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Advanced pancreatic cancer treated with camrelizumab combined with apatinib:A case report

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 284-290页

作者： Yun-Hao Luo Ting He Lu Lin rong-Qiu Wang Hong-Xia Cai Wen hu Department of Critical Care Medicine Chengdu First People's HospitalChengdu 610000Sichuan ProvinceChina Department of Radiology Sichuan Second Hospital of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina Department of Oncology Chengdu Seventh People's HospitalChengdu 610000Sichuan ProvinceChina Department of Oncology West China Tianfu HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina

BACKGROUND The 5-year survival rate for patients with pancreatic cancer(PC)is 4%-12%.Surgery is the only treatment that offers curative potential,but only 15%-20%of patients are eligible for *** is prone to recurrence and metastasis,and the antitumor effect of chemotherapy is notably *** SUMMARY Histopathological analysis of a 53-year-old female PC patient who underwent Whipple surgery revealed poorly differentiated tumor cells infiltrating nerves,lymphatics,and blood *** patient received two different first-line chemotherapy regimens consecutively;however,both regimens struggled to control disease *** this period,the patient underwent liver metastasis ablation surgery,Candida albicans liver abscess,and stereotactic body *** the addition of camrelizumab to the modified FOLFIRINOX regimen,tumor control was *** patient subsequently refused to continue chemotherapy,and the antitumor regimen was changed to a combination of camrelizumab and *** patients received a combination of immunotherapy and targeted therapy,the length of hospital stay was significantly ***,all side effects were within acceptable limits,leading to an improved quality of life and prolonged progression-free ***,the pain associated with cancer,coupled with the side effects of opioid analgesics,has led the patient to reject all available anticancer treatment *** one month after camrelizumab and apatinib were discontinued without medical authorization,the PC recurred and rapidly progressed to widespread metastasis,ultimately leading to the patient's death approximately one month *** overall survival was 2 *** Immunotherapy and targeted therapy have the potential to increase both the quality of life and survival time of PC patients,particularly those whose tumor progression is not effectively controlled by chemotherapy ***,further clinical trials a

关键词： Advanced pancreatic cancer Immunotherapy Camrelizumab Targeted therapy Apatinib Case report

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基于颤振稳定性的悬索桥加劲梁梁高的确定

同济大学学报（自然科学版） 2002年第5期30卷 573-577页

作者：马如进陈艾荣胡晓红同济大学桥梁工程系上海200092

在悬索桥的抗风设计中 ,流线型箱梁由于具有较好的抗风性能而得到广泛应用 .通过经验公式分析和有限元两种方法得出箱梁梁高对悬索桥颤振稳定性的影响规律 ,并提出了常用桥宽下悬索桥梁高设计的近似公式 .另外。

关键词：颤振稳定性悬索桥加劲梁梁高振型耦合参数分析

Curcumol ameliorates diabetic retinopathy via modulating fat mass and obesity-associated protein-demethylated MAF transcription factor G antisense RNA 1

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World Journal of Diabetes 2025年第4期16卷 220-235页

作者： Han rong Yu hu Wei Wei Department of Ophthalmology The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Ophthalmology Huai’an Maternal and Child Health Care Hospital Affiliated to Yangzhou UniversityHuai’an 223002Jiangsu ProvinceChina Department of Nephrology The Affiliated Huai’an Hospital of Xuzhou Medical UniversityThe Second People’s Hospital of Huai’anHuai’an 223002Jiangsu ProvinceChina First College of Clinical Medicine Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina.

BACKGROUND Diabetic retinopathy(DR)is a major microvascular complication of diabetes mellitus,leading to significant visual impairment and blindness among *** treatment options are limited,making it essential to explore novel therapeutic ***,a sesquiterpenoid derived from traditional Chinese medicine,has shown anti-inflammatory and anti-cancer properties,but its potential role in DR remains *** To investigate the therapeutic effects of curcumol on the progression of DR and to elucidate the underlying molecular mechanisms,particularly its impact on the fat mass and obesity-associated(FTO)protein and the long non-coding RNA(lncRNA)MAF transcription factor G antisense RNA 1(MAFG-AS1).METHODS A streptozotocin-induced mouse model of DR was established,followed by treatment with *** damage and inflammation were evaluated through histological analysis and molecular *** retinal vascular endothelial cells were exposed to high glucose conditions to simulate diabetic environments in *** proliferation,migration,and inflammation markers were assessed in curcumoltreated *** microarray analysis identified key molecules regulated by curcumol,and further experiments were conducted to confirm the involvement of FTO and MAFG-AS1 in the progression of *** Curcumol treatment significantly reduced blood glucose levels and alleviated retinal damage in streptozotocininduced DR mouse *** high-glucose-treated human retinal vascular endothelial cells,curcumol inhibited cell proliferation,migration,and inflammatory *** microarray analysis identified MAFG-AS1 as the most upregulated lncRNA following curcumol ***,FTO demethylated MAFG-AS1,stabilizing its *** experiments demonstrated that the protective effects of curcumol against DR were mediated through the FTO/MAFG-AS1 signaling *** Curcumol ameliorates the progression of DR by modulating the FTO

关键词： Diabetic retinopathy Curcumol MAF transcription factor G antisense RNA 1 Fat mass and obesity-associated protein Diabetes mellitus

Airborne Investigation of Riming: Cloud and Precipitation Microphysics within a Weak Convective System in North China

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ADVANCES IN ATMOSPHERIC SCIENCES 2025年第3期42卷 515-526页

作者： hu, Xiangfeng huang, Hao Hou, Shaoyu Zhao, Kun Zhao, Chuanfeng Lu, Yinghui Yang, Jiefang Zhang, rong Zhao, Delong Liu, Weiguo Zhang, Dan Xiao, Haixia China Meteorol Adm Key Lab Radar Meteorol Beijing 100044 Peoples R China China Meteorol Adm State Key Lab Severe Weather Beijing 100044 Peoples R China China Meteorol Adm Xiongan Atmospher Boundary Layer Key Lab Xiongan New Area Hebei 071703 Peoples R China Hebei Prov Weather Modificat Ctr Shijiazhuang 051430 Hebei Peoples R China Nanjing Univ Sch Atmospher Sci Key Lab Mesoscale Severe Weather MOE Jiangsu 210023 Peoples R China Nanjing Univ Frontiers Sci Ctr Crit Earth Mat Cycling Jiangsu 210023 Peoples R China Peking Univ Sch Phys Dept Atmospher & Ocean Sci Beijing 100871 Peoples R China Chinese Acad Sci Inst Atmospher Phys Lab Cloud Precipitat Phys & Severe Storms Beijing 100029 Peoples R China China Meteorol Adm Cloud Precipitat Phys & Weather Modificat Key Lab Beijing 100044 Peoples R China Beijing Weather Modificat Ctr Beijing 100089 Peoples R China Nanjing Joint Inst Atmospher Sci Nanjing 210000 Peoples R China

The process of riming significantly impacts the microphysical characteristics of clouds. This study uses aircraft and radar observation data in stratiform clouds with convection embedded that occurred in the central and southern regions of North China on 22 May 2017. The microphysical structural characteristics and processes near the embedded convection core and in the stratiform cloud are analyzed comparatively. Particular attention is given to the effect of riming on the microphysical properties near the upper boundary of the melting layer and to the factors influencing riming efficiency. The collaborative observations reveal that the particle size distributions observed near the convection core and in the stratiform region are close, while the particle properties like habit and riming degree are quite different. Above the melting layer, larger plate-like ice particles and supercooled water droplets (D > 50 mu m) are more abundant near the convective core, leading to higher collision efficiencies between ice particles and supercooled water droplets. Larger fluctuation amplitudes of vertical airflow near the convective core also contribute to the increased riming activity and the formation of more heavily rimed particles, such as graupel. Furthermore, in situ measurements from airborne probes also revealed that above the melting layer, the riming process involves two stages: the mass of snow crystals grows as supercooled droplets merge internally without changing size, followed by external freezing that significantly enlarges the crystals.

关键词： riming collision efficiency airflow fluctuation particle habit aircraft measurement

Correlation between gut microbiota and tumor immune microenvironment:A bibliometric and visualized study

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World Journal of Clinical Oncology 2025年第2期16卷 110-129页

作者： Zheng-Jun hu hui-rong Zhu Yong-Jie jin Pan Liu Xiao-Wei Yu Yu-Ren Zhang Department of Oncology Shanghai Jiading District Hospital of Traditional Chinese MedicineShanghai 200000China Department of Oncology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200000China School of Chinese Medicine Anhui University of Traditional Chinese MedicineHefei 230000Anhui ProvinceChina

BACKGROUND In recent years,numerous reports have been published regarding the relationship between the gut microbiota and the tumor immune microenvironment(TIME).However,to date,no systematic study has been conducted on the relationship between gut microbiota and the TIME using bibliometric *** To describe the current global research status on the correlation between gut microbiota and the TIME,and to identify the most influential countries,research institutions,researchers,and research hotspots related to this *** We searched for all literature related to gut microbiota and TIME published from January 1,2014,to May 28,2024,in the Web of Science Core Collection *** then conducted a bibliometric analysis and created visual maps of the published literature on countries,institutions,authors,keywords,references,etc.,using CiteSpace(6.2R6),VOSviewer(1.6.20),and bibliometrics(based on R 4.3.2).RESULTS In total,491 documents were included,with a rapid increase in the number of publications starting in *** country with the highest number of publications was China,followed by the United *** has the highest number of citations in *** a centrality perspective,the United States has the highest influence in this *** institutions with the highest number of publications were Shanghai Jiao Tong University and Zhejiang ***,the institution with the most citations was the United States National Cancer *** authors,Professor Giorgio Trinchieri from the National Institutes of Health has the most local impact in this *** most cited author was Fan *** results of journal publications showed that the top three journals with the highest number of published papers were Frontiers in Immunology,Cancers,and Frontiers in *** three most frequently used keywords were gut microbiota,tumor microenvironment,and *** This study systematically elaborates on the research progress re

关键词： Gut microbiota Tumor immune microenvironment Bibliometric CiteSpace VOSviewer R-bibliometrics

Failure mechanisms of AlGaN/GaN HEMTs irradiated by high-energy heavy ions with and without bias

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Nuclear Science and Techniques 2025年第1期36卷 49-58页

作者： Pei-Pei hu Li-Jun Xu Sheng-Xia Zhang Peng-Fei Zhai Ling Lv Xiao-Yu Yan Zong-Zhen Li Yan-rong Cao Xue-Feng Zheng Jian Zeng Yuan He Jie Liu Institute of Modern Physics Chinese Academy of Sciences(CAS)Lanzhou 730000China Key Laboratory of Wide Band‑gap Semiconductor Materials Ministry of EducationXidian UniversityXi’an 710071China University of Chinese Academy of Sciences(UCAS) Beijing 100049China

Gallium nitride(GaN)-based devices have significant potential for space ***,the mechanisms of radiation damage to the device,particularly from strong ionizing radiation,remains *** study investigates the effects of radiation on p-gate AlGaN/GaN high-electron-mobility transistors(HEMTs).Under a high voltage,the HEMT leakage current increased sharply and was accompanied by a rapid increase in power density that caused"thermal burnout"of the *** addition,a burnout signature appeared on the surface of the burned devices,proving that a single-event burnout effect ***,degradation,including an increase in the on-resistance and a decrease in the breakdown voltage,was observed in devices irradiated with high-energy heavy ions and without *** latent tracks induced by heavy ions penetrated the heterojunction interface and extended into the GaN ***,a new type of N_(2)bubble defect was discovered inside the tracks using Fresnel *** accumulation of N_(2)bubbles in the heterojunction and buffer layers is more likely to cause leakage and *** study indicates that electrical stress accelerates the failure rate and that improving heat dissipation is an effective reinforcement method for GaN-based devices.

关键词： GaN HEMTs Heavy ions Single-event burnout Latent tracks Degradation

Near-infrared organic photosensitizers with aggregation-induced emission and switchable fluorescence for fungal infection therapy

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Science China Chemistry 2025年

作者： Xinzhe Yang Zixuan huang Keke Ding huili Yang Lirong Wang Qing Xia rong hu Guang Shi Bingjia Xu Anjun Qin School of Chemistry South China Normal University State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates Center for Aggregation-Induced Emission AIE Institute South China University of Technology Department of Urology The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College) School of Chemistry and Chemical Engineering University of South China

The development of near-infrared (NIR) photosensitizers with aggregation-induced emission (AIE) properties,switchable luminescence colors,and satisfactory photodynamic therapy (PDT) effects on the treatment of fungal infection is of great importance but very ***,two ionic organic luminogens are constructed by employing diphenylamine,diphenylacrylonitrile/1,2-diphenylethene,and methylated quinoline cation as building *** is found that the resulting compounds TCQF and TQF show apparent AIE properties and produce intense fluorescence with high photoluminescence quantum yields of up to 31.2%in the solid *** the meantime,their emission colors can be switched between red and NIR and in the NIR region by mechanical force and solvent vapor,respectively,thereby enabling remarkable and reversible mechanochromism with emission variations of up to 104 *** excitingly,TCQF and TQF can efficiently generate ROS under the illumination of white light and show excellent antimicrobial activities and satisfactory PDT *** by the unique anti-fungus properties,TCQF is employed as a biocompatible NIR photosensitizer for treating wound infection with ***,and apparent PDT effects are *** work provides a new direction for the development of multifunctional NIR materials with AIE properties.

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光子计数探测器CT诊断老年患者胆囊阴性结石1例

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中华放射学杂志 2025年第2期59卷 223-224页

作者：胡蓉金东生陈骥梁罗松南京医科大学附属老年医院放射科南京210024 西门子数字医疗科技(上海)有限公司CT科研合作部上海200135

该文报道光子计数探测器CT(PCD-CT)诊断胆囊多发阴性结石1例。患者女,95岁,因右上腹疼痛、皮肤黄染入院,能量积分探测器CT腹部平扫胆囊未见明显结石影。进一步行PCD-CT腹部增强扫描后,采用单能谱曲线多个能量显示其内多发异常密度,低ke... 详细信息

该文报道光子计数探测器CT(PCD-CT)诊断胆囊多发阴性结石1例。患者女,95岁,因右上腹疼痛、皮肤黄染入院,能量积分探测器CT腹部平扫胆囊未见明显结石影。进一步行PCD-CT腹部增强扫描后,采用单能谱曲线多个能量显示其内多发异常密度,低keV下呈低密度,高keV下呈稍高密度。腹部MRI证实为胆囊多发结石。PCD-CT常规成像即可进行能量CT成像分析,可提高胆囊阴性结石诊断敏感性。

关键词：体层摄影术,X线计算机光子计数探测器能量积分探测器胆囊阴性结石

Comparison of bilateral implantation of extended depth-of-focus intraocular lens and mix-and-match implantation of extended depth-of-focus intraocular lens with a diffractive bifocal intraocular lens

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国际眼科杂志 2025年第3期25卷 337-343页

作者： Li Tong Li Zhuoya Guo rong hu Xiaomin Zhang hui Department of Ophthalmology the First People s Hospital of XianyangXianyang 712000Shaanxi ProvinceChina Department of Ophthalmology Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

AIM:To compare the clinical outcomes of extended depth-of-focus intraocular lenses(EDOF IOLs)using either micromonovision implantation or mixed implantation of EDOF and diffractive bifocal ***:This retrospective clinical trial included 130 patients(260 eyes),who were divided into two *** RR comprised 70 patients(140 eyes)bilaterally implanted with ZXR00 IOLs(Tecnis ZXR00,where one target was-0.5 D to-0.75 D and the other was 0 to-0.25 D).Group RM comprised 60 patients(120 eyes)unilaterally implanted with both ZXR00 and ZMB00 IOLs(Tecnis ZMB00,0 to-0.25 D).Postoperative outcomes were compared after 3 mo,including visual acuity,defocus curves,stereoacuity,modulation transfer functions(MTFs),higher-order aberrations,and Visual Function-14(VF-14)questionnaire ***:Group RR had superior bilateral intermediate vision,while the group RM had superior bilateral near vision(both P0.05).CONCLUSION:The implantation of micromonovision has significantly improved near *** and their collocation can be customized according to individual patient needs to achieve precise treatment and provide cataract patients with high-quality vision.

关键词： extended depth-of-focus(EDOF)intraocular lens Tecnis ZMB00 defocus curve micromonovision mix-and-match vision