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New insights into ATR inhibition in muscle invasive bladder cancer:The role of apolipoprotein B mRNA editing catalytic subunit 3B

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Oncology Research 2024年第6期32卷 1021-1030页

作者： HYUNHO KIM UIJU CHO SOOK HEE HONG HYUNG SOON PARK IN-HO KIM HO JUNG AN BYOUNG YONG SHIM jin hyoung kang Division of Medical Oncology Department of Internal MedicineSt.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwonKorea Department of Pathology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwonKorea Division of Medical Oncology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulKorea

Background:Apolipoprotein B mRNA editing catalytic polypeptide(APOBEC),an endogenous mutator,induces DNA damage and activates the ataxia telangiectasia and Rad3-related(ATR)-checkpoint kinase 1(Chk1)*** cisplatin-based therapy is the mainstay for muscle-invasive bladder cancer(MIBC),it has a poor survival ***,this study aimed to evaluate the efficacy of an ATR inhibitor combined with cisplatin in the treatment of APOBEC catalytic subunit 3B(APOBEC3B)expressing ***:Immunohistochemical staining was performed to analyze an association between APOBEC3B and ATR in patients with *** APOBEC3B expression in MIBC cell lines was assessed using real-time polymerase chain reaction and western blot *** blot analysis was performed to confirm differences in phosphorylated Chk1(pChk1)expression according to the APOBEC3B *** viability and apoptosis analyses were performed to examine the anti-tumor activity of ATR inhibitors combined with ***:There was a significant association between APOBEC3B and ATR expression in the tumor tissues obtained from patients with *** with higher APOBEC3B expression showed higher pChk1 expression than cells expressing low APOBEC3B *** treatment of ATR inhibitor and cisplatin inhibited cell growth in MIBC cells with a higher APOBEC3B *** to cisplatin single treatment,combination treatment induced more apoptotic cell death in the cells with higher APOBEC3B ***:Our study shows that APOBEC3B’s higher expression status can enhance the sensitivity of MIBC to cisplatin upon ATR *** result provides new insight into appropriate patient selection for the effective application of ATR inhibitors in MIBC.

关键词： Apolipoprotein B mRNA editing catalytic polypeptide(APOBEC) Ataxia telangiectasia and Rad3-related(ATR) Bladder cancer DNA damage response DNA replication stress

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Boosted Lithium-Ion Transport Kinetics in n-Type Siloxene Anodes Enabled by Selective Nucleophilic Substitution of Phosphorus

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Nano-Micro Letters 2024年第10期16卷 618-637页

作者： Se In Kim Woong-Ju Kim jin Gu kang Dong-Wan Kim School of Civil Environmental and Architectural EngineeringKorea University02841 SeoulSouth Korea Nanophotonics Research Center Korea Institute of Science and Technology02792 SeoulSouth Korea

Doped two-dimensional(2D)materials hold significant promise for advancing many technologies,such as microelectronics,optoelectronics,and energy ***,n-type 2D oxidized Si nanosheets,namely n-type siloxene(n-SX),are employed as Li-ion battery *** thermal evaporation of sodium hypophosphite at 275℃,P atoms are effectively incorporated into siloxene(SX)without compromising its 2D layered morphology and unique Kautsky-type crystal ***,selective nucleophilic substitution occurs,with only Si atoms being replaced by P atoms in the O_(3)≡Si-H *** resulting n-SX possesses two delocalized electrons arising from the presence of two electron donor types:(i)P atoms residing in Si sites and(ii)H *** doping concentrations are varied by controlling the amount of precursors or their mean free *** at 2000 mA g^(-1),the n-SX electrode with the optimized doping concentration(6.7×10^(19) atoms cm^(-3))delivers a capacity of 594 mAh g^(-1) with a 73%capacity retention after 500 *** improvements originate from the enhanced kinetics of charge transport processes,including electronic conduction,charge transfer,and solid-state *** approach proposed herein offers an unprecedented route for engineering SX anodes to boost Li-ion storage.

关键词： Li-ion battery Two-dimensional N-type siloxene Doping mechanism Kinetics

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Numerical modeling of fracture propagation of supercritical CO_(2)compound fracturing

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2607-2628页

作者： Hao Chen Yong kang Wanchun jin Changhai Li Can Cai School of Mechanical Engineering Southwest Petroleum UniversityChengdu610500China Laboratory of High-pressure Jet Theory and Application Technology Southwest Petroleum UniversityChengdu610500China Hubei Key Laboratory of Waterjet Theory and New Technology Wuhan UniversityWuhan430072China Sinopec International Petroleum Exploration and Production Corporation Beijing 100029China

The exploitation of shale gas is promising due to depletion of the conventional energy and intensification of the greenhouse *** this paper,we proposed a heat-fluid-solid coupling damage model of supercritical CO_(2)(SC-CO_(2))compound fracturing which is expected to be an efficient and environmentally friendly way to develop shale *** coupling model is solved by the finite element method,and the results are in good agreement with the analytical solutions and fracturing *** on this model,the fracture propagation characteristics at the two stages of compound fracturing are studied and the influence of pressurization rate,in situ stress,bedding angle,and other factors are *** results show that at the SC-CO_(2)fracturing stage,a lower pressurization rate is conducive to formation of the branches around main fractures,while a higher pressurization rate inhibits formation of the branches around main fractures and promotes formation of the main *** bedding and in situ stress play a dominant role in the fracture *** the in situ stress ratio(sx/sy)is 1,the presence of bedding can reduce the initiation pressure and failure ***,it will cause the fracture to propagate along the bedding direction,reducing the fracture *** rocks without bedding,hydraulic fracturing has the lengthening and widening effects for SC-CO_(2)induced *** shale,fractures induced at the hydraulic fracturing stage are more likely to be dominated by in situ stresses and have a shorter reorientation ***,fracture branches propagating along the maximum principal stress direction may be generated around the main fractures induced by SC-CO_(2)at the hydraulic fracturing *** the branches converge with the main fractures,fracture zones are easily formed,and thus the fracture complexity and damage area can be significantly *** results are instructive for the design and application of SC-CO_(2

关键词： Compound fracturing Fracture propagation Finite element method Damage evolution

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Broadband Dual-Input Doherty Power Amplifier Design Based on a Simple Adaptive Power Dividing Ratio Function

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China Communications 2024年第5期21卷 97-112页

作者： Dai Zhijiang Zhong kang Li Mingyu Pang jingzhou jin Yi School of Microelectronics and Communication Engineering Chongqing UniversityChongqing 400044China Xi’an Branch of China Academy of Space Technology Xi’an 710100China

In this paper,a simple adaptive power dividing function for the design of a dual-input Doherty power amplifier(DPA)is *** the presented approaches,the signal separation function(SSF)at different frequency points can be characterized by a *** in the practical test,the coefficients of SSF can be determined by measuring a small number of data points of input *** as other dualinput DPAs,the proposed approach can also achieve high output power and back-off efficiency in a broadband operation band by adjusting the power distribution ratio ***,a 1.5-2.5 GHz highefficiency dual-input Doherty power amplifier is implemented according to this *** test results show that the peak power is 48.6-49.7d Bm,and the 6-d B back-off efficiency is 51.0-67.0%,and the saturation efficiency is 52.4-74.6%.The digital predistortion correction is carried out at the frequency points of 1.8/2.1GHz,and the adjacent channel power ratio is lower than-54.5d *** and experiment results can verify the effectiveness and correctness of the proposed method.

关键词： broadband doherty power amplifier dualinput efficiency enhancement load modulation

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Ultrasound-guided sphenopalatine ganglion block for effective analgesia during awake fiberoptic nasotracheal intubation: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2451-2456页

作者： Hangil kang Seongjae Park Yehun jin Department of Anesthesiology and Pain Medicine National Cancer CenterGoyang-si 10408Gyeonggi-doSouth Korea

BACKGROUND Awake fiberoptic nasotracheal intubation(AFNI)is the preferred airway ma-nagement strategy for patients with difficult ***,this procedure can cause significant physical and psychological *** case report explores the application of a sphenopalatine ganglion(SPG)block as an alternative anal-gesic modality to mitigate the discomfort associated with *** SUMMARY A 63-year-old female with a history of right maxillary osteosarcoma underwent craniotomy for a suspected malignant brain *** patient’s medical history included prior surgery,chemotherapy,and radiation therapy,resulting in signi-ficant jaw impairment and limited neck *** the anticipated air-way challenges,AFNI was planned.A SPG block was performed under real-time ultrasound guidance,providing effective analgesia during nasotracheal *** The SPG block represents a promising analgesic approach in AFNI,offering po-tential benefits in alleviating pain involving the nasal and nasopharyngeal regions as well as improving patient cooperation.

关键词： Sphenopalatine ganglion block Nerve block Regional anesthesia Analgesia Awake fiberoptic nasotracheal intubation Case report

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Low-Carbon Dispatching for Virtual Power Plant with Aggregated Distributed Energy Storage Considering Spatiotemporal Distribution of Cleanness Value

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 346-358页

作者： Hongchao Gao Tai jin Guanxiong Wang Qixin Chen Chongqing kang jingkai Zhu State Key Laboratory of Power System Operation and Control Department of Electrical EngineeringTsinghua UniversityBeijing 100084China Sichuan Energy Internet Research Institute Tsinghua University Chengdu 200016China Power Dispatching and Control Center of Shanghai Municipal Electric Power Company Shanghai 200122China IEEE

The scale of distributed energy resources is increasing,but imperfect business models and value transmission mechanisms lead to low utilization ratio and poor *** address this issue,the concept of cleanness value of distributed energy storage(DES)is proposed,and the spatiotemporal distribution mechanism is discussed from the perspectives of electrical energy and *** on this,an evaluation system for the environmental benefits of DES is constructed to balance the interests between the aggregator and the power system ***,an optimal low-carbon dispatching for a virtual power plant(VPP)with aggregated DES is constructed,where-in energy value and cleanness value are both *** achieve the goal,a green attribute labeling method is used to establish a correlation constraint between the nodal carbon potential of the distribution network(DN)and DES behavior,but as a cost,it brings multiple nonlinear ***,a solution method based on the convex envelope(CE)linear re-construction method is proposed for the multivariate nonlinear programming problem,thereby improving solution efficiency and ***,the simulation verification based on the IEEE 33-bus DN is *** simulation results show that the multidimensional value recognition of DES motivates the willingness of resource users to ***,resolving the impact of DES on the nodal carbon potential can effectively alleviate overcompensation of the cleanness value.

关键词： Distributed energy storage virtual power plant(VPP) spatiotemporal distribution low-carbon dispatching

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Micropillar compression using discrete dislocation dynamics and machine learning

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Theoretical & Applied Mechanics Letters 2024年第1期14卷 39-47页

作者： jin Tao Dean Wei Junshi Yu Qianhua Kan Guozheng kang Xu Zhang School of Mechanics and Aerospace Engineering Southwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China

Discrete dislocation dynamics(DDD)simulations reveal the evolution of dislocation structures and the interaction of *** study investigated the compression behavior of single-crystal copper micropillars using fewshot machine learning with data provided by DDD *** types of features are considered:external features comprising specimen size and loading orientation and internal features involving dislocation source length,Schmid factor,the orientation of the most easily activated dislocations and their distance from the free *** yielding stress and stress-strain curves of single-crystal copper micropillar are predicted well by incorporating both external and internal features of the sample as separate or combined *** is found that the machine learning accuracy predictions for single-crystal micropillar compression can be improved by incorporating easily activated dislocation features with external ***,the effect of easily activated dislocation on yielding is less important compared to the effects of specimen size and Schmid factor which includes information of orientation but becomes more evident in small-sized ***,incorporating internal features,especially the information of most easily activated dislocations,improves predictive capabilities across diverse sample sizes and orientations.

关键词： Discrete dislocation dynamics simulations Machine learning Size effects Orientation effects Microstructural features

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Advanced preparation and application of bimetallic materials in lithium-sulfur batteries:A review

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Journal of Energy Chemistry 2024年第1期88卷 469-512,I0011页

作者： Yongbing jin Nanping Deng Yanan Li Hao Wang Meiling Zhang Weimin kang Bowen Cheng State Key Laboratory of Separation Membranes and Membrane Processes/National Center for International Joint Research on Separation Membranes School of Textile Science and EngineeringTiangong UniversityTianjin 300387China

Lithium-sulfur(Li-S)batteries are considered highly promising as next-generation energy storage systems due to high theoretical capacity(2600 Wh kg^(-1))and energy density(1675 mA h g^(-1))as well as the abundant natural reserves,low cost of elemental sulfur,and environmentally friendly ***,several challenges impede its commercialization including low conductivity of sulfur itself,the severe“shuttle effect”caused by lithium polysulfides(LiPSs)during charge–discharge processes,volume expansion effects and sluggish reaction *** a solution,polar metal particles and their compounds have been introduced as the main hosts for sulfur cathode due to their robust catalytic activity and adsorption capability,effectively suppressing the“shuttle effect”of Li *** alloys and their compounds with multi-functional properties exhibit remarkable electrochemical performance more readily when compared to single-metal ***-designed bimetallic materials demonstrate larger specific surface areas and richer active sites,enabling simultaneous high adsorption capability and strong catalytic *** synergistic effect of the“adsorption-catalysis”sites accelerates the adsorptiondiffusion-conversion process of Li PSs,ultimately achieving a long-lasting Li-S ***,the latest progress and performance of bimetallic materials in cathodes,separators,and interlayers of Li-S batteries are systematically ***,the principles and challenges of Li-S batteries are briefly ***,various mechanisms for suppressing“shuttle effects”of Li PSs are emphasized at the ***,the performance parameters of various bimetallic materials are comprehensively summarized,and some improvement strategies are proposed based on these ***,the future prospects of bimetallic materials are discussed,with the hope of providing profound insights for the rational design and manufacturing of high-performance bimetallic materia

关键词： Bimetallic materials Lithium-sulfur batteries Effectively suppress shuttle effect of LiPSs Significantly improve reaction kinetics Exceptionally long lifespan

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Possibility and stabilizing effect of Mo clusters in the Ni-based single-crystal superalloy

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Communications in Theoretical Physics 2024年第8期76卷 189-194页

作者： Yiqun Du Huixin jin Rongkai kang Boya Zhang Han Wang Jianxin Zhang Key Laboratory for Liquid–Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and Engineering Shandong University Department of Materials Science and Technology Tokyo University of Science

Nickel-based single-crystal superalloys are crucial materials for the preparation of aero-engine turbine blades. Many solute elements are added to superalloys for strengthening. However, the relationship between the clustering behavior of solute atoms and the properties of nickel-based single-crystal superalloys is still unclear. Herein, we conduct first-principles calculations onγ phases with Mo-Mo and Mo-Mo-Ru clusters to reveal the possibility and stabilizing mechanism of solute clusters. Introducing Mo lowers the total energy, binding energy, and formation energy of the γ phase due to the replacement of weak Ni-Ni interaction with strong Mo-Ni bonding. Note that the γ phase containing the Mo-Mo cluster is more stable than that containing a Mo single atom, possibly owing to a wide affecting range. The Ru atom added to the γ phase can further boost system stability, and it tends to form a Mo-Mo-Ru cluster. The stabilizing impact of the Mo-Mo-Ru cluster is demonstrated to be the replacement of weak Ni-Mo interaction by the strong Ru-Mo interaction, which may be derived from the enhanced d-orbital hybridization.

关键词： density functional theory solute cluster superalloys

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Analytical Model and Topology Optimization of Doubly-fed Induction Generator

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CES Transactions on Electrical Machines and Systems 2024年第2期8卷 162-169页

作者： Lu Sun Haoyu kang jin Wang Zequan Li Jianjun Liu Yiming Ma Libing Zhou the State Key Laboratory of Advanced Electromagnetic Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China IEEE Dongfang Electric Machinery Co. LtdDongfang Electric CorporationDeyangChina CSG PGC Energy Storage Research Institute Southern Power Grid Energy Storage Co.LtdGuangzhou 510630China

As the core component of energy conversion for large wind turbines,the output performance of doubly-fed induction generators (DFIGs) plays a decisive role in the power quality of wind *** realize the fast and accurate design optimization of DFIGs,this paper proposes a novel hybriddriven surrogate-assisted optimization *** firstly establishes an accurate subdomain model of DFIGs to analytically predict performance ***,taking the inexpensive analytical dataset produced by the subdomain model as the source domain and the expensive finite element analysis dataset as the target domain,a high-precision surrogate model is trained in a transfer learning way and used for the subsequent multi-objective optimization *** on this model,taking the total harmonic distortion of electromotive force,cogging torque,and iron loss as objectives,and the slot and inner/outer diameters as parameters for optimizing the topology,achieve a rapid and accurate electromagnetic design for ***,experiments are carried out on a 3MW DFIG to validate the effectiveness of the proposed method.

关键词： Doubly-fed induction generators Accurate subdomain model Surrogate-assisted Transfer learning

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