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Tetramic acid-motif natural products from a marine fungus Tolypocladium cylindrosporum FB06 and their anti-Parkinson activities

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Marine life Science & Technology 2024年第1期6卷 84-92页

作者： Yuna Jung Chaesun Kwon Taeyeon Kim jin woo l.e Min-Kyoo Shin Sang Hee Shim Natural Products Research Institute College of PharmacySeoul National UniversitySeoul 08826Republic of Korea Col.ege of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea Col.ege of Pharmacy Duksung Women’s UniversitySeoul 01369Republic of Korea

Tetramic acid-containing natural products are attracting significantly increasing attention from biologists and chemists due to their intriguing structures and biological *** the present study,two new tetramic acid alkaloids tolypyridone I(1)and tolypyridone J(2),together with five known ones(3–7),were isolated from cultures of a marine fungus Tolypocladium cylindrosporum FB06 isolate obtained from a marine sediment in Beaufort sea of North *** structures were elucidated using 1D,2D NMR,and *** configurations were established on the basis of 1H coupling constants,ROeSY correlations and DP4 *** 2 was isolated as mixtures of rotational isomers with C-3 to C-7 axis between 4-hydroxy-2-pyridone and 1-ethyl-3,5-dimethylcyclohexane,hindering *** our unbiased screening to discover neuroprotective compounds in an in vitro Parkinson’s disease(PD)model,SH-SY5Y dopaminergic cells were treated with isolated compounds followed by treatment with 1-methyl-4-phenylpyridinium(MPP^(+)),a parkinsonian *** tested compounds,F-14329(7)significantly protected cells from MPP^(+)-induced ***^(+)-mediated cell death is known to be related to the regulation of Bcl-2 family proteins,specifically the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax *** with 2 mmol/l of MPP^(+)for 24 h significantly reduced Bcl-2 levels compared to control treated with ***,treatment with F-14329(7)attenuated such *** study demonstrates that tetramic acid-motif compounds could be potential lead compounds for treating PD.

关键词： Tolypocladium cylindrosporum Tetramic acid Tolypyridone Parkinson’s disease

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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye jin Shin wooseong l.e Keun Bon Ku Gun Young Yoon Hyun-woo Moon Chonsaeng Kim Mi-Hwa Kim Yoon-Sun Yi Sangmi Jun Bum-Tae Kim Jong-Won Oh Al.em Siddiqui Seong-Jun Kim Department of Convergent Research of emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular al.erations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the eGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial.elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the eGFR signal cascade and subsequently induces mitochondrial.eGFR trafficking,contributing to abnormal OXPHOS process and viral *** eGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced eGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACe2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced al.erations in mitochondrial dynamics and eGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that eGFR is an attractive host target for combating COVID-19.

关键词： al.erations aberrant thereby

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Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

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Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-Hyeon eom Dong-Hyeok Kwon Dae-jin Jung Dae-Hyun Kim Jun-Koo Yi Jae-Jung Ha Ji-Hyun l.e Seong-Beom l.e woo-Jae Son Soo-Young Yum Won-Wu l.e Goo Jang laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea lARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by T7e1 *** first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MSTN/BlG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant cal.es by targeted deep *** recipients were transferred for MSTN/PRNP,4 cal.es were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MSTN/BlG,and four of the six cal.es that were born had mutations in both *** These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MSTN and PRNP from beef cattle and MSTN and BlG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 electroporation Knockout MSTN PRNP

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effect of Shape and Placement of Twisted Pin Fins in a Rectangular Channel on Thermo-Hydraulic Performance

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Journal of Thermal Science 2024年第5期33卷 1773-1793页

作者： lI Yong ZHANG jin ZHANG Yingchun ZHANG Jiajie MA Suxia SUNDeN Bengt XIe Gongnan Col.ege of electrical and Power engineering Taiyuan University of TechnologyTaiyuan 030024China Key laboratory of Cleaner Intelligent Control on Coal.electricity Ministry of EducationTaiyuan 030024China Shanxi Provincial Key laboratory of High efficiency Heat Storage and low Carbon Heat Supply Taiyuan 030008China School of energy and Power engineering North University of ChinaTaiyuan 030051China Department of energy Sciences Lund UniversityP.O.Box 118Lund SE 22100Sweden School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072China

To enhance the thermo-hydraulic performance of cooling channels,this investigation examines the infl.ence of distinct cross-sectional shapes(i.e.,triangular,rectangular,and hexagonal)of twisted pin fins and their arrangements in straight and cross *** ambient air cooling test platform was established to numerically and experimentally investigate the flow and heat transfer characteristics of 360°twisted pin fins at Re=*** findings reveal that straight rows exhibit higher Nu val.es than cross rows for triangular and rectangular twisted pin fins,and Nu increases with *** contrast,for hexagonal twisted pin fins,only straight rows at Re=19000 exhibit superior overall thermal performance compared to cross ***,the heat transfer performance of the cooling channel with hexagonal twisted fins surpasses both triangular and rectangular configurations,especially at high Reynolds numbers(Re=22800).Although the heat transfer coefficient of the cooling channel with hexagonal twisted fins is significantly enhanced by 132.71%compared to the flat channel,it also exhibits the highest thermal resistance and relative friction among the three types of twisted fins,the maximum of which are 2.14 and ***,the hydrothermal performance factor(HTPF)of the cooling channels with different types of twisted pin fins depends on the Reynolds number and arrangement *** Re=15200,the highest HTPF achieved for the cross-row hexagonal twisted pin fins is 0.99.

关键词： twisted pin fin cross arrangement heat transfer pressure drop HTPF

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A statistical analysis of the Kappa-type energy spectrum distribution of radiation belt electrons observed by Van Al.en Probes

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earth and Planetary Physics 2024年第2期8卷 368-374页

作者： luHuai Jiao Xin Ma YuanNong Zhang TaiFeng jin Song Fu BinBin Ni Department of Space Physics School of Electronic InformationWuhan UniversityWuhan 430072China

The energy spectrum of energetic electrons is a key factor representing the dynamic variations of earth’s Van Al.en radiation *** measurements have indicated that the commonly used Maxwellian and Kappa distributions are inadequate for capturing the realistic spectral distributions of radiation belt *** we adopt the Kappa-type(KT)distribution as the fitting function and perform a statistical analysis to investigate the radiation belt electron flux spectra observed by the Van Al.en *** calculating the optimal val.es of the key KT distribution parameters(i.e.,κandθ2)from the observed spectral shapes,we fit the radiation belt electron fluxes at different l-shells under different geomagnetic *** this manner,we obtain typical val.es of the KT distribution parameters,which are statistically feasible for modeling the radiation belt electron flux profiles during either geomagnetically quiet or active periods.A comparison of the KT distribution model results with those using the Maxwellian or Kappa distribution reveals the advantage of the KT distribution for studying the overall properties of the radiation belt electron spectral distribution,which has important implications for deepening the current understanding of the radiation belt electron dynamics under evolving geomagnetic conditions.

关键词： radiation belt electron Kappa-type distribution fitting geomagnetic storm

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The inhomogeneous incompressible Hall-MHD system with only bounded density

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Science China Mathematics 2024年

作者： jin Tan lan Zhang laboratoire de Math′ematiques AGM UMR CNRS 8088 Cergy Paris Universit′e Center for Mathematical Sciences and Department of Mathematics Wuhan University of Technology

This paper is dedicated to the global-in-time existence and uniqueness issues of solutions for the inhomogeneous incompressible Hall-magnetohydrodynamics(MHD) system with merely bounded density. In a three-dimensional case, assuming that the initial density is a small perturbation of a positive constant in the l∞norm, we prove global well-posedness for small initial velocity and magnetic fields in critical Besov spaces. Next, we consider the so-cal.ed 21/2D flows for the inhomogeneous Hall-MHD system(that is 3D flows independent of the vertical variable) and establish the global.existence of strong solutions by only assuming that the initial magnetic field is small in critical spaces and the initial density is bounded and bounded away from zero. In particular, those solutions allow piecewise constant density with jumps so that a mixture of fluids can be considered. Compared with inhomogeneous incompressible Navier-Stokes equations, the new difficulties of proving these results come from the additional so-cal.ed Hall term, which endows the magnetic equation with a quasi-linear character. In order to overcome them, we reformulate the system by taking advantage of the curl form of the magnetic equation and develop some new maximal regularity estimates for the Stokes system with just bounded coefficients.

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Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening

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Current Medical Science 2024年第4期44卷 748-758页

作者： Shan-shan HU Tong-yao WANG lu NI Fan-xin HU Bo-wen YUe Ying ZHeNG Tian-lun WANG Abhishek KUMAR Yan-yan WANG jin-e WANG Zhi-yong ZHOU Third-grade Pharmacological laboratory of Traditional Chinese Medicine State Administration of Traditional Chinese MedicineChina Three Gorges UniversityYichang 443002China Col.ege of Medicine and Health Sciences China Three Gorges UniversityYichang 443002China Col.ege of Basic Medical Science China Three Gorges UniversityYichang 443002China

Objective Icariin(ICA)has a good neuroprotective effect and can upregulate neuronal basal autophagy in naturally aging *** dysfunction is associated with brain aging-related neurodegenerative *** opening of the mitochondrial permeability transition pore(mPTP)is a crucial factor in mitochondrial dysfunction and is associated with excessive *** study aimed to explore that ICA protects against neuronal injury by blocking the mPTP opening and down-regulating autophagy levels in a D-galactose(D-gal)-induced cell injury *** A cell model of neuronal injury was established in rat pheochromocytoma cells(PC12 cells)treated with 200 mmol/l D-gal for 48 *** this cell model,PC12 cells were pre-treated with different concentrations of ICA for 24 *** was used to detect cell *** associatedβ-galactosidase(SA-β-Gal)staining was used to observe cell *** blot analysis was performed to detect the expression levels of a senescence-related protein(p21),autophagy markers(lC3B,p62,Atg7,Atg5 and Beclin 1),mitochondrial fission and fusion-related proteins(Drp1,Mfn2 and Opa1),and mitophagy markers(Pink1 and Parkin).The changes of autophagic flow were detected by using mRFP-GFP-lC3 *** intracellular ultrastructure was observed by transmission electron *** was used to detect mPTP,mitochondrial membrane potential(MMP),mitochondrial reactive oxygen species(mtROS)and ROS *** and apoptosis levels were detected by flow *** D-gal treatment significantly decreased the viability of PC12 cells,and markedly increased the SA-β-Gal positive cells as compared to the control *** the D-gal stimulation,the expression of p21 was significantly ***,D-gal stimulation resul.ed in an elevated lC3B II/I ratio and decreased p62 ***,autophagosomes and autolysosomes were significantly increased,indicating abnormal activation of autophag

关键词： icariin neuronal injury mitochondrial dysfunction mitochondrial permeability transition pore autophagy

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effect of Menopausal Hormone Replacement Therapy on Cytokine Patterns in a Perimenopausal Mouse Model.established by the Ovarian Castration Method

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Chinese Journal of Biomedical.engineering(english edition) 2024年第1期33卷 40-48页

作者： He Bin-bin ZHANG Ju-shun WANG jin-yong longyan First Affiliated Hospital of Fujian Medical University Longyan Fujian 364000China

Objective: To investigate the effect of perimenopausal hormone replacement therapy(HRT) on cytokine patterns in a perimenopausal mouse model.established by ovarian castration. Methods: The mice were divided into natural menopause group,ovariectomy group and HRT group, with 15 mice in each group, and the estrous cycle, estrous frequency and menopausal time of the mice were determined by vaginal cytology,and the estrous cycle, estrous frequency and menopausal time were compared among the three groups. The serum levels of estradiol.e2) and progesterone(P4) in each group were detected by double-antibody sandwich elISA, and the levels of interferon gamma(IFN-γ), interleukin-2(Il-2), Il-4 and Il-10 in the spl.en γ tissues of mice were detected by elISA. Results: The time of menopause(53.07±3.99) d in the HRT group was between that of the natural menopause group(80.80±3.26) d and that of the ovariectomy group(16.27±4.35) d, with a statistically significant difference in the two-by-two comparison of the three groups(Pe levels of serum e2(694.4±128.3) ng/l and P4(14.2 ±6.0) ng/l in the HRT therapy group are between those of the ovariectomy group and the natural menopause group, with statistically significant differences between the groups(Pe levels of Il-2(30.9±5.3) pg/ml, Il-4(9.4±1.6) pg/ml, Il-10(19.7±3.1) pg/ml, IFN-γ(22.0±3.7) pg/ml in the HRT group were all between those of natural menopause group and ovariectomy group. The Th1/Th2 ratio in the ovariectomy group was 7.55±1.57, higher than that in the natural menopause group(1.53±0.48) and HRT group(2.38 ±0.44), with statistically significant differences(Plusion:Menopausal HRT can partially correct the imbalance of Th1/Th2 cytokines, which is able to provide an experimental basis for the regulation of menopause-related immune imbalance by HRT.

关键词： menopause hormone replacement therapy(HRT) ovariectomy mouse model cytokine pattern

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A micro-crosslinked amphoteric hydrophobic association copolymer as high temperature-and salt-resistance fluid loss reducer for water-based drilling fluids

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Petroleum Science 2024年第3期21卷 1980-1991页

作者： Jian li Yu-Xi Ji Xiao-Xiao Ni Kai-He lv Xian-Bin Huang jin-Sheng Sun School of Petroleum engineering China University of Petroleum(East China)Qingdao266580ShandongChina Key laboratory of Unconventional Oil&Gas Development China University of Petroleum(East China)Qingdao26650ShandongChina Inspection and Testing Center of Huabei Oil Field Company PetroChinaRenqiu062552HebeiChina Drilling Fluid Research Institute CNPC Engineering Technology R&D Company LimitedBeijing102206China

During ultradeep oil and gas drilling,fluid loss reducers are highly important for water-based drilling fluids,while preparing high temperature-and salt-resistance fluid loss reducers with excel.ent rheology and filtration performance remains a ***,a micro-crosslinked amphoteric hydrophobic association copolymer(i.e.,DADC)was synthesized using N,N-dimethyl acrylamide,diallyl dimethyl ammonium chloride,2-acrylamido-2-methylpropane sulfonic acid,hydrophobic monomer,and pentaerythritol triallyl.ether *** to the synergistic effects of hydrogen bonds,electrostatic interaction,hydrophobic association,and micro-crosslinking,the DADC copolymer exhibited outstanding temperature-and *** rheological.experiments have shown that the DADC copolymer had excel.ent shear dilution performance and a certain degree of salt-responsive viscosity-increasing *** DADC copolymer could effectively adsorb on the surface of bentonite particles through electrostatic interaction and hydrogen bonds,which bring more negative charge to the bentonite,thus improving the hydration and dispersion of bentonite particles as well as the colloidal stability of the drilling ***,the drilling fluids constructed based on the DADC copolymer exhibited satisfactory rheological and filtration properties(FlHTHP=12 m l)after aging at high temperatures(up to200℃)and high salinity(saturated salt)***,this work provided new insights into designing and fabricating high-performance drilling fluid treatment agents,demonstrating good potential applications in deep and ultradeep drilling engineering.

关键词： Fluid loss reducer Temperature-and salt-resistance Hydrophobic association Amphoteric Micro-crosslinking

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Manipulating the Macroscopic and Microscopic Morphology of large-Area Gravure-Printed ZnO Films for High-Performance Flexible Organic Solar Cells

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energy & environmental Materials 2024年第2期7卷 229-239页

作者： Zhenguo Wang jingbo Guo Yaqin Pan jin Fang Chao Gong lixin Mo Qun luo Jian lin Changqi Ma School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China i-lab&Printable electronics Research Center Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of Sciences(CAS)Suzhou 215123China Beijing engineering Research Center of Printed electronics Beijing Institute of Graphic CommunicationBeijing 102600China Jiangxi Institute of Nanotechnology Chinese Academy of Sciences(CAS)Nanchang 330200China

Gravure printing is a promising large-scale fabrication method for flexible organic solar cells(FOSCs)because it is compatible with two-dimension patternable roll-to-roll ***,the unsuitable rheological property of ZnO nanoinks resul.ed in unevenness and looseness of the gravure-printed ZnO interfacial *** we propose a strategy to manipulate the macroscopic and microscopic of the gravure-printed ZnO films through using mixed sol.ent and poly(vinylpyrrolidone)(PVP)*** regulation of drying speed effectively manipulates the droplets fusion and leveling process and eliminates the printing ribbing structure in the macroscopic *** additive of PVP effectively regulates the rheological property and improves the microscopic compactness of the *** this method,large-area ZnO∶PVP films(28×9 cm^(2))with excel.ent uniformity,compactness,conductivity,and bending durability were *** power conversion efficiencies of FOSCs with gravure-printed AgNWs and ZnO∶PVP films reached 14.34%and 17.07%for the 1 cm^(2)PM6:Y6 and PM6∶l8-BO flexible *** efficiency of 17.07%is the highest val.e to date for the 1 cm^(2)*** use of mixed sol.ent and PVP addition also significantly enlarged the printing window of ZnO ink,ensuring high-quality printed thin films with thicknesses varying from 30 to 100 nm.

关键词： flexible organic solar cell gravure printing large-area flexible interfacial layer rheology properties zinc oxide

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