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西安体育学院学报 2003年第5期20卷 42-43页

作者：魏锦龙马莉李世荣延安大学体育学院陕西延安716000

采用文献研究法、调查研究法和数理统计法等,对延安大学98年入校的本科学生的身体形态、机能、身体素质进行了4年追踪研究,得出延安大学学生在校期间体质健康状况发展变化的特点、规律、趋势及存在的差异和原因,并针对存在的问题提出了... 详细信息

采用文献研究法、调查研究法和数理统计法等,对延安大学98年入校的本科学生的身体形态、机能、身体素质进行了4年追踪研究,得出延安大学学生在校期间体质健康状况发展变化的特点、规律、趋势及存在的差异和原因,并针对存在的问题提出了改进措施与建议。

关键词：大学生体质健康

MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang ma jing wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng Qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian Tang Yuan-Ming Pan wei Li Rui-Qiong ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

NASICON-Structured NaTi2（PO4）3 for Sustainable Energy Storage

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Nano-Micro Letters 2019年第3期11卷 119-154页

作者： Mingguang Wu wei Ni jin Hu Jianmin ma School of Physics and Electronics Hunan UniversityChangsha410082People’s Republic of China Faculty of Technology University of Oulu90014OuluFinland Panzhihua University Panzhihua617000People’s Republic of China Key Laboratory of materials Processing and Mold Ministry of EducationZhengzhou UniversityZhengzhou450002People’s Republic of China

Several emerging energy storage technologies and systems have been demonstrated that feature low cost,high rate capability,and durability for potential use in large-scale grid and high-power *** to its outstanding ion conductivity,ultrafast Na-ion insertion kinetics,excellent structural stability,and large theoretical capacity,the sodium superionic conductor(NASICON)-structured insertion material NaTi2(PO4)3(NTP)has attracted considerable attention as the optimal electrode material for sodium-ion batteries(SIBs)and Na-ion hybrid capacitors(NHCs).On the basis of recent studies,NaTi2(PO4)3 has raised the rate capabilities,cycling stability,and mass loading of rechargeable SIBs and NHCs to commercially acceptable *** this comprehensive review,starting with the structures and electrochemical properties of NTP,we present recent progress in the application of NTP to SIBs,including non-aqueous batteries,aqueous batteries,aqueous batteries with desalination,and sodium-ion hybrid *** a thorough discussion of the unique NASICON structure of NTP,various strategies for improving the performance of NTP electrode have been presented and summarized in ***,the major challenges and perspectives regarding the prospects for the use of NTP-based electrodes in energy storage systems have also been summarized to offer a guideline for further improving the performance of NTP-based electrodes.

关键词： NaTi2(PO4)3 Sodium superionic conductor Anode Batteries Hybrid capacitors

多次重复静脉应用氨甲环酸减少初次全髋关节置换术失血有效性与安全性的前瞻性对照研究

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中国骨与关节杂志 2016年第12期5卷 885-890页

作者：姚欢谢锦伟岳辰马俊裴福兴四川大学华西医院骨科成都610041

目的探讨多次重复静脉应用氨甲环酸(tranexamic acid,TXA)减少初次全髋关节置换术(total hip arthroplasty,THA)围手术期失血的有效性及安全性。方法选择2014年12月至2015年9月拟行初次THA患者90例,按TXA的不同用法以数字表法随机分为3... 详细信息

目的探讨多次重复静脉应用氨甲环酸(tranexamic acid,TXA)减少初次全髋关节置换术(total hip arthroplasty,THA)围手术期失血的有效性及安全性。方法选择2014年12月至2015年9月拟行初次THA患者90例,按TXA的不同用法以数字表法随机分为3组。单次给药组:30例术前静脉滴注TXA20 mg/kg;重复给药组:30例术前静脉滴注TXA 20 mg/kg后,3 h再次静脉滴注TXA 10 mg/kg;多次给药组:30例术前静脉滴注TXA 20 mg/kg后,3、6 h再次静脉滴注TXA 10 mg/kg。3组均于术中3个时点局部使用总量1.5 g的TXA。主要指标为隐性失血量、术后血红蛋白下降最大值、总失血量、输血率、术后血栓发生事件;次要指标为术后引流量、住院时间及伤口并发症。结果多次给药组隐性失血量(308.21±221.91)ml、总失血量(589.34±190.85)ml、血红蛋白下降最大值(20.07±6.06)g/L、均明显低于重复给药组(509.91±237.82)ml、(815.57±234.31)ml、(25.53±8.30)g/L、和单次给药组(681.86±380.82)ml、(1037.53±367.68)ml、(29.60±10.30)g/L,差异有统计学意义(P0.05)。3组患者输血率均为0,无一例出现肺栓塞及下肢深静脉血栓。结论在THA术中使用TXA可以减少患者围手术期隐性失血及血红蛋白丢失,且不增加血栓风险。多次重复应用TXA可有效安全的进一步减少围手术期隐性失血及血红蛋白丢失,其中以3 h、6 h多次给药效果显著。

关键词：氨甲环酸关节成形术,置换,髋失血,手术髋关节

An Integrated Incentive Framework for Mobile Crowdsourced Sensing

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Tsinghua Science and Technology 2016年第2期21卷 146-156页

作者： wei Dai Yufeng Wang Qun jin Jianhua ma College of Telecommunications and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China. Department of Human Informatics and Cognitive Sciences Waseda UniversitySaitama 359-1192Japan. Faculty of Computer&Information Sciences Hosei UniversityTokyo 184-8584Japan

Currently, mobile devices （e.g., smartphones） are equipped with multiple wireless interfaces and rich builtin functional sensors that possess powerful computation and communication capabilities, and enable numerous Mobile Crowdsourced Sensing （MCS） applications. Generally, an MCS system is composed of three components： a publisher of sensing tasks, crowd participants who complete the crowdsourced tasks for some kinds of rewards, and the crowdsourcing platform that facilitates the interaction between publishers and crowd participants. Incentives are a fundamental issue in MCS. This paper proposes an integrated incentive framework for MCS, which appropriately utilizes three widely used incentive methods： reverse auction, gamification, and reputation updating. Firstly, a reverse-auction-based two-round participant selection mechanism is proposed to incentivize crowds to actively participate and provide high-quality sensing data. Secondly, in order to avoid untruthful publisher feedback about sensing-data quality, a gamification-based verification mechanism is designed to evaluate the truthfulness of the publisher＇s feedback. Finally, the platform updates the reputation of both participants and publishers based on their corresponding behaviors. This integrated incentive mechanism can motivate participants to provide high-quality sensed contents, stimulate publishers to give truthful feedback, and make the platform profitable.

关键词： mobile crowdsourced sensing incentive mechanism reverse auction gamification reputation updating

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自激式混合原子自旋振荡器的实验研究

原子与分子物理学报 2025年第4期42卷 108-112页

作者：马千金李二伟刘国宾中国科学院国家授时中心西安710600 中国科学院大学北京100049

基于碱金属-惰性气体混合自旋体系的原子共磁力计被广泛应用于寻找新相互作用、暗物质粒子等基础物理研究,以及惯性导航与生物磁探测等现实应用领域.基于Rb-Xe原子共磁力计,我们实现了一种自激式的混合原子自旋振荡器.其原理是在z轴方... 详细信息

基于碱金属-惰性气体混合自旋体系的原子共磁力计被广泛应用于寻找新相互作用、暗物质粒子等基础物理研究,以及惯性导航与生物磁探测等现实应用领域.基于Rb-Xe原子共磁力计,我们实现了一种自激式的混合原子自旋振荡器.其原理是在z轴方向上使用圆偏振光将碱金属原子极化,碱金属与惰性气体原子在高温下发生碰撞,进而将惰性气体的核自旋极化.当外磁场存在时,核自旋磁矩将在磁力矩的作用下以拉莫尔频率绕外磁场进动.在x方向上使用线偏振光进行探测,可得到原子自旋振荡信号,通过将光检信号放大、滤波、移相再施加到横向激励磁场线圈上,产生的交变磁场同步驱动核自旋进动,实现闭环自激的原子自旋无衰减振荡信号.本文从实验角度研究了该自旋振荡器的开环频率响应特性,及闭环状态下的自旋振荡频率移动随增益、相位参数变化的关系.实验结果与前期理论预期基本符合,并为提高该振荡器的频率稳定性提供重要参考.

关键词：原子自旋振荡器频移增益相位

Effects of adverse pressure gradient on Reynolds stresses inturbulent boundary layers

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航空动力学报 2017年第2期32卷 463-469页

作者： LUO Xiao-tian ZHANG Ce ma wei TENG jin-fang School of Aeronautics and Astronautics Shanghai Jiao Tong University

The effects of adverse pressure gradient(APG)on Reynolds stresses in turbulent boundary layers(TBLs)with APG were *** difficulty of this work was attributable to the Reynolds stresses in TBLs with APG under two combined effects,i.e.:effect of upstream flow and effect of *** effect of upstream flow is an inherent effect no matter pressure gradient exists or *** individual effect was analyzed from absolute developments of Reynolds stresses in TBLs with zero pressure gradient(ZPG)*** of APG was then analyzed from absolute developments of Reynolds stresses in TBLs with *** showed that,for absolute development of mean streamwise Reynolds stresses,APG accelerated its development in TBL with ZPG;for absolute development of mean normal or shear Reynolds stresses,APG increased their magnitude in the outer part,and decreased their extent of large value region.

关键词： turbulent boundary layer adverse pressure gradient zero pressure gradient Reynolds stresses flat plate

Gamma-,neutron-,and muon-induced environmental background simulations for 100Mo-based bolometric double-beta decay experiment at jinping Underground Laboratory

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Nuclear Science and Techniques 2023年第9期34卷 50-57页

作者： wei Chen Long ma jin-Hui Chen Huan-Zhong Huang Key Laboratory of Nuclear Physics and Ion-Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China University of California Los AngelesCA 90095USA

The sensitivity of an experiment to detect the majorana neutrino mass via neutrinoless double-beta decay(0νββ) strongly depends on the rate of background events that can mimic this decay. One major source of this background is the radioactive emissions from the laboratory environment. In our study, we focused on assessing the background contributions from environmental gamma rays, neutrons, and underground muons to the jinping bolometric demonstration experiment. This experiment uses an array of lithium molybdate crystal bolometers to probe the potential 0νββ decay of the100Mo isotope at the China jinping Underground Laboratory. We also evaluated the shielding effectiveness of the experimental setup through an attenuation study. Our simulations indicate that the combined background from environmental gamma rays, neutrons, and muons in the relevant100Mo 0νββ Q-value region can be reduced to approximately 0.003 cts/kg/keV/yr.

关键词： Neutrinoless double-beta decay Geant4 CUPID

maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun ma Peng-Peng Li Hai-wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin