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Development and validation of a nomogram for predicting in-hospital mortality of intensive care unit patients with liver cirrhosis

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World Journal of Hepatology 2024年第4期16卷 625-639页

作者： Xiao-Wei Tang wen-Sen Ren Shu Huang Kang Zou Huan Xu Xiao-Min Shi Wei Zhang Lei Shi Mu-Han Lü Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Nuclear Medicine and Molecular Imaging Key Laboratory The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Department of Gastroenterology Lianshui People’Hospital of Kangda College Affiliated to Nanjing Medical UniversityHuaian 223499Jiangsu ProvinceChina

BACKGROUND Liver cirrhosis patients admitted to intensive care unit(ICU)have a high mortality *** To establish and validate a nomogram for predicting in-hospital mortality of ICU patients with liver *** We extracted demographic,etiological,vital sign,laboratory test,comorbidity,complication,treatment,and severity score data of liver cirrhosis patients from the Medical Information Mart for Intensive Care IV(MIMIC-IV)and electronic ICU(eICU)collaborative research database(eICU-CRD).Predictor selection and model building were based on the MIMIC-IV *** variables selected through least absolute shrinkage and selection operator analysis were further screened through multivariate regression analysis to obtain final *** final predictors were included in the multivariate logistic regression model,which was used to construct a ***,we conducted external validation using the *** area under the receiver operating characteristic curve(AUC),decision curve,and calibration curve were used to assess the efficacy of the *** Risk factors,including the mean respiratory rate,mean systolic blood pressure,mean heart rate,white blood cells,international normalized ratio,total bilirubin,age,invasive ventilation,vasopressor use,maximum stage of acute kidney injury,and sequential organ failure assessment score,were included in the multivariate logistic *** model achieved AUCs of 0.864 and 0.808 in the MIMIC-IV and eICU-CRD databases,*** calibration curve also confirmed the predictive ability of the model,while the decision curve confirmed its clinical *** The nomogram has high accuracy in predicting in-hospital *** the included predictors may help improve the prognosis of patients.

关键词： Liver cirrhosis Intensive care unit Nomogram Predicting model Mortality

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引导传导督导:城市设计综合运作系统构建——基于深圳实践的思考

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城市规划 2024年第1期48卷 71-78,89页

作者：周劲崔翀深圳市规划国土发展研究中心(深圳市城市设计促进中心) 哈尔滨工业大学(深圳)建筑学院

经过40多年的探索和实践,深圳在城市设计领域逐渐形成了通则引导、导则传导和规则督导的技术和行政管理机制。针对城市设计的综合运作过程,尝试提出理念、技术和组织三大环节,以及价值、目标、方法、团队、政策和操作6个维度的系统框架... 详细信息

经过40多年的探索和实践,深圳在城市设计领域逐渐形成了通则引导、导则传导和规则督导的技术和行政管理机制。针对城市设计的综合运作过程,尝试提出理念、技术和组织三大环节,以及价值、目标、方法、团队、政策和操作6个维度的系统框架。认为理念环节应该明晰其作为社会动力激发者、经济活力助推者和环境魅力塑造者的价值认知,并根据管理服务对象确定底线、中线和高线的差异化导控目标;技术环节要组织专家、专职和专班相互配合的专业技术团队,加强通则、导则和规则等综合手段;组织环节应在操作中遵循公平、公正、公开的原则,通过公共政策加强对全社会引导、传导和督导的组织实施,使城市设计的美好意图贯穿始终。

关键词：城市设计运作机制导控通则导则规则

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去中心化背景下数字身份识别的法律风险及其应对

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四川师范大学学报（社会科学版） 2024年第5期51卷 69-79,202页

作者：靳梦戈山东大学法学院(威海)

数字身份是数字化时代对个体传统身份的突破和超越的产物,是以数字化方式呈现的身份样态,具有唯一性与可验证性、动态性与跨界性、私有性与匿名性的特征。以用户自主控制身份数据为核心理念的去中心化身份识别技术已成为当下数字身份管... 详细信息

数字身份是数字化时代对个体传统身份的突破和超越的产物,是以数字化方式呈现的身份样态,具有唯一性与可验证性、动态性与跨界性、私有性与匿名性的特征。以用户自主控制身份数据为核心理念的去中心化身份识别技术已成为当下数字身份管理识别的主流。然而,去中心化背景下数字身份识别存在隐私与数据安全、身份盗用与身份欺诈、法律监管以及跨境数据流动等风险。构建安全、可靠、高效、公平的数字身份识别体系,应当注重激励隐私保护并强化数据安全规定,建立数字身份的法定技术标准,构建法律与技术相均衡的协调机制,推进数字身份国际合作的法律协调。

关键词：数字身份去中心化身份识别数据安全隐私保护

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地震亚失稳过程中前兆异常演化的综合解释——以2014年鲁甸6.5级地震为例

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地震地质 2024年第3期46卷 513-535页

作者：蒋海昆邓世广姚琪宋金王锦红中国地震台网中心北京100045 中国地震局地震预测研究所北京100036

文中以2014年鲁甸6.5级地震为例,在亚失稳实验及理论指导下,基于震前地震活动及地球物理观测资料并结合地震成核数值模拟结果,综合分析前兆异常时空演化与亚失稳过程的关系,首次提供了一个可明确佐证亚失稳阶段震源区成核、震源区附近... 详细信息

文中以2014年鲁甸6.5级地震为例,在亚失稳实验及理论指导下,基于震前地震活动及地球物理观测资料并结合地震成核数值模拟结果,综合分析前兆异常时空演化与亚失稳过程的关系,首次提供了一个可明确佐证亚失稳阶段震源区成核、震源区附近协同化过程持续加剧的典型震例和观测事实。研究结果显示,依据大区域强震活动及流动重力观测,可判定鲁甸地震前研究区已处于高应力状态。在高应力背景判定的基础上,依据地震活动及地球物理观测前兆异常,可粗略判定鲁甸地震亚失稳过程可能起始于震前7、8个月,最突出的现象或判定指标是由震中附近小地震活跃所表征的断层应力状态由积累为主向释放为主的转变,以及由定点地球物理观测异常数量显著增加所表征的断层运动协同化现象,从地震成核的角度与成核后期核心弱化区扩张过程有关。之后至主震发生,还有2个时间节点需要关注:一是震前4、5个月,定点地球物理观测异常空间分布范围自震中附近向外围的明显扩展,显示断层变形的加速协同化;二是震前2个月之后,震中附近小地震活动开始减弱、微震活动及定点地球物理异常出现向震中的迁移收缩,与地震成核过程核心弱化区扩展之后的收缩过程相关联。

关键词：亚失稳阶段应力状态变化断层变形协同化鲁甸M 6.5地震小地震活动地球物理观测

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Regulating microstructure and composition by carbonizing in-situ grown metal-organic frameworks on cotton fabrics for boosting electromagnetic wave absorption

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Nano Research 2024年第8期17卷 7290-7300页

作者： Jie jin Hongsen Long Hu Liu Yan Guo Tiantian Bai Ben Bin Xu Mohammed A.Amin Hua Qiu Mohamed H.Helal Chuntai Liu Changyu Shen Zeinhom M.El-Bahy Zhanhu Guo State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002China China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410000China School of Electronic Engineering North China University of Water Resources and Electric PowerZhengzhou 450046China Complex Conditions of High-end Tire Technology Innovation Center Shuguang Rubber Industry Research&Design Institute Co.LtdGuilin 541004China Integrated Composites Lab Department of Mechanical and Civil EngineeringNorthumbria UniversityNewcastle Upon TyneNE18STUK Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Chemistry Faculty of Arts and ScienceNorthern Border UniversityRafha 73213Saudi Arabia Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City 11884CairoEgypt

High-temperature carbonized metal-organic frameworks(MOFs)derivatives have demonstrated their superiority for promising electromagnetic wave(EMW)absorbers,but they still suffer from limited EMW absorption capacity and narrow *** the advantage of microstructure and chemical composition regulation for the design of EMW absorber,hierarchical heterostructured MoS_(2)/CoS_(2)-Co_(3)O_(4)@cabonized cotton fabric(CF)(MCC@CCF)is prepared by growing ZIF-67 MOFs onto CF surface,chemical etching,and *** from the dual loss mechanism of magnetic-dielectric multicomponent carbonized MOFs,chemical etching and carbonization process can effectively introduce abundant micro-gap structure that can result in better impedance matching and stronger absorption capacity via internal reflection,doped heteroatoms(Mo,N,S)to supply additional dipolar polarization loss,and numerous heterointerfaces among MoS_(2),CoS_(2),Co_(3)O_(4),and CCF that produce promoted conduction loss and interfacial polarization ***,a minimal reflection loss of−52.87 dB and a broadest effective absorption bandwidth of 6.88 GHz were achieved via tunning the sample thickness and filler loading,showing excellent EMW absorption *** research is of great value for guiding the research on MOFs derivatives based EMW absorbing materials.

关键词： metal-organic frameworks hierarchical structure chemical etching sulfurization electromagnetic wave absorption

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面向局部学习的点云分割分类网络

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激光与红外 2024年第1期54卷 24-30页

作者：冯锦梁王蕾温智成叶森辉马晗东华理工大学江西南昌330013

在各种3D对象表示中,三维点云越来越受欢迎,其中基于点的方法在各种数据集上都表现出了良好的性能。针对PointNet++只关注了点本身的信息,并未关注相邻点的信息,同时它采用最大池化聚合局部信息,导致丢失次最大值信息。由此,文中提出Con... 详细信息

在各种3D对象表示中,三维点云越来越受欢迎,其中基于点的方法在各种数据集上都表现出了良好的性能。针对PointNet++只关注了点本身的信息,并未关注相邻点的信息,同时它采用最大池化聚合局部信息,导致丢失次最大值信息。由此,文中提出Con-PointNet++网络,该网络利用增强局部信息模块,以关注相邻点的信息,从而增强局部信息特征提取;采用局部注意力机制下的融合池化模块,将最大池化与注意力池化特征信息融合,得到更为丰富的局部特征信息。本文方法在室内数据集S3DIS的Area_5区域上评估模型语义分割能力,mIoU达55.2%;在数据集ModelNet40上评估模型分类效果,OA达91.2%。与其他方法相比,所提模型性能均有提升,进一步证明了本文方法的有效性。

关键词：三维点云语义分割分类局部注意力机制局部增强模块

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Computer-assisted three-dimensional individualized extreme liver resection for hepatoblastoma in proximity to the major liver vasculature

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1066-1077页

作者： wen-Li Xiu Jie Liu jing-Li Zhang jing-Miao Wang Xue-Feng Wang Fei-Fei Wang Jie Mi Xi-Wei Hao NanXia Qian Dong Department of Pediatric Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Pediatric Surgery Yijishan Hospital of Wannan Medical CollegeWuhu 241000Anhui ProvinceChina Shandong Provincial Key Laboratory of Digital Medicine and Computer-assisted Surgery Shandong College Collaborative Innovation Center of Digital Medicine Clinical Treatment and Nutrition HealthQingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND The management of hepatoblastoma(HB)becomes challenging when the tumor remains in close proximity to the major liver vasculature(PMV)even after a full course of neoadjuvant chemotherapy(NAC).In such cases,extreme liver resection can be considered a potential *** To explore whether computer-assisted three-dimensional individualized extreme liver resection is safe and feasible for children with HB who still have PMV after a full course of *** We retrospectively collected data from children with HB who underwent surgical resection at our center from June 2013 to June *** then analyzed the detailed clinical and three-dimensional characteristics of children with HB who still had PMV after a full course of *** Sixty-seven children diagnosed with HB underwent surgical *** age at diagnosis was 21.4±18.8 months,and 40 boys and 27 girls were ***-nine(88.1%)patients had a single tumor,39(58.2%)of which was located in the right lobe of the liver.A total of 47 patients(70.1%)had PRE-TEXT III or ***-nine patients(58.2%)underwent delayed *** a full course of NAC,16 patients still had close PMV(within 1 cm in two patients,touching in 11 patients,compressing in four patients,and showing tumor thrombus in three patients).There were 6 patients of tumors in the middle lobe of the liver,and four of those patients exhibited liver anatomy *** 16 children underwent extreme liver resection after comprehensive preoperative *** procedures were performed according to the preoperative plan,and the operations were successfully ***,the 3-year event-free survival of 67 children with HB is 88%.Among the 16 children who underwent extreme liver resection,three experienced recurrence,and one died due to multiple *** Extreme liver resection for HB that is still in close PMV after a full course of NAC is both safe and *** approach not only reduces th

关键词： Children Hepatoblastoma Surgery Three-dimensional Computer-assisted

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共振非弹性X射线散射在量子材料领域的应用

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物理学报 2024年第19期73卷 103-121页

作者：周克瑾英国钻石同步辐射光源哈维尔园区迪德科特OX110DE

共振非弹性X射线散射(resonant inelastic X-ray scattering,RIXS)是一种先进的基于同步辐射和自由电子激光光源的光进光出的谱学探测手段.在过去的十几年,RIXS的能量分辨不断被提高,其对凝聚态物质的研究也从最初的晶体场分裂和电荷转... 详细信息

共振非弹性X射线散射(resonant inelastic X-ray scattering,RIXS)是一种先进的基于同步辐射和自由电子激光光源的光进光出的谱学探测手段.在过去的十几年,RIXS的能量分辨不断被提高,其对凝聚态物质的研究也从最初的晶体场分裂和电荷转移激发,发展到产生于包括电荷、自旋、轨道、晶格4个量子自由度的集体激发行为及相关的序参量.本文总结了近几年高分辨软X射线RIXS在量子材料领域,如铜基和镍基高温超导材料等离子激发及磁激发的研究,量子材料中的集体轨道激发、激子激发和高阶磁激发,以及对磁性金属和拓扑磁性材料中磁激发的探测.

关键词：共振非弹性X射线散射元激发高温超导一维量子自旋链拓扑磁性材料

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High-throughput screening of novel TFEB agonists in protecting against acetaminopheninduced liver injury in mice

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Acta Pharmaceutica Sinica B 2024年第1期14卷 190-206页

作者： Xiaojuan Chao Mengwei Niu Shaogui Wang Xiaowen Ma Xiao Yang Hua Sun Xujia Hu Hua Wang Li Zhang Ruili Huang Menghang Xia Andrea Ballabio Hartmut Jaeschke Hong-Min Ni wen-Xing Ding Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKS 66160USA NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Oncology the First Affiliated Hospital of Anhui Medical UniversityAnhui Medical UniversityHefei 230032China National Center for Advancing Translational Sciences National Institutes of HealthBethesdaMD 20892USA Telethon Institute of Genetics and Medicine TIGEMPozzuoliNaples 80131Italy Medical Genetics Department of Translational MedicineFederico II UniversityNaples 80131Italy Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Department of Internal Medicine Division of GastroenterologyHepatology&MotilityUniversity of Kansas Medical CenterKansas CityKS 66160USA

Macroautophagy(referred to as autophagy hereafter)is a major intracellular lysosomal degradation pathway that is responsible for the degradation of misfolded/damaged proteins and *** studies showed that autophagy protects against acetaminophen(APAP)-induced injury(AILI)via selective removal of damaged mitochondria and APAP protein *** lysosome is a critical organelle sitting at the end stage of autophagy for autophagic degradation via fusion with *** the present study,we showed that transcription factor EB(TFEB),a master transcription factor for lysosomal biogenesis,was impaired by APAP resulting in decreased lysosomal biogenesis in mouse *** loss-of and gain-of function of hepatic TFEB exacerbated or protected against AILI,***,overexpression of TFEB increased clearance of APAP protein adducts and mitochondria biogenesis as well as SQSTM1/p62-dependent non-canonical nuclear factor erythroid 2-related factor 2(NRF2)activation to protect against *** also performed an unbiased cell-based imaging high-throughput chemical screening on TFEB and identified a group of TFEB *** these agonists,salinomycin,an anticoccidial and antibacterial agent,activated TFEB and protected against AILI in *** conclusion,genetic and pharmacological activating TFEB may be a promising approach for protecting against AILI.

关键词： Autophagy DILI Drug screening Hepatotoxicity Lysosome Mitochondria Mitophagy NRF2

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Experimental study on the mechanism of flow blockage formation in fast reactor

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Nuclear Science and Techniques 2023年第6期34卷 171-182页

作者： wen-Hui jin Song-Bai Cheng Xiao-Xing Liu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai519082China

Various sources of solid particles might exist in the coolant flow of a liquid metal cooled fast reactor(e.g.,through chemical interaction between the coolant and impurities,air,or water,through corrosion of structural materials,or from damaged/molten fuel).Such particles may cause flow blockage accidents in a fuel assembly,resulting in a reduction in coolant flow,which potentially causes a local temperature rise in the fuel cladding,cladding failure,and fuel *** understand the blockage formation mechanism,in this study,a series of simulated experiments was conducted by releasing different solid particles from a release device into a reducer pipe using *** detailed analyses,the influence of various experimental parameters(e.g.,particle diameter,capacity,shape,and static friction coefficient,and the diameter and height of the particle release nozzle)on the blockage characteristics(i.e.,blockage probability and position)was *** the current range of experimental conditions,the blockage was significantly influenced by the aforementioned *** ratio between the particle diameter and outlet size of the reducer pipe might be one of the determining factors governing the occurrence of ***,increasing the ratio enhanced blockage(i.e.,larger probability and higher position within the reducer pipe).Increasing the particle size,particle capacity,particle static friction coefficient,and particle release nozzle diameter led to a rise in the blockage probability;however,increasing the particle release nozzle height had a downward influence on the blockage ***,blockage was more likely to occur in non-spherical particles case than that of spherical *** study provides a large experimental database to promote an understanding of the flow blockage mechanism and improve the validation process of fast reactor safety analysis codes.

关键词： Liquid metal cooled fast reactor Flow blockage Granular jamming Experimental study

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