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Bleeding after endoscopic papillectomy and its risk factors:A single center experience of 196 cases

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Hepatobiliary & Pancreatic Diseases International 2024年第6期23卷 613-619页

作者： jin ho choi Won Chul Kim Joo Kyung Park Jong Kyun Lee Kyu Taek Lee Kwang Hyuck Lee Department of Medicine Division of GastroenterologySamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Korea

Background:Endoscopic papillectomy(EP)is an effective method to remove an ampulla of Vater(AoV)adenoma with minimal *** reviewed the clinical outcomes and prognosis of patients undergoing EP,including tumor recurrence and adverse ***:A total of 196 patients who underwent EP from January 2004 to December 2017 were *** information was collected through electronic medical records,and risk factors to predict postprocedural bleeding were analyzed using a multivariate logistic regression ***:A total of 93.9%patients(184/196)underwent complete *** the follow-up period,14.7%patients(27/184)experienced tumor recurrence,and two of seven surgically resected tumors were malignant.A total of 45.4%patients(89/196)experienced adverse events related to *** bleeding occurred in 16.3%of the patients(32/196),and they were all successfully treated with endoscopic hemostasis and conservative *** most frequent site of delayed bleeding was the distal end of the papillary orifice,and 56.3%(18/32)patients of delayed bleeding were classified as having mild severity,the others had moderate *** adenomatous polyposis(FAP)[odds ratio(OR)=3.80,95%confidence interval(CI):1.01-14.29;Phowed statistical significance in predicting delayed post-EP ***:EP for AoV adenoma was a highly effective and safe *** risk of post-EP delayed bleeding was increased in patients with FAP syndrome and male patients,and post-EP bleeding occurred most commonly in the distal part of the AoV.

关键词： Ampullary neoplasm Endoscopic papillectomy Post-procedural bleeding Risk factor

Safety of endoscopic ultrasound-guided ethanol ablation for pancreatic cystic lesions: A single-center experience of 214 patients

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Hepatobiliary & Pancreatic Diseases International 2019年第6期18卷 562-568页

作者： jin ho choi Sang Hyub Lee Young hoon choi Min Su You Bang-Sup Shin Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim Department of Internal Medicine Liver Research Institute Seoul National University College of Medicine

Background:Endoscopic ultrasound-guided ethanol ablation(EUS-EA)for pancreatic cystic lesions(PCLs)has been used in recent years as a feasible treatment modality for low malignant probability PCLs or patients considered high-risk for *** present study aimed to confirm the safety of EUS-EA and to find predictive factors for adverse event(AE).Methods:A retrospective review was performed from the prospectively maintained database of patients who underwent EUS-EA for PCLs from June 2006 to April 2018 at Seoul National University *** primary outcomes of the study were the rates of AEs and severe AEs by *** secondary outcome was the predictive factors of AEs including acute pancreatitis and abdominal ***:A total of 214 patients were evaluated and the diagnoses of PCLs according to cystic fluid analysis and clinical features were as follows:serous cystic neoplasm(32.2%),mucinous cystic neoplasm(26.6%),branch duct type intraductal papillary mucinous neoplasm(BD-IPMN)(29.4%),and pseudocyst(11.7%).Three patients(1.4%)experienced severe ***,AEs occurred in 71(33.2%)***-IPMN(OR:2.87;95%CI:1.05–7.84;P=0.040),multilocular cysts(OR:3.59;95%CI:1.09–11.85;P=0.036),suspected ethanol leakage during procedure(OR:10.68;95%CI:1.98–57.53;P=0.006),and sticky cystic fluid(OR:3.83;95%CI:1.20–12.24;P=0.024)were predictive factors for post-procedural acute *** of uncinate process(OR:2.99;95%CI:1.22–7.35;P=0.017)and PCLs with exophytic portion(OR:3.70;95%CI:1.96–7.01;P<0.001)were predictive factors for post-procedural abdominal ***:EUS-EA is a safe procedure with a very low rate of severe *** seems possible to predict the AEs according to the features of the procedure and PCLs.

关键词： Pancreatic cyst EUS-guided ethanol ablation Adverse events

Folfirinox chemotherapy prolongs stent patency in patients with malignant biliary obstruction due to unresectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 590-595页

作者： jinwoo Kang Sang Hyub Lee jin ho choi Woo Hyun Paik Dong-Won Ahn Ji Bong Jeong Ji Kon Ryu Yong-Tae Kim Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoulKorea Department of Internal Medicine SMG-SNU Boramae Medical CenterSeoulKorea

Background:Stent insertion for biliary decompression to relieve jaundice and subsequent biliary infection is necessary for patients with biliary obstruction caused by pancreatic cancer,and it is important to keep the stent patent as long as ***,few studies have compared stent patency in terms of chemotherapy in patients with pancreatic *** study aimed to evaluate the differences in stent patency in terms of recently evolving ***:Between January 2015 and May 2017,161 patients with pancreatic cancer who had undergone biliary stent insertion with a metal stent were retrospectively *** relationship between chemotherapy and stent patency was ***,overall survival according to the treatment,risk factors for stent patency,and long-term adverse events were ***:Median stent patency was 42 days for patients with the best supportive care and 217 days for patients with chemotherapy(conventional gemcitabine-based chemotherapy and folfirinox)(Phowed the longest median stent patency and overall survival,with 283 days and 466 days,respectively(Pho underwent folfirinox chemotherapy after stent insertion had better stent patency in multivariate analysis(HR=0.26;95%CI:0.12–0.60;P=0.001).Conclusions:Compared with patients who received best supportive care only,patients who underwent chemotherapy after stent insertion had better stent *** prolonged stent patency can be expected for patients with folfirinox than conventional gemcitabine-based chemotherapy.

关键词： Stent patency Malignant distal biliary obstruction Pancreatic cancer Folfirinox Chemotherapy

Acetylsalicylic acid for metal stent in malignant distal common bile duct obstruction:A randomized controlled trial

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 493-499页

作者： jin ho choi Kyong Joo Lee Woo Hyun Paik Namyoung Park Jung Won Chun Sang Hyub Lee Ji Kon Ryu Yong-Tae Kim Department of Internal Medicine Liver Research InstituteSeoul National University College of MedicineSeoulKorea Department of Internal Medicine Yonsei University Wonju College of MedicineWonjuKorea

Background:Endoscopic biliary drainage is the treatment of choice for patients with malignant distal common bile duct ***-expandable metal stents have clinical advantages including an increased duration of patency that may be prolonged by acetylsalicylic acid(ASA)*** aim of this study was to investigate whether ASA had a positive effect on the patency of self-expandable metal stents compared with ***:This prospective,multicenter,double-blinded,and randomized placebo-controlled trial was conducted from October 2017 to May 2020 in *** who underwent palliative endoscopic biliary drainage with self-expandable metal stents for malignant distal bile duct obstruction were enrolled,and allocated to ASA treatment or *** study outcomes were the rate of stent dysfunction at 6 months,duration of stent patency,risk factors for stent dysfunction,and any adverse ***:Interim analysis included 24 and 28 patients in the ASA and placebo groups,*** was no significant difference between the ASA and placebo groups in stent dysfunction(25.0%vs.20.7%,P=0.761)or the duration of stent patency(150.97±10.55 vs.158.07±8.70 days,P=0.497).Six patients experienced suspected ASA-related adverse events,and there was one lethal ***:ASA did not prolong stent *** study was terminated early because of the possibility of serious adverse events related to ASA treatment of these patients receiving palliative care.

关键词： Endoscopic retrograde cholangiopancreatography Self expandable metallic stents Randomized controlled trial Acetylsalicylic acid

Survival benefit of adjuvant treatment for ampullary cancer with lymph nodal involvement:A systematic review and meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2024年第6期23卷 559-565页

作者： Min Kyu Kim jin ho choi In Rae Cho Sang Hyub Lee Ji Kon Ryu Yong-Tae Kim Woo Hyun Paik Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Internal Medicine Liver Research InstituteSeoul National University HospitalSeoul National University College of MedicineSeoulKorea

Background:The efficacy of adjuvant treatment(AT)in ampullary cancer(AmC)remains *** systematic review and meta-analysis aimed to evaluate the role of AT for *** sources:A comprehensive systematic search was performed in PubMed,EMBASE,Cochrane Library,and Web of Science *** comparing overall survival(OS)and recurrence-free survival(RFS)of patients who underwent AT or not following AmC resection were ***:A total of 3971 patients in 21 studies were *** pooled data showed no significant difference in effect on the OS by AT[hazard ratio(HR)=0.998,95%confidence interval(CI):0.768–1.297].No significant difference in recurrence between the AT and non-AT(nAT)groups was noted(HR=1.158,95%CI:0.764–1.755).In subgroup analysis,patients who received AT showed favorable outcomes in the OS compared with those who received nAT in nodal-positive AmC(HR=0.627,95%CI:0.451–0.870).Neither AT consisted of adjuvant chemotherapy with radiotherapy(HR=0.804,95%CI:0.563–1.149)nor AT with adjuvant chemotherapy(HR=0.883,95%CI:0.642–1.214)showed any significant effect on the ***:The effect of AT in AmC on survival and recurrence did not show a significant ***,effectiveness according to AT strategies did not show enhancement in *** had an advantage in survival compared with nAT strategy in nodal-positive *** cases of AmC with positive lymph nodal involvement,AT may be warranted regardless of detailed strategies.

关键词： Ampulla of Vater Adjuvant chemotherapy Adjuvant chemoradiotherapy Meta-analysis

In-situ observations of novel single-atom thick 2D tin membranes embedded in graphene

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Nano Research 2021年第3期14卷 747-753页

作者： Xiaoqin Yang Huy Q.Ta Wei Li Rafael G.Mendes Yu Liu Qitao Shi Sami Ullah Alicja Bachmatiuk jinping Luo Lijun Liu jin-ho choi Mark H.Rummeli School of Energy and Power Engineering Xi’an Jiaotong UniversityNo.28Xianning West RoadXian710049China

There is ongoing research in freestanding single-atom thick elemental metal patches,including those suspended in a two-dimensional(2D)material,due to their utility in providing new structural and energetic insight into novel metallic 2D *** pores have shown promise as support systems for suspending such *** study explores the potential of Sn atoms to form freestanding stanene and/or Sn patches in graphene *** atoms were deposited on graphene,where they formed novel single-atom thick 2D planar clusters/patches(or membranes)ranging from 1 to 8 atoms within the graphene *** of three or more atoms adopted either a star-like or close-packed structural *** functional theory(DFT)calculations were conducted to look at the cluster configurations and energetics(without the graphene matrix)and were found to deviate from experimental observations for 2D patches larger than five *** was attributed to interfacial interactions between the graphene pore edges and Sn *** presented findings help advance the development of single-atom thick 2D elemental metal membranes.

关键词： in-situ transmission electron microscopy Sn atoms planar cluster graphene vacancy

Pattern of instent neointimal formation compared to native atherosclerosis in the coronary bifurcation lesions： volumetric intravascular ultrasound analysis

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Chinese Medical Journal 2013年第18期126卷 3505-3510页

作者： XU Jian-qiang Young Bin Song Joo-Yong Hahn Seung-Hyuk choi jin-ho choi LU Cheng-zhi Sang hoon Lee Kyung Pyo hong Jeung Euy Park Hyeon-Cheol Gwon Division of Cardiology Department of Medicine Samsung MedicalCenter Sungkyunkwan University School of Medicine Seoul Korea Cardiovascular CenterTianjin First Central hospital Tianjin 300192 China

Background No clinical study has systematically analyzed and compared circumferential neointimal and plaque distribution of stent neointimal proliferation and in native atherosclerotic plaques. This study aimed to investigate and compare the pattern of instent neointimal formation and native atherosclerosis in the coronary bifurcation lesions by volumetric analysis using systematic intravascular ultrasound （IVUS）. Methods We examined bifurcation lesions in native coronary artery （plaque group, n=102） and stented bifurcations at 9-month follow-up （neointima group, n=51） using volumetric IVUS analysis of both the main vessel （MV） and side branch （SB）. Three 5-mm segments were analyzed; the proximal MV （MVp）, distal MV （MVd） and SB ostium （SBo）. For each segment, volumetric analysis was performed in each of four quadrants （divided according to the branch takeoff and the geometric center of the lumen）; carinal, epicardial, abcarinal, and myocardial. The eccentricity index was defined as the ratio of the abcarinal plaque （or neointimal） volume to the carinal plaque （or neointimal） volume. Results The plaque distribution differed significantly between the four quadrants, with the largest in the abcarinal quadrant, followed by the myocardial, epicardial, and carinal quadrants. The distribution of neointima was similar in the MV, but the four quadrants in the SB did not differ significantly. The eccentricity indices of both the MVd （P 〈0.001） and SBo （P=-0.001） were significantly higher for the plaque group than the neointima group. Conclusions The distribution of neointimal proliferation seems to have a similar pattern to that of atherosclerotic plaque in native coronary arteries. Darticularlv in the main vessel, but the trend is less prominent.

关键词： atherosclerosis bifurcations plaque distribution neointimal distribution intravascular ultrasound

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碳纳米管提升氧化亚硅负极稳定性的起源

Science China Materials 2023年第9期66卷 3461-3467页

作者：周军华王佳琪施启涛连雪玉刘玉刘立军 Alicja Bachmatiuk 孙靖宇杨瑞枝 jin-ho choi Mark H.Rümmeli College of Energy Soochow Institute for Energy and Materials Innovations(SIEMIS)Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215006China School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an 710049China LUKASIEWICZ Research Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland Beijing Graphene Institute(BGI) Beijing 100095China Leibniz Institute for Solid State and Materials Research Dresden P.O.Box 270116D-01171 DresdenGermany Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie-Sklodowskiej 34Zabrze 41-819Poland Institute of Environmental Technology VSB-Technical University of Ostrava17.Listopadu 15Ostrava70833Czech Republic

高容量的SiO (SO)合金基材料是最有希望的下一代锂离子电池负极之一.使用碳纳米管(CNTs)导电添加剂,虽然可以有效地解决SO较差的循环寿命这一难题,然而除了动力学因素之外,其它潜在的作用机理目前仍不明确.在本工作中,一系列的测试结果... 详细信息

高容量的SiO (SO)合金基材料是最有希望的下一代锂离子电池负极之一.使用碳纳米管(CNTs)导电添加剂,虽然可以有效地解决SO较差的循环寿命这一难题,然而除了动力学因素之外,其它潜在的作用机理目前仍不明确.在本工作中,一系列的测试结果表明CNTs可以使电极在循环后依然维持完整的导电网络,确保均匀的电化学反应.CNTs也使得电极局部的体积膨胀得到了抑制,从而避免了固态电解质界面的不断生长,活性材料从集流体剥离,甚至析锂.得益于CNTs的上述作用, SO-CNTs负极在0.5 C (1 C=1600 mA g^(-1))下可以稳定循环200次,其容量保持率为96.2%. CNTs的作用机理也进一步地在商业化的SO/石墨复合负极(SO650-CNTs, 1 C=650 mA g^(-1))中得到了验证,SO650-CNTs在1 C下循环400次后容量保持率为80.6%.本工作为导电添加剂的作用机理提出了新的见解,并将有助于加速合金类负极的商业化进程.

关键词：导电添加剂固态电解质电化学反应动力学因素活性材料体积膨胀硅负极导电网络

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo jin Cho Xuelian jin Byung Gon Kim Jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration