检索结果-南通市图书馆

World Journal of Gastroenterology 2024年第20期30卷 2689-2708页

作者： Lian-Meng Huang ming-jin zhang Department of General Surgery The 901st Hospital of PLAHefei 230031Anhui ProvinceChina

BACKGROUND The regulatory effects of KIF26B on gastric cancer(GC)have been confirmed,but the specific mechanism still needs further ***-cancer analysis shows that the KIF26B expression is highly related to immune infiltration of cancerassociated fibroblasts(CAFs),and CAFs promote macrophage M2 polarization and affect cancers’*** To investigate the regulatory functions of KIF26B on immune and metastasis of *** We analyzed genes’mRNA levels by quantitative real-time polymerase chain *** levels of target proteins were detected by immunohistochemistry,ELISA,and Western *** injected AGS cells into nude mice for the establishment of a xenograft tumor model and observed the occurrence and metastasis of *** degree of inflammatory infiltration in pulmonary nodes was observed through hematoxylin-eosin *** and wound healing assays were performed for the evaluation of cell invasion and migration *** formation assay was used for detecting angiogenesis.M2-polarized macrophages were estimated by immunofluorescence and flow *** KIF26B was significantly overexpressed in cells and tissues of GC,and the higher expression of KIF26B was related to GC metastasis and *** to in vivo experiments,KIF26B promoted tumor formation and metastasis of ***26B expression was positively associated with CAFs’degree of ***,CAFs could regulate M2-type polarization of macrophages,affecting GC cells’migration,angiogenesis,invasion,and epithelial-mesenchymal transition *** KIF26B regulated M2 polarization of macrophage through activating CAFs,regulating the occurrence and metastasis of GC.

关键词： metastasis invasion macrophage

Elastodynamic analysis of synergistic oscillation system driven by double servomotors for continuous casting mold

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2022年第1期29卷 115-123页

作者： Da-wei Liu Chen Lv jin-ming zhang Xin jin College of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina National Engineering Technology Research Center of Cold Rolling Strip Equipment and Technology Yanshan UniversityQinhuangdao 066004HebeiChina

Based on the principle of speed superposition,the oscillation system for continuous casting mold synchronously driven by double servomotors can adjust all parameters online with high reliability and high bearing *** elastodynamic model of the oscillation system was presented to analyze the oscillation characteristics affected by multiple ***,the working principle of the system was illustrated,with the kinematic model of the system *** the elastic deformation of mechanical components,the lumped parameter method was used to establish the equivalent component and elastodynamic model of the oscillation *** on Runge–Kutta method,the oscillation response of the system was *** validity of the elastodynamic model was validated by comparing the simulated solution and experimental data,and the oscillation characteristics of the system were analyzed emphatically with model *** results showed that the first three harmonic frequencies of the eccentric shafts are the main cause of harmonic resonance,which has a strong relationship with the system *** increase in the fluctuation coefficients and the decrease in the phase difference enhanced the elastic oscillation of the *** elastic error tends to show linear growth with the increase in the friction force of the slab.

关键词： Continuous casting Mold Non-sinusoidal oscillation Elastic response

Functional Cellulose Materials Fabricated by Using Ionic Liquids as the Solvent

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2023年第4期41卷 483-499,I0005页

作者： Yi-Rong Wang Chun-Chun Yin jin-ming zhang jin Wu Jian Yu Jun zhang CAS Key Laboratory of Engineering Plastics and CAS Research/Education Center for Excellence in Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing100190China College of Chemistry University of Chinese Academy of SciencesBeijing100049China

Cellulose is one of the most abundant natural polymers in the nature,which has many attractive advantages,such as renewability,biodegradability,and ***,due to the strong hydrogen bond network and hierarchical structure,cellulose is extremely difficult to be dissolved and *** recently,a class of novel eco-friendly solvents,ionic liquids,have been found to be able to efficiently dissolve cellulose,providing a versatile platform for cellulose processing and ***,we highlight recent advances in efficiently fabricating functional cellulose derivatives via the homogeneous chemical modification and developing all-biomass materials via controlling the dissolution-regeneration process in ionic *** effective and environmentally-friendly utilization of cellulose not only reduces dependence on fossil resources but also protects the environment.

关键词： Cellulose Ionic liquids Homogeneous modification Functional materials Cellulose derivatives

A Mild Oxidant for the Regeneration of Carbonyl Compounds from Oximes in Nonaqueous Condition

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2001年第2期12卷 99-102页

作者： Qing Zhi zhang Shen Song zhang Xin ming LIU jin ming zhang College of Chemistry and Environmental Science Henan Normal UniversityXinxiang 453002

Dioxane-NO2 was employed to oxidize oximes to corresponding aldehydes and ketones in high yield in nonaqueous condition at room temperature. Thr reaction proved to be mild and selective.

关键词： Dioxane-NO2 oxidize oximes ketones aldehydes.

Effect of Molecular Structure on the Gas Permeability of Cellulose Aliphatate Esters

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2014年第1期32卷 1-1,2-8页

作者： jing Chen jin-ming zhang Ye Feng Jia-song He 张军 Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of Chemistry Chinese Academy of Sciences

In this work, four kinds of cellulose aliphatate esters, cellulose acetate （CA）, cellulose propionate （CP）, cellulose butyrate （CB） and cellulose acetate butyrate （CAB） are synthesized by the homogeneous acylation reactions in cellulose/AmimC1 solutions. These cellulose aliphatate esters are used to prepare gas separation membranes and the effects of molecular structure, such as substituent type, degree of substitution （DS） and distribution of substituents, on the gas permeability are studied. For CAs, as the DS increases, their gas permeabilities for all five gases （02, N2, CH4, CO and CO2） increase, and the ideal permselectivity significantly increases first and then slightly decreases. At similar DS value, the homogenously synthesized CA （distribution order of acetate substituent： C6 〉 C3 〉 C2） is superior to the heterogeneously synthesized CA （distribution order of acetate substituent： C3 〉 C2 〉 C6） in gas separation. With the increase of chain length of aliphatate substituents from acetate to propionate, and to butyrate, the gas permeability of cellulose aliphatate esters gradually increases. The cellulose mixed ester CAB with short acetate groups and relatively long butyrate groups exhibits higher gas permeability or better permselectivity than individual CA or CB via the alteration of the DS of two substituents.

关键词： Cellulose aliphatate ester Structure Gas permeability.

Synthesis and Characterization of Temperature-sensitive Cellulose-graftPoly(N-isopropylacrylamide) Copolymers

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2015年第12期33卷 1640-1649页

作者： Li-li Yang jin-ming zhang Jia-song He 张军甘志华 Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Engineering Plastics Institute of ChemistryChinese Academy of Sciences (CAS) University of Chinese Academy of Sciences State Key Laboratory of Organic-inorganic Composites Beijing Laboratory of Biomaterials College of Life Science and Technology Beijing University of Chemical Technology

A new series of cellulose-graft-poly（N-isopropylacrylamide）（cellulose-g-PNIPAM） copolymers were prepared by atom transfer radical polymerization （ATRP） of N-isopropylacrylamide monomers from a cellulose-based macro-initiator, which was homogeneously synthesized in an ionic liquid 1-allyl-3-methylimidazolium chloride （AmimC1）. The composition of cellulose-g-PNIPAM copolymers could be adjusted by altering the feeding ratio and reaction time. The resultant copolymers with relatively high content of PNIPAM segments （molar substitution of PNIPAM ≥ 18.3） were soluble in water at room temperature. Aqueous solutions of cellulose-g-PNIPAM copolymers exhibited clear temperature-sensitive behavior, and their sol-to-gel phase transition properties were investigated by dynamic light scattering （DLS） and UV measurements. Compared with pure PNIPAM, the cellulose-g-PNIPAM copolymers possessed higher lower critical solution temperatures （LCST） in a range from 36.9 ℃ to 40.8 ℃, which are close to normal human body temperature, and could be tuned by adjusting the content of PNIPAM segments in copolymers. Spherical structure of cellulose-g-PNIPAM copolymers formed at temperatures above LCST and its morphology was observed by TEM and SEM. These novel cellulose-g-PNIPAM copolymers may be attractive substrates for some biomedical applications, such as drug release and tissue engineering.

关键词： Cellulose-g-PNIPAM ATRP Temperature-sensitive Water soluble.

Application of fracturing technology to increase gas production in low-permeability hydrate reservoir:A numerical study

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2021年第6期34卷 267-277页

作者： Peng-Fei Shen Gang Li Xiao-Sen Li Bo Li jin-ming zhang State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China School of Resources and Safety Engineering Chongqing UniversityChongqing 400044China Key Laboratory of Gas Hydrate Guangzhou Institute of Energy ConversionChinese Academy of SciencesGuangzhou 510640China Guangzhou Center for Gas Hydrate Research Chinese Academy of SciencesGuangzhou 510640China

Low temperature and low permeability are the challenges for the development of hydrate reservoirs in *** ice produced around the production well caused by high depressurization driving force reduces the gas production,and it is necessary to reduce the effect of ice production on gas *** this work,a new combination of fracturing technology and depressurization method was proposed to evaluate the gas production potential at the site DK-2 in Qinghai-Tibet Plateau Permafrost.A relatively higher intrinsic permeability of the fracture zone surround the horizontal production well was created by the fracturing *** simulation results showed that the fracture zone reduced the blocking of production ice to production wells and promoted the propagation of production *** the gas production increased by 2.1 times as the radius of the fracture zone increased from 0 to 4 m in 30 *** half of the hydrate reservoirs were dissociated in 30 years,and greater than 51.7%of the gas production was produced during the first 10 ***,production behaviours were sensitive to the depressurization driving force but not to the thermal *** growth of gas production was not obvious with the intrinsic permeability of the fracture zone higher than 100 m *** effect of ice production on gas production by fracturing technology and depressurization method was limited.

关键词： Gas hydrates Fracturing technology Depressurization Low-permeability Permafrost

Radiosynthesis of N-^(11) C-meisoindigotin as a novel PET agent for imaging of cyclin-dependent kinases and GSK-3β

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2012年第2期23卷 205-207页

作者： jin ming zhang Xiao Jun zhang Zhi Hong Xu Jia He Tian Department of Nuclear Medicine The PLA General HospitalBeijing 100853China Huayi Chemicals Co. Ltd.Changshu 215522China

Meisoindigotin has been demonstrated as a new type of cancer chemotherapeutic agent.N-^（11）C-meisoindigotin was synthesized by N-^（11）C-methyIation of the isoindigotin precursor with ^（11）C-labelled methyl *** decay corrected radiochemical yields were 15-25%,and the specific radioactivity was 1.0-1.2 Ci/μmol at the end of *** cellular uptake of[N-^（11）C]-meisoindigotin was evaluated in four different lung cancer cell *** results showed that the A549,GLC-82,95D cell lines exhibited higher uptake than 95C cell line after incubation for 60 min.N-^（11）-meisoindigotin was a promising candidate for further development as a novel PET radiotracer for imaging of cyclin-dependent kinases（CDKs） and GSK-3β.

关键词： N-methylisoindigotin Tumor imaging agent Cyclin-dependent kinases

The setereoselective preparation ofβ-keto esters using baker's yeast in the presence of rice wine koji

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第3期19卷 311-313页

作者： jin Cui ming Jie zhang Xiang Qian Wang Nai jing Cui School of Science Tianjin University Ttanjin 300072 China

By the addition of rice wine koji, enhancement of the reactivity was observed for the baker＇s yeast reduction of β-keto esters into （S）-β-hydroxy esters with high enantiomeric purity （73-98%）.

关键词： Baker's yeast Biocatalyst Rice wine koji β-Keto esters

Cellulose Acetate Thermoplastics with High Modulus, Dimensional Stability and Anti-migration Properties by Using CA-g-PLA as Macromolecular Plasticizer

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2020年第10期38卷 1141-1148页

作者： Ru-Meng Xu Tian-Tian Yang Elvira Vidovi? Ruo-Nan Jia jin-ming zhang Qin-Yong Mi Jun zhang CAS Key Laboratory of Engineering Plastics CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences (CAS) University of Chinese Academy of Sciences Faculty of Chemical Engineering and Technology University of Zagreb

Cellulose diacetate(CDA) can be melt-processed to produce numerous and widely-used plastic ***,due to the high glass transition temperature(Tg) of CDA,the addition of up to 30 wt% of micromolecular plasticizers is indispensable,which significantly reduces the dimensional stability and raises safety concerns from the migration of *** this work,a series of CDA-graft-poly(lactic acid)(CDA-gPLA) copolymers were synthesized by ring-opening polymerization of lactide onto the hydroxyl groups of *** resultant CDA-g-PLA copolymers possess adjustable degrees of substitution(DSPLA) and side chain length(DPPLA) by controlling the reaction time and feed *** Tgs and thermal flow temperatures(Tfs) of CDA-g-PLA strongly depend on DPPLA,such as the Tgs decrease linearly with the increase of *** CDA-g-PLA copolymers with the DPPLAof 3-9 can be directly processed to transparent plastics by melt processing without any external plasticizers,because of their low Tfs of 170-215 ℃.More impressively,the CDA-g-PLA can act as the macromolecular *** obtained CDA/CDA-g-PLA has higher storage modulus,flexural modulus and Young’s modulus than the commercial CDA plasticized with triethyl *** addition,the CDA/CDA-g-PLA exhibits high dimensional stability and anti-migration *** a long-term treatment at 80℃ and 60% humidity,the CDA/CDA-g-PLA can retain the initial ***,this work not only proposes a facile method for achieving a direct thermoplastic processing of CDA,but also provides a macromolecular plasticizer for CDA to make lightweight,stable and safer biobased thermoplastics.

关键词： Cellulose diacetate Thermoplastic processing Macromolecular plasticizer Poly(lactic acid)