-720South Korea

AIM:To investigate whether expressing biliary phenotype predicted poor outcome after the surgical treatment in primary liver cancers. METHODS:Out of 204 patients that underwent liver resection due to hepatocellular carcinoma (HCC), liver specimens of 70 patients with HCC were evaluated for biliary components by cytokeratin (CK) 19 immunostain (CK19 - HCC and CK19 + HCC). CK19 positivity was defined as membranous and/or cytoplasmic expression in ≥ 5% of tumor cells with moderate or strong intensity. Patients with other primary liver cancers, such as com- bined HCC and cholangiocarcinoma (cHCC-CC), intrahe- patic cholangiocarcinoma (ICC) who received curative liver resection, were also included in the study. Clinical characteristics of CK19-HCC and CK19 + HCC patients, including survival outcome after curative liver resection, were compared with that of cHCC-CC and ICC patients. RESULTS: The overall survival (OS) rate of CK19 - HCC(n = 49) after the curative surgical treatment was 90.7%, and 80.4% at 1 and 5 years after the resection. OS rate of CK19 + HCC (n = 21) was 74.3%, 28.9% and OS rate of cHCC-CC (n = 22) was 66.7%, 32.2% at 1 and 5 years after the surgery. For ICC (n = 19), 1 and 5-year-OS rate was 50.2% and 14.3% after the cura-tive resection. The OS rates of CK19 + HCC and cHCC-CC were significantly lower than that of CK19-HCC, but higher than the OS rate of ICC (P = 0.000). There was no statistically significant difference in OS rate between CK19 + HCC and cHCC-CC. The disease free survival (DFS) rate of CK19-HCC was 72.0% and 54.5% at 1 and 3 years after the surgical treatment. DFS rate of CK19 + HCC was 53.3%, 34.3% and DFS rate of cHCC- CC was 51.5%, 39.2% at 1 and 3 years after the resection. For ICC, 1 and 3-year-DFS rate was 28.0% and 14.0% after the curative resection. DFS rate of CK19-HCC was significantly higher than that of ICC (P = 0.017), but marginally higher than DFS rate of either CK19 + HCC or cHCC-CC (P = 0.097, P = 0.089, respec-tively).

关键词： Cytokeratin 19 Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Liver cancers Hepa-tectomy

Tetramic acid-motif natural products from a marine fungus Tolypocladium cylindrosporum FB06 and their anti-Parkinson activities

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Marine Life Science & Technology 2024年第1期6卷 84-92页

作者： Yuna Jung Chaesun Kwon Taeyeon Kim jin woo lee Min-Kyoo Shin Sang Hee Shim Natural Products Research Institute College of PharmacySeoul National UniversitySeoul 08826Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea College of Pharmacy Duksung Women’s UniversitySeoul 01369Republic of Korea

Tetramic acid-containing natural products are attracting significantly increasing attention from biologists and chemists due to their intriguing structures and biological *** the present study,two new tetramic acid alkaloids tolypyridone I(1)and tolypyridone J(2),together with five known ones(3–7),were isolated from cultures of a marine fungus Tolypocladium cylindrosporum FB06 isolate obtained from a marine sediment in Beaufort sea of North *** structures were elucidated using 1D,2D NMR,and *** configurations were established on the basis of 1H coupling constants,ROESY correlations and DP4 *** 2 was isolated as mixtures of rotational isomers with C-3 to C-7 axis between 4-hydroxy-2-pyridone and 1-ethyl-3,5-dimethylcyclohexane,hindering *** our unbiased screening to discover neuroprotective compounds in an in vitro Parkinson’s disease(PD)model,SH-SY5Y dopaminergic cells were treated with isolated compounds followed by treatment with 1-methyl-4-phenylpyridinium(MPP^(+)),a parkinsonian *** tested compounds,F-14329(7)significantly protected cells from MPP^(+)-induced ***^(+)-mediated cell death is known to be related to the regulation of Bcl-2 family proteins,specifically the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax *** with 2 mmol/L of MPP^(+)for 24 h significantly reduced Bcl-2 levels compared to control treated with ***,treatment with F-14329(7)attenuated such *** study demonstrates that tetramic acid-motif compounds could be potential lead compounds for treating PD.

关键词： Tolypocladium cylindrosporum Tetramic acid Tolypyridone Parkinson’s disease

Does the bile duct angulation affect recurrence of choledocholithiasis?

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World Journal of Gastroenterology 2011年第36期17卷 4118-4123页

作者： Dong Beom Seo Byoung wook Bang Seok Jeong Don Haeng lee Shin Goo Park Yong Sun Jeon Jung Il lee jin-woo lee Division of Gastroenterology Department of Internal MedicineInha University School of MedicineIncheon 400-711South Korea Division of Gastroenterology Department of Internal Medicine and Center for Advanced Medical Education by BK21 ProjectInha University School of Medicineand Utah-Inha DDS and Advanced Therapeutics Research CenterIncheon 400-711South Korea Department of Occupational and Environmental Medicine Inha University School of MedicineIncheon 400-711South Korea Department of Radiology Inha University School of MedicineIncheon400-711South Korea

AIM:To investigate whether bile duct angulation and T-tube choledochostomy influence the recurrence of ***:We conducted a retrospective study including 259 patients who underwent endoscopic sphincterotomy and cholecystectomy for choledocholithiasis between 2000 and *** imaginary line was drawn along the center of the bile duct and each internal angle was measured at the two angulation sites ofthe bile duct *** values of both angles were added *** then tested our hypothesis by examining whether T-tube choledochostomy was performed and stone recurrence occurred by reviewing each subject's medical ***:The overall recurrence rate was 9.3% (24 of 259 patients).The mean value of sums of angles in the recurrence group was 268.3°± 29.6°,while that in the non-recurrence group was 314.8°± 19.9° (P < 0.05).Recurrence rate of the T-tube group was 15.9% (17 of 107),while that of the non T-tube group was 4.6% (7 of 152) (P < 0.05).Mean value of sums of angles after T-tube drainage was 262.5°± 24.6° and that before T-tube drainage was 298.0°± 23.9° in 22 patients (P < 0.05).CONCLUSION:The bile duct angulation and T-tube choledochostomy may be risk factors of recurrence of bile duct stones.

关键词： Choledocholithiasis Common bile duct Cholecystectomy Recurrence Endoscopic retrograde cholangio pancreatography

Complete remission of advanced hepatocellular carcinoma by sorafenib: A case report

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World Journal of Gastrointestinal Oncology 2013年第2期5卷 38-42页

作者： Min Su Kim Young-Joo jin jin-woo lee Jung-il lee Young soo Kim Sun young lee Myoung Hun Chae Department of Internal Medicine Inha University HospitalInha University School of Medicine

Hepatocellular carcinoma (HCC) is the fifth most common malignant disease worldwide, and curative treatment remains difficult because the majority of cases are diagnosed in the advanced stage. Sorafenib is the only known effective systemic treatment, but patients rarely achieve complete remission (CR). A 66-year-old man with a history of alcoholic liver cirrhosis with a diagnosis of advanced HCC, was initially treated with transarterial chemoembolization on four occasions. However, the disease progressed with portal vein thrombosis. Therefore, sorafenib was started, and 4 mo later, the patient achieved CR. The treatment was continued for 12 mo, and CR was maintained up to 4 mo after sorafenib discontinuation.

关键词： Hepatocellular carcinoma Sorafenib Portal vein thrombosis Complete remission

Investigating the Calculation of Rotational Viscosity of the Mixture Comprising Different Kinds of Liquid Crystals： Molecular Dynamics Computer Simulation Approach

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Chinese Journal of Chemistry 2011年第1期29卷 48-52页

作者： Kim, jinsoo Jamil, Muhammad Jung, Jae Eun Jang, Jae Eun Farzana, Ahmad jin, woo lee Sang, woo Park woo, Min-Kyung Kwak, Ji Yeon Jeon, Young-Jae Liquid Crystal Research Centre Department of Chemistry Konkuk University 143-701 Seoul Korea Division of International Affairs University College Konkuk University 143-701 Seoul Korea Samsung Advanced Institute of Technology (SAID) Yongin-shi Gyeonggi-do 446-712 Korea

Molecular dynamics （MD） computer simulation techniques, as a powerful tool commonly utilized by the liquid crystal display （LCD） community, usually are employed for computing the equilibrium and transport properties of a classical many body system, since they are very similar to real experiments in many respects. In this paper we pre- sent molecular dynamics computer simulation results taken for a mixture of the two different kinds of nematic liq- uid crystals （LCs）. We calculated rotational viscosity from Brownian behavior with friction of the mean director of the mixture comprising pentylcyanobiphenol （5CB） and decylcyanobiphenol （10CB） by using molecular dynamics computer simulation, where intermolecular potential parameter is Generalized AMBER force field （GAFF）. Our computed results show a good agreement with the experimental results.

关键词： liquid crystal mixture ab initio calculations rotational viscosity generalized AMBER force field(GAFF) molecular dynamics simulation nematic liquid crystals computer simulation

Survival outcome of patients with spontaneously ruptured hepatocellular carcinoma treated surgically or by transarterial embolization

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World Journal of Gastroenterology 2013年第28期19卷 4537-4544页

作者： Young-Joo jin jin-woo lee Seoung-wook Park Jung Il lee Don Haeng lee Young Soo Kim Soon Gu Cho Yong Sun Jeon Kun Young lee Seung-Ik Ahn Department of Internal Medicine Inha University Hospital Inha University School of Medicine Incheon 400-711 South Korea Department of Internal Medicine Yonsei University College of Medicine Seoul 120-752 South Korea Department of Internal Medicine and Center for Advanced Medical Education by Brain Korea 21 Project Inha University School of Medicine and Utah-Inha DDS and Advanced Therapeutics Research Center Incheon 400-711 South Korea Department of Radiology Inha University Hospital Inha University School of Medicine Incheon 400-711 South Korea Department of Surgery Inha University Hospital Inha University School of Medicine Incheon 400-711 South Korea

AIM: To evaluate clinical outcomes of patients that underwent surgery, transarterial embolization (TAE), or supportive care for spontaneously ruptured hepatocellular carcinoma (HCC). METHODS: A consecutive 54 patients who diagnosed as spontaneously ruptured HCC at our institution between 2003 and 2012 were retrospectively enrolled. HCC was diagnosed based on the diagnostic guidelines issued by the 2005 American Association for the Study of Liver Diseases. HCC rupture was defined as disruption of the peritumoral liver capsule with enhanced fluid collection in the perihepatic area adjacent to the HCC by dynamic liver computed tomography, and when abdominal paracentesis showed an ascitic red blood cell count of > 50000 mm 3 /mL in bloody fluid. RESULTS: Of the 54 patients, 6 (11.1%) underwent surgery, 25 (46.3%) TAE, and 23 (42.6%) supportive care. The 2-, 4and 6-mo cumulative survival rates at 2, 4 and 6 mo were significantly higher in the surgery (60%, 60% and 60%) or TAE (36%, 20% and 20%) groups than in the supportive care group (8.7%, 0% and 0%), respectively (each, P < 0.01), and tended to be higher in the surgical group than in the TAE group. Multivariate analysis showed that serum bilirubin (HR = 1.09, P < 0.01), creatinine (HR = 1.46, P = 0.04), and vasopressor requirement (HR = 2.37, P = 0.02) were significantly associated with post-treatment mortality, whereas surgery (HR = 0.41, P < 0.01), and TAE (HR = 0.13, P = 0.01) were inversely associated with posttreatment mortality. CONCLUSION: Post-treatment survival after surgery or TAE was found to be better than after supportive care, and surgery tended to provide better survival benefit than TAE.

关键词： Ruptured hepatocellular carcinoma Surgery Transarterial embolization