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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： jie jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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Compound Chai jin jie Yu Tablets,Acts as An Antidepressant by Promoting Synaptic Function in the Hippocampal Neurons

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Digital Chinese Medicine 2020年第2期3卷 80-95页

作者： LI Zi-Rong HAN Yuan-Shan WU Meng-Yao LIU Jian jin Shi ZHANG Xi WANG Yu-Hong State Key Laboratory of Chinese Medicine Powder and Medicine Innovation in Hunan Hunan University of Chinese MedicineChangshaHunan 410208China The First Hospital of Hunan University of Chinese Medicine ChangshaHunan 410007China Qianjin Pharmaceutical Co. Ltd.ZhuzhouHunan 412000China Hunan Provincial Brain Hospital ChangshaHunan 410007China

Objective To investigate the effectiveness of compound Chai jin jie Yu Tablets(CJJYT)in ameliorating cognitive impairment associated with depression and its potential mechanism of *** In vitro experiments,the hippocampus was isolated from the whole brain of the fetal rat and cultured into hippocampal neuron cells.50μM corticosterone(CORT)was added to each group 18 h before the experiment for modeling depression,with the exception of the control *** modeling,the blank serum group was added with 10%blank serum,the CJJYT group and the venlafaxine group were added with the corresponding 10%drug-containing serum,and the control group and the model group were added with equal volumes of culture *** intracellular Ca^2+mean fluorescence intensity,miniature excitatory postsynaptic current(mEPSC)current amplitude,and frequency of different hippocampal neurons were evaluated as indicators of synaptic function in the hippocampal *** addition,the expression of synaptic plasticity related proteins,synaptophysin-α(SYN-α),N-methyl-D-aspartate receptor 2A(NR2A),N-methyl-Daspartate receptor 2B(NR2B),post synaptic density 95 protein(PSD-95),calcium/calmodulin dependent protein kinaseⅡ(CaMKⅡ)and synaptic associated protein(SynGAP)were detected in the hippocampal neurons by immunofluorescence staining and high content analysis(HCA)***,reverse transcription-polymerase chain reaction(RT-PCR)was used to detect the mRNA expression levels of SYN-α,NR2A,NR2B,PSD-95,CaMKⅡand *** in vivo experiments,except for those in the blank control group,all rats were treated within a single cage for chronic unpredictable stress-induced depression modeling and subjected to corresponding drug *** tests were used to detect depressive behavior and determine learning,memory and other cognitive abilities,whereas enzyme-linked immunosorbent assay(ELISA)was used to detect the CORT ***-Cox staining was used to observe changes in the syna

关键词： Compound Chai jin jie Yu Tablets(CJJYT) Depression SYN-α/NR Synaptic plasticity Cognition

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Chloride resistance of Cr-bearing alloy steels in carbonated concrete pore solutions

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International Journal of Minerals,Metallurgy and Materials 2020年第4期27卷 494-504页

作者： jing Ming jin-jie Shi Jiangsu Key Laboratory of Construction Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China

The effect of carbonation on the chloride resistance of low-carbon steel and two Cr-bearing alloy steels in simulated concrete pore solutions was *** chloride threshold values of steels were determined on the basis of corrosion potential(Ecorr)and polarization resistance(Rp).Moreover,the chloride-induced corrosion behavior of steels was evaluated using electrochemical impedance spectroscopy,cyclic voltammetry,cathodic potentiodynamic polarization,and scanning electron microscopy/energy dispersive X-ray spectroscopy *** steels have higher chloride resistance than low-carbon steel in carbonated and non-carbonated concrete pore *** chloride resistance of alloy steels improves with increasing Cr *** addition,the chloride resistance of all steels is negatively affected by the carbonation of concrete pore solution,especially for alloy steel with high Cr content in the presence of high chloride content.

关键词： alloy steel concrete pore solution carbonation chloride resistance electrochemical measurements

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Electrochemical and analytical characterization of three corrosion inhibitors of steel in simulated concrete pore solutions

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International Journal of Minerals,Metallurgy and Materials 2012年第1期19卷 38-47页

作者： jin-jie Shi Wei Sun School of Materials Science end Engineering Southeast University Nanjing 211189 China Jiangsu Key Laboratory of Construction Materials Southeast University Nanjing 211189 China

Corrosion inhibitors for steel, such as sodium phosphate （Na3PO4）, sodium nitrite （NaNO2）, and benzotriazole （BTA）, in simulated concrete pore solutions （saturated Ca（OH）2） were investigated. Corrosion behaviors of steel in different solutions were studied by means of corrosion potential （Ecorr）, linear polarization resistance （LPR）, electrochemical impedance spectroscopy （EIS）, and potentiodynamic polarization （PDP）. A field emission scanning electron microscope （FESEM） equipped with energy dispersive X-ray analysis （EDXA） was used for observing the microstructures and morphology of corrosion products of steel. The results indicate that, compared with the commonly used nitrite-based inhibitors, Na3PO4 is not a good inhibitor, while BTA may be a potentially effective inhibitor to prevent steel from corrosion in simulated concrete pore solutions.

关键词： steel corrosion inhibitors electrochemical analysis concrete solutions

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Influence of mill scale and rust layer on the corrosion resistance of low-alloy steel in simulated concrete pore solution

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International Journal of Minerals,Metallurgy and Materials 2017年第1期24卷 64-74页

作者： jin-jie Shi jing Ming Jiangsu Key Laboratory of Construction Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China

Electrochemical impedance spectroscopy, cyclic potentiodynamic polarization measurements, and scanning electron microscopy in conjunction with energy-dispersive X-ray spectroscopy were used to investigate the influence of mill scale and rust layer on the passivation capability and chloride-induced corrosion behaviors of conventional low-carbon（LC） steel and low-alloy（LA） steel in simulated concrete pore solution. The results show that mill scale exerts different influences on the corrosion resistance of both steels at various electrochemical stages. We propose that the high long-term corrosion resistance of LA steel is mainly achieved through the synergistic effect of a gradually formed compact, adherent and well-distributed Cr-enriched inner rust layer and the physical barrier protection effect of mill scale.

关键词： steel reinforced concrete low alloy steel low carbon steel steel corrosion corrosion resistance

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The development,performances and applications of the monochromatic X-rays facilities in(0.218–301)keV at NIM,China

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Nuclear Science and Techniques 2021年第6期32卷 108-121页

作者： Si-Ming Guo jin-jie Wu Dong-jie Hou National Institute of Metrology BeijingChina

Space scientific exploration is rapidly becoming the primary battlefield for humankind to explore the *** worldwide have launched numerous space exploration *** calibration of the detectors on the ground is a crucial element for space science satellites to obtain observational *** the purpose of providing calibration for various satellite-borne detectors,multiple monochromatic X-rays facilities have been built at the National Institute of Metrology,***(NIM).These facilities mainly pertain to grating diffraction and Bragg diffraction,and the energy range of the produced monochromatic X-rays is 0.218–301 ke *** facilities have a high performance in terms of energy stability,monochromaticity,and flux *** monochromaticity was greater than 3.0%.The energy stability of the facility is 0.02%at 25 ke V over 8 h,and the flux stability was within 1.0%at 25 ke V over 8 *** experiments on the properties of satellite-borne detectors,such as energy linearity,energy resolution,detection efficiency,and temperature response,can be conducted at the *** far,the calibration of two satellites has been completed by the authors,and the work on three other satellites is in *** study will contribute to the advancement of X-ray astronomy the development of Chinese space science.

关键词： Monochromatic X-rays Monochromator Bragg diffraction Energy spectra Calibration

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Pulsar/CNS integrated navigation based on federated UKF

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Journal of Systems Engineering and Electronics 2010年第4期21卷 675-681页

作者： jin Liu jie Ma jinwen Tian State Key Laboratory for Multi-spectral Information Processing Technologies Institue for Pattern Recognition and artifical Intelligence Huazhong University of Science and Technology Wuhan 430074 P. R. China

In order to improve the autonomous navigation capability of satellite,a pulsar/CNS（celestial navigation system） integrated navigation method based on federated unscented Kalman filter（UKF） is *** celestial navigation is a mature and stable navigation ***,its position determination performance is not satisfied due to the low accuracy of horizon *** pulsar navigation is a new navigation method,which can provide highly accurate range *** major drawback of single pulsar navigation is that the system is completely *** two methods are complementary to each other,the federated UKF is used here for fusing the navigation data from single pulsar navigation and *** to the traditional celestial navigation method and single pulsar navigation,the integrated navigation method can provide better navigation *** simulation results demonstrate the feasibility and effectiveness of the navigation method.

关键词： autonomous navigation celestial navigation system(CNS) pulsar federated unscented Kalman filter(UKF).

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A new stationary droplet evaporation model and its validation

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Chinese Journal of Aeronautics 2017年第4期30卷 1407-1416页

作者： Fang WANG jie YAO Shaofeng YANG Rui LIU jie jin Aero-engine Numerical Simulation Research Center School of Energy and Power Engineering Beihang University Beijing100083 China Co-Innovation Center for Advanced Aero-Engine Beijing 100083 China

The liquid droplet evaporation character is important for not only combustion chamber design process but also high-accuracy spray combustion simulation. In this paper, the suspended droplets＇ evaporation character was measured in a quiescent high-temperature environment by micro high-speed camera system. The gasoline and kerosene experimental results are consistent with the reference data. Methanol, common kerosene and aviation kerosene droplet evaporation characteristics, as well as their evaporation rate changing with temperature, were obtained. The evaporation rate experimental data were compared with the prediction result of Ranz-Marshall boiling temperature model（RMB）, Ranz-Marshall low-temperature model（RML）, drift flux model（DFM）, mass analogy model（MAM）, and stagnant film model（SFM）. The disparity between the experimental data and the model prediction results was mainly caused by the neglect of the natural convection effect, which was never introduced into the droplet evaporation concept. A new droplet evaporation model with consideration of natural convection buoyancy force effect was proposed in this paper. Under the experimental conditions in this paper, the calculation results of the new droplet evaporation model were agreed with the experimental data for kerosene, methanol and other fuels, with less than 20% relative deviations. The relative deviations between the new evaporation model predictions for kerosene and the experimental data from the references were within 10%.

关键词： Droplet Evaporation model Evaporation rate Kerosene Natural convection Thick exchange layer theory

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Pitting corrosion resistance of a novel duplex alloy steel in alkali-activated slag extract in the presence of chloride ions

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International Journal of Minerals,Metallurgy and Materials 2017年第10期24卷 1134-1144页

作者： jin-jie Shi jing Ming Xin Liu Jiangsu Key Laboratory of Construction Materials School of Materials Science and Engineering Southeast University Nanjing 211189 China

In this study, two types of reinforcing steels(conventional low-carbon steel and a novel duplex alloy steel with Cr and Mo) were exposed to chloride-contaminated extract solutions(ordinary Portland cement(OPC) extract and alkali-activated slag(AAS) extract) to investigate their pitting corrosion resistance. The results confirm that the pitting corrosion resistance of the alloy steel is much higher than that of the low-carbon steel in both extract solutions with various Na Cl concentrations. Moreover, for each type of steel, the AAS extract contributes to a higher pitting corrosion resistance compared with the OPC extract in the presence of chloride ions, likely because of the formation of flocculent precipitates on the steel surface.

关键词： pitting corrosion resistance alloy steel alkali-activated slag chloride ions electrochemical impedance spectroscopy cyclic potentiodynamic polarization

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Neutronic analysis of silicon carbide cladding accident-tolerant fuel assemblies in pressurized water reactors

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Nuclear Science and Techniques 2019年第3期30卷 105-113页

作者： Zhi-Xiong Tan jie-jin Cai School of Electric Power South China University of Technology

In resonance with the Fukushima Daiichi Nuclear Power Plant accident lesson, a novel fuel design to enhance safety regarding severe accident scenarios has become increasingly appreciated in the nuclear power industry. This research focuses on analysis of the neutronic properties of a silicon carbide(SiC) cladding fuel assembly, which provides a greater safety margin as a type of accident-tolerant fuel for pressurized water reactors. The general physical performance of SiC cladding is explored to ascertain its neutronic performance. The neutron spectrum, accumulation of ^(239)Pu, physical characteristics,temperature reactivity coefficient, and power distribution are analyzed. Furthermore, the influences of a burnable poison rod and enrichment are explored. SiC cladding assemblies show a softer neutron spectrum and flatter power distribution than conventional Zr alloy cladding fuel assemblies. Lower enrichment fuel is required when SiC cladding is adopted. However, the positive reactivity coefficient associated with the SiC material remains to be offset. The results reveal that SiC cladding assemblies show broad agreement with the neutronic performance of conventional Zr alloy cladding fuel. In the meantime, its unique physical characteristics can lead to improved safety and economy.

关键词： Accident-tolerant fuels Silicon carbide cladding Neutronic characteristics Pressurized water reactor

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