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皮肤淋巴细胞浸润症1例

中国皮肤性病学杂志 2006年第12期20卷 755-757页

作者：李峰晋红中中国医学科学院中国协和医科大学北京协和医院皮肤科北京100730

报告1例皮肤淋巴细胞浸润症。患者女,55岁。右颧部紫红色斑块2月,组织病理示真皮毛囊周围、毛细血管周围大量淋巴细胞团块状浸润;免疫组化示CD4+T细胞为主的淋巴细胞浸润。经雷公藤等药物治疗10周后,皮损消退。

关键词：淋巴细胞浸润斑块紫红色

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小汗腺汗孔瘤1例

临床皮肤科杂志 2005年第9期34卷 603-604页

作者：晋红中方凯中国医学科学院中国协和医科大学北京协和医院皮肤科北京100730

报告1例左足趾小汗腺汗孔瘤。患者女,55岁。1年前左足第2趾出现一约1.5cm×1.2cm大的肿块,组织病理诊断为小汗腺汗孔瘤。

关键词：小汗腺汗孔瘤

外用他克莫司与卡泊三醇治疗斑块状银屑病的疗效与安全性评价

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临床皮肤科杂志 2012年第10期41卷 626-628页

作者：赵娜晋红中中国医学科学院、北京协和医学院北京协和医院皮肤科北京100730

目的:评价外用他克莫司和卡泊三醇软膏对四肢斑块状银屑病的疗效和安全性。方法:选取门诊斑块状银屑病患者,四肢左右两侧分别外用他克莫司软膏及卡泊三醇软膏,治疗2周及6周各复诊1次,观察四肢左右侧皮损消退情况,用单侧银屑病皮损面积... 详细信息

目的:评价外用他克莫司和卡泊三醇软膏对四肢斑块状银屑病的疗效和安全性。方法:选取门诊斑块状银屑病患者,四肢左右两侧分别外用他克莫司软膏及卡泊三醇软膏,治疗2周及6周各复诊1次,观察四肢左右侧皮损消退情况,用单侧银屑病皮损面积及严重度指数(PASI)评分进行评价。结果:29例患者参加自身左右侧药物对比,有3例患者(10.3%)应用他克莫司后出现皮肤刺激症状而停用,其中1例患儿出现红皮病样改变。2周时有13例患者复诊,达到PASI_(50)的患者中他克莫司侧4例,卡泊三醇侧5例;达到PASI_(75)的患者中他克莫司侧1例,卡泊三醇侧2例。6周时14例患者复诊,达到PASI_(50)的患者中他克莫司侧14例,卡泊三醇侧13例;达到PASI_(75)的患者中他克莫司侧7例,卡泊三醇侧9例。2周及6周时比较双侧PASI_(50)及PASI75,用Fisher精确概率检验法,发现两者差异无统计学意义。结论:对于四肢的斑块状银屑病,外用他克莫司和卡泊三醇软膏均有肯定疗效。部分患者应用他克莫司出现皮肤刺激症状,停药后症状多可消退。

关键词：银屑病,斑块状他克莫司卡泊三醇 PASI评分

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黏液水肿性苔藓2例

临床皮肤科杂志 2005年第7期34卷 457-459页

作者：晋红中方凯中国医学科学院中国协和医科大学北京协和医院皮肤科北京100730

报告2例黏液水肿性苔藓。例1.女,16岁。全身起丘疹、结节2个月,以手部结节损害为特征。例2.女,40岁。四肢、躯干丘疹3年,伴面部斑块1年,以眉间隆起的纵向斑块为特征。此2例患者的丘疹、结节组织病理检查均示真皮胶原纤维疏松,成纤维细... 详细信息

报告2例黏液水肿性苔藓。例1.女,16岁。全身起丘疹、结节2个月,以手部结节损害为特征。例2.女,40岁。四肢、躯干丘疹3年,伴面部斑块1年,以眉间隆起的纵向斑块为特征。此2例患者的丘疹、结节组织病理检查均示真皮胶原纤维疏松,成纤维细胞增生,胶原纤维束间阿新蓝染色阳性。

关键词：苔藓黏液水肿性

Nano polystyrene microplastics could accumulate in Nile tilapia(Oreochromis niloticus):Negatively impacts on the intestinal and liver health through water exposure

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Journal of Environmental Sciences 2024年第3期137卷 604-614页

作者： Di Wu Xing Lu Li-Xue Dong Juan Tian jin Deng Lei Wei Hua Wen Shan zhong Ming Jiang School of Basic Medical Sciences Wuhan UniversityWuhan 430071China Key Laboratory of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural AffairsYangtze River Fisheries Research InstituteChinese Academy of Fishery SciencesWuhan 430223China Hubei Province Key Laboratory of Allergy and Immunology Wuhan 430071China

Microplastics(MPs)have become a significant concern for their potential ***,the correlation between the size of plastic particles and their toxicity remains ***,we investigate the toxic effects of different sizes(80 nm,800 nm,8μm and 80μm)polystyrene MPs(PS-MPs)on the model organism Nile tilapia(Oreochromis niloticus).The results of bioluminescent imaging indicate that the 80 nm PS-MPs are more likely to invade the body.H&E staining shows severe damage on the intestinal villi and distinct hepatic steatosis in the 80 nm *** U labeling shows that the proliferation activity of intestinal and liver cells reduces significantly in the 80 nm *** gut microbiome analysis shows a severe imbalance of gut microbiota homeostasis in the 80 nm *** analysis of liver transcriptomics and metabolomics shows that the liver lipid metabolism is disordered in the 80 nm *** conclusion,this study confirms that the 80 nm PS-MPs are more likely to induce intestinal and liver *** the above lay the foundation for further study on the pathological damage of MPs to other organisms.

关键词： Microplastics(MPs) Intestinal toxicity Liver toxicity Gut microbiome Lipid metabolism

泼尼松联合依那西普治疗并发坏疽性脓皮病的关节病性银屑病

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临床皮肤科杂志 2016年第3期45卷 197-199页

作者：吴超方凯晋红中中国医学科学院北京协和医学院北京协和医院皮肤科北京100730

报告1例关节病性银屑病并发坏疽性脓皮病。患者男,42岁。因反复全身红斑及鳞屑伴关节疼痛10年,右髋部溃疡1年就诊。免疫指标均正常,溃疡分泌物细菌及真菌培养均阴性。右髋部溃疡处皮损组织病理检查:溃疡形成,真皮浅中层毛细血管扩张、增... 详细信息

报告1例关节病性银屑病并发坏疽性脓皮病。患者男,42岁。因反复全身红斑及鳞屑伴关节疼痛10年,右髋部溃疡1年就诊。免疫指标均正常,溃疡分泌物细菌及真菌培养均阴性。右髋部溃疡处皮损组织病理检查:溃疡形成,真皮浅中层毛细血管扩张、增生,部分血管壁呈纤维蛋白样变性,可见大量淋巴细胞、组织细胞及浆细胞呈弥漫性浸润,散在中性粒细胞浸润。诊断:关节病性银屑病并发坏疽性脓皮病。予口服泼尼松联合皮下注射依那西普治疗,疗效显著。右髋部溃疡愈合后原位置出现银屑病同形反应。

关键词：银屑病,关节病性坏疽性脓皮病同形反应

A new classification of nevus of Ota

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Chinese Medical Journal 2013年第20期126卷 3910-3914页

作者： Huang Wen-hui Wang hong-wei Sun Qiu-ning jin hong-zhong Liu Yue-hua Ma Dong-lai Zuo Ya-gang Zheng He-yi Wan Kuo jing Quan Zhao Yong-liang Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Dermatol Beijing 100730 Peoples R China Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Stomatol Beijing 100730 Peoples R China

Background The nevus of Ota, is a common benign pigmentary dermatosis, mainly involve innervation area of first and second branch of trigeminal nerve. The classification of nevus of Ota was proposed by Tanino, based on 26 cases of nevus of Ota from 1937 to 1940. Studies about its classification are rarely seen in last 70 years, while it is still practical today.

关键词： nevus of Ota classification, trigeminal nerve

A Composite Elastomer with Photo-responsive Shape Memory and Programmable Hygroscopic Actuation Functionalities

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Chinese Journal of Polymer Science 2024年第10期42卷 1470-1478,I0009页

作者： Xiang-Xi Cui Li Shang zhong-Wen Liu Zhao-Tie Liu jin-Qiang Jiang Guo Li Key Laboratory of Syngas Conversion of Shaanxi Province School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an710062China

Developing hydroscopic actuators with simultaneous high elasticity,shape programmability and tunable actuating behaviors are highly desired but still *** this study,we propose an orthogonal composite design to develop such a *** developed composite elastomer comprises carboxyl group-grafted polystyrene-block-poly(ethylene-co-butylene)-block-polystyrene(SEBS-g-COOH)as the elastic substrate,and a synthesized azobenzene derivative as the functional filler(Azo12).By surface treatment using acidic and base solutions,the carboxyl groups on the surface can reversibly transform into carboxylate groups,which render the composite tunable hygroscopic actuating *** another aspect,the added filler undergoes trans-to-cis isomerization when exposed to UV light irradiation,leading to liquefaction of the crystalline aggregates formed by Azo12 *** liquefied Azo12 molecules can autonomously resotre their trans form and reform the crystalline *** reversible change in crystralline structure is utilized to realize the shape memory property,and 5 wt%of Azo12addition is adequate for the composite to exhibit photo-responsive shape memory behavior without compromising much of the *** regualtion of external geometry by shape memory effect is effective in altering the actuating *** proposed method can be extend to designing different composites with the demonstrated functionalities.

关键词： Actuator Shape memory Photo-responsive Hygroscopic responsive Azobenzene

Microbial Fertilizer: A Sustainable Strategy for Medicinal Plants Production

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1221-1236页

作者： Chuang Liu jing Xie Hao Liu Can zhong Gen Pan Shuihan Zhang Jian jin Hunan Academy of Chinese Medicine Hunan University of Chinese MedicineChangsha410036China Institute of Chinese Medicine Resources Hunan Academy of Chinese MedicineChangsha410013China

Medicinal plants have aroused considerable interest as an alternative to chemical drugs due to the beneﬁcial effects of their active secondary ***,the extensive use of chemical fertilizers and pesticides in pursuit of yield has caused serious pollution to the environment,which is not conducive to sustainable devel-opment in theﬁeld of medicinal *** fertilizers are a type of“green fertilizer”containing speciﬁc microorganisms that can improve the soil microbial structure,enhance plant resistance to biological and abiotic stresses,and increase the yield of medicinal *** root exudates of medicinal plants attract different micro-organisms to the rhizosphere,which then migrate further to the plant *** microbes can increase the levels of soil nutrients,and improve the physical and chemical properties of soil through nitrogenﬁxation,and phosphorus and potassium *** addition,soil microbes can promote the synthesis of hormones that increase plant growth and the accumulation of active compounds,eventually improving the quality of med-icinal *** 2022,the total value of the global microbial fertilizer market was$4.6 billion and is estimated to reach$10.36 billion by *** this review,we have summarized the types of microbial fertilizers,the coloniza-tion and migration of microorganisms to plant tissues,and the beneﬁcial effects of microbial *** addi-tion,the prospects of developing microbial fertilizers and their application for medicinal plants have also been *** aims to provide a reference for the rational application of microbial fertilizers in theﬁeld of med-icinal plants and the green and sustainable development of medicinal plant resources.

关键词： Microbial fertilizers market overview rhizosphere microorganisms endophytic bacteria beneﬁcial effects